PubRank

Andrew P McMahon

Author PubWeight™ 302.70‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol 2002 13.87
2 Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med 2004 8.89
3 Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 2005 7.64
4 Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol 2009 7.34
5 Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 2006 7.08
6 Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell 2004 7.01
7 Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell 2008 6.54
8 Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell 2008 5.76
9 Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 2005 4.91
10 Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell 2008 4.68
11 Mouse brain organization revealed through direct genome-scale TF expression analysis. Science 2004 4.55
12 Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 2002 4.18
13 A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development 2002 4.13
14 Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 2008 3.86
15 Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev 2004 3.83
16 Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron 2003 3.76
17 The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell 2003 3.66
18 Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 2002 3.49
19 WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature 2005 3.44
20 Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 2008 3.30
21 Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A 2008 3.10
22 Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 2003 3.08
23 A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res 2006 3.06
24 Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest 2013 3.03
25 Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development 2005 2.98
26 Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell 2005 2.95
27 Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development 2007 2.92
28 Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A 2010 2.87
29 The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet 2007 2.85
30 Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol 2004 2.77
31 Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev 2008 2.74
32 Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest 2004 2.72
33 Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development 2007 2.70
34 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev 2008 2.66
35 The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell 2006 2.62
36 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development 2007 2.60
37 A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development 2009 2.55
38 Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev 2010 2.50
39 Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell 2008 2.44
40 Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell 2007 2.41
41 Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development 2004 2.39
42 Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev 2003 2.34
43 Neural crest origins of the neck and shoulder. Nature 2005 2.31
44 A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet 2005 2.26
45 The GUDMAP database--an online resource for genitourinary research. Development 2011 2.20
46 Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell 2013 2.17
47 Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A 2008 2.15
48 A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev 2002 2.09
49 Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney. Dev Biol 2008 2.08
50 Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A 2009 2.04
51 Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev 2003 2.00
52 Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development 2008 1.90
53 Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod 2012 1.88
54 The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev 2007 1.87
55 FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J 2003 1.85
56 High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol 2009 1.84
57 Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol 2009 1.83
58 Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest 2005 1.82
59 Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol 2007 1.82
60 Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol 2012 1.80
61 Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development 2002 1.78
62 Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell 2011 1.77
63 A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns 2007 1.77
64 Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell 2012 1.75
65 Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development 2004 1.74
66 Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development 2004 1.72
67 Shifting paradigms in Hedgehog signaling. Curr Opin Cell Biol 2007 1.67
68 Regulation of skeletogenic differentiation in cranial dermal bone. Development 2007 1.65
69 Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis. J Am Soc Nephrol 2012 1.65
70 Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development 2002 1.61
71 Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell 2009 1.61
72 Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr Patterns 2002 1.61
73 A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development 2002 1.60
74 Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet 2007 1.59
75 Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. Nat Genet 2005 1.58
76 Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell 2011 1.55
77 Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development 2008 1.54
78 Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int 2010 1.54
79 Recent genetic studies of mouse kidney development. Curr Opin Genet Dev 2004 1.45
80 BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A 2005 1.44
