Published in Nat Immunol on November 01, 2001
Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94
Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med (2005) 2.08
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A (2008) 1.85
Checkpoints in lymphocyte development and autoimmune disease. Nat Immunol (2009) 1.84
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. J Clin Invest (2003) 1.80
A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice. J Exp Med (2003) 1.62
Dominant role of antigen dose in CD4+Foxp3+ regulatory T cell induction and expansion. J Immunol (2009) 1.59
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J Exp Med (2002) 1.58
How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A (2005) 1.55
Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy (2009) 1.53
Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest (2006) 1.52
Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.51
Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med (2003) 1.39
Cellular FLICE-inhibitory protein: an attractive therapeutic target? Expert Opin Ther Targets (2003) 1.21
Qualitative and quantitative abnormalities in splenic dendritic cell populations in NOD mice. Clin Exp Immunol (2004) 1.18
Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. Proc Natl Acad Sci U S A (2004) 1.17
RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes. J Exp Med (2008) 1.14
Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus. BMC Immunol (2003) 1.13
Langerhans cells are not required for the CD8 T cell response to epidermal self-antigens. J Immunol (2009) 1.12
In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists. Infect Immun (2004) 1.11
Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in mice. Diabetes (2008) 1.07
B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice. J Immunol (2004) 1.05
Nasal administration of CTB-insulin induces active tolerance against autoimmune diabetes in non-obese diabetic (NOD) mice. Clin Exp Immunol (2002) 1.05
Do the peptide-binding properties of diabetogenic class II molecules explain autoreactivity? Curr Opin Immunol (2007) 1.03
Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes (2008) 1.01
Thymic negative selection is functional in NOD mice. J Exp Med (2012) 1.00
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Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. J Exp Med (2009) 0.93
B cells in autoimmune diabetes. Rev Diabet Stud (2005) 0.93
Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells. Diabetes (2010) 0.91
Dendritic cell-targeted pancreatic beta-cell antigen leads to conversion of self-reactive CD4(+) T cells into regulatory T cells and promotes immunotolerance in NOD mice. Rev Diabet Stud (2010) 0.89
Forced IDO1 expression in dendritic cells restores immunoregulatory signalling in autoimmune diabetes. J Cell Mol Med (2014) 0.87
Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes. PLoS One (2012) 0.87
Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice. J Clin Invest (2011) 0.86
APC activation restores functional CD4(+)CD25(+) regulatory T cells in NOD mice that can prevent diabetes development. PLoS One (2008) 0.86
Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner. J Immunol (2013) 0.86
Death pathways in T cell homeostasis and their role in autoimmune diabetes. Rev Diabet Stud (2006) 0.85
Double negative (CD3+ 4- 8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetes. PLoS One (2010) 0.85
Role of caspase-8 in thymus function. Cell Death Differ (2013) 0.85
Up-regulation of fas and fasL pro-apoptotic genes expression in type 1 diabetes patients after autologous haematopoietic stem cell transplantation. Clin Exp Immunol (2012) 0.84
Elevated CXCL12 expression in the bone marrow of NOD mice is associated with altered T cell and stem cell trafficking and diabetes development. BMC Immunol (2008) 0.84
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity. Vaccines (Basel) (2015) 0.83
Programming of neuroendocrine self in the thymus and its defect in the development of neuroendocrine autoimmunity. Front Neurosci (2013) 0.83
Hydrophobic CDR3 residues promote the development of self-reactive T cells. Nat Immunol (2016) 0.81
Induction of mixed chimerism with MHC-mismatched but not matched bone marrow transplants results in thymic deletion of host-type autoreactive T-cells in NOD mice. Diabetes (2011) 0.81
Nonobese diabetic CD4 lymphocytosis maps outside the MHC locus on chromosome 17. Immunogenetics (2004) 0.81
The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice. PLoS One (2012) 0.80
Complete diabetes protection despite delayed thymic tolerance in NOD8.3 TCR transgenic mice due to antigen-induced extrathymic deletion of T cells. Diabetes (2011) 0.80
Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. PLoS One (2011) 0.80
Efficient T cell receptor-mediated apoptosis in nonobese diabetic mouse thymocytes. Nat Immunol (2003) 0.80
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How Does Thymus Infection by Coxsackievirus Contribute to the Pathogenesis of Type 1 Diabetes? Front Immunol (2015) 0.79
Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice. Eur J Immunol (2008) 0.78
Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice. J Immunol (2010) 0.78
Antigen-Experienced CD4lo T Cells Are Linked to Deficient Contraction of the Immune Response in Autoimmune Diabetes. Autoimmune Dis (2010) 0.77
T-helper cell tolerance to ubiquitous nuclear antigens. Scand J Immunol (2003) 0.76
Mechanisms of autoimmunity in the non-obese diabetic mouse: effector/regulatory cell equilibrium during peak inflammation. Immunology (2016) 0.76
Gene therapy for type 1 diabetes: a novel approach for targeted treatment of autoimmunity. J Clin Invest (2004) 0.75
Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPα(+) DC function. Eur J Immunol (2016) 0.75
Thymocyte development in the absence of matrix metalloproteinase-9/gelatinase B. Sci Rep (2016) 0.75
Reduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome. PLoS One (2014) 0.75
Of the multiple mechanisms leading to type 1 diabetes, T cell receptor revision may play a prominent role (is type 1 diabetes more than a single disease?). Clin Exp Immunol (2016) 0.75
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