Published in Science on July 16, 2004
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A (2010) 4.17
Vertebrate limb bud development: moving towards integrative analysis of organogenesis. Nat Rev Genet (2009) 2.67
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66
Tissue remodelling through branching morphogenesis. Nat Rev Mol Cell Biol (2009) 2.06
An Fgf/Gremlin inhibitory feedback loop triggers termination of limb bud outgrowth. Nature (2008) 1.55
Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev (2008) 1.41
Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development. PLoS Genet (2010) 1.35
Vertebrate limb development: moving from classical morphogen gradients to an integrated 4-dimensional patterning system. Cold Spring Harb Perspect Biol (2009) 1.31
Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development (2005) 1.11
Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum Mol Genet (2010) 1.07
GLI3 constrains digit number by controlling both progenitor proliferation and BMP-dependent exit to chondrogenesis. Dev Cell (2012) 1.07
Sall genes regulate region-specific morphogenesis in the mouse limb by modulating Hox activities. Development (2009) 1.02
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Hum Mol Genet (2012) 1.00
Delineating a conserved genetic cassette promoting outgrowth of body appendages. PLoS Genet (2013) 0.99
Polydactyly in the mouse mutant Doublefoot involves altered Gli3 processing and is caused by a large deletion in cis to Indian hedgehog. Mech Dev (2008) 0.99
A second wave of Sonic hedgehog expression during the development of the bat limb. Proc Natl Acad Sci U S A (2008) 0.98
Genetic evidence that SOST inhibits WNT signaling in the limb. Dev Biol (2010) 0.98
Occurrence of polymelia in a female child. J Clin Imaging Sci (2013) 0.95
Shh pathway activation is present and required within the vertebrate limb bud apical ectodermal ridge for normal autopod patterning. Proc Natl Acad Sci U S A (2010) 0.92
Biological determinants of bladder cancer gene expression subtypes. Sci Rep (2015) 0.90
Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds. BMC Dev Biol (2012) 0.90
Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth. Dev Dyn (2011) 0.89
The interplay between morphogens and tissue growth. EMBO Rep (2011) 0.89
Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1. PLoS Genet (2013) 0.86
Sonic hedgehog-expressing cells in the developing limb measure time by an intrinsic cell cycle clock. Nat Commun (2014) 0.86
Hedgehog Signaling during Appendage Development and Regeneration. Genes (Basel) (2015) 0.80
Molecular anatomy of the developing limb in the coquí frog, Eleutherodactylus coqui. Evol Dev (2012) 0.80
Dynamics of BMP signaling in limb bud mesenchyme and polydactyly. Dev Biol (2014) 0.80
Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina. Development (2015) 0.77
Saunders's framework for understanding limb development as a platform for investigating limb evolution. Dev Biol (2016) 0.76
T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. Elife (2016) 0.76
Limb patterning genes and heterochronic development of the emu wing bud. Evodevo (2016) 0.75
Sonic Hedgehog Signaling in Limb Development. Front Cell Dev Biol (2017) 0.75
Pleiotropic patterning response to activation of Shh signaling in the limb apical ectodermal ridge. Dev Dyn (2011) 0.75
Intrinsic properties of limb bud cells can be differentially reset. Development (2017) 0.75
John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work? Dev Biol (2017) 0.75
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89
The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development (2006) 7.08
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54
Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis (2002) 6.11
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76
Bmp4 and morphological variation of beaks in Darwin's finches. Science (2004) 5.65
Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol (2003) 5.40
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell (2005) 4.91
Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development (2002) 4.18
The calmodulin pathway and evolution of elongated beak morphology in Darwin's finches. Nature (2006) 4.14
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development (2002) 4.13
Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell (2005) 3.98
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science (2008) 3.86
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet (2006) 3.79
The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature (2005) 3.78
A somitic compartment of tendon progenitors. Cell (2003) 3.77
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism. Nat Genet (2005) 3.66
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev (2002) 3.49
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30
Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis. PLoS Genet (2006) 3.27
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science (2013) 3.15
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest (2013) 3.03
Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol (2009) 3.02
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development (2005) 2.98
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell (2005) 2.95
Villification: how the gut gets its villi. Science (2013) 2.94
Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development (2007) 2.92
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (2007) 2.92
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet (2007) 2.85
On the growth and form of the gut. Nature (2011) 2.82
Epidermal stem cells arise from the hair follicle after wounding. FASEB J (2007) 2.81
MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes (2007) 2.80
The African coelacanth genome provides insights into tetrapod evolution. Nature (2013) 2.78
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol (2004) 2.77
Sequencing of the sea lamprey (Petromyzon marinus) genome provides insights into vertebrate evolution. Nat Genet (2013) 2.76
Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell (2006) 2.62
The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development (2007) 2.60
Transmembrane protein 16A (TMEM16A) is a Ca2+-regulated Cl- secretory channel in mouse airways. J Biol Chem (2009) 2.59
Conserved function for embryonic nodal cilia. Nature (2002) 2.56
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50
Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development (2004) 2.39
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev (2003) 2.34
Studies on expression and function of the TMEM16A calcium-activated chloride channel. Proc Natl Acad Sci U S A (2009) 2.33
Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32
Neural crest origins of the neck and shoulder. Nature (2005) 2.31
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20
A re-examination of proximodistal patterning during vertebrate limb development. Nature (2002) 2.20
Multi-trait evolution in a cave fish, Astyanax mexicanus. Evol Dev (2008) 2.17
Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell (2013) 2.17
Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A (2008) 2.15
Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene. Dev Dyn (2007) 2.11
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev (2002) 2.09
Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport. J Biol Chem (2009) 2.07
Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function. Nature (2005) 2.07
Distinct compartments of the proepicardial organ give rise to coronary vascular endothelial cells. Dev Cell (2012) 2.06
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04
Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature (2013) 2.02
Somitic origin of limb muscle satellite and side population cells. Proc Natl Acad Sci U S A (2006) 2.01
WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Curr Biol (2010) 2.00
Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev (2003) 2.00
LPS induces KH-type splicing regulatory protein-dependent processing of microRNA-155 precursors in macrophages. FASEB J (2009) 1.99
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98