Published in Neurobiol Dis on November 01, 2005
The many faces of tau. Neuron (2011) 2.89
Controversies and priorities in amyotrophic lateral sclerosis. Lancet Neurol (2013) 2.52
Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev (2011) 2.25
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet (2011) 1.72
SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. Hum Mol Genet (2009) 1.16
What Renders TAU Toxic. Front Neurol (2013) 1.00
What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? Mol Neurodegener (2009) 0.98
Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system. Brain Struct Funct (2009) 0.97
Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans. Neurobiol Dis (2010) 0.97
PTL-1 regulates neuronal integrity and lifespan in C. elegans. J Cell Sci (2013) 0.90
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. J Neurosci (2010) 0.90
Metal-induced neurodegeneration in C. elegans. Front Aging Neurosci (2013) 0.89
Use of Caenorhabditis elegans as a model to study Alzheimer's disease and other neurodegenerative diseases. Front Genet (2014) 0.86
Curcumin and neurodegenerative diseases. Biofactors (2013) 0.86
Alzheimer's Disease Drug Discovery: In-vivo screening using C. elegans as a model for β-amyloid peptide-induced toxicity. Drug Discov Today Technol (2013) 0.82
The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. PLoS One (2014) 0.81
Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis. NPJ Aging Mech Dis (2016) 0.81
Pharmacological maintenance of protein homeostasis could postpone age-related disease. Aging Cell (2012) 0.79
Animal models for Alzheimer's disease and frontotemporal dementia: a perspective. ASN Neuro (2009) 0.78
Alzheimer's disease models and functional genomics-How many needles are there in the haystack? Front Physiol (2012) 0.77
Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases. Chem Cent J (2015) 0.77
Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau. J Neurochem (2015) 0.76
Planarian GSK3s are involved in neural regeneration. Dev Genes Evol (2008) 0.76
The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons. Cell Rep (2016) 0.75
Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models. Front Genet (2017) 0.75
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell (2006) 7.14
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell (2006) 4.50
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell (2009) 3.43
Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol (2002) 3.23
The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell (2009) 3.14
Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science (2010) 2.66
gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. J Neurosci (2009) 2.49
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. Science (2003) 2.20
Role of C. elegans TAT-1 protein in maintaining plasma membrane phosphatidylserine asymmetry. Science (2008) 1.93
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells (2005) 1.86
Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans. Nature (2003) 1.79
Sensory neuron fates are distinguished by a transcriptional switch that regulates dendrite branch stabilization. Neuron (2013) 1.77
Potent amyloidogenicity and pathogenicity of Aβ43. Nat Neurosci (2011) 1.76
An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation. Neuron (2010) 1.70
Active gamma-secretase complexes contain only one of each component. J Biol Chem (2007) 1.69
The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Mol Cell Biol (2007) 1.67
Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. J Biol Chem (2006) 1.66
C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1. Nat Cell Biol (2007) 1.63
Caenorhabditis elegans drp-1 and fis-2 regulate distinct cell-death execution pathways downstream of ced-3 and independent of ced-9. Mol Cell (2008) 1.61
HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. Cell (2002) 1.61
Genetically encoded green fluorescent Ca2+ indicators with improved detectability for neuronal Ca2+ signals. PLoS One (2012) 1.52
Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem (2003) 1.52
Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol (2002) 1.51
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem (2003) 1.49
A seed for Alzheimer amyloid in the brain. J Neurosci (2004) 1.45
A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in alpha-synuclein transgenic C. elegans. Hum Mol Genet (2008) 1.44
Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo. Nat Methods (2006) 1.44
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci (2002) 1.42
Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function. J Biol Chem (2006) 1.37
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry (2004) 1.32
