Published in Biochemistry on January 22, 2002
Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A (2003) 5.95
The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol (2009) 2.69
Binary bacterial toxins: biochemistry, biology, and applications of common Clostridium and Bacillus proteins. Microbiol Mol Biol Rev (2004) 2.60
Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proc Natl Acad Sci U S A (2002) 2.51
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci U S A (2002) 2.31
Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A (2004) 2.23
Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys J (2004) 1.87
The Actin cross-linking domain of the Vibrio cholerae RTX toxin directly catalyzes the covalent cross-linking of actin. J Biol Chem (2006) 1.82
Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers. Nat Struct Mol Biol (2010) 1.62
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A (2003) 1.59
A model of anthrax toxin lethal factor bound to protective antigen. Proc Natl Acad Sci U S A (2005) 1.58
Inactivation of small Rho GTPases by the multifunctional RTX toxin from Vibrio cholerae. Cell Microbiol (2007) 1.56
A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci U S A (2003) 1.54
Membrane translocation by anthrax toxin. Mol Aspects Med (2009) 1.42
Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax. Infect Immun (2007) 1.40
Ratcheting up protein translocation with anthrax toxin. Protein Sci (2012) 1.38
Potent antitumor activity of a urokinase-activated engineered anthrax toxin. Proc Natl Acad Sci U S A (2003) 1.38
Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma. J Mol Biol (2010) 1.36
Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors. PLoS Pathog (2010) 1.35
Anthrax toxins induce shock in rats by depressed cardiac ventricular function. PLoS One (2007) 1.32
Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation. Proc Natl Acad Sci U S A (2008) 1.25
Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin. J Biol Chem (2006) 1.25
Anthrax vaccine design: strategies to achieve comprehensive protection against spore, bacillus, and toxin. Med Immunol (2005) 1.22
The unfolding story of anthrax toxin translocation. Mol Microbiol (2011) 1.19
Receptors of anthrax toxin and cell entry. Mol Aspects Med (2009) 1.18
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc Natl Acad Sci U S A (2006) 1.18
Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin. Nat Biotechnol (2005) 1.17
Potent neutralization of anthrax edema toxin by a humanized monoclonal antibody that competes with calmodulin for edema factor binding. Proc Natl Acad Sci U S A (2009) 1.14
Association of Bacillus anthracis capsule with lethal toxin during experimental infection. Infect Immun (2008) 1.08
LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. PLoS Pathog (2007) 1.05
Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake. Proc Natl Acad Sci U S A (2010) 1.03
Expression of either lethal toxin or edema toxin by Bacillus anthracis is sufficient for virulence in a rabbit model of inhalational anthrax. Infect Immun (2012) 1.01
Solubilization and characterization of the anthrax toxin pore in detergent micelles. Protein Sci (2009) 1.00
Clostridium perfringens iota toxin: characterization of the cell-associated iota b complex. Biochem J (2002) 0.98
Anthrax edema toxin induces maturation of dendritic cells and enhances chemotaxis towards macrophage inflammatory protein 3beta. Infect Immun (2009) 0.95
Model of the toxic complex of anthrax: responsive conformational changes in both the lethal factor and the protective antigen heptamer. Protein Sci (2006) 0.95
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling. Proc Natl Acad Sci U S A (2011) 0.94
An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci (2009) 0.93
Anthrax toxin protective antigen--insights into molecular switching from prepore to pore. Protein Sci (2012) 0.92
Frequent and seasonally variable sublethal anthrax infections are accompanied by short-lived immunity in an endemic system. J Anim Ecol (2014) 0.90
Assembly and disassembly kinetics of anthrax toxin complexes. Biochemistry (2006) 0.89
Selection and characterization of human antibodies neutralizing Bacillus anthracis toxin. Bioorg Med Chem (2007) 0.89
The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin. PLoS One (2010) 0.89
Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants. PLoS One (2012) 0.89
Amiodarone and bepridil inhibit anthrax toxin entry into host cells. Antimicrob Agents Chemother (2007) 0.88
Cationic polyamines inhibit anthrax lethal factor protease. BMC Pharmacol (2006) 0.88
New developments in vaccines, inhibitors of anthrax toxins, and antibiotic therapeutics for Bacillus anthracis. Curr Med Chem (2011) 0.88
The potential contributions of lethal and edema toxins to the pathogenesis of anthrax associated shock. Toxins (Basel) (2011) 0.88
A kinetic analysis of protein transport through the anthrax toxin channel. J Gen Physiol (2011) 0.88
AB toxins: a paradigm switch from deadly to desirable. Toxins (Basel) (2010) 0.88
Onset of anthrax toxin pore formation. Biophys J (2006) 0.87
Bacillus anthracis edema factor substrate specificity: evidence for new modes of action. Toxins (Basel) (2012) 0.87
Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol (2005) 0.87
