Published in Neuron on March 12, 2009
Measured motion: searching for simplicity in spinal locomotor networks. Curr Opin Neurobiol (2009) 2.40
Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. J Neurosci (2013) 2.08
Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Cell Stem Cell (2010) 1.42
Motor axon pathfinding. Cold Spring Harb Perspect Biol (2010) 1.31
MicroRNA miR-9 modifies motor neuron columns by a tuning regulation of FoxP1 levels in developing spinal cords. J Neurosci (2011) 1.24
Sustained Hox5 gene activity is required for respiratory motor neuron development. Nat Neurosci (2012) 1.07
Programming embryonic stem cells to neuronal subtypes. Curr Opin Neurobiol (2010) 1.06
GDE2 regulates subtype-specific motor neuron generation through inhibition of Notch signaling. Neuron (2011) 0.99
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res (2014) 0.98
A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation. Neuron (2012) 0.96
Global gene expression profiling of somatic motor neuron populations with different vulnerability identify molecules and pathways of degeneration and protection. Brain (2010) 0.95
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice. Bone Res (2013) 0.94
Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development (2012) 0.93
Wnt4 participates in the formation of vertebrate neuromuscular junction. PLoS One (2012) 0.90
From nerve net to nerve ring, nerve cord and brain - evolution of the nervous system. Nat Rev Neurosci (2015) 0.89
The transcription factors Nkx2.2 and Nkx2.9 play a novel role in floor plate development and commissural axon guidance. Development (2010) 0.88
Identification of multiple subsets of ventral interneurons and differential distribution along the rostrocaudal axis of the developing spinal cord. PLoS One (2013) 0.87
The lineage contribution and role of Gbx2 in spinal cord development. PLoS One (2011) 0.86
Wnt4 is not sufficient to induce lobuloalveolar mammary development. BMC Dev Biol (2009) 0.85
Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Dev Dyn (2010) 0.85
PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol (2013) 0.83
Wnt7A identifies embryonic γ-motor neurons and reveals early postnatal dependence of γ-motor neurons on a muscle spindle-derived signal. J Neurosci (2012) 0.83
From classical to current: analyzing peripheral nervous system and spinal cord lineage and fate. Dev Biol (2014) 0.83
Directed midbrain and spinal cord neurogenesis from pluripotent stem cells to model development and disease in a dish. Front Neurosci (2014) 0.82
Motor neurons and the generation of spinal motor neuron diversity. Front Cell Neurosci (2014) 0.82
Cellular dissection of the spinal cord motor column by BAC transgenesis and gene trapping in zebrafish. Front Neural Circuits (2013) 0.81
Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Development (2014) 0.81
UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit. Development (2012) 0.78
Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification. Cell Rep (2016) 0.77
Wnt and extraocular muscle sparing in amyotrophic lateral sclerosis. Invest Ophthalmol Vis Sci (2014) 0.77
Detailed expression analysis of regulatory genes in the early developing human neural tube. Stem Cells Dev (2013) 0.77
Somatotopic organization of lumbar muscle-innervating neurons in the ventral horn of the rat spinal cord. J Anat (2010) 0.77
Nkx2.2+ progenitors generate somatic motoneurons in the chick spinal cord. PLoS One (2012) 0.76
Concentration-dependent effects of WNTLESS on WNT1/3A signaling. Dev Dyn (2014) 0.76
Distinct adhesion-independent functions of β-catenin control stage-specific sensory neurogenesis and proliferation. BMC Biol (2015) 0.76
Changing Faces of Transcriptional Regulation Reflected by Zic3. Curr Genomics (2015) 0.75
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (1996) 11.46
Neuronal specification in the spinal cord: inductive signals and transcriptional codes. Nat Rev Genet (2000) 9.54
Secreted antagonists of the Wnt signalling pathway. J Cell Sci (2003) 8.02
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell (2003) 7.93
Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature (1994) 6.57
Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem (2006) 6.32
A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo. Development (1999) 5.85
Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes. Cell (1994) 5.64
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell (2000) 5.49
Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity. Neuron (1999) 4.68
Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. Cell (1997) 4.40
Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science (2003) 4.18
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development (2002) 4.13
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66
Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds. Development (1993) 3.66
A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity. Cell (2005) 3.58
Transcriptional codes and the control of neuronal identity. Annu Rev Neurosci (2002) 3.48
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet (2001) 3.47
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling. Nature (1999) 3.40
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30
A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science (1997) 2.90
Active suppression of interneuron programs within developing motor neurons revealed by analysis of homeodomain factor HB9. Neuron (1999) 2.83
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc Natl Acad Sci U S A (1999) 2.73
Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell (2008) 2.60
LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell (1998) 2.50
Motor neuron columnar fate imposed by sequential phases of Hox-c activity. Nature (2003) 2.47
Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron (2008) 2.44
Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips. Development (1996) 1.99
Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons. Cell (1998) 1.94
Wnts as ligands: processing, secretion and reception. Oncogene (2006) 1.90
Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids. Neuron (2001) 1.81
A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons. Neuron (2003) 1.75
BMPs as mediators of roof plate repulsion of commissural neurons. Neuron (1999) 1.74
Wnt signaling inhibitors regulate the transcriptional response to morphogenetic Shh-Gli signaling in the neural tube. Dev Cell (2006) 1.65
Wnt canonical pathway restricts graded Shh/Gli patterning activity through the regulation of Gli3 expression. Development (2007) 1.60
The development of motor projection patterns in the chick hind limb. J Physiol (1978) 1.56
Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning. Development (2008) 1.54
Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord. Neuron (2007) 1.52
Helping Wingless take flight: how WNT proteins are secreted. Nat Rev Mol Cell Biol (2007) 1.42
Hoxc10 and Hoxd10 regulate mouse columnar, divisional and motor pool identity of lumbar motoneurons. Development (2008) 1.34
A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron (2005) 1.33
Wnt expression patterns in chick embryo nervous system. Mech Dev (1995) 1.33
Retinoid receptor signaling in postmitotic motor neurons regulates rostrocaudal positional identity and axonal projection pattern. Neuron (2003) 1.32
The spinal motor system in early vertebrates and some of its evolutionary changes. Brain Behav Evol (1992) 1.20
Genetic and epigenetic mechanisms contribute to motor neuron pathfinding. Nature (2000) 1.18
The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types. Nat Neurosci (2000) 1.13
Ectopic expression of Hoxd10 in thoracic spinal segments induces motoneurons with a lumbosacral molecular profile and axon projections to the limb. Dev Dyn (2004) 1.09
Wnt signaling determines ventral spinal cord cell fates in a time-dependent manner. Development (2008) 1.08
Pathway selection by chick lumbosacral motoneurons during normal development. Proc R Soc Lond B Biol Sci (1981) 1.03
A review of the organization and evolution of motoneurons innervating the axial musculature of vertebrates. Brain Res (1987) 1.01
Development and migration of avian sympathetic preganglionic neurons. J Comp Neurol (1991) 0.94
Migration patterns of sympathetic preganglionic neurons in embryonic rat spinal cord. J Neurobiol (1991) 0.86
Early embryonic expression of a LIM-homeobox gene Cs-lhx3 is downstream of beta-catenin and responsible for the endoderm differentiation in Ciona savignyi embryos. Development (2001) 0.86
Hypaxial muscle activity during running and breathing in dogs. J Exp Biol (2002) 0.84
The development of motoneurons in the embryonic spinal cord of the mouse mutant, muscular dysgenesis (mdg/mdg): survival, morphology, and biochemical differentiation. Dev Biol (1986) 0.84
Development of the brachial lateral motor column in the wingless mutant chick embryo: motoneuron survival under varying degrees of peripheral load. J Comp Neurol (1987) 0.77
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol (2002) 13.87
Directed differentiation of embryonic stem cells into motor neurons. Cell (2002) 9.76
Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat Neurosci (2007) 7.77
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34
Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development (2006) 7.08
Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell (2004) 7.01
Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54
Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell (2008) 5.76
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell (2005) 4.91
Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev Cell (2006) 4.89
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell (2008) 4.68
Mouse brain organization revealed through direct genome-scale TF expression analysis. Science (2004) 4.55
Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development (2002) 4.18
A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development (2002) 4.13
The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells (2003) 4.11
Retracted A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation. Nat Cell Biol (2007) 3.97
Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science (2008) 3.86
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes Dev (2004) 3.83
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches. Neuron (2003) 3.76
The morphogen sonic hedgehog is an axonal chemoattractant that collaborates with netrin-1 in midline axon guidance. Cell (2003) 3.66
A Hox regulatory network establishes motor neuron pool identity and target-muscle connectivity. Cell (2005) 3.58
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev (2002) 3.49
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development (2008) 3.30
Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep (2001) 3.08
Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development (2003) 3.08
A novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog pathway. Cancer Res (2006) 3.06
Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest (2013) 3.03
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development. Development (2005) 2.98
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction. Dev Cell (2005) 2.95
Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science (2004) 2.95
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A (2002) 2.93
Wnt/beta-catenin signaling regulates nephron induction during mouse kidney development. Development (2007) 2.92
Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87
The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros. PLoS Genet (2007) 2.85
Type II cadherin ectodomain structures: implications for classical cadherin specificity. Cell (2006) 2.85
Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol (2004) 2.77
A cluster of cholinergic premotor interneurons modulates mouse locomotor activity. Neuron (2009) 2.75
Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes Dev (2008) 2.74
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb. Genes Dev (2008) 2.66
The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell (2006) 2.62
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain. Neuron (2006) 2.60
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development (2007) 2.60
Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell (2008) 2.60
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55
Genetic identification of spinal interneurons that coordinate left-right locomotor activity necessary for walking movements. Neuron (2004) 2.54
Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev (2010) 2.50
PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron (2006) 2.48
The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Neuron (2002) 2.48
Motor neuron columnar fate imposed by sequential phases of Hox-c activity. Nature (2003) 2.47
Atlas of gene expression in the developing kidney at microanatomic resolution. Dev Cell (2008) 2.44
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev (2002) 2.41
Measured motion: searching for simplicity in spinal locomotor networks. Curr Opin Neurobiol (2009) 2.40
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeleton. Development (2004) 2.39
Ectodermal Wnt3/beta-catenin signaling is required for the establishment and maintenance of the apical ectodermal ridge. Genes Dev (2003) 2.34
Regulation of motor neuron pool sorting by differential expression of type II cadherins. Cell (2002) 2.32
Neural crest origins of the neck and shoulder. Nature (2005) 2.31
Hox networks and the origins of motor neuron diversity. Curr Top Dev Biol (2009) 2.30
Genetic ablation of V2a ipsilateral interneurons disrupts left-right locomotor coordination in mammalian spinal cord. Neuron (2008) 2.28
Functional properties of motoneurons derived from mouse embryonic stem cells. J Neurosci (2004) 2.27
A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification. Neuron (2006) 2.26
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
The GUDMAP database--an online resource for genitourinary research. Development (2011) 2.20
Modeling recent human evolution in mice by expression of a selected EDAR variant. Cell (2013) 2.17
ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Neuron (2002) 2.17
Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways. Proc Natl Acad Sci U S A (2008) 2.15
Clarke's column neurons as the focus of a corticospinal corollary circuit. Nat Neurosci (2010) 2.13
Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epidemiol Biomarkers Prev (2007) 2.11
A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron (2003) 2.10
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord. Genes Dev (2002) 2.09
Regulation of mammalian tooth cusp patterning by ectodin. Science (2005) 2.05
Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. Proc Natl Acad Sci U S A (2009) 2.04
Progressive induction of caudal neural character by graded Wnt signaling. Nat Neurosci (2002) 2.02
Wnt signaling plays an essential role in neuronal specification of the dorsal spinal cord. Genes Dev (2002) 2.01
Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev (2003) 2.00
Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions. Neuron (2003) 1.98
Identification of a link between the tumour suppressor APC and the kinesin superfamily. Nat Cell Biol (2002) 1.93
Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron (2003) 1.91
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90
Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Neuron (2005) 1.89
Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh. Genes Dev (2005) 1.89
Specificity of sensory-motor connections encoded by Sema3e-Plxnd1 recognition. Nature (2009) 1.88
Temporal differences in granulosa cell specification in the ovary reflect distinct follicle fates in mice. Biol Reprod (2012) 1.88
The Hedgehog-binding proteins Gas1 and Cdo cooperate to positively regulate Shh signaling during mouse development. Genes Dev (2007) 1.87
FGFR1 is independently required in both developing mid- and hindbrain for sustained response to isthmic signals. EMBO J (2003) 1.85
High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Dev Biol (2009) 1.84
Gating of Sema3E/PlexinD1 signaling by neuropilin-1 switches axonal repulsion to attraction during brain development. Neuron (2007) 1.83
Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol (2010) 1.83
Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Dev Biol (2009) 1.83
Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest (2005) 1.82
Beta-catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state. Dev Biol (2007) 1.82
Mammalian kidney development: principles, progress, and projections. Cold Spring Harb Perspect Biol (2012) 1.80
Shh signaling within the dental epithelium is necessary for cell proliferation, growth and polarization. Development (2002) 1.78