Published in RNA on June 29, 2005
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
Processing of intronic microRNAs. EMBO J (2007) 6.32
Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40
Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat Genet (2008) 5.26
Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci U S A (2007) 5.20
Characterization and identification of microRNA core promoters in four model species. PLoS Comput Biol (2007) 2.86
The expansion of the metazoan microRNA repertoire. BMC Genomics (2006) 2.80
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol (2008) 2.43
miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. J Biol Chem (2010) 2.05
Highly dynamic and sex-specific expression of microRNAs during early ES cell differentiation. PLoS Genet (2009) 1.96
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Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter. Mol Cell Biol (2008) 1.74
The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 1.74
Cell cycle regulation by MicroRNAs in embryonic stem cells. Cancer Res (2009) 1.69
UV-B responsive microRNA genes in Arabidopsis thaliana. Mol Syst Biol (2007) 1.68
Characterization of microRNAs involved in embryonic stem cell states. Stem Cells Dev (2010) 1.62
Evolution of small nucleolar RNAs in nematodes. Nucleic Acids Res (2006) 1.58
Conservation of small RNA pathways in platypus. Genome Res (2008) 1.51
MicroRNAs: regulating a change of heart. Circulation (2009) 1.37
Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A (2011) 1.33
Small RNAs in early mammalian development: from gametes to gastrulation. Development (2011) 1.33
MicroRNAs in adult and embryonic neurogenesis. Neuromolecular Med (2009) 1.22
microRNA expression during trophectoderm specification. PLoS One (2009) 1.22
miRNAs: effectors of environmental influences on gene expression and disease. Toxicol Sci (2008) 1.21
The evolution of core proteins involved in microRNA biogenesis. BMC Evol Biol (2008) 1.14
Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells. RNA (2006) 1.13
Novel microRNA candidates and miRNA-mRNA pairs in embryonic stem (ES) cells. PLoS One (2008) 1.11
The role of miRNAs and endogenous siRNAs in maternal-to-zygotic reprogramming and the establishment of pluripotency. EMBO Rep (2010) 1.08
Two miRNA clusters reveal alternative paths in late-stage reprogramming. Cell Stem Cell (2014) 1.04
The roles of microRNAs in tumorigenesis and angiogenesis. Int J Physiol Pathophysiol Pharmacol (2010) 1.03
microRNA control of mouse and human pluripotent stem cell behavior. Annu Rev Cell Dev Biol (2013) 1.02
Evidence for post-transcriptional regulation of clustered microRNAs in Drosophila. BMC Genomics (2011) 1.02
Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region gene family. Mol Biol Evol (2009) 0.99
miRNAs regulate expression and function of extracellular matrix molecules. Matrix Biol (2012) 0.98
Biogenesis of intronic miRNAs located in clusters by independent transcription and alternative splicing. RNA (2013) 0.96
Role of CTCF in the regulation of microRNA expression. Front Genet (2012) 0.95
Mesenchymal stem cells for cardiac regeneration: translation to bedside reality. Stem Cells Int (2012) 0.92
Inherited variation in miR-290 expression suppresses breast cancer progression by targeting the metastasis susceptibility gene Arid4b. Cancer Res (2013) 0.89
A Biogenesis Step Upstream of Microprocessor Controls miR-17∼92 Expression. Cell (2015) 0.85
miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep (2015) 0.85
Embryonic stem cell miRNAs and their roles in development and disease. Semin Cancer Biol (2012) 0.84
Transcripts that associate with the RNA binding protein, DEAD-END (DND1), in embryonic stem (ES) cells. BMC Mol Biol (2011) 0.84
Staged miRNA re-regulation patterns during reprogramming. Genome Biol (2013) 0.82
Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC. Nucleic Acids Res (2011) 0.82
MicroRNAs in opioid addiction: elucidating evolution. Front Genet (2012) 0.81
Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins. BMC Genomics (2008) 0.80
Evolution and genomic organization of muscle microRNAs in fish genomes. BMC Evol Biol (2014) 0.80
A positive feedback mechanism that regulates expression of miR-9 during neurogenesis. PLoS One (2014) 0.79
Oncoviruses and Pathogenic MicroRNAs in Humans. Open Virol J (2009) 0.78
Genomic features and computational identification of human microRNAs under long-range developmental regulation. BMC Genomics (2011) 0.78
Integration of expressed sequence tag data flanking predicted RNA secondary structures facilitates novel non-coding RNA discovery. PLoS One (2011) 0.77
PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation. Stem Cells Dev (2014) 0.76
Evolution of the miR-290-295/miR-371-373 cluster family seed repertoire. PLoS One (2014) 0.76
A non-invasive method to determine the pluripotent status of stem cells by culture medium microRNA expression detection. Sci Rep (2016) 0.75
miR290-5p/292-5p activate the immunoglobulin kappa locus in B cell development. PLoS One (2012) 0.75
Cell Pluripotency Levels Associated with Imprinted Genes in Human. Comput Math Methods Med (2015) 0.75
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell (2005) 96.87
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62
Prediction of mammalian microRNA targets. Cell (2003) 53.70
Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
CLUSTAL: a package for performing multiple sequence alignment on a microcomputer. Gene (1988) 42.41
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
The nuclear RNase III Drosha initiates microRNA processing. Nature (2003) 35.49
Identification of tissue-specific microRNAs from mouse. Curr Biol (2002) 34.55
An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science (2001) 31.33
The microRNA Registry. Nucleic Acids Res (2004) 29.45
RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev (2001) 26.16
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86
Asymmetry in the assembly of the RNAi enzyme complex. Cell (2003) 22.18
