Published in Dev Cell on February 01, 2005
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Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell (2010) 3.78
The aged niche disrupts muscle stem cell quiescence. Nature (2012) 3.46
Advances in early kidney specification, development and patterning. Development (2009) 2.62
Hormonal and local control of mammary branching morphogenesis. Differentiation (2006) 2.60
Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell (2006) 2.27
Non-canonical Wnt5a/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension. Hum Mol Genet (2014) 2.19
Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science (2011) 2.12
Tissue remodelling through branching morphogenesis. Nat Rev Mol Cell Biol (2009) 2.06
Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell (2010) 2.03
An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development (2007) 1.95
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol (2007) 1.82
Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. Dev Cell (2009) 1.81
MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy. J Biol Chem (2011) 1.68
Novel mechanisms of early upper and lower urinary tract patterning regulated by RetY1015 docking tyrosine in mice. Development (2012) 1.64
Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest (2006) 1.63
Periodic stripe formation by a Turing mechanism operating at growth zones in the mammalian palate. Nat Genet (2012) 1.60
Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nat Genet (2009) 1.55
Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev (2006) 1.54
Intermolecular interactions of Sprouty proteins and their implications in development and disease. Mol Pharmacol (2009) 1.52
Molecular regulation of kidney development: is the answer blowing in the Wnt? Pediatr Nephrol (2007) 1.52
A dosage-dependent role for Spry2 in growth and patterning during palate development. Mech Dev (2007) 1.51
Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis. PLoS Biol (2016) 1.49
The ECM protein nephronectin promotes kidney development via integrin alpha8beta1-mediated stimulation of Gdnf expression. Development (2007) 1.42
Kidney development in the absence of Gdnf and Spry1 requires Fgf10. PLoS Genet (2010) 1.40
Comparative mechanisms of branching morphogenesis in diverse systems. J Mammary Gland Biol Neoplasia (2006) 1.39
Cell and molecular biology of kidney development. Semin Nephrol (2009) 1.32
Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. PLoS Genet (2008) 1.27
Semaphorin3a inhibits ureteric bud branching morphogenesis. Mech Dev (2007) 1.24
Genetic controls and cellular behaviors in branching morphogenesis of the renal collecting system. Wiley Interdiscip Rev Dev Biol (2013) 1.19
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Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation. J Clin Invest (2010) 1.17
Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatr Res (2008) 1.16
FGF/EGF signaling regulates the renewal of early nephron progenitors during embryonic development. Development (2011) 1.16
BMP receptor ALK3 controls collecting system development. J Am Soc Nephrol (2008) 1.14
PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Dev Biol (2007) 1.12
Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo. Dev Biol (2008) 1.10
Regulation of tooth number by fine-tuning levels of receptor-tyrosine kinase signaling. Development (2011) 1.08
GDNF/Ret signaling and renal branching morphogenesis: From mesenchymal signals to epithelial cell behaviors. Organogenesis (2011) 1.08
Sprouty proteins inhibit receptor-mediated activation of phosphatidylinositol-specific phospholipase C. Mol Biol Cell (2010) 1.06
The many faces of RET dysfunction in kidney. Organogenesis (2009) 1.05
FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet (2011) 1.04
Using mouse models to understand normal and abnormal urogenital tract development. Organogenesis (2009) 1.04
Overexpression of Spry1 in chondrocytes causes attenuated FGFR ubiquitination and sustained ERK activation resulting in chondrodysplasia. Dev Biol (2008) 1.04
Maturation of ureter-bladder connection in mice is controlled by LAR family receptor protein tyrosine phosphatases. J Clin Invest (2009) 1.01
Genetic and developmental basis for urinary tract obstruction. Pediatr Nephrol (2008) 1.01
Kidney development: from ureteric bud formation to branching morphogenesis. Curr Opin Genet Dev (2009) 1.01
The transcription factors Etv4 and Etv5 mediate formation of the ureteric bud tip domain during kidney development. Development (2010) 0.99
p53 regulates metanephric development. J Am Soc Nephrol (2009) 0.99
Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys. Dev Biol (2012) 0.98
Repression of Fgf signaling by sprouty1-2 regulates cortical patterning in two distinct regions and times. J Neurosci (2010) 0.97
Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation. FASEB J (2010) 0.97
Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. J Clin Invest (2010) 0.95