81 Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis 2003 1.43
82 Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol 2003 1.41
83 The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science 2004 1.40
84 Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Birth Defects Res A Clin Mol Teratol 2006 1.39
85 Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell 2009 1.38
86 Reproducible and inducible knockdown of gene expression in mice. Genesis 2006 1.37
87 Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development 2010 1.37
88 Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol 2012 1.34
89 Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc Natl Acad Sci U S A 2002 1.33
90 Wnt-1 and Wnt-4 regulate thymic cellularity. Eur J Immunol 2002 1.33
91 Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat Neurosci 2002 1.32
92 Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell 2007 1.31
93 Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A 2012 1.31
94 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A 2010 1.28
95 Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development 2004 1.28
96 Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 2003 1.26
97 Neural-specific Sox2 input and differential Gli-binding affinity provide context and positional information in Shh-directed neural patterning. Genes Dev 2012 1.24
98 Cell-specific translational profiling in acute kidney injury. J Clin Invest 2014 1.23
99 An ES cell system for rapid, spatial and temporal analysis of gene function in vitro and in vivo. Nucleic Acids Res 2005 1.22
100 Motor neurons with axial muscle projections specified by Wnt4/5 signaling. Neuron 2009 1.22
101 Cholesterol modification of Hedgehog family proteins. J Clin Invest 2002 1.17
102 Wnt4/β-catenin signaling in medullary kidney myofibroblasts. J Am Soc Nephrol 2013 1.16
103 The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. Proc Natl Acad Sci U S A 2012 1.14
104 Gene regulatory networks mediating canonical Wnt signal-directed control of pluripotency and differentiation in embryo stem cells. Stem Cells 2013 1.14
105 Mouse Disp1 is required in sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 2004 1.13
106 Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development 2012 1.13
107 Fate-mapping of the epithelial seam during palatal fusion rules out epithelial-mesenchymal transformation. Dev Biol 2005 1.11
108 Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development 2011 1.10
109 Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol 2008 1.10
110 Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen. Development 2007 1.09
111 Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein. J Am Chem Soc 2006 1.07
112 In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. J Biol Chem 2008 1.06
113 Noggin antagonism of BMP4 signaling controls development of the axial skeleton in the mouse. Dev Biol 2005 1.06
114 Independent regulation of skeletal growth by Ihh and IGF signaling. Dev Biol 2006 1.03
115 Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development. Development 2003 1.03
116 Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development 2003 0.99
117 Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol 2007 0.99
118 An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. J Am Chem Soc 2008 0.98
119 Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol 2012 0.98
120 Defining kidney biology to understand renal disease. Clin J Am Soc Nephrol 2013 0.96
121 Signaling by SHH rescues facial defects following blockade in the brain. Dev Dyn 2012 0.95
122 Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns 2008 0.94
123 Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol 2012 0.93
124 Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development 2013 0.92
125 Mutations in Hedgehog pathway genes in fetal rhabdomyomas. J Pathol 2013 0.92
126 Lkb1/Stk11 regulation of mTOR signaling controls the transition of chondrocyte fates and suppresses skeletal tumor formation. Proc Natl Acad Sci U S A 2013 0.91
127 Developmental biology. Grasping limb patterning. Science 2008 0.91
128 A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices 2010 0.90
129 Hedgehog signalling: Kif7 is not that fishy after all. Curr Biol 2009 0.89
130 Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev 2002 0.89
131 An Hh-dependent pathway in lateral plate mesoderm enables the generation of left/right asymmetry. Curr Biol 2009 0.89
132 Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One 2012 0.87
133 Modeling the spatio-temporal network that drives patterning in the vertebrate central nervous system. Biochim Biophys Acta 2009 0.86
134 A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci 2012 0.84
135 Retracted Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development 2004 0.84
136 Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye. Dev Biol 2008 0.81
137 Using mechanistic Bayesian networks to identify downstream targets of the sonic hedgehog pathway. BMC Bioinformatics 2009 0.79
138 An embryonic stem cell-based system for rapid analysis of transcriptional enhancers. Genesis 2012 0.79
139 Progenitor programming in mammalian nephrogenesis. Nephrology (Carlton) 2013 0.78
140 Hedgehog signaling: iguana debuts as a nuclear gatekeeper. Curr Biol 2004 0.78
141 Disp1 regulates growth of mammalian long bones through the control of Ihh distribution. Dev Biol 2008 0.77
142 Corrigendum: The dynamics of methylammonium ions in hybrid organic-inorganic perovskite solar cells. Nat Commun 2015 0.77
143 Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation. PLoS Genet 2016 0.75
144 A novel site comes into sight. Elife 2013 0.75
145 Retraction: Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development 2005 0.75