Published in Dev Biol on June 15, 2004
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci (2009) 21.94
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell (2008) 2.68
Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome. Am J Hum Genet (2008) 2.65
Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool. Dev Biol (2008) 2.38
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev (2007) 1.87
Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Mol Cell Biol (2007) 1.64
Zfp423 is required for normal cerebellar development. Mol Cell Biol (2006) 1.62
Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages. Proc Natl Acad Sci U S A (2009) 1.58
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell (2011) 1.55
Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development. Proc Natl Acad Sci U S A (2010) 1.46
Abnormalities in brain structure and behavior in GSK-3alpha mutant mice. Mol Brain (2009) 1.44
Deletion of Atoh1 disrupts Sonic Hedgehog signaling in the developing cerebellum and prevents medulloblastoma. Science (2009) 1.42
Cerebellum morphogenesis: the foliation pattern is orchestrated by multi-cellular anchoring centers. Neural Dev (2007) 1.42
LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A (2007) 1.41
The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning. Dev Biol (2007) 1.39
Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron (2011) 1.35
A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury. Sci Transl Med (2011) 1.35
The functional diversity of retinal ganglion cells in the mouse. Nature (2016) 1.27
Retinoid signaling in progenitors controls specification and regeneration of the urothelium. Dev Cell (2013) 1.23
Timing neurogenesis and differentiation: insights from quantitative clonal analyses of cerebellar granule cells. J Neurosci (2008) 1.19
Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) regulates growth and patterning of the postnatal mouse cerebellum. Dev Biol (2008) 1.18
Primary cilia in neurodevelopmental disorders. Nat Rev Neurol (2013) 1.14
Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar development. J Neurosci (2006) 1.11
Characterization of transgenic mouse lines expressing Cre recombinase in the retina. Neuroscience (2009) 1.11
Multiple developmental programs are altered by loss of Zic1 and Zic4 to cause Dandy-Walker malformation cerebellar pathogenesis. Development (2011) 1.11
The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum. Development (2010) 1.09
Sonic Hedgehog promotes the development of multipotent neural crest progenitors endowed with both mesenchymal and neural potentials. Proc Natl Acad Sci U S A (2007) 1.05
Differential modulation of Sonic-hedgehog-induced cerebellar granule cell precursor proliferation by the IGF signaling network. Dev Neurosci (2010) 1.03
The autism susceptibility gene met regulates zebrafish cerebellar development and facial motor neuron migration. Dev Biol (2009) 1.03
Congenital hypoplasia of the cerebellum: developmental causes and behavioral consequences. Front Neuroanat (2013) 1.02
Sonic hedgehog signaling during adrenal development. Mol Cell Endocrinol (2011) 0.95
Sonic hedgehog is required for vascular outgrowth in the hindbrain choroid plexus. Dev Biol (2010) 0.94
Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development (2011) 0.94
The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliation. PLoS One (2011) 0.94
Analysis of human samples reveals impaired SHH-dependent cerebellar development in Joubert syndrome/Meckel syndrome. Proc Natl Acad Sci U S A (2012) 0.94
Trps1 and its target gene Sox9 regulate epithelial proliferation in the developing hair follicle and are associated with hypertrichosis. PLoS Genet (2012) 0.92
Altered cerebellar development in nuclear receptor TAK1/ TR4 null mice is associated with deficits in GLAST(+) glia, alterations in social behavior, motor learning, startle reactivity, and microglia. Cerebellum (2010) 0.91
Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling. EMBO Rep (2013) 0.89
Consensus Paper: Cerebellar Development. Cerebellum (2016) 0.89
Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms. Mol Endocrinol (2014) 0.88
Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. Cancer Res (2014) 0.88
Cerebellar zonal patterning relies on Purkinje cell neurotransmission. J Neurosci (2014) 0.87
Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-Cre transgenic mouse line. J Comp Neurol (2013) 0.87
F3/contactin and TAG1 play antagonistic roles in the regulation of sonic hedgehog-induced cerebellar granule neuron progenitor proliferation. Development (2011) 0.87
A Sonic hedgehog (Shh) response deficit in trisomic cells may be a common denominator for multiple features of Down syndrome. Prog Brain Res (2012) 0.87
The Purkinje neuron acts as a central regulator of spatially and functionally distinct cerebellar precursors. Dev Cell (2013) 0.86
Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma. Oncogene (2012) 0.86
Glucocorticoid treatment of MCMV infected newborn mice attenuates CNS inflammation and limits deficits in cerebellar development. PLoS Pathog (2013) 0.86
Clonal analysis reveals granule cell behaviors and compartmentalization that determine the folded morphology of the cerebellum. Development (2015) 0.86
Cellular commitment in the developing cerebellum. Front Cell Neurosci (2015) 0.86
Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. PLoS One (2014) 0.85
Loss of apoptosis-inducing factor results in cell-type-specific neurogenesis defects. J Neurosci (2008) 0.85
Preterm delivery disrupts the developmental program of the cerebellum. PLoS One (2011) 0.85
Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development (2011) 0.84
A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis. Dev Biol (2011) 0.84
Nuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations. Dev Dyn (2014) 0.84
The compartmental restriction of cerebellar interneurons. Front Neural Circuits (2013) 0.83
Cerebellar cortical lamination and foliation require cyclin A2. Dev Biol (2013) 0.82
Thyroid hormone regulates the expression of the sonic hedgehog signaling pathway in the embryonic and adult Mammalian brain. Endocrinology (2011) 0.82
β-Catenin is critical for cerebellar foliation and lamination. PLoS One (2013) 0.82
Subcellular distribution of patched and smoothened in the cerebellar neurons. Cerebellum (2012) 0.82
Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential. Mol Cell Endocrinol (2011) 0.81
Sonic hedgehog signaling in the development of the mouse hypothalamus. Front Neuroanat (2015) 0.81
FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum. PLoS One (2014) 0.80
PEX13 deficiency in mouse brain as a model of Zellweger syndrome: abnormal cerebellum formation, reactive gliosis and oxidative stress. Dis Model Mech (2010) 0.80
TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23). Elife (2015) 0.80
Cerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin(+) progenitors. Nat Neurosci (2017) 0.80
An essential role for p38 MAPK in cerebellar granule neuron precursor proliferation. Acta Neuropathol (2012) 0.79
Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PLoS One (2012) 0.79
Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation. J Neurosci (2015) 0.79
Cyclin-dependent kinase 5 is required for normal cerebellar development. Mol Cell Neurosci (2012) 0.79
Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development. Hum Mol Genet (2015) 0.78
Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. PLoS One (2014) 0.78
Cre-mediated recombination efficiency and transgene expression patterns of three retinal bipolar cell-expressing Cre transgenic mouse lines. Mol Vis (2013) 0.77
MicroRNA Biogenesis and Hedgehog-Patched Signaling Cooperate to Regulate an Important Developmental Transition in Granule Cell Development. Genetics (2016) 0.76
Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum. Development (2016) 0.76
In ovo RNAi opens new possibilities for temporal and spatial control of gene silencing during development of the vertebrate nervous system. J RNAi Gene Silencing (2006) 0.76
Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases. J Exp Neurosci (2016) 0.76
The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression. J Clin Invest (2017) 0.75
Differential timing of granule cell production during cerebellum development underlies generation of the foliation pattern. Neural Dev (2016) 0.75
Wnt5a is a crucial regulator of neurogenesis during cerebellum development. Sci Rep (2017) 0.75
The Purkinje neuron: A central orchestrator of cerebellar neurogenesis. Neurogenesis (Austin) (2015) 0.75
INSM1 increases N-myc stability and oncogenesis via a positive-feedback loop in neuroblastoma. Oncotarget (2015) 0.75
β-Catenin signaling regulates temporally discrete phases of anterior taste bud development. Development (2015) 0.75
Proteoglycans specify Sonic Hedgehog effect. Nat Neurosci (2009) 0.75
LKB1 Regulates Cerebellar Development by Controlling Sonic Hedgehog-mediated Granule Cell Precursor Proliferation and Granule Cell Migration. Sci Rep (2015) 0.75
Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet (2017) 0.75
Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway. Cell Death Dis (2017) 0.75
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development (2006) 7.08
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell (2005) 4.91
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development (2002) 4.18
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development (2002) 4.13
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science (2008) 3.86
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev (2002) 3.49
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest (2013) 3.03
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development (2005) 2.98
