Published in J Biol Chem on December 11, 2001
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci U S A (2003) 2.32
Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc Natl Acad Sci U S A (2007) 2.10
Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol (2004) 1.91
Antimicrobial characterization of human beta-defensin 3 derivatives. Antimicrob Agents Chemother (2003) 1.63
Toll-like receptor 2-mediated expression of beta-defensin-2 in human corneal epithelial cells. Microbes Infect (2005) 1.62
Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci. Infect Immun (2010) 1.48
Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle. Clin Diagn Lab Immunol (2004) 1.47
Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. Infect Immun (2002) 1.40
Duplication and selection in the evolution of primate beta-defensin genes. Genome Biol (2003) 1.37
beta-Defensin-3 and -4 in intestinal epithelial cells display increased mRNA expression in ulcerative colitis. Clin Exp Immunol (2004) 1.35
The role of antimicrobial peptides at the ocular surface. Ophthalmic Res (2008) 1.32
Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. Eur J Immunol (2011) 1.27
Human antimicrobial peptides and proteins. Pharmaceuticals (Basel) (2014) 1.23
Antiviral mechanisms of human defensins. J Mol Biol (2013) 1.22
A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia. Hum Mutat (2011) 1.21
Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption. Antimicrob Agents Chemother (2006) 1.16
Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity. Antimicrob Agents Chemother (2010) 1.14
Trp-26 imparts functional versatility to human alpha-defensin HNP1. J Biol Chem (2010) 1.12
Wall teichoic acid deficiency in Staphylococcus aureus confers selective resistance to mammalian group IIA phospholipase A(2) and human beta-defensin 3. Infect Immun (2008) 1.07
Ocular surface expression and in vitro activity of antimicrobial peptides. Curr Eye Res (2007) 1.06
Antimicrobial actions of the human epididymis 2 (HE2) protein isoforms, HE2alpha, HE2beta1 and HE2beta2. Reprod Biol Endocrinol (2004) 1.04
The complexity of selection at the major primate beta-defensin locus. BMC Evol Biol (2005) 1.02
The interaction of streptococcal inhibitor of complement (SIC) and its proteolytic fragments with the human beta defensins. Immunology (2004) 1.01
Defensins and other antimicrobial peptides at the ocular surface. Ocul Surf (2004) 1.00
A folding-dependent mechanism of antimicrobial peptide resistance to degradation unveiled by solution structure of distinctin. Proc Natl Acad Sci U S A (2005) 0.96
Dimerization of plant defensin NaD1 enhances its antifungal activity. J Biol Chem (2012) 0.96
Protein conformational changes studied by diffusion NMR spectroscopy: application to helix-loop-helix calcium binding proteins. Protein Sci (2003) 0.95
The antimicrobial activity of CCL28 is dependent on C-terminal positively-charged amino acids. Eur J Immunol (2010) 0.94
NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5. Biochemistry (2012) 0.94
A study of host defence peptide beta-defensin 3 in primates. Biochem J (2003) 0.94
Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution. J Biol Chem (2010) 0.92
The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis. Mol Cell Biol (2015) 0.89
Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function. PLoS One (2013) 0.87
Human macrophage inflammatory protein 3alpha: protein and peptide nuclear magnetic resonance solution structures, dimerization, dynamics, and anti-infective properties. Antimicrob Agents Chemother (2007) 0.87
Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation. Oncotarget (2016) 0.86
Membrane damage and repair in primary monocytes exposed to human β-defensin-3. J Leukoc Biol (2012) 0.86
Peptides and Peptidomimetics for Antimicrobial Drug Design. Pharmaceuticals (Basel) (2015) 0.85
Mechanisms of decreased susceptibility to beta-defensins by Treponema denticola. Infect Immun (2007) 0.85
Molecular and functional analysis of human β-defensin 3 action at melanocortin receptors. Chem Biol (2013) 0.85
Decreased susceptibility of Staphylococcus aureus small-colony variants toward human antimicrobial peptides. J Invest Dermatol (2014) 0.84
A 15-amino acid C-terminal peptide of beta-defensin-3 inhibits bone resorption by inhibiting the osteoclast differentiation and disrupting podosome belt formation. J Mol Med (Berl) (2017) 0.83
Immunology: Peptide gets in shape for self-defence. Nature (2011) 0.81
Membrane disruptive antimicrobial activities of human β-defensin-3 analogs. Eur J Med Chem (2014) 0.81
Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and Pathways. PLoS One (2015) 0.80
An evolutionary history of defensins: a role for copy number variation in maximizing host innate and adaptive immune responses. Front Immunol (2015) 0.80
Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus. Acta Crystallogr D Biol Crystallogr (2013) 0.80
Molecular cloning and characterization of three beta-defensins from canine testes. Infect Immun (2005) 0.80
Tissue expression and developmental regulation of chicken cathelicidin antimicrobial peptides. J Anim Sci Biotechnol (2012) 0.80
Increased human defensine levels hint at an inflammatory etiology of bisphosphonate-associated osteonecrosis of the jaw: an immunohistological study. J Transl Med (2011) 0.80
Progressive structuring of a branched antimicrobial peptide on the path to the inner membrane target. J Biol Chem (2012) 0.79
Modelling study of dimerization in mammalian defensins. BMC Bioinformatics (2006) 0.79
Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins. PLoS One (2013) 0.78
NMR structure of temporin-1 ta in lipopolysaccharide micelles: mechanistic insight into inactivation by outer membrane. PLoS One (2013) 0.78
Peptide fragments of a beta-defensin derivative with potent bactericidal activity. Antimicrob Agents Chemother (2010) 0.78
Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool. Int J Nanomedicine (2015) 0.78
The Role of Human Beta-Defensin-2 in Pseudomonas aeruginosa Pulmonary Infection in Cystic Fibrosis Patients. Infect Dis Ther (2013) 0.77
Antifungal effects of synthetic human β-defensin 3-C15 peptide. Restor Dent Endod (2016) 0.77
Expression and new exon mutations of the human Beta defensins and their association on colon cancer development. PLoS One (2015) 0.77
Purification, crystallization and preliminary X-ray diffraction analysis of crotamine, a myotoxic polypeptide from the Brazilian snake Crotalus durissus terrificus. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
N-terminus three residues deletion mutant of human beta-defensin 3 with remarkably enhanced salt-resistance. PLoS One (2015) 0.77
Characterization of the antimicrobial peptide family defensins in the Tasmanian devil (Sarcophilus harrisii), koala (Phascolarctos cinereus), and tammar wallaby (Macropus eugenii). Immunogenetics (2016) 0.77
An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule. Sci Rep (2015) 0.77
Structure of human MIP-3alpha chemokine. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.76
Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 3. J Biol Chem (2012) 0.76
Electrostatic Similarity Analysis of Human β-Defensin Binding in the Melanocortin System. Biophys J (2015) 0.76
In-silico homology modeling of three isoforms of insect defensins from the dengue vector mosquito, Aedes aegypti (Linn., 1762). J Mol Model (2008) 0.76
Rattusin structure reveals a novel defensin scaffold formed by intermolecular disulfide exchanges. Sci Rep (2017) 0.75
Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum. Sci Rep (2017) 0.75
Activation of Molecular Signatures for Antimicrobial and Innate Defense Responses in Skin with Transglutaminase 1 Deficiency. PLoS One (2016) 0.75
Human β-defensin 4 with non-native disulfide bridges exhibit antimicrobial activity. PLoS One (2015) 0.75
The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity. PLoS One (2016) 0.75
Variations in the interaction of human defensins with Escherichia coli: Possible implications in bacterial killing. PLoS One (2017) 0.75
Structural perspectives on antimicrobial chemokines. Front Immunol (2012) 0.75
The synthetic human beta-defensin-3 C15 peptide exhibits antimicrobial activity against Streptococcus mutans, both alone and in combination with dental disinfectants. J Microbiol (2017) 0.75
HMDB: the Human Metabolome Database. Nucleic Acids Res (2007) 13.38
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell (2008) 11.24
HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res (2008) 11.23
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science (2008) 6.28
Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs. Biochem J (2007) 3.69
Current prospects for RNA interference-based therapies. Nat Rev Genet (2011) 3.63
Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth. Sci Transl Med (2010) 3.36
Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock. Crit Care Med (2014) 2.97
Adherens junction protein nectin-4 is the epithelial receptor for measles virus. Nature (2011) 2.94
Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung. Nature (2012) 2.94