Receptor-directed chimeric toxins created by sortase-mediated protein fusion. Mol Cancer Ther (2013) 0.87
Efficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin. PLoS One (2011) 0.86
Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore. Biochemistry (2011) 0.84
Monitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance. Biochemistry (2013) 0.84
Cellular and physiological effects of anthrax exotoxin and its relevance to disease. Front Cell Infect Microbiol (2012) 0.84
pH effects on binding between the anthrax protective antigen and the host cellular receptor CMG2. Protein Sci (2012) 0.83
Lethal factor of anthrax toxin binds monomeric form of protective antigen. Biochem Biophys Res Commun (2007) 0.83
A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion. J Biol Chem (2012) 0.81
Vaccination of rhesus macaques with the anthrax vaccine adsorbed vaccine produces a serum antibody response that effectively neutralizes receptor-bound protective antigen in vitro. Clin Vaccine Immunol (2010) 0.80
Designing inhibitors of anthrax toxin. Expert Opin Drug Discov (2014) 0.80
Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment. PLoS One (2012) 0.80
Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA). PLoS One (2012) 0.80
Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice. Crit Care Med (2011) 0.80
Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells. PLoS One (2011) 0.80
Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen. Sci Rep (2015) 0.79
Enhanced Immune Response to DNA Vaccine Encoding Bacillus anthracis PA-D4 Protects Mice against Anthrax Spore Challenge. PLoS One (2015) 0.79
Bacillus anthracis edema toxin inhibits Staphylococcus aureus enterotoxin B effects in vitro: a potential protein therapeutic? Infect Immun (2005) 0.78
Toxicity of anthrax toxin is influenced by receptor expression. Clin Vaccine Immunol (2008) 0.78
Lethal factor, but not edema factor, is required to cause fatal anthrax in cynomolgus macaques after pulmonary spore challenge. Am J Pathol (2014) 0.77
Studying macromolecular complex stoichiometries by peptide-based mass spectrometry. Proteomics (2015) 0.77
Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. ACS Chem Biol (2013) 0.77
Polylysine-mediated translocation of the diphtheria toxin catalytic domain through the anthrax protective antigen pore. Biochemistry (2014) 0.77
Channel-forming bacterial toxins in biosensing and macromolecule delivery. Toxins (Basel) (2014) 0.77
High-sensitivity MALDI-TOF MS quantification of anthrax lethal toxin for diagnostics and evaluation of medical countermeasures. Anal Bioanal Chem (2015) 0.77
Both CD4+ and CD8+ T cells respond to antigens fused to anthrax lethal toxin. Infect Immun (2008) 0.77
Bacillus cereus Certhrax ADP-ribosylates vinculin to disrupt focal adhesion complexes and cell adhesion. J Biol Chem (2014) 0.76
Molecular assembly of lethal factor enzyme and pre-pore heptameric protective antigen in early stage of translocation. J Mol Model (2015) 0.76
Antigen delivered by anthrax lethal toxin induces the development of memory CD8+ T cells that can be rapidly boosted and display effector functions. Infect Immun (2007) 0.76
Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins. Membranes (Basel) (2016) 0.75
Inhibiting bacterial toxins by channel blockage. Pathog Dis (2015) 0.75
Characterization of the native form of anthrax lethal factor for use in the toxin neutralization assay. Clin Vaccine Immunol (2013) 0.75
Impact of Dendrimer Terminal Group Chemistry on Blockage of the Anthrax Toxin Channel: A Single Molecule Study. Toxins (Basel) (2016) 0.75
Rapid vascular responses to anthrax lethal toxin in mice containing a segment of chromosome 11 from the CAST/Ei strain on a C57BL/6 genetic background. PLoS One (2012) 0.75
Structure of anthrax lethal toxin prepore complex suggests a pathway for efficient cell entry. J Gen Physiol (2016) 0.75
Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem (2007) 5.38
A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science (2005) 4.10
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A (2004) 3.10
Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient. J Mol Biol (2005) 2.69
PA63 channel of anthrax toxin: an extended beta-barrel. Biochemistry (2002) 2.57
Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem (2004) 2.57
Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proc Natl Acad Sci U S A (2002) 2.51
Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin. J Mol Biol (2004) 2.35
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci U S A (2002) 2.31
Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A (2004) 2.23
An open letter to Elias Zerhouni. Science (2005) 2.19
Receptor-specific requirements for anthrax toxin delivery into cells. Proc Natl Acad Sci U S A (2005) 2.15
GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore. Nat Struct Mol Biol (2008) 1.91
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol (2003) 1.91
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc Natl Acad Sci U S A (2004) 1.91
Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys J (2004) 1.87
Mapping the anthrax protective antigen binding site on the lethal and edema factors. J Biol Chem (2001) 1.62