Loss of Sprouty1 rescues renal agenesis caused by Ret mutation. J Am Soc Nephrol (2008) 0.95
Sall1-dependent signals affect Wnt signaling and ureter tip fate to initiate kidney development. Development (2010) 0.95
Sprouty is a negative regulator of transforming growth factor β-induced epithelial-to-mesenchymal transition and cataract. Mol Med (2012) 0.95
Characterisation of a new regulator of BDNF signalling, Sprouty3, involved in axonal morphogenesis in vivo. Development (2010) 0.94
Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum. Development (2011) 0.94
Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns (2008) 0.94
Spry1 and spry2 are essential for development of the temporomandibular joint. J Dent Res (2012) 0.94
Sprouty genes function in suppression of prostate tumorigenesis. Proc Natl Acad Sci U S A (2012) 0.93
Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis. Pediatr Nephrol (2008) 0.93
Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding. Mol Cell Biol (2014) 0.92
Stromal expression of decorin, Semaphorin6D, SPARC, Sprouty1 and Tsukushi in developing prostate and decreased levels of decorin in prostate cancer. PLoS One (2012) 0.92
Genetics of vesicoureteral reflux. Nat Rev Urol (2011) 0.92
Expression profiles of congenital renal dysplasia reveal new insights into renal development and disease. Pediatr Nephrol (2007) 0.90
Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling. Dev Biol (2011) 0.89
Downregulation of Spry-1, an inhibitor of GDNF/Ret, causes angiotensin II-induced ureteric bud branching. Kidney Int (2008) 0.89
Traditional and targeted exome sequencing reveals common, rare and novel functional deleterious variants in RET-signaling complex in a cohort of living US patients with urinary tract malformations. Hum Genet (2012) 0.89
Conditional expression of Spry1 in neural crest causes craniofacial and cardiac defects. BMC Dev Biol (2010) 0.89
Spry1 and Spry4 differentially regulate human aortic smooth muscle cell phenotype via Akt/FoxO/myocardin signaling. PLoS One (2013) 0.88
Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo. Dev Biol (2011) 0.88
Spry1 and Spry2 are necessary for lens vesicle separation and corneal differentiation. Invest Ophthalmol Vis Sci (2011) 0.88
Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape. Cell Rep (2015) 0.87
Sprouty4 regulates endothelial cell migration via modulating integrin β3 stability through c-Src. Angiogenesis (2013) 0.87
Lower urinary tract development and disease. Wiley Interdiscip Rev Syst Biol Med (2013) 0.87
Gene regulatory network of renal primordium development. Pediatr Nephrol (2013) 0.87
Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma. Oncogene (2011) 0.86
Development of the Mammalian Kidney. Curr Top Dev Biol (2016) 0.86
Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling. PLoS One (2012) 0.86
A secreted BMP antagonist, Cer1, fine tunes the spatial organization of the ureteric bud tree during mouse kidney development. PLoS One (2011) 0.86
Sprouty1 haploinsufficiency prevents renal agenesis in a model of Fraser syndrome. J Am Soc Nephrol (2012) 0.86
Vesicoureteric reflux and reflux nephropathy: from mouse models to childhood disease. Pediatr Nephrol (2014) 0.85
Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning. Cereb Cortex (2012) 0.84
Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts. J Clin Invest (2006) 0.84
Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol (2013) 0.84
Angiotensin II-induced activation of c-Ret signaling is critical in ureteric bud branching morphogenesis. Mech Dev (2009) 0.84
Spry1 as a novel regulator of erythropoiesis, EPO/EPOR target, and suppressor of JAK2. Blood (2012) 0.83
Protein kinase A regulates GDNF/RET-dependent but not GDNF/Ret-independent ureteric bud outgrowth from the Wolffian duct. Dev Biol (2010) 0.83
Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. Development (2012) 0.83
Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo. BMC Genomics (2010) 0.83
Fibroblast growth factor signaling in the vasculature. Curr Atheroscler Rep (2015) 0.82
Negative Regulation of Receptor Tyrosine Kinase (RTK) Signaling: A Developing Field. Biomark Insights (2007) 0.82
Genetic analysis reveals an unexpected role of BMP7 in initiation of ureteric bud outgrowth in mouse embryos. PLoS One (2011) 0.82
Renin-angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms. Pediatr Nephrol (2011) 0.82
Branching morphogenesis. Circ Res (2009) 0.82
Yap and Taz are required for Ret-dependent urinary tract morphogenesis. Development (2015) 0.82
Spry1 and Spry2 are necessary for eyelid closure. Dev Biol (2013) 0.81
To bud or not to bud: the RET perspective in CAKUT. Pediatr Nephrol (2014) 0.81
Expression and functional role of sprouty-2 in breast morphogenesis. PLoS One (2013) 0.81
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell (2010) 15.20
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature (2008) 10.73
