Frequency of formation of chimeric molecules as a consequence of PCR coamplification of 16S rRNA genes from mixed bacterial genomes.

PubWeight™: 7.09‹?› | Rank: Top 1%

🔗 View Article (PMC 168786)

Published in Appl Environ Microbiol on December 01, 1997

Authors

G C Wang1, Y Wang

Author Affiliations

1: Institute of Molecular and Cell Biology, National University of Singapore, Singapore.

Articles citing this

UCHIME improves sensitivity and speed of chimera detection. Bioinformatics (2011) 29.22

Chimeric 16S rRNA sequence formation and detection in Sanger and 454-pyrosequenced PCR amplicons. Genome Res (2011) 17.21

16S ribosomal DNA sequence analysis of a large collection of environmental and clinical unidentifiable bacterial isolates. J Clin Microbiol (2000) 16.27

At least 1 in 20 16S rRNA sequence records currently held in public repositories is estimated to contain substantial anomalies. Appl Environ Microbiol (2005) 15.41

New screening software shows that most recent large 16S rRNA gene clone libraries contain chimeras. Appl Environ Microbiol (2006) 10.78

Heteroduplexes in mixed-template amplifications: formation, consequence and elimination by 'reconditioning PCR'. Nucleic Acids Res (2002) 6.07

PCR-induced sequence artifacts and bias: insights from comparison of two 16S rRNA clone libraries constructed from the same sample. Appl Environ Microbiol (2005) 5.97

Empirical and theoretical bacterial diversity in four Arizona soils. Appl Environ Microbiol (2002) 4.26

Culture-independent analysis of gut bacteria: the pig gastrointestinal tract microbiota revisited. Appl Environ Microbiol (2002) 4.26

Identification and characterization of IS2404 and IS2606: two distinct repeated sequences for detection of Mycobacterium ulcerans by PCR. J Clin Microbiol (1999) 3.96

Evaluation of PCR-generated chimeras, mutations, and heteroduplexes with 16S rRNA gene-based cloning. Appl Environ Microbiol (2001) 3.76

A new approach to utilize PCR-single-strand-conformation polymorphism for 16S rRNA gene-based microbial community analysis. Appl Environ Microbiol (1998) 3.01

Spatial and resource factors influencing high microbial diversity in soil. Appl Environ Microbiol (2002) 2.99

Microvariation artifacts introduced by PCR and cloning of closely related 16S rRNA gene sequences. Appl Environ Microbiol (2001) 2.68

The human vaginal bacterial biota and bacterial vaginosis. Interdiscip Perspect Infect Dis (2009) 2.56

Bacterial primary colonization and early succession on surfaces in marine waters as determined by amplified rRNA gene restriction analysis and sequence analysis of 16S rRNA genes. Appl Environ Microbiol (2000) 2.54

rpoB-based microbial community analysis avoids limitations inherent in 16S rRNA gene intraspecies heterogeneity. Appl Environ Microbiol (2000) 2.50

Rhizosphere microbial community structure in relation to root location and plant iron nutritional status. Appl Environ Microbiol (2000) 2.26

Archaeal population dynamics during sequential reduction processes in rice field soil. Appl Environ Microbiol (2000) 2.12

Host distributions of uncultivated fecal Bacteroidales bacteria reveal genetic markers for fecal source identification. Appl Environ Microbiol (2005) 2.06

PCR bias in ecological analysis: a case study for quantitative Taq nuclease assays in analyses of microbial communities. Appl Environ Microbiol (2000) 1.96

Polyphyly and gene flow between non-sibling Heliconius species. BMC Biol (2006) 1.92

cpnDB: a chaperonin sequence database. Genome Res (2004) 1.83

Quantitative community fingerprinting methods for estimating the abundance of operational taxonomic units in natural microbial communities. Appl Environ Microbiol (2009) 1.75

Sequence analysis of marine virus communities reveals that groups of related algal viruses are widely distributed in nature. Appl Environ Microbiol (2002) 1.46

Bacterial communities of two ubiquitous Great Barrier Reef corals reveals both site- and species-specificity of common bacterial associates. PLoS One (2010) 1.42

Quantitative tracing, by Taq nuclease assays, of a synechococcus ecotype in a highly diversified natural population. Appl Environ Microbiol (2002) 1.39

