Published in Gene on February 06, 2002
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell (2007) 2.82
Histone H3 lysine 4 (H3K4) methylation in development and differentiation. Dev Biol (2009) 2.24
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06
Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol Cell Biol (2004) 1.94
Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes. Mol Cell Endocrinol (2009) 1.25
Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS One (2011) 1.19
MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A (2004) 1.16
Transcription factor Ap2delta associates with Ash2l and ALR, a trithorax family histone methyltransferase, to activate Hoxc8 transcription. Proc Natl Acad Sci U S A (2008) 1.05
The mutational landscape of chromatin regulatory factors across 4,623 tumor samples. Genome Biol (2013) 1.03
Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Cancer Lett (2014) 0.97
Analysis of the binding of mixed lineage leukemia 1 (MLL1) and histone 3 peptides to WD repeat domain 5 (WDR5) for the design of inhibitors of the MLL1-WDR5 interaction. J Med Chem (2010) 0.97
Molecular pathways in pancreatic carcinogenesis. J Surg Oncol (2012) 0.95
An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes. Nucleic Acids Res (2015) 0.92
Use of chromosome engineering to model a segmental deletion of chromosome band 7q22 found in myeloid malignancies. Blood (2010) 0.90
A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity. J Biol Chem (2012) 0.89
Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3. Development (2012) 0.88
Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse. Blood (2015) 0.86
Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders. Epigenomics (2015) 0.86
Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction. ACS Med Chem Lett (2013) 0.85
Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation. PLoS One (2012) 0.83
Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis. Cancers (Basel) (2012) 0.83
Photoperiod influences growth and mll (mixed-lineage leukaemia) expression in Atlantic cod. PLoS One (2012) 0.81
Molecular signature of pancreatic adenocarcinoma: an insight from genotype to phenotype and challenges for targeted therapy. Expert Opin Ther Targets (2015) 0.81
Excess congenital non-synonymous variation in leukemia-associated genes in MLL- infant leukemia: a Children's Oncology Group report. Leukemia (2013) 0.80
Isolation and bioinformatics analysis of differentially methylated genomic fragments in human gastric cancer. World J Gastroenterol (2008) 0.79
Coiled coil structures and transcription: an analysis of the S. cerevisiae coilome. Mol Genet Genomics (2007) 0.79
Interaction between MLL3 genetic polymorphisms, smoking, and alcohol drinking in laryngeal cancer: a case-control study. Cancer Med (2016) 0.78
Loss of Mll3 Catalytic Function Promotes Aberrant Myelopoiesis. PLoS One (2016) 0.76
Colorectal Cancer Genetic Heterogeneity Delineated by Multi-Region Sequencing. PLoS One (2016) 0.75
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes. J Biol Chem (2016) 0.75
Ancestral reconstruction of segmental duplications reveals punctuated cores of human genome evolution. Nat Genet (2007) 10.38
A recurrent 15q13.3 microdeletion syndrome associated with mental retardation and seizures. Nat Genet (2008) 8.44
A genome-wide comparison of recent chimpanzee and human segmental duplications. Nature (2005) 5.51
Characterization of missing human genome sequences and copy-number polymorphic insertions. Nat Methods (2010) 5.44
Noninvasive whole-genome sequencing of a human fetus. Sci Transl Med (2012) 3.94
A burst of segmental duplications in the genome of the African great ape ancestor. Nature (2009) 3.63
Evolutionary toggling of the MAPT 17q21.31 inversion region. Nat Genet (2008) 3.42
Heterozygous submicroscopic inversions involving olfactory receptor-gene clusters mediate the recurrent t(4;8)(p16;p23) translocation. Am J Hum Genet (2002) 3.09
Great ape genetic diversity and population history. Nature (2013) 2.95
A genome-wide survey of structural variation between human and chimpanzee. Genome Res (2005) 2.61
A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk. Nat Genet (2010) 2.57
Recurrent reciprocal genomic rearrangements of 17q12 are associated with renal disease, diabetes, and epilepsy. Am J Hum Genet (2007) 2.54
The bonobo genome compared with the chimpanzee and human genomes. Nature (2012) 2.49
The genomic architecture of segmental duplications and associated copy number variants in dogs. Genome Res (2009) 2.44
Analysis of copy number variations among diverse cattle breeds. Genome Res (2010) 2.02
Characterization of six human disease-associated inversion polymorphisms. Hum Mol Genet (2009) 2.00
Analysis of segmental duplications and genome assembly in the mouse. Genome Res (2004) 1.89
Death and resurrection of the human IRGM gene. PLoS Genet (2009) 1.72
A preliminary comparative analysis of primate segmental duplications shows elevated substitution rates and a great-ape expansion of intrachromosomal duplications. Genome Res (2006) 1.69
