Published in Proc Natl Acad Sci U S A on December 26, 2001
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A (2003) 6.82
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab (2008) 5.83
Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol (2004) 5.66
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 5.53
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
PPARdelta regulates glucose metabolism and insulin sensitivity. Proc Natl Acad Sci U S A (2006) 3.29
PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest (2006) 3.17
Trophoblast differentiation during embryo implantation and formation of the maternal-fetal interface. J Clin Invest (2004) 2.95
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature (2016) 2.50
Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell (2009) 2.44
The Randle cycle revisited: a new head for an old hat. Am J Physiol Endocrinol Metab (2009) 2.39
Regulatory circuits controlling white versus brown adipocyte differentiation. Biochem J (2006) 2.23
PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med (2009) 2.21
The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling. Proc Natl Acad Sci U S A (2002) 2.20
PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A (2003) 2.10
All-trans-retinoic acid represses obesity and insulin resistance by activating both peroxisome proliferation-activated receptor beta/delta and retinoic acid receptor. Mol Cell Biol (2009) 1.88
Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A (2006) 1.84
PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. Proc Natl Acad Sci U S A (2008) 1.68
PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta (2011) 1.60
Involvement of PPAR nuclear receptors in tissue injury and wound repair. J Clin Invest (2006) 1.55
Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity. Cell (2014) 1.53
Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource. Nat Commun (2012) 1.51
Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol (2006) 1.49
Mitochondrial dysfunction in obesity. Curr Opin Endocrinol Diabetes Obes (2010) 1.42
Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence. Cell Host Microbe (2013) 1.41
The prognostic significance of peroxisome proliferator-activated receptor β expression in the vascular endothelial cells of colorectal cancer. J Gastroenterol (2013) 1.40
PPAR delta as a therapeutic target in metabolic disease. FEBS Lett (2007) 1.38
Peroxisome proliferator-activated receptors (PPARs) and ovarian function--implications for regulating steroidogenesis, differentiation, and tissue remodeling. Reprod Biol Endocrinol (2005) 1.36
Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol (2009) 1.29
PPARs and the cardiovascular system. Antioxid Redox Signal (2009) 1.28
Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases. Mediators Inflamm (2013) 1.27
The Role of PPARs in Cancer. PPAR Res (2008) 1.26
Deregulation of tumor angiogenesis and blockade of tumor growth in PPARbeta-deficient mice. EMBO J (2007) 1.24
Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. Proc Natl Acad Sci U S A (2006) 1.23
PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair. J Hepatol (2009) 1.20
Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes. Genes Dev (2006) 1.19
Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol (2010) 1.19
Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart. Circ Res (2010) 1.19
Targeted genetic disruption of peroxisome proliferator-activated receptor-delta and colonic tumorigenesis. J Natl Cancer Inst (2009) 1.16
Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. Immunol Rev (2012) 1.15
Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol (2005) 1.12
Expression of PPARdelta in multistage carcinogenesis of the colorectum: implications of malignant cancer morphology. Br J Cancer (2006) 1.09
Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice. Mol Cell Biol (2003) 1.09
Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management. Pediatr Res (2005) 1.06
Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis. PPAR Res (2008) 1.05
Expression profiling of peroxisome proliferator-activated receptor-delta (PPAR-delta) in mouse tissues using tissue microarray. Histochem Cell Biol (2007) 1.04
Tissue-selective, bidirectional regulation of PEX11 alpha and perilipin genes through a common peroxisome proliferator response element. Mol Cell Biol (2004) 1.04
Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. Mol Pharmacol (2010) 1.02
Nuclear receptors and inflammatory diseases. Exp Biol Med (Maywood) (2008) 1.01
Vascular PPARδ protects against stroke-induced brain injury. Arterioscler Thromb Vasc Biol (2011) 1.01
In vivo actions of peroxisome proliferator-activated receptors: glycemic control, insulin sensitivity, and insulin secretion. Diabetes Care (2013) 0.98
PPAR Signaling in Placental Development and Function. PPAR Res (2008) 0.97
Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. J Lipid Res (2009) 0.97
Activation of PPARδ: from computer modelling to biological effects. Br J Pharmacol (2014) 0.97
