Published in J Biol Chem on January 30, 2002
A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J Exp Med (2003) 3.30
Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A (2006) 2.75
Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut (2003) 2.37
Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (2005) 2.08
During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems. Cell Microbiol (2007) 1.94
Salmonella effector AvrA regulation of colonic epithelial cell inflammation by deubiquitination. Am J Pathol (2007) 1.94
Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius. Immunology (2006) 1.73
Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells. PLoS One (2008) 1.28
Toll like receptor-5: protecting the gut from enteric microbes. Semin Immunopathol (2007) 1.10
Decreased potency of the Vibrio cholerae sheathed flagellum to trigger host innate immunity. Infect Immun (2008) 1.06
Epithelial toll-like receptor 5 is constitutively localized in the mouse cecum and exhibits distinctive down-regulation during experimental colitis. Clin Vaccine Immunol (2006) 1.04
Use of toll-like receptor assays to detect and identify microbial contaminants in biological products. J Clin Microbiol (2009) 0.95
The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection. Infect Immun (2005) 0.90
Bordetella bronchiseptica flagellin is a proinflammatory determinant for airway epithelial cells. Infect Immun (2005) 0.89
Interleukin-8 production by human airway epithelial cells in response to Pseudomonas aeruginosa clinical isolates expressing type a or type b flagellins. Clin Vaccine Immunol (2010) 0.87
Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice. Mamm Genome (2006) 0.86
Bacterial protein AvrA stabilizes intestinal epithelial tight junctions via blockage of the C-Jun N-terminal kinase pathway. Tissue Barriers (2015) 0.80
Bacterial cell shape-dependent inflammatory response in mammary epithelial cells. Curr Microbiol (2006) 0.75
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science (2010) 12.54
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22
Bacterial invasion: the paradigms of enteroinvasive pathogens. Science (2004) 4.95
Deletion of TLR5 results in spontaneous colitis in mice. J Clin Invest (2007) 4.18
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol (2003) 4.00
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem (2003) 3.83
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses. Nat Immunol (2006) 3.41
Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut. Cell Host Microbe (2013) 3.05
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc Natl Acad Sci U S A (2005) 2.88
Cutting edge: Salmonella AvrA effector inhibits the key proinflammatory, anti-apoptotic NF-kappa B pathway. J Immunol (2002) 2.70
Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nat Rev Microbiol (2009) 2.62
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe (2009) 2.52
Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice. Cell Host Microbe (2012) 2.48
Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol (2003) 2.43
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut (2013) 2.32
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med (2011) 2.25
Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol (2002) 2.22
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21
Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity (2002) 2.17
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A (2003) 2.16
Type III secretion effectors of the IpaH family are E3 ubiquitin ligases. Cell Host Microbe (2007) 2.08
Flagellin treatment protects against chemicals, bacteria, viruses, and radiation. J Immunol (2008) 2.07
Polyethylenimine-based siRNA nanocomplexes reprogram tumor-associated dendritic cells via TLR5 to elicit therapeutic antitumor immunity. J Clin Invest (2009) 2.06
Dysregulation of inflammatory responses by chronic circadian disruption. J Immunol (2010) 2.05
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP. Gastroenterology (2005) 2.03
The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model. J Exp Med (2002) 2.00
Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol (2002) 1.95
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94
Fecal lipocalin 2, a sensitive and broadly dynamic non-invasive biomarker for intestinal inflammation. PLoS One (2012) 1.90
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection. Am J Pathol (2006) 1.77
The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol Med (2012) 1.75
Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione. Gut (2010) 1.73
Increased NF-kappaB activity in fibroblasts lacking the vitamin D receptor. Am J Physiol Endocrinol Metab (2006) 1.68
In situ stimulation of CD40 and Toll-like receptor 3 transforms ovarian cancer-infiltrating dendritic cells from immunosuppressive to immunostimulatory cells. Cancer Res (2009) 1.67
The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism. Cell Host Microbe (2011) 1.66
Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases. Nat Struct Mol Biol (2008) 1.65