A novel host defense system of airways is defective in cystic fibrosis. Am J Respir Crit Care Med (2006) 2.61
Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A (2002) 2.56
The porcine lung as a potential model for cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 2.53
Cytokine-mediated regulation of antimicrobial proteins. Nat Rev Immunol (2008) 2.46
The expanding scope of antimicrobial peptide structures and their modes of action. Trends Biotechnol (2011) 2.35
Pseudomonas aeruginosa rugose small-colony variants have adaptations that likely promote persistence in the cystic fibrosis lung. J Bacteriol (2009) 2.22
Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed. J Clin Invest (2008) 2.21
Rapid generation of a mouse model for Middle East respiratory syndrome. Proc Natl Acad Sci U S A (2014) 2.17
Calmodulin's flexibility allows for promiscuity in its interactions with target proteins and peptides. Mol Biotechnol (2004) 2.14
Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med (2013) 2.14
Tryptophan- and arginine-rich antimicrobial peptides: structures and mechanisms of action. Biochim Biophys Acta (2006) 2.14
T-cell immunoglobulin and mucin domain 1 (TIM-1) is a receptor for Zaire Ebolavirus and Lake Victoria Marburgvirus. Proc Natl Acad Sci U S A (2011) 2.12
The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs. Sci Transl Med (2011) 2.01
Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children. Am J Respir Crit Care Med (2010) 1.94
Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events. J Virol (2007) 1.93
Human beta-defensins 2 and 3 demonstrate strain-selective activity against oral microorganisms. J Clin Microbiol (2004) 1.91
Correlation between beta-defensin expression and induction profiles in gingival keratinocytes. Mol Immunol (2004) 1.90
Structural biology of bacterial iron uptake. Biochim Biophys Acta (2007) 1.90
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem (2002) 1.89
Antimicrobial peptides in animals and their role in host defences. Int J Antimicrob Agents (2003) 1.84
[beta]-defensins in lung host defense. Annu Rev Physiol (2002) 1.80
Current understanding of fatty acid biosynthesis and the acyl carrier protein. Biochem J (2010) 1.66
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2. Am J Physiol Lung Cell Mol Physiol (2004) 1.64
The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol (2010) 1.61
Innate immune functions of the airway epithelium. Contrib Microbiol (2008) 1.57
Haemophilus influenzae forms biofilms on airway epithelia: implications in cystic fibrosis. Am J Respir Crit Care Med (2006) 1.56
Feasibility of identifying pancreatic cancer based on serum metabolomics. Cancer Epidemiol Biomarkers Prev (2010) 1.51
Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol (2005) 1.49
Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc (2011) 1.48
miR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production. Am J Respir Crit Care Med (2014) 1.45
Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha. J Virol (2003) 1.45
PLUNC is a novel airway surfactant protein with anti-biofilm activity. PLoS One (2010) 1.44
Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits. Proc Natl Acad Sci U S A (2002) 1.41
Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. Infect Immun (2002) 1.40
Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. PLoS One (2010) 1.38
piggyBac transposase tools for genome engineering. Proc Natl Acad Sci U S A (2013) 1.35
Haemophilus influenzae from patients with chronic obstructive pulmonary disease exacerbation induce more inflammation than colonizers. Am J Respir Crit Care Med (2005) 1.34
An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy. J Proteome Res (2007) 1.34
TonB or not TonB: is that the question? Biochem Cell Biol (2011) 1.32
TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol (2005) 1.31
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest (2013) 1.30
CCL20 is an inducible product of human airway epithelia with innate immune properties. Am J Respir Cell Mol Biol (2003) 1.28
Tryptophan-rich antimicrobial peptides: comparative properties and membrane interactions. Biochem Cell Biol (2002) 1.26
Siderophore uptake in bacteria and the battle for iron with the host; a bird's eye view. Biometals (2010) 1.26
Structural basis for simultaneous binding of two carboxy-terminal peptides of plant glutamate decarboxylase to calmodulin. J Mol Biol (2003) 1.26
Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection. J Virol (2014) 1.25
Inactivation of human beta-defensins 2 and 3 by elastolytic cathepsins. J Immunol (2003) 1.24
