Published in Biochemistry on June 15, 2004
Kinetic intermediate reveals staggered pH-dependent transitions along the membrane insertion pathway of the diphtheria toxin T-domain. Biochemistry (2009) 1.32
Interactions of fluorinated surfactants with diphtheria toxin T-domain: testing new media for studies of membrane proteins. Biophys J (2008) 1.20
Receptor binding enables botulinum neurotoxin B to sense low pH for translocation channel assembly. Cell Host Microbe (2011) 1.06
Conformational switching of the diphtheria toxin T domain. J Mol Biol (2010) 1.06
The N-terminal domain of Bcl-xL reversibly binds membranes in a pH-dependent manner. Biochemistry (2006) 1.00
Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J (2011) 1.00
pH-triggered conformational switching along the membrane insertion pathway of the diphtheria toxin T-domain. Toxins (Basel) (2013) 0.93
FCS study of the thermodynamics of membrane protein insertion into the lipid bilayer chaperoned by fluorinated surfactants. Biophys J (2008) 0.91
Comparison of membrane insertion pathways of the apoptotic regulator Bcl-xL and the diphtheria toxin translocation domain. Biochemistry (2013) 0.87
Crucial role of H322 in folding of the diphtheria toxin T-domain into the open-channel state. Biochemistry (2013) 0.87
Oligomerization of membrane-bound diphtheria toxin (CRM197) facilitates a transition to the open form and deep insertion. Biophys J (2007) 0.85
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Thermodynamics of Membrane Insertion and Refolding of the Diphtheria Toxin T-Domain. J Membr Biol (2014) 0.81
Structural plasticity in the topology of the membrane-interacting domain of HIV-1 gp41. Biophys J (2014) 0.81
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Role of acidic residues in helices TH8-TH9 in membrane interactions of the diphtheria toxin T domain. Toxins (Basel) (2015) 0.78
Targeting acidity in diseased tissues: mechanism and applications of the membrane-inserting peptide, pHLIP. Arch Biochem Biophys (2014) 0.77
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The pH-Dependent Trigger in Diphtheria Toxin T Domain Comes with a Safety Latch. Biophys J (2016) 0.75
Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature (2005) 7.72
A comprehensive classification system for lipids. J Lipid Res (2005) 6.52
Anthrax toxin: receptor binding, internalization, pore formation, and translocation. Annu Rev Biochem (2007) 5.38
Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature (2007) 4.60
A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science (2005) 4.10
Membrane insertion of a potassium-channel voltage sensor. Science (2005) 3.30
Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proc Natl Acad Sci U S A (2004) 3.10
Interface connections of a transmembrane voltage sensor. Proc Natl Acad Sci U S A (2005) 2.92
Stoichiometry of anthrax toxin complexes. Biochemistry (2002) 2.86
Protein translocation through the anthrax toxin transmembrane pore is driven by a proton gradient. J Mol Biol (2005) 2.69
PA63 channel of anthrax toxin: an extended beta-barrel. Biochemistry (2002) 2.57
Binding stoichiometry and kinetics of the interaction of a human anthrax toxin receptor, CMG2, with protective antigen. J Biol Chem (2004) 2.57
Mapping the lethal factor and edema factor binding sites on oligomeric anthrax protective antigen. Proc Natl Acad Sci U S A (2002) 2.51
Acid-induced unfolding of the amino-terminal domains of the lethal and edema factors of anthrax toxin. J Mol Biol (2004) 2.35
The lethal and edema factors of anthrax toxin bind only to oligomeric forms of the protective antigen. Proc Natl Acad Sci U S A (2002) 2.31
Evidence that translocation of anthrax toxin's lethal factor is initiated by entry of its N terminus into the protective antigen channel. Proc Natl Acad Sci U S A (2004) 2.23
An open letter to Elias Zerhouni. Science (2005) 2.19
Structure and hydration of membranes embedded with voltage-sensing domains. Nature (2009) 2.15
Receptor-specific requirements for anthrax toxin delivery into cells. Proc Natl Acad Sci U S A (2005) 2.15
Experimental validation of molecular dynamics simulations of lipid bilayers: a new approach. Biophys J (2004) 2.09