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development (2006) 7.08
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76
Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. Nat Genet (2003) 5.16
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell (2005) 4.91
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol (2006) 4.81
The branching programme of mouse lung development. Nature (2008) 4.73
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb. Nat Cell Biol (2009) 4.32
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development (2002) 4.18
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development (2002) 4.13
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity (2013) 4.08
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation. Blood (2009) 4.00
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science (2008) 3.86
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature (2010) 3.84
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev (2002) 3.49
Functions of FGF signalling from the apical ectodermal ridge in limb development. Nature (2002) 3.47
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
Specification of jaw subdivisions by Dlx genes. Science (2002) 3.33
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol (2005) 3.14
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell (2013) 3.13
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med (2004) 3.10
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest (2013) 3.03
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development (2005) 2.98
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (2007) 2.92
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell (2010) 2.89
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet (2007) 2.85
Sprouty2, a mouse deafness gene, regulates cell fate decisions in the auditory sensory epithelium by antagonizing FGF signaling. Dev Cell (2005) 2.84
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat Genet (2009) 2.84
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol (2004) 2.77
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell (2004) 2.74
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood (2010) 2.71
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell (2006) 2.62
Histone deacetylase inhibitors in cancer therapy: is transcription the primary target? Cancer Cell (2003) 2.61
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development (2007) 2.60
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood (2007) 2.58
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development (2006) 2.50
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
The Dlx5 and Dlx6 homeobox genes are essential for craniofacial, axial, and appendicular skeletal development. Genes Dev (2002) 2.48
Tbx3 improves the germ-line competency of induced pluripotent stem cells. Nature (2010) 2.46
Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44
A common progenitor for haematopoietic and endothelial lineages in the zebrafish gastrula. Nature (2006) 2.42
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development (2005) 2.40
MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells (2007) 2.40
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development (2004) 2.39
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev (2003) 2.34
Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genet (2005) 2.32
Neural crest origins of the neck and shoulder. Nature (2005) 2.31
Sprouty genes control diastema tooth development via bidirectional antagonism of epithelial-mesenchymal FGF signaling. Dev Cell (2006) 2.27
GDNF/Ret signaling and the development of the kidney. Bioessays (2006) 2.27
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell (2003) 2.20
Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell (2013) 2.17
Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A (2008) 2.15
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev (2002) 2.09
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04
Sprouty1 regulates reversible quiescence of a self-renewing adult muscle stem cell pool during regeneration. Cell Stem Cell (2010) 2.03
Genetic evidence that FGFs have an instructive role in limb proximal-distal patterning. Nature (2008) 2.01
HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. J Clin Invest (2010) 2.00
Aberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis. Mol Cell Biol (2003) 2.00
Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev (2003) 2.00
Deciphering skeletal patterning: clues from the limb. Nature (2003) 2.00
Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis. Dev Biol (2008) 1.97
E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks. Proc Natl Acad Sci U S A (2008) 1.97
An FGF signaling loop sustains the generation of differentiated progeny from stem cells in mouse incisors. Development (2007) 1.95
Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development (2011) 1.92
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90