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell (2005) 2.95
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (2007) 2.92
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet (2007) 2.85
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell (2006) 2.62
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development (2007) 2.60
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development (2004) 2.39
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity. Nat Immunol (2008) 2.34
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev (2003) 2.34
Neural crest origins of the neck and shoulder. Nature (2005) 2.31
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20
Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell (2013) 2.17
Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A (2008) 2.15
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev (2002) 2.09
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04
Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev (2003) 2.00
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90
Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod (2012) 1.88
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev (2007) 1.87
FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J (2003) 1.85
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol (2009) 1.84
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol (2009) 1.83
Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest (2005) 1.82
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol (2007) 1.82
Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol (2012) 1.80
Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development (2002) 1.78
Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. Dev Cell (2011) 1.77
A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns (2007) 1.77
Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell (2012) 1.75
Hedgehog signaling is essential for endothelial tube formation during vasculogenesis. Development (2004) 1.74
Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the hedgehog antagonists patched 1 and Hhip1. Development (2004) 1.72
Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell (2011) 1.67
Shifting paradigms in Hedgehog signaling. Curr Opin Cell Biol (2007) 1.67
Regulation of skeletogenic differentiation in cranial dermal bone. Development (2007) 1.65
Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis. J Am Soc Nephrol (2012) 1.65
Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling. Development (2002) 1.61
Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis. Cell Stem Cell (2009) 1.61
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr Patterns (2002) 1.61
A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development (2002) 1.60
Lrp4 modulates extracellular integration of cell signaling pathways in development. PLoS One (2008) 1.60
Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate. Nat Genet (2012) 1.60
Modulation of morphogenesis by noncanonical Wnt signaling requires ATF/CREB family-mediated transcriptional activation of TGFbeta2. Nat Genet (2007) 1.59
Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. Nat Genet (2005) 1.58
Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. Dev Cell (2011) 1.55
Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development (2008) 1.54
Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int (2010) 1.54
Recent genetic studies of mouse kidney development. Curr Opin Genet Dev (2004) 1.45
BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A (2005) 1.44
Maternal inheritance of Cre activity in a Sox2Cre deleter strain. Genesis (2003) 1.43
Branching morphogenesis of the lung: new molecular insights into an old problem. Trends Cell Biol (2003) 1.41
The limb bud Shh-Fgf feedback loop is terminated by expansion of former ZPA cells. Science (2004) 1.40
Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test. Birth Defects Res A Clin Mol Teratol (2006) 1.39
Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb. Dev Cell (2009) 1.38
Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract. Development (2010) 1.37
Reproducible and inducible knockdown of gene expression in mice. Genesis (2006) 1.37
Hedgehog-Gli pathway activation during kidney fibrosis. Am J Pathol (2012) 1.34
Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc Natl Acad Sci U S A (2002) 1.33
Wnt-1 and Wnt-4 regulate thymic cellularity. Eur J Immunol (2002) 1.33
Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells. Nat Neurosci (2002) 1.32
Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. Dev Cell (2007) 1.31
Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways. Proc Natl Acad Sci U S A (2012) 1.31
Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.28
Temporal requirement for hedgehog signaling in ventral telencephalic patterning. Development (2004) 1.28