Published in Shock on January 01, 2002
Simvastatin improves sepsis-induced mortality and acute kidney injury via renal vascular effects. Kidney Int (2006) 1.83
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol (2007) 1.60
Renal blood flow in sepsis. Crit Care (2005) 1.59
Caffeine restores myocardial cytochrome oxidase activity and improves cardiac function during sepsis. Crit Care Med (2009) 1.51
An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. J Exp Med (2005) 1.29
TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism. Am J Physiol Heart Circ Physiol (2010) 1.22
Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice. Am J Physiol Renal Physiol (2008) 1.17
Scavenger receptor class a plays a central role in mediating mortality and the development of the pro-inflammatory phenotype in polymicrobial sepsis. PLoS Pathog (2012) 1.10
Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]. J Immunol (2009) 1.09
Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury. Pharmacol Ther (2012) 0.93
Pulmonary microvascular albumin leak is associated with endothelial cell death in murine sepsis-induced lung injury in vivo. PLoS One (2014) 0.89
Impaired heart rate regulation and depression of cardiac chronotropic and dromotropic function in polymicrobial sepsis. Shock (2015) 0.88
VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis. Crit Care (2009) 0.88
Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis. PLoS One (2012) 0.83
The role of hepatic cytochrome P-450 in sepsis. Int J Clin Exp Med (2009) 0.81
Altered L-type Ca2+ channel activity contributes to exacerbated hypoperfusion and mortality in smooth muscle cell BK channel-deficient septic mice. Am J Physiol Regul Integr Comp Physiol (2014) 0.80
Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis. Inflammation (2016) 0.77
Adjuvant potential of selegiline in attenuating organ dysfunction in septic rats with peritonitis. PLoS One (2014) 0.77
Leukocyte Dectin-1 expression is differentially regulated in fungal versus polymicrobial sepsis. Crit Care Med (2009) 0.76
Current Murine Models of Sepsis. Surg Infect (Larchmt) (2016) 0.75
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation. Cell (2012) 8.41
MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med (2007) 5.48
A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc Natl Acad Sci U S A (2009) 4.23
Cecal ligation and puncture. Shock (2005) 3.93
Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infect Immun (2003) 3.61
A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology (2002) 3.58
Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr (2007) 3.45
Poly[bis[aquaneodymium(III)]-mu2-oxalato-di-mu4-succinato]. Acta Crystallogr C (2007) 2.84
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol (2010) 2.47
A phase diagram for jammed matter. Nature (2008) 2.45
The effect of intraoperative rectal washout on local recurrence after rectal cancer surgery: a meta-analysis. Ann Surg Oncol (2012) 2.38
Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol (2005) 2.38
Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med (2008) 2.34
Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex. Cereb Cortex (2006) 2.28
Adenosine A2A receptor activation: another potential therapy for trauma and hemorrhagic shock. Crit Care Med (2006) 2.18
A heterozygous moth genome provides insights into herbivory and detoxification. Nat Genet (2013) 2.13
Direct evidence for endothelial vascular endothelial growth factor receptor-1 function in nitric oxide-mediated angiogenesis. Circ Res (2006) 2.12
Endoscopic submucosal dissection for treatment of esophageal submucosal tumors originating from the muscularis propria layer. Gastrointest Endosc (2011) 2.08
A 70-year-old man with blue skin. Clin Chem (2014) 2.03
Structural insights into the YAP and TEAD complex. Genes Dev (2010) 2.00
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood (2005) 1.99
Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology (2008) 1.97
Regulatory T cell populations in sepsis and trauma. J Leukoc Biol (2007) 1.96
Immune evasion versus recovery after acute hepatitis C virus infection from a shared source. J Exp Med (2005) 1.93
The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med (2006) 1.92
Oral hygiene care for critically ill patients to prevent ventilator-associated pneumonia. Cochrane Database Syst Rev (2013) 1.91
Cortical layer-dependent BOLD and CBV responses measured by spin-echo and gradient-echo fMRI: insights into hemodynamic regulation. Neuroimage (2006) 1.90
Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proc Natl Acad Sci U S A (2005) 1.88
Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice. Mamm Genome (2009) 1.87
The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients. Clin Chest Med (2008) 1.86
Relationship between obesity and diabetes in a US adult population: findings from the National Health and Nutrition Examination Survey, 1999-2006. Obes Surg (2011) 1.85
Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem (2003) 1.82
A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. Nature (2008) 1.79
Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency. Am J Pathol (2002) 1.78
Antiangiogenic properties of gold nanoparticles. Clin Cancer Res (2005) 1.78
A novel method to determine the engulfment of apoptotic cells by macrophages using pHrodo succinimidyl ester. J Immunol Methods (2009) 1.78
Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit Care (2011) 1.78
Vitamin D deficiency, myositis-myalgia, and reversible statin intolerance. Curr Med Res Opin (2011) 1.77
Improved spatial localization of post-stimulus BOLD undershoot relative to positive BOLD. Neuroimage (2006) 1.76
PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia. Cancer Cell (2010) 1.75
Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities. Shock (2013) 1.74
The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron (2010) 1.74
The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis. Shock (2007) 1.71
Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri. J Clin Microbiol (2009) 1.71
Targeting DNA-PKcs and ATM with miR-101 sensitizes tumors to radiation. PLoS One (2010) 1.70
MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T. Magn Reson Med (2012) 1.67
Orexigenic hormone ghrelin ameliorates gut barrier dysfunction in sepsis in rats. Crit Care Med (2009) 1.67
Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med (2005) 1.66
Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J Clin Invest (2003) 1.66
Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge. Crit Care Med (2005) 1.65
Mechanism of estrogen-mediated intestinal protection following trauma-hemorrhage: p38 MAPK-dependent upregulation of HO-1. Am J Physiol Regul Integr Comp Physiol (2008) 1.61
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res (2013) 1.61
A review of statistical methods for expression quantitative trait loci mapping. Mamm Genome (2006) 1.60
A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol (2007) 1.60
Administration of human inter-alpha-inhibitors maintains hemodynamic stability and improves survival during sepsis. Crit Care Med (2002) 1.60
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera. Genetics (2011) 1.60
Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol (2005) 1.60
Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China. Environ Health Perspect (2006) 1.60
Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities. Protein Sci (2008) 1.60
Evaluation of the human transmission risk of an atypical bovine spongiform encephalopathy prion strain. J Virol (2008) 1.59
Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice. Crit Care Med (2011) 1.58
Scientific priorities and strategic planning for resuscitation research and life saving therapy following traumatic injury: report of the PULSE Trauma Work Group. Acad Emerg Med (2002) 1.57
Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa. Biochem J (2011) 1.57
Nonarteritic anterior ischemic optic neuropathy: associations with homozygosity for the C677T methylenetetrahydrofolate reductase mutation. J Lab Clin Med (2004) 1.57
C2A activates a cryptic Ca(2+)-triggered membrane penetration activity within the C2B domain of synaptotagmin I. Proc Natl Acad Sci U S A (2002) 1.56
Influence of sex and age on mods and cytokines after multiple injuries. Shock (2007) 1.56
Adipocyte extracellular matrix composition, dynamics and role in obesity. Cell Mol Life Sci (2010) 1.56
Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology (2011) 1.55
The salient characteristics of the central effects of acupuncture needling: limbic-paralimbic-neocortical network modulation. Hum Brain Mapp (2009) 1.55
Magnetic resonance imaging of the Amine-Proton EXchange (APEX) dependent contrast. Neuroimage (2011) 1.54
Procoagulants and osteonecrosis. J Rheumatol (2003) 1.54
Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol (2012) 1.52
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity. J Clin Invest (2015) 1.52
Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation. Crit Care Med (2009) 1.52
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature (2016) 1.52
Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol Med (2009) 1.52
Tumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner. Crit Care Med (2002) 1.52
Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J Mol Neurosci (2011) 1.52
Modern analytical techniques in metabolomics analysis. Analyst (2011) 1.52
Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem (2007) 1.52
The physiologic effects of caloric restriction are reflected in the in vivo adipocyte-enriched proteome of overweight/obese subjects. J Proteome Res (2009) 1.51
Analysis and prediction of the metabolic stability of proteins based on their sequential features, subcellular locations and interaction networks. PLoS One (2010) 1.51
Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations. Pharmacogenomics (2008) 1.50
Dendritic cell-derived exosomes containing milk fat globule epidermal growth factor-factor VIII attenuate proinflammatory responses in sepsis. Shock (2006) 1.50
Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J (2008) 1.50