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin. Am J Physiol Cell Physiol (2004) 1.65
A crypt-specific core microbiota resides in the mouse colon. MBio (2012) 1.64
ATP-mediated Erk1/2 activation stimulates bacterial capture by filopodia, which precedes Shigella invasion of epithelial cells. Cell Host Microbe (2011) 1.63
Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A (2004) 1.63
Bacterial activation of beta-catenin signaling in human epithelia. Am J Physiol Gastrointest Liver Physiol (2004) 1.60
Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival? Immunol Cell Biol (2007) 1.60
Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium. J Immunol (2002) 1.59
Acute depletion of activated memory B cells involves the PD-1 pathway in rapidly progressing SIV-infected macaques. J Clin Invest (2010) 1.59
Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies. Trends Microbiol (2002) 1.59
NLR functions beyond pathogen recognition. Nat Immunol (2011) 1.57
Activation of toll-like receptor 3 protects against DSS-induced acute colitis. Inflamm Bowel Dis (2007) 1.57
Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol (2006) 1.55
Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J Immunol (2006) 1.54
Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling. Gastroenterology (2012) 1.52
Shigella impairs T lymphocyte dynamics in vivo. Proc Natl Acad Sci U S A (2013) 1.52
TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. J Immunol (2006) 1.50
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol (2005) 1.49
Crosstalk between NF-kappaB and beta-catenin pathways in bacterial-colonized intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol (2005) 1.45
PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. EMBO J (2006) 1.45
Humoral immune response to flagellin requires T cells and activation of innate immunity. J Immunol (2006) 1.45
IL-6 induces NF-kappa B activation in the intestinal epithelia. J Immunol (2003) 1.42
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol (2007) 1.41
Elevated flagellin-specific immunoglobulins in Crohn's disease. Am J Physiol Gastrointest Liver Physiol (2004) 1.41
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep (2005) 1.41
Shanthi V. Sitaraman, MD, PhD: physician, scientist, educator, and humanitarian. Gastroenterology (2011) 1.39
Toll-like receptor-gut microbiota interactions: perturb at your own risk! Annu Rev Physiol (2011) 1.38
In"sight" into immune blindness: Helicobacter pylori-induced gastritis requires T cells primed in the small intestine Peyer's patches. Gastroenterology (2007) 1.38
TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism. Am J Physiol Gastrointest Liver Physiol (2003) 1.38
Toll-like receptors 4 and 5 induce distinct types of vasculitis. Circ Res (2009) 1.37
TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin. Eur J Immunol (2010) 1.37
Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease. Infect Immun (2008) 1.37
The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses. J Pediatr (2010) 1.36
Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression. J Exp Med (2008) 1.33
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis. Am J Physiol Gastrointest Liver Physiol (2009) 1.31
Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin. J Immunol (2008) 1.30
Latent cytomegalovirus infection exacerbates experimental colitis. Am J Pathol (2009) 1.30
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem (2005) 1.28
Promoting an environment of professionalism: the University of Chicago "Roadmap". Acad Med (2007) 1.27
Microbiota-liver axis in hepatic disease. Hepatology (2013) 1.27
The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells. PLoS Pathog (2009) 1.26
Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis. J Immunol (2006) 1.25
Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis. Gut (2011) 1.25
Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome. Am J Physiol Regul Integr Comp Physiol (2007) 1.23
Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol (2003) 1.22
Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis. J Immunol (2012) 1.22
The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2. J Biol Chem (2003) 1.22
The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. J Biol Chem (2002) 1.20
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity. Eur J Immunol (2009) 1.19
Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella. EMBO J (2008) 1.18
IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis. J Immunol (2004) 1.18
Roles for T and NK cells in the innate immune response to Shigella flexneri. J Immunol (2005) 1.17
New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies. J Immunol (2007) 1.17
Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract. Cell Microbiol (2010) 1.16
Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri. J Bacteriol (2002) 1.16
Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells. Immunity (2003) 1.15
Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP. J Immunol (2003) 1.15