Copy number variation of individual cattle genomes using next-generation sequencing. Genome Res (2012) 1.62
Alu repeat discovery and characterization within human genomes. Genome Res (2010) 1.62
Genomic characteristics of cattle copy number variations. BMC Genomics (2011) 1.48
Recurrent duplication-driven transposition of DNA during hominoid evolution. Proc Natl Acad Sci U S A (2006) 1.47
Copy number variation of CCL3-like genes affects rate of progression to simian-AIDS in Rhesus Macaques (Macaca mulatta). PLoS Genet (2009) 1.43
Analysis of recent segmental duplications in the bovine genome. BMC Genomics (2009) 1.36
Evolution and diversity of copy number variation in the great ape lineage. Genome Res (2013) 1.29
Sequencing human-gibbon breakpoints of synteny reveals mosaic new insertions at rearrangement sites. Genome Res (2008) 1.21
Independent centromere formation in a capricious, gene-free domain of chromosome 13q21 in Old World monkeys and pigs. Genome Biol (2006) 1.13
Chromosome 6 phylogeny in primates and centromere repositioning. Mol Biol Evol (2003) 1.13
Organization and evolution of primate centromeric DNA from whole-genome shotgun sequence data. PLoS Comput Biol (2007) 1.13
Genome-wide characterization of centromeric satellites from multiple mammalian genomes. Genome Res (2010) 1.12
Human paralogs of KIAA0187 were created through independent pericentromeric-directed and chromosome-specific duplication mechanisms. Genome Res (2002) 1.10
Hominoid chromosomal rearrangements on 17q map to complex regions of segmental duplication. Genome Biol (2008) 1.04
Non-invasive fetal genome sequencing: opportunities and challenges. Am J Med Genet A (2012) 0.98
Punctuated duplication seeding events during the evolution of human chromosome 2p11. Genome Res (2005) 0.97
Evolutionary history of chromosome 10 in primates. Chromosoma (2002) 0.97
Complex events in the evolution of the human pseudoautosomal region 2 (PAR2). Genome Res (2003) 0.96
BAGE genes generated by juxtacentromeric reshuffling in the Hominidae lineage are under selective pressure. Genomics (2003) 0.94
Heterochromatic genes undergo epigenetic changes and escape silencing in immunodeficiency, centromeric instability, facial anomalies (ICF) syndrome. PLoS One (2011) 0.91
Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer. Genes Chromosomes Cancer (2005) 0.91
Rates and patterns of great ape retrotransposition. Proc Natl Acad Sci U S A (2013) 0.90
Initial analysis of copy number variations in cattle selected for resistance or susceptibility to intestinal nematodes. Mamm Genome (2010) 0.89
Analysis of high-identity segmental duplications in the grapevine genome. BMC Genomics (2011) 0.89
Evolutionary history of chromosome 11 featuring four distinct centromere repositioning events in Catarrhini. Genomics (2007) 0.88
Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21. Genome Res (2006) 0.88
Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms. Gene (2003) 0.86
Polymorphisms of genes of the cardiac calcineurin pathway and cardiac hypertrophy. Eur J Hum Genet (2003) 0.86
BAGE hypomethylation, a new epigenetic biomarker for colon cancer detection. Cancer Epidemiol Biomarkers Prev (2008) 0.86
Evolutionary dynamism of the primate LRRC37 gene family. Genome Res (2012) 0.85
Analysis of chromosome conservation in Lemur catta studied by chromosome paints and BAC/PAC probes. Chromosoma (2002) 0.85
Human chromosome 16 conservation in primates. Chromosome Res (2003) 0.83
New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile. Eur J Hum Genet (2002) 0.82
Recombination across the centromere of disjoined and non-disjoined chromosome 21. Hum Mol Genet (2003) 0.82
Characterization and expression analysis during embryo development of the mouse ortholog of MLL3. Gene (2006) 0.81
Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution. Genet Test (2004) 0.78
Molecular and evolutionary characteristics of the fraction of human alpha satellite DNA associated with CENP-A at the centromeres of chromosomes 1, 5, 19, and 21. BMC Genomics (2010) 0.78
Emergence of a Homo sapiens-specific gene family and chromosome 16p11.2 CNV susceptibility. Nature (2016) 0.77
DNA replication is altered in Immunodeficiency Centromeric instability Facial anomalies (ICF) cells carrying DNMT3B mutations. Eur J Hum Genet (2012) 0.77
Characterization and in vitro differentiation potency of early-passage canine amnion- and umbilical cord-derived mesenchymal stem cells as related to gestational age. Mol Reprod Dev (2014) 0.77
Hominoid fission of chromosome 14/15 and the role of segmental duplications. Genome Res (2013) 0.77
Nasal epithelial cells: a tool to study DNA methylation in airway diseases. Epigenomics (2015) 0.76
BAGE Hypomethylation Is an Early Event in Colon Transformation and Is Frequent in Histologically Advanced Adenomas. Cancers (Basel) (2009) 0.75
Centromeres and neocentromeres. Methods Mol Biol (2004) 0.75
Corrigendum: The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2. Genome Res (2017) 0.75
Localization of a new highly repeated DNA sequence of Lemur cafta (Lemuridae, Strepsirhini). Genome (2002) 0.75