GroEL as a molecular scaffold for structural analysis of the anthrax toxin pore. Nat Struct Mol Biol (2008) 1.91
The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nat Struct Mol Biol (2003) 1.91
Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor. Proc Natl Acad Sci U S A (2004) 1.91
MPEx: a tool for exploring membrane proteins. Protein Sci (2009) 1.89
Protein translocation through anthrax toxin channels formed in planar lipid bilayers. Biophys J (2004) 1.87
AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences. Rev Sci Instrum (2006) 1.86
A voltage-sensor water pore. Biophys J (2006) 1.63
Mapping the anthrax protective antigen binding site on the lethal and edema factors. J Biol Chem (2001) 1.62
Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis. Proc Natl Acad Sci U S A (2003) 1.59
Arginine in membranes: the connection between molecular dynamics simulations and translocon-mediated insertion experiments. J Membr Biol (2010) 1.58
A model of anthrax toxin lethal factor bound to protective antigen. Proc Natl Acad Sci U S A (2005) 1.58
A soluble receptor decoy protects rats against anthrax lethal toxin challenge. J Infect Dis (2005) 1.54
A dually active anthrax vaccine that confers protection against both bacilli and toxins. Proc Natl Acad Sci U S A (2003) 1.54
Folding amphipathic helices into membranes: amphiphilicity trumps hydrophobicity. J Mol Biol (2007) 1.52
Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation. Biochemistry (2007) 1.40
Rhomboid protease dynamics and lipid interactions. Structure (2009) 1.40
Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus. Proc Natl Acad Sci U S A (2008) 1.39
A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1. Infect Immun (2006) 1.38
Predicting in vivo clinical performance of anterior cruciate ligament fixation methods from in vitro analysis: industrial tests of fatigue life and tolerance limits are more useful than other cyclic loading parameters. Am J Sports Med (2005) 1.38
Interfacial folding and membrane insertion of a designed helical peptide. Biochemistry (2004) 1.38
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. PLoS Pathog (2006) 1.34
Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assembly. EMBO Rep (2006) 1.33
2001: a year of major advances in anthrax toxin research. Trends Microbiol (2002) 1.32
Insertion of short transmembrane helices by the Sec61 translocon. Proc Natl Acad Sci U S A (2009) 1.31
Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. J Biol Chem (2005) 1.30
Insertion of anthrax protective antigen into liposomal membranes: effects of a receptor. J Biol Chem (2006) 1.26
Phenylalanine-427 of anthrax protective antigen functions in both pore formation and protein translocation. Proc Natl Acad Sci U S A (2008) 1.25
Combining anthrax vaccine and therapy: a dominant-negative inhibitor of anthrax toxin is also a potent and safe immunogen for vaccines. Infect Immun (2005) 1.22
Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helices. Proc Natl Acad Sci U S A (2008) 1.21
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. J Biol Chem (2004) 1.20
Evidence for a proton-protein symport mechanism in the anthrax toxin channel. J Gen Physiol (2009) 1.20
In silico partitioning and transmembrane insertion of hydrophobic peptides under equilibrium conditions. J Am Chem Soc (2011) 1.20
Anthrax toxin complexes: heptameric protective antigen can bind lethal factor and edema factor simultaneously. Biochem Biophys Res Commun (2004) 1.19
A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proc Natl Acad Sci U S A (2006) 1.18
Anthrax toxin receptor 2 determinants that dictate the pH threshold of toxin pore formation. PLoS One (2007) 1.16
Self-induced docking site of a deeply embedded peripheral membrane protein. Biophys J (2006) 1.14
Investigation of finite system-size effects in molecular dynamics simulations of lipid bilayers. J Phys Chem B (2006) 1.12
A semisynthesis platform for investigating structure-function relationships in the N-terminal domain of the anthrax Lethal Factor. ACS Chem Biol (2010) 1.12
An experiment-based algorithm for predicting the partitioning of unfolded peptides into phosphatidylcholine bilayer interfaces. Biochemistry (2005) 1.11