Microscopic examination of distribution and phenotypic properties of phylogenetically diverse Chloroflexaceae-related bacteria in hot spring microbial mats. Appl Environ Microbiol (2002) 1.30

Hybridization analysis of chesapeake bay virioplankton Appl Environ Microbiol (1999) 1.26

Extensive profiling of a complex microbial community by high-throughput sequencing. Appl Environ Microbiol (2002) 1.23

Novel electrochemically active bacterium phylogenetically related to Arcobacter butzleri, isolated from a microbial fuel cell. Appl Environ Microbiol (2009) 1.21

Impact of dilution on microbial community structure and functional potential: comparison of numerical simulations and batch culture experiments. Appl Environ Microbiol (2001) 1.18

Sequence diversity of the intergenic spacer region of the rRNA gene of Malassezia globosa colonizing the skin of patients with atopic dermatitis and healthy individuals. J Clin Microbiol (2003) 1.15

Evaluation of genetic diversity among Pseudomonas citronellolis strains isolated from oily sludge-contaminated sites. Appl Environ Microbiol (2003) 1.15

Coexistence of multiple proteobacterial endosymbionts in the gills of the wood-boring Bivalve Lyrodus pedicellatus (Bivalvia: Teredinidae). Appl Environ Microbiol (2002) 1.10

Comparison of ileum microflora of pigs fed corn-, wheat-, or barley-based diets by chaperonin-60 sequencing and quantitative PCR. Appl Environ Microbiol (2005) 1.10

Diversity and heterogeneity of epibiotic bacterial communities on the marine nematode Eubostrichus dianae. Appl Environ Microbiol (1999) 1.09

Bacterial community composition in Central European running waters examined by temperature gradient gel electrophoresis and sequence analysis of 16S rRNA genes. Appl Environ Microbiol (2007) 1.06

Phylogenetic analysis of bacterial communities associated with ectoparasitic chewing lice of pocket gophers: a culture-independent approach. Microb Ecol (2002) 1.06

Identification of some charcoal-black-pigmented CDC fermentative coryneform group 4 isolates as Rothia dentocariosa and some as Corynebacterium aurimucosum: proposal of Rothia dentocariosa emend. Georg and Brown 1967, Corynebacterium aurimucosum emend. Yassin et al. 2002, and Corynebacterium nigricans Shukla et al. 2003 pro synon. Corynebacterium aurimucosum. J Clin Microbiol (2004) 1.04

Modeling bacterial species abundance from small community surveys. Microb Ecol (2003) 1.02

Fast evolving 18S rRNA sequences from Solenogastres (Mollusca) resist standard PCR amplification and give new insights into mollusk substitution rate heterogeneity. BMC Evol Biol (2010) 0.99

Sample richness and genetic diversity as drivers of chimera formation in nSSU metagenetic analyses. Nucleic Acids Res (2012) 0.98

Microbial community profiling of human saliva using shotgun metagenomic sequencing. PLoS One (2014) 0.98

Complete genome sequence of Leptospirillum ferrooxidans strain C2-3, isolated from a fresh volcanic ash deposit on the island of Miyake, Japan. J Bacteriol (2012) 0.96

Archaeal diversity at the great salt plains of Oklahoma described by cultivation and molecular analyses. Microb Ecol (2009) 0.95

Impact of colonoscopy bowel preparation on intestinal microbiota. PLoS One (2013) 0.95

Bacterial population changes in a membrane bioreactor for graywater treatment monitored by denaturing gradient gel electrophoretic analysis of 16S rRNA gene fragments. Appl Environ Microbiol (2003) 0.94

Bacterial diversity in faeces from polar bear (Ursus maritimus) in Arctic Svalbard. BMC Microbiol (2010) 0.94

Fine analysis of genetic diversity of the tpr gene family among treponemal species, subspecies and strains. PLoS Negl Trop Dis (2013) 0.93

Ecological characterisation of the colonic microbiota in arctic and sub-arctic seals. Microb Ecol (2010) 0.89

Suicide polymerase endonuclease restriction, a novel technique for enhancing PCR amplification of minor DNA templates. Appl Environ Microbiol (2005) 0.87