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22
Quantitative metabolomic profiling of serum, plasma, and urine by (1)H NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals. J Proteome Res (2012) 1.21
Killing of African trypanosomes by antimicrobial peptides. J Infect Dis (2003) 1.21
Integration site choice of a feline immunodeficiency virus vector. J Virol (2006) 1.20
Rho GTPases modulate entry of Ebola virus and vesicular stomatitis virus pseudotyped vectors. J Virol (2009) 1.20
X-ray crystallographic structures of the Escherichia coli periplasmic protein FhuD bound to hydroxamate-type siderophores and the antibiotic albomycin. J Biol Chem (2002) 1.20
Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia. J Virol (2002) 1.18
The solution structure of the C-terminal domain of TonB and interaction studies with TonB box peptides. J Mol Biol (2004) 1.18
Persistent gene expression in mouse nasal epithelia following feline immunodeficiency virus-based vector gene transfer. J Virol (2005) 1.18
Expression and activity of beta-defensins and LL-37 in the developing human lung. J Immunol (2005) 1.17
Protein-peptide interaction studies demonstrate the versatility of calmodulin target protein binding. Protein Pept Lett (2006) 1.17
In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins. J Virol (2002) 1.16
Interactions of the designed antimicrobial peptide MB21 and truncated dermaseptin S3 with lipid bilayers: molecular-dynamics simulations. Biochem J (2003) 1.15
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. J Virol (2009) 1.15
Persistent expression of factor VIII in vivo following nonprimate lentiviral gene transfer. Blood (2005) 1.14
ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol (2005) 1.14
Impact of single-residue mutations on the structure and function of ovispirin/novispirin antimicrobial peptides. Protein Eng (2002) 1.14
Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures. BMC Plant Biol (2008) 1.14
PLUNC is a secreted product of neutrophil granules. J Leukoc Biol (2008) 1.13
Nuclear magnetic resonance solution structure of the periplasmic signalling domain of the TonB-dependent outer membrane transporter FecA from Escherichia coli. Mol Microbiol (2005) 1.13
Metal ion binding properties and conformational states of calcium- and integrin-binding protein. Biochemistry (2004) 1.12
Expression of beta-defensins in gingival health and in periodontal disease. J Oral Pathol Med (2004) 1.12
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proc Natl Acad Sci U S A (2010) 1.12
MD-2-dependent pulmonary immune responses to inhaled lipooligosaccharides: effect of acylation state. Am J Respir Cell Mol Biol (2008) 1.11
A microRNA-regulated and GP64-pseudotyped lentiviral vector mediates stable expression of FVIII in a murine model of Hemophilia A. Mol Ther (2011) 1.11
Activity of novispirin G10 against Pseudomonas aeruginosa in vitro and in infected burns. Antimicrob Agents Chemother (2002) 1.11
Quantitative metabolomic profiling of serum and urine in DSS-induced ulcerative colitis of mice by (1)H NMR spectroscopy. J Proteome Res (2010) 1.10
The interactions of antimicrobial peptides derived from lysozyme with model membrane systems. Biochim Biophys Acta (2005) 1.10
CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia. Am J Physiol Lung Cell Mol Physiol (2005) 1.09
Differences in metabolism between the biofilm and planktonic response to metal stress. J Proteome Res (2011) 1.09
A salt-bridge motif involved in ligand binding and large-scale domain motions of the maltose-binding protein. Biophys J (2005) 1.09
Quality assessment of ginseng by (1)H NMR metabolite fingerprinting and profiling analysis. J Agric Food Chem (2009) 1.08
Structural and functional characterization of the conserved salt bridge in mammalian paneth cell alpha-defensins: solution structures of mouse CRYPTDIN-4 and (E15D)-CRYPTDIN-4. J Biol Chem (2006) 1.08
SPLUNC1/BPIFA1 contributes to pulmonary host defense against Klebsiella pneumoniae respiratory infection. Am J Pathol (2013) 1.08
Advances in cell and gene-based therapies for cystic fibrosis lung disease. Mol Ther (2012) 1.08
Distribution of pentachlorophenol in phospholipid bilayers: a molecular dynamics study. Biophys J (2004) 1.07
Lentivirus vector can be readministered to nasal epithelia without blocking immune responses. J Virol (2008) 1.07
A microRNA network regulates expression and biosynthesis of wild-type and DeltaF508 mutant cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci U S A (2012) 1.07