T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis.

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Published in Microbiol Mol Biol Rev on June 01, 2002

Authors

Christopher S Sullivan1, James M Pipas

Author Affiliations

1: Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

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The hallmarks of cancer. Cell (2000) 113.05

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A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (1986) 13.96

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The regulation of E2F by pRB-family proteins. Genes Dev (1998) 12.77

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Effects of an Rb mutation in the mouse. Nature (1992) 11.06

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (1992) 8.16

Simian virus 40 DNA replication in vitro. Proc Natl Acad Sci U S A (1984) 7.76

Cellular targets for transformation by the adenovirus E1A proteins. Cell (1989) 7.53

Requirement for a functional Rb-1 gene in murine development. Nature (1992) 6.87

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Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein. Nature (1990) 6.45

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Regulation of the specific DNA binding function of p53. Cell (1992) 6.16

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Structure of simian virus 40 at 3.8-A resolution. Nature (1991) 5.96

The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev (2000) 5.93

Human polyomavirus JC virus genome. J Virol (1984) 5.87

Peptide binding and release by proteins implicated as catalysts of protein assembly. Science (1989) 5.84

Activation of the SV40 late promoter: direct effects of T antigen in the absence of viral DNA replication. Cell (1984) 5.30

Binding and modulation of p53 by p300/CBP coactivators. Nature (1997) 5.12

Recruitment of p300/CBP in p53-dependent signal pathways. Cell (1997) 5.10

The Pezcoller lecture: cancer cell cycles revisited. Cancer Res (2000) 5.08

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol (1999) 4.98

Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell (1993) 4.90

T antigen repression of SV40 early transcription from two promoters. Cell (1981) 4.83

GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1. EMBO J (1997) 4.68

Structural evidence for the authenticity of the human retinoblastoma gene. Science (1987) 4.67

Synergistic activation of transcription by CBP and p53. Nature (1997) 4.54

Role of the heat shock response and molecular chaperones in oncogenesis and cell death. J Natl Cancer Inst (2000) 4.54

Role of the major heat shock proteins as molecular chaperones. Annu Rev Cell Biol (1993) 4.51

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Peptide-binding specificity of the molecular chaperone BiP. Nature (1991) 4.36

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Hip, a novel cochaperone involved in the eukaryotic Hsc70/Hsp40 reaction cycle. Cell (1995) 3.99

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Kinetics of molecular chaperone action. Science (1994) 3.91

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p53-dependent apoptosis suppresses tumor growth and progression in vivo. Cell (1994) 3.69

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Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61

In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology (1984) 3.50

Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev (1994) 3.47

Role of the human heat shock protein hsp70 in protection against stress-induced apoptosis. Mol Cell Biol (1997) 3.39

Common and unique features of T antigens encoded by the polyomavirus group. J Virol (1992) 3.31

Crystal structure of the nucleotide exchange factor GrpE bound to the ATPase domain of the molecular chaperone DnaK. Science (1997) 3.31

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Hsp90 & Co. - a holding for folding. Trends Biochem Sci (1999) 3.23

Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. EMBO J (1995) 3.22

Cell and molecular biology of simian virus 40: implications for human infections and disease. J Natl Cancer Inst (1999) 3.20

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Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5. Mol Cell Biol (1988) 3.07

Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells. J Virol (1979) 3.04

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Molecular evolution of the HSP70 multigene family. J Mol Evol (1994) 3.00

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Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity. J Virol (1990) 2.96

The retinoblastoma gene family in differentiation and development. Oncogene (1999) 2.95

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth. J Virol (1993) 2.92

MDM2--master regulator of the p53 tumor suppressor protein. Gene (2000) 2.92

Target gene specificity of E2F and pocket protein family members in living cells. Mol Cell Biol (2000) 2.85

The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication. J Biol Chem (1994) 2.85

Identification of cellular proteins required for simian virus 40 DNA replication. J Biol Chem (1989) 2.84

A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Cell (1993) 2.80

An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell (1989) 2.78

ATP-induced protein-Hsp70 complex dissociation requires K+ but not ATP hydrolysis. Nature (1993) 2.77

Structural basis of DNA recognition by the heterodimeric cell cycle transcription factor E2F-DP. Genes Dev (1999) 2.73

Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev (1996) 2.71

The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Mol Cell Biol (2000) 2.69

Role of the J-domain in the cooperation of Hsp40 with Hsp70. Proc Natl Acad Sci U S A (1998) 2.66

Analysis of an activatable promoter: sequences in the simian virus 40 late promoter required for T-antigen-mediated trans activation. Mol Cell Biol (1985) 2.55

Nucleotide-induced conformational changes in the ATPase and substrate binding domains of the DnaK chaperone provide evidence for interdomain communication. J Biol Chem (1995) 2.53

Control of pRB phosphorylation. Curr Opin Genet Dev (1998) 2.49

Nuclear organization of DNA replication in primary mammalian cells. Genes Dev (2000) 2.48

E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell (2000) 2.48

The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein. J Biol Chem (1991) 2.47

Interaction of the Hsp70 molecular chaperone, DnaK, with its cochaperone DnaJ. Proc Natl Acad Sci U S A (1998) 2.44

Role of the Escherichia coli DnaK and DnaJ heat shock proteins in the initiation of bacteriophage lambda DNA replication. Proc Natl Acad Sci U S A (1988) 2.42

Association of p300 and CBP with simian virus 40 large T antigen. Mol Cell Biol (1996) 2.40

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol (1990) 2.40

Identification of a 60-kilodalton stress-related protein, p60, which interacts with hsp90 and hsp70. Mol Cell Biol (1993) 2.36

The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain. Mol Cell Biol (1997) 2.33

A bipartite signaling mechanism involved in DnaJ-mediated activation of the Escherichia coli DnaK protein. J Biol Chem (1996) 2.26

Chaperones get in touch: the Hip-Hop connection. Trends Biochem Sci (1997) 2.24

A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc Natl Acad Sci U S A (1995) 2.17

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