Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design.

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Published in J Med Chem on December 20, 2001

Authors

P D Greenspan1, K L Clark, R A Tommasi, S D Cowen, L W McQuire, D L Farley, J H van Duzer, R L Goldberg, H Zhou, Z Du, J J Fitt, D E Coppa, Z Fang, W Macchia, L Zhu, M P Capparelli, R Goldstein, A M Wigg, J R Doughty, R S Bohacek, A K Knap

Author Affiliations

1: Arthritis and Bone Metabolism Research, Novartis Pharmaceuticals Corporation, 556 Morris Avenue, Summit, New Jersey 07901, USA. paul.greenspan@pharma.novartis.com

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