Caenorhabditis elegans mboa-7, a member of the MBOAT family, is required for selective incorporation of polyunsaturated fatty acids into phosphatidylinositol. Mol Biol Cell (2007) 1.31
Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Hum Mol Genet (2006) 1.27
Caenorhabditis elegans transthyretin-like protein TTR-52 mediates recognition of apoptotic cells by the CED-1 phagocyte receptor. Nat Cell Biol (2010) 1.24
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS One (2013) 1.23
A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep (2002) 1.22
Translational control of maternal glp-1 mRNA by POS-1 and its interacting protein SPN-4 in Caenorhabditis elegans. Development (2003) 1.21
Emergence of cooperation in public goods games. Proc Biol Sci (2009) 1.20
γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Cell Rep (2013) 1.20
Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. J Biol Chem (2005) 1.17
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition. J Neurosci (2007) 1.17
Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun (2004) 1.16
Kinetics and strain variation of phagosome proteins of Entamoeba histolytica by proteomic analysis. Mol Biochem Parasitol (2005) 1.16
Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Res (2005) 1.16
Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry (2003) 1.15
The SM protein VPS-45 is required for RAB-5-dependent endocytic transport in Caenorhabditis elegans. EMBO Rep (2007) 1.15
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. Hum Mol Genet (2007) 1.15
The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs. PLoS Genet (2012) 1.12
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics (2009) 1.12
DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry (2006) 1.12
EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity. Cell Metab (2010) 1.10
An efficient transgenic system by TA cloning vectors and RNAi for C. elegans. Biochem Biophys Res Commun (2006) 1.10
Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. J Biol Chem (2002) 1.09
Control of sex-specific apoptosis in C. elegans by the BarH homeodomain protein CEH-30 and the transcriptional repressor UNC-37/Groucho. Genes Dev (2007) 1.09
Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. Hepatology (2010) 1.08
Bone marrow-derived mesenchymal stem cells favor the immunosuppressive T cells skewing in a Helicobacter pylori model of gastric cancer. Stem Cells Dev (2013) 1.07
Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis (2009) 1.06
Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3. Nat Struct Mol Biol (2008) 1.06
Alzheimer's disease: beta-Amyloid protein and tau. J Neurosci Res (2002) 1.06
The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans. Mol Biol Cell (2010) 1.05
Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. J Biol Chem (2008) 1.04
RNA surveillance is required for endoplasmic reticulum homeostasis. Proc Natl Acad Sci U S A (2012) 1.03
Member of the membrane-bound O-acyltransferase (MBOAT) family encodes a lysophospholipid acyltransferase with broad substrate specificity. Genes Cells (2008) 1.03
Nematode chondroitin polymerizing factor showing cell-/organ-specific expression is indispensable for chondroitin synthesis and embryonic cell division. J Biol Chem (2004) 1.03
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry (2003) 1.02
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia. EMBO Rep (2008) 1.00
Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes Cells (2011) 0.99
NBRP databases: databases of biological resources in Japan. Nucleic Acids Res (2009) 0.99
Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel. PLoS One (2010) 0.99
Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans. PLoS One (2010) 0.99
Effects of intervention using a community-based walking program for prevention of mental decline: a randomized controlled trial. J Am Geriatr Soc (2012) 0.98
CED-1, CED-7, and TTR-52 regulate surface phosphatidylserine expression on apoptotic and phagocytic cells. Curr Biol (2012) 0.98
Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. J Biol Chem (2007) 0.97
Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. EMBO Mol Med (2012) 0.96
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. J Biol Chem (2005) 0.96
Pathology of clinical and preclinical Alzheimer's disease. Eur Arch Psychiatry Clin Neurosci (2013) 0.96
Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. J Biol Chem (2004) 0.95
Part of membrane-bound Abeta exists in rafts within senile plaques in Tg2576 mouse brain. Neurobiol Aging (2005) 0.95
Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans. Development (2005) 0.95
Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides. FEBS Lett (2005) 0.95
Single/low-copy integration of transgenes in Caenorhabditis elegans using an ultraviolet trimethylpsoralen method. BMC Biotechnol (2012) 0.94