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A (2003) 1.59
A model of anthrax toxin lethal factor bound to protective antigen. Proc Natl Acad Sci U S A (2005) 1.58
A soluble receptor decoy protects rats against anthrax lethal toxin challenge. J Infect Dis (2005) 1.54
A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci U S A (2003) 1.54
Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation. Biochemistry (2007) 1.40
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc Natl Acad Sci U S A (2008) 1.39
A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Infect Immun (2006) 1.38
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog (2006) 1.34
2001: a year of major advances in anthrax toxin research. Trends Microbiol (2002) 1.32
Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. J Biol Chem (2005) 1.30
Insertion of anthrax protective antigen into liposomal membranes: effects of a receptor. J Biol Chem (2006) 1.26
Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation. Proc Natl Acad Sci U S A (2008) 1.25
Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun (2005) 1.22
Evidence for a proton-protein symport mechanism in the anthrax toxin channel. J Gen Physiol (2009) 1.20
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem (2004) 1.20
Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously. Biochem Biophys Res Commun (2004) 1.19
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc Natl Acad Sci U S A (2006) 1.18
Reversible refolding of the diphtheria toxin T-domain on lipid membranes. Biochemistry (2004) 1.17
Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. PLoS One (2007) 1.16
A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor. ACS Chem Biol (2010) 1.12
Whole-cell voltage clamp measurements of anthrax toxin pore current. J Biol Chem (2005) 1.09
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature. Proc Natl Acad Sci U S A (2008) 1.08
Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen. Mol Oncol (2012) 1.07
Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol (2004) 1.06
Conformational switching of the diphtheria toxin T domain. J Mol Biol (2010) 1.06
Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth. Cancer Res (2007) 1.03
Chemical dissection of protein translocation through the anthrax toxin pore. Angew Chem Int Ed Engl (2011) 1.01
Characterization of dominant-negative forms of anthrax protective antigen. Mol Med (2003) 1.01
Solubilization and characterization of the anthrax toxin pore in detergent micelles. Protein Sci (2009) 1.00
Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J (2011) 1.00
Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen. Cell Microbiol (2010) 0.98
Changing the receptor specificity of anthrax toxin. MBio (2012) 0.98
Effects of introducing a single charged residue into the phenylalanine clamp of multimeric anthrax protective antigen. J Biol Chem (2010) 0.96
Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics. Biochemistry (2005) 0.95
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling. Proc Natl Acad Sci U S A (2011) 0.94
Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras. Cell Microbiol (2010) 0.93
An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci (2009) 0.93
Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin. Biochemistry (2008) 0.92
Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function. PLoS One (2010) 0.90
Assembly and disassembly kinetics of anthrax toxin complexes. Biochemistry (2006) 0.89
Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma. J Med Chem (2009) 0.89
Anthrax delivers a lethal blow to host immunity. Nat Med (2003) 0.89
Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers. Proc Natl Acad Sci U S A (2011) 0.88
Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol (2005) 0.87
Receptor-directed chimeric toxins created by sortase-mediated protein fusion. Mol Cancer Ther (2013) 0.87
Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD). Bioorg Med Chem Lett (2011) 0.86
Exchange characteristics of calcium ions bound to anthrax protective antigen. Biochem Biophys Res Commun (2003) 0.86
Use of phage display and polyvalency to design inhibitors of protein-protein interactions. Methods Mol Biol (2004) 0.85
Cys-Cys cross-linking shows contact between the N-terminus of lethal factor and Phe427 of the anthrax toxin pore. Biochemistry (2011) 0.84
Monitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance. Biochemistry (2013) 0.84
Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin. Infect Immun (2007) 0.84
Anthrax protective antigen: efficiency of translocation is independent of the number of ligands bound to the prepore. Biochemistry (2004) 0.82
Functions of phenylalanine residues within the beta-barrel stem of the anthrax toxin pore. PLoS One (2009) 0.82
Identification of peptide antagonists to glycoprotein Ibalpha that selectively inhibit von Willebrand factor dependent platelet aggregation. Biochemistry (2008) 0.81
Polylysine-mediated translocation of the diphtheria toxin catalytic domain through the anthrax protective antigen pore. Biochemistry (2014) 0.77
Fluorescence resonance energy transfer studies on anthrax lethal toxin. FEBS Lett (2003) 0.77
Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. ACS Chem Biol (2013) 0.77