Hydration of POPC bilayers studied by 1H-PFG-MAS-NOESY and neutron diffraction. Eur Biophys J (2007) 1.10
Whole-cell voltage clamp measurements of anthrax toxin pore current. J Biol Chem (2005) 1.09
Determining the membrane topology of proteins: insertion pathway of a transmembrane helix of annexin 12. Biochemistry (2002) 1.09
Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature. Proc Natl Acad Sci U S A (2008) 1.08
Water wires in atomistic models of the Hv1 proton channel. Biochim Biophys Acta (2011) 1.07
Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen. Mol Oncol (2012) 1.07
Effects of dynamin inactivation on pathways of anthrax toxin uptake. Eur J Cell Biol (2004) 1.06
Conformational switching of the diphtheria toxin T domain. J Mol Biol (2010) 1.06
Down-state model of the voltage-sensing domain of a potassium channel. Biophys J (2010) 1.06
CD spectroscopy of peptides and proteins bound to large unilamellar vesicles. J Membr Biol (2010) 1.04
Mutant anthrax toxin B moiety (protective antigen) inhibits angiogenesis and tumor growth. Cancer Res (2007) 1.03
Dynamics of SecY translocons with translocation-defective mutations. Structure (2010) 1.02
Characterization of dominant-negative forms of anthrax protective antigen. Mol Med (2003) 1.01
Aggregation behavior of an ultra-pure lipopolysaccharide that stimulates TLR-4 receptors. Biophys J (2008) 1.01
Chemical dissection of protein translocation through the anthrax toxin pore. Angew Chem Int Ed Engl (2011) 1.01
Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J (2011) 1.00
Solubilization and characterization of the anthrax toxin pore in detergent micelles. Protein Sci (2009) 1.00
Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum. Proc Natl Acad Sci U S A (2011) 0.99
Role of CypA and Hsp90 in membrane translocation mediated by anthrax protective antigen. Cell Microbiol (2010) 0.98
Changing the receptor specificity of anthrax toxin. MBio (2012) 0.98
Effects of introducing a single charged residue into the phenylalanine clamp of multimeric anthrax protective antigen. J Biol Chem (2010) 0.96
Hydrogen-bond energetics drive helix formation in membrane interfaces. Biochim Biophys Acta (2011) 0.95
Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics. Biochemistry (2005) 0.95
Interactions of anthrax lethal factor with protective antigen defined by site-directed spin labeling. Proc Natl Acad Sci U S A (2011) 0.94
Acyl-chain methyl distributions of liquid-ordered and -disordered membranes. Biophys J (2011) 0.94
pH dependence of sphingosine aggregation. Biophys J (2009) 0.93
An approach to characterizing single-subunit mutations in multimeric prepores and pores of anthrax protective antigen. Protein Sci (2009) 0.93
Imaging the cell entry of the anthrax oedema and lethal toxins with fluorescent protein chimeras. Cell Microbiol (2010) 0.93
Amino acid residues involved in membrane insertion and pore formation of Clostridium botulinum C2 toxin. Biochemistry (2008) 0.92
Membrane partitioning: "classical" and "nonclassical" hydrophobic effects. J Membr Biol (2010) 0.91
Structure and dynamics of cholesterol-containing polyunsaturated lipid membranes studied by neutron diffraction and NMR. J Membr Biol (2010) 0.90
Disulfide bonds in the ectodomain of anthrax toxin receptor 2 are required for the receptor-bound protective-antigen pore to function. PLoS One (2010) 0.90
Diffraction-based density restraints for membrane and membrane-peptide molecular dynamics simulations. Biophys J (2006) 0.90
Assembly and disassembly kinetics of anthrax toxin complexes. Biochemistry (2006) 0.89
Proton-coupled dynamics in lactose permease. Structure (2012) 0.89
Anthrax delivers a lethal blow to host immunity. Nat Med (2003) 0.89
Charge composition features of model single-span membrane proteins that determine selection of YidC and SecYEG translocase pathways in Escherichia coli. J Biol Chem (2013) 0.88
Reversible unfolding of beta-sheets in membranes: a calorimetric study. J Mol Biol (2004) 0.88
Ultrasensitive detection of protein translocated through toxin pores in droplet-interface bilayers. Proc Natl Acad Sci U S A (2011) 0.88