Genetically distinct populations of the dinoflagellate Peridinium limbatum in neighboring Northern Wisconsin lakes. Microb Ecol (2004) 0.87

Pitfalls of haplotype phasing from amplicon-based long-read sequencing. Sci Rep (2016) 0.84

Allelic differences within and among sister spores of the arbuscular mycorrhizal fungus Glomus etunicatum suggest segregation at sporulation. PLoS One (2013) 0.84

Borrelia burgdorferi erp (ospE-related) gene sequences remain stable during mammalian infection. Infect Immun (2002) 0.84

Heteroplasmy suggests paternal co-transmission of multiple genomes and pervasive reversion of maternally into paternally transmitted genomes of mussel (Mytilus) mitochondrial DNA. J Mol Evol (2003) 0.82

The nature and frequency of chimeras in eukaryotic metagenetic samples. J Nematol (2012) 0.81

Studying genome heterogeneity within the arbuscular mycorrhizal fungal cytoplasm. Genome Biol Evol (2015) 0.80

Use of PCR-DGGE Based Molecular Methods to Analyse Microbial Community Diversity and Stability during the Thermophilic Stages of an ATAD Wastewater Sludge Treatment Process as an Aid to Performance Monitoring. ISRN Biotechnol (2013) 0.80

Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen. Cancer Lett (2014) 0.79

Validation of the PLEX-ID™ mass spectrometry mitochondrial DNA assay. Int J Legal Med (2012) 0.79

Preferential access to genetic information from endogenous hominin ancient DNA and accurate quantitative SNP-typing via SPEX. Nucleic Acids Res (2009) 0.79

Considerations For Optimizing Microbiome Analysis Using a Marker Gene. Front Nutr (2016) 0.77

CATCh, an ensemble classifier for chimera detection in 16S rRNA sequencing studies. Appl Environ Microbiol (2014) 0.77

Long term effect of methylparathion contamination on soil microbial community diversity estimated by 16S rRNA gene cloning. Ecotoxicology (2006) 0.75

Examining Sources of Error in PCR by Single-Molecule Sequencing. PLoS One (2017) 0.75

Analysis of RecA-independent recombination events between short direct repeats related to a genomic island and to a plasmid in Escherichia coli K12. PeerJ (2017) 0.75

Phylogenetic profiling of bacterial community from two intimately located sites in Balramgari, North-East coast of India. Indian J Microbiol (2009) 0.75

It Is Imperative to Establish a Pellucid Definition of Chimeric RNA and to Clear Up a Lot of Confusion in the Relevant Research. Int J Mol Sci (2017) 0.75

Articles cited by this

Phylogenetic identification and in situ detection of individual microbial cells without cultivation. Microbiol Rev (1995) 62.96

Genetic diversity in Sargasso Sea bacterioplankton. Nature (1990) 35.15

Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli. J Mol Biol (1981) 29.04

16S rRNA sequences reveal numerous uncultured microorganisms in a natural community. Nature (1990) 26.48

Bias caused by template annealing in the amplification of mixtures of 16S rRNA genes by PCR. Appl Environ Microbiol (1996) 20.84

The ribosomal database project. Nucleic Acids Res (1993) 17.20

Differential amplification of rRNA genes by polymerase chain reaction. Appl Environ Microbiol (1992) 14.96

Remarkable archaeal diversity detected in a Yellowstone National Park hot spring environment. Proc Natl Acad Sci U S A (1994) 11.41

Recognition of chimeric small-subunit ribosomal DNAs composed of genes from uncultivated microorganisms. Appl Environ Microbiol (1994) 8.26

The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species. Microbiology (1996) 7.78

Perspectives on archaeal diversity, thermophily and monophyly from environmental rRNA sequences. Proc Natl Acad Sci U S A (1996) 7.17

DNA damage promotes jumping between templates during enzymatic amplification. J Biol Chem (1990) 6.59

Bacterial diversity among small-subunit rRNA gene clones and cellular isolates from the same seawater sample. Appl Environ Microbiol (1997) 6.20

16S rRNA sequences of uncultivated hot spring cyanobacterial mat inhabitants retrieved as randomly primed cDNA. Appl Environ Microbiol (1991) 5.81

Intraspecific variation in small-subunit rRNA sequences in GenBank: why single sequences may not adequately represent prokaryotic taxa. Int J Syst Bacteriol (1995) 5.66

Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive periodontitis. Infect Immun (1994) 4.28

Effect of PCR template concentration on the composition and distribution of total community 16S rDNA clone libraries. Mol Ecol (1997) 3.78

Evaluation of nearest-neighbor methods for detection of chimeric small-subunit rRNA sequences. Appl Environ Microbiol (1995) 3.39

A new computational method for detection of chimeric 16S rRNA artifacts generated by PCR amplification from mixed bacterial populations. Appl Environ Microbiol (1997) 3.02

The actinomycete Thermobispora bispora contains two distinct types of transcriptionally active 16S rRNA genes. J Bacteriol (1997) 2.96

Wide diversity of Crenarchaeota. Nature (1996) 2.84

Amplification of DNA from native populations of soil bacteria by using the polymerase chain reaction. Appl Environ Microbiol (1992) 2.73

General method for amplifying regions of very high G+C content. Nucleic Acids Res (1993) 2.68

The impact of the PCR plateau phase on quantitative PCR. Biochim Biophys Acta (1994) 2.60

Biodiversity as a source of innovation in biotechnology. Annu Rev Microbiol (1992) 2.11

Gene organization and primary structure of a ribosomal RNA gene cluster from Streptomyces griseus subsp. griseus. Gene (1993) 1.18

A proposal to transfer Microbispora bispora (Lechevalier 1965) to a new genus, Thermobispora gen. nov., as Thermobispora bispora comb. nov. Int J Syst Bacteriol (1996) 1.14

Articles by these authors

(truncated to the top 100)

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet (2005) 24.57

Gene transfer into mouse lyoma cells by electroporation in high electric fields. EMBO J (1982) 17.98

Complete genome sequence of Methanobacterium thermoautotrophicum deltaH: functional analysis and comparative genomics. J Bacteriol (1997) 12.21

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54

Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet (2011) 9.20

The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12.4 years. Diabetes Care (1999) 9.16

WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00

Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med (2000) 8.47

Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet (2014) 8.04

Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science (1997) 7.95

The frequency of chimeric molecules as a consequence of PCR co-amplification of 16S rRNA genes from different bacterial species. Microbiology (1996) 7.78

Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron (1996) 7.20

A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature (1996) 7.04

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science (1999) 6.93

TFAR19, a novel apoptosis-related gene cloned from human leukemia cell line TF-1, could enhance apoptosis of some tumor cells induced by growth factor withdrawal. Biochem Biophys Res Commun (1999) 6.33

Effects of prenatal and postnatal methylmercury exposure from fish consumption on neurodevelopment: outcomes at 66 months of age in the Seychelles Child Development Study. JAMA (1998) 6.30

Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med (1997) 5.93

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation. Proc Natl Acad Sci U S A (1992) 5.60

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA. Chem Biol (1997) 5.49

Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice. Science (1992) 5.46

Blood transfusion in elderly patients with acute myocardial infarction. N Engl J Med (2001) 5.43

IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs. Cancer Res (1998) 5.41

Genetic diversity and disease control in rice. Nature (2000) 5.34

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function. Nat Cell Biol (2000) 5.29

Racial differences in the use of cardiac catheterization after acute myocardial infarction. N Engl J Med (2001) 5.29

Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science (2000) 5.27

Differential signaling via the same axon of neocortical pyramidal neurons. Proc Natl Acad Sci U S A (1998) 4.59

POWER_SAGE: comparing statistical tests for SAGE experiments. Bioinformatics (2000) 4.56

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci (2001) 4.54

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45

Do "America's Best Hospitals" perform better for acute myocardial infarction? N Engl J Med (1999) 4.30

Fringe is a glycosyltransferase that modifies Notch. Nature (2000) 4.09

Broadly protective vaccine for Staphylococcus aureus based on an in vivo-expressed antigen. Science (1999) 4.08

Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. Proc Natl Acad Sci U S A (1994) 3.85

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A (1996) 3.78

Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet (1997) 3.69

The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Neuron (2001) 3.68

Signal timing across the macaque visual system. J Neurophysiol (1998) 3.66

The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells. Proc Natl Acad Sci U S A (1999) 3.53

Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Genet (2004) 3.45

The ica locus of Staphylococcus epidermidis encodes production of the capsular polysaccharide/adhesin. Infect Immun (1998) 3.44

Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell (1994) 3.41

Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci U S A (2001) 3.41

A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature (1999) 3.40

Midzone microtubule bundles are continuously required for cytokinesis in cultured epithelial cells. J Cell Biol (1996) 3.36

Criteria and recommendations for vitamin C intake. JAMA (1999) 3.32

Wildtype Kras2 can inhibit lung carcinogenesis in mice. Nat Genet (2001) 3.27

Male fertility potential in terms of semen quality: a review of the past, a study of the present. Fertil Steril (1979) 3.19

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3. J Biol Chem (1987) 3.19

The rate-pressure product as an index of myocardial oxygen consumption during exercise in patients with angina pectoris. Circulation (1978) 3.19

Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol In Vitro (2014) 3.10

Renoprotective role of the vitamin D receptor in diabetic nephropathy. Kidney Int (2007) 3.06

Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. Proc Natl Acad Sci U S A (1998) 3.05

Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci (2000) 3.00

Changes in reliability of synaptic function as a mechanism for plasticity. Nature (1994) 2.97

Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nat Med (1996) 2.96

Facilitation and depression at single central synapses. Neuron (1995) 2.95

Vam3p structure reveals conserved and divergent properties of syntaxins. Nat Struct Biol (2001) 2.92

Effectiveness of laser therapy and topical desensitising agents in treating dentine hypersensitivity: a systematic review. J Oral Rehabil (2011) 2.91

Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr (2010) 2.91

A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science (1997) 2.90

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem (2000) 2.89

Coronectomy vs. total removal for third molar extraction: a systematic review. J Dent Res (2012) 2.84

Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release (2001) 2.84

Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J Cell Sci (2001) 2.76

Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. Nat Genet (2001) 2.75

Distinct types of rRNA operons exist in the genome of the actinomycete Thermomonospora chromogena and evidence for horizontal transfer of an entire rRNA operon. J Bacteriol (1999) 2.72

Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J (2000) 2.71

National use and effectiveness of beta-blockers for the treatment of elderly patients after acute myocardial infarction: National Cooperative Cardiovascular Project. JAMA (1998) 2.70

A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res (1999) 2.69

Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med (1998) 2.69

Feasibility of a high-speed gamma-camera design using the high-yield-pileup-event-recovery method. J Nucl Med (2001) 2.69

A high-affinity iron permease essential for Candida albicans virulence. Science (2000) 2.68

Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell (1999) 2.68

Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proc Natl Acad Sci U S A (1998) 2.68

Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. J Clin Invest (1995) 2.65

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis. Obes Rev (2008) 2.62

In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B. Cancer Res (2001) 2.62

Genome-wide identification of NBS genes in japonica rice reveals significant expansion of divergent non-TIR NBS-LRR genes. Mol Genet Genomics (2004) 2.56

Biology and action of colony--stimulating factor-1. Mol Reprod Dev (1997) 2.52

The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis. Cancer Res (2001) 2.51

Malignant transformation in a nontumorigenic human prostatic epithelial cell line. Cancer Res (2001) 2.50

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci U S A (1997) 2.50

Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene (2009) 2.49

Utility of the lethargic (lh/lh) mouse model of absence seizures in predicting the effects of lamotrigine, vigabatrin, tiagabine, gabapentin, and topiramate against human absence seizures. Epilepsia (1997) 2.48

A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nat Genet (1998) 2.48

Pattern-mixture models for multivariate incomplete data with covariates. Biometrics (1996) 2.47

Predominant role for C5b-9 in renal ischemia/reperfusion injury. J Clin Invest (2000) 2.45

Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem (2000) 2.43

Mutations in the glucocerebrosidase gene are associated with early-onset Parkinson disease. Neurology (2007) 2.41

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature (1992) 2.39

Pattern of marine mass extinction near the Permian-Triassic boundary in South China. Science (2000) 2.38

Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Cancer Res (2001) 2.37

The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A (2001) 2.36

MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol (2001) 2.33

Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell (2001) 2.33

Essential role for Gab2 in the allergic response. Nature (2001) 2.32

B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion. J Exp Med (1998) 2.32

The role of Fas in autoimmune diabetes. Cell (1997) 2.30