PPAR Action in Human Placental Development and Pregnancy and Its Complications. PPAR Res (2008) 0.96
The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. Nutr J (2007) 0.96
Peroxisome proliferator-activated receptors and cancer: challenges and opportunities. Br J Pharmacol (2011) 0.95
PPARδ regulates satellite cell proliferation and skeletal muscle regeneration. Skelet Muscle (2011) 0.95
Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis. Cancer Metastasis Rev (2011) 0.95
Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors. PPAR Res (2013) 0.94
Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes. Cell Signal (2011) 0.94
Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. Placenta (2008) 0.94
Genetic manipulations of PPARs: effects on obesity and metabolic disease. PPAR Res (2007) 0.94
PPARs and ERRs: molecular mediators of mitochondrial metabolism. Curr Opin Cell Biol (2014) 0.94
Peroxisome proliferator-activated receptors as mediators of phthalate-induced effects in the male and female reproductive tract: epidemiological and experimental evidence. PPAR Res (2008) 0.93
The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease. PPAR Res (2008) 0.93
Peroxisome proliferator-activated receptors alpha, Beta, and gamma mRNA and protein expression in human fetal tissues. PPAR Res (2010) 0.92
A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development. Proc Natl Acad Sci U S A (2009) 0.92
Crosstalk of oncogenic and prostanoid signaling pathways. J Cancer Res Clin Oncol (2004) 0.92
PPARδ activation protects endothelial function in diabetic mice. Diabetes (2012) 0.92
Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity. Mol Metab (2015) 0.92
PPARδ activation acts cooperatively with 3-phosphoinositide-dependent protein kinase-1 to enhance mammary tumorigenesis. PLoS One (2011) 0.91
An immunohistochemical perspective of PPAR beta and one of its putative targets PDK1 in normal ovaries, benign and malignant ovarian tumours. Br J Cancer (2008) 0.91
PPARgamma and PPARdelta as Modulators of Neoplasia and Cell Fate. PPAR Res (2008) 0.91
Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity. PLoS One (2012) 0.90
Structural basis for ligand regulation of the fatty acid-binding protein 5, peroxisome proliferator-activated receptor β/δ (FABP5-PPARβ/δ) signaling pathway. J Biol Chem (2014) 0.90
PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling. PLoS One (2013) 0.90
PPARδ induces estrogen receptor-positive mammary neoplasia through an inflammatory and metabolic phenotype linked to mTOR activation. Cancer Res (2013) 0.89
Peroxisome proliferator-activated receptors and progression of colorectal cancer. PPAR Res (2008) 0.88
The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival. Mol Endocrinol (2010) 0.88
Role of nuclear receptors in blastocyst implantation. Semin Cell Dev Biol (2013) 0.87
Regulation of Cell Proliferation and Differentiation by PPARbeta/delta. PPAR Res (2008) 0.87
The role of peroxisome proliferator-activated receptors in pulmonary vascular disease. PPAR Res (2007) 0.87
PPAR-delta in Vascular Pathophysiology. PPAR Res (2009) 0.87
Fatty acid oxidation in the human fetus: implications for fetal and adult disease. J Inherit Metab Dis (2006) 0.87
Peroxisome proliferator-activated receptor (PPAR) gene profiling uncovers insulin-like growth factor-1 as a PPARalpha target gene in cardioprotection. J Biol Chem (2011) 0.87
Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors. Cancer Res (2008) 0.87
Alternative splicing of human peroxisome proliferator-activated receptor delta (PPAR delta): effects on translation efficiency and trans-activation ability. BMC Mol Biol (2007) 0.86
High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes. J Mol Cell Cardiol (2009) 0.85
PPARβ/δ and PPARγ maintain undifferentiated phenotypes of mouse adult neural precursor cells from the subventricular zone. Front Cell Neurosci (2015) 0.85
Placental implications of peroxisome proliferator-activated receptors in gestation and parturition. PPAR Res (2008) 0.84
A Role for PPARbeta/delta in Tumor Stroma and Tumorigenesis. PPAR Res (2008) 0.84
Knockdown of PPAR δ gene promotes the growth of colon cancer and reduces the sensitivity to bevacizumab in nude mice model. PLoS One (2013) 0.84
Peroxisome proliferator-activated receptor genetic polymorphisms and nonalcoholic Fatty liver disease: any role in disease susceptibility? PPAR Res (2013) 0.84
Integrative and systemic approaches for evaluating PPARβ/δ (PPARD) function. Nucl Recept Signal (2015) 0.84
The Role of PPARs in Placental Immunology: A Systematic Review of the Literature. PPAR Res (2013) 0.84
Potentiation of colon cancer susceptibility in mice by colonic epithelial PPAR-δ/β overexpression. J Natl Cancer Inst (2014) 0.83
Mechanisms of vascular dysfunction in mice with endothelium-specific deletion of the PPAR-δ gene. Am J Physiol Heart Circ Physiol (2014) 0.83
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