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans. Genes Dev (2001) 21.82
MicroRNA genes are transcribed by RNA polymerase II. EMBO J (2004) 20.65
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell (2000) 20.32
A uniform system for microRNA annotation. RNA (2003) 20.28
MicroRNA maturation: stepwise processing and subcellular localization. EMBO J (2002) 19.47
A species of small antisense RNA in posttranscriptional gene silencing in plants. Science (1999) 19.34
The microRNAs of Caenorhabditis elegans. Genes Dev (2003) 17.70
The Microprocessor complex mediates the genesis of microRNAs. Nature (2004) 17.70
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev (2003) 17.64
Vertebrate microRNA genes. Science (2003) 17.42
Nuclear export of microRNA precursors. Science (2003) 16.59
siRNAs can function as miRNAs. Genes Dev (2003) 16.08
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Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Embryonic stem cell-specific MicroRNAs. Dev Cell (2003) 13.05
Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48
Regulation of flowering time and floral organ identity by a MicroRNA and its APETALA2-like target genes. Plant Cell (2003) 11.69
The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev (2004) 11.58
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (2004) 11.52
The small RNA profile during Drosophila melanogaster development. Dev Cell (2003) 11.46
Searching protein sequence libraries: comparison of the sensitivity and selectivity of the Smith-Waterman and FASTA algorithms. Genomics (1991) 9.65
Human embryonic stem cells express a unique set of microRNAs. Dev Biol (2004) 8.87
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA (2004) 8.31
Promotion of trophoblast stem cell proliferation by FGF4. Science (1998) 8.02
A protein sensor for siRNA asymmetry. Science (2004) 7.77
Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43
Molecular evolution of a microRNA cluster. J Mol Biol (2004) 5.94
A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol Cell (2000) 4.26
Trans-splicing and polyadenylation of let-7 microRNA primary transcripts. RNA (2004) 3.18
Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identification. RNA (2004) 2.17
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Core transcriptional regulatory circuitry in human embryonic stem cells. Cell (2005) 34.93
Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature (2008) 30.29
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature (2007) 28.24
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41
Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
Predictive identification of exonic splicing enhancers in human genes. Science (2002) 16.86
Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38
siRNAs can function as miRNAs. Genes Dev (2003) 16.08
Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proc Natl Acad Sci U S A (2010) 15.13
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods (2007) 13.94
Embryonic stem cell-specific MicroRNAs. Dev Cell (2003) 13.05
Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol (2009) 12.40
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
c-Myc regulates transcriptional pause release. Cell (2010) 11.64
Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (2008) 11.33
Divergent transcription from active promoters. Science (2008) 11.03
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68
Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84
Cre-lox-regulated conditional RNA interference from transgenes. Proc Natl Acad Sci U S A (2004) 9.33
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis. Nucleic Acids Res (2005) 8.69
Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science (2003) 8.48
c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell (2007) 8.46
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell (2013) 7.99
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91
Gene silencing in mammals by small interfering RNAs. Nat Rev Genet (2002) 7.80
Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A (2008) 7.52
Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol (2003) 7.38
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17
HDAC2 negatively regulates memory formation and synaptic plasticity. Nature (2009) 6.96
Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc Natl Acad Sci U S A (2008) 6.89
Short RNAs repress translation after initiation in mammalian cells. Mol Cell (2006) 6.70
Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells. Genesis (2006) 6.64
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
siRNA-directed inhibition of HIV-1 infection. Nat Med (2002) 6.36
Roles for microRNAs in conferring robustness to biological processes. Cell (2012) 6.32
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
Chromosomal instability and tumors promoted by DNA hypomethylation. Science (2003) 6.02
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
Chromosomal silencing and localization are mediated by different domains of Xist RNA. Nat Genet (2002) 5.51
miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One (2007) 5.43
Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell (2008) 5.40
Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell (2007) 5.29
RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proc Natl Acad Sci U S A (2007) 5.26
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues. Cell (2010) 5.13
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A (2010) 5.00
Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes Dev (2007) 4.79
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression. Neuron (2006) 4.74
Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells (2008) 4.67
Chromatin structure and gene expression programs of human embryonic and induced pluripotent stem cells. Cell Stem Cell (2010) 4.59
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell (2011) 4.52
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome. Proc Natl Acad Sci U S A (2005) 4.52
Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A (2008) 4.48
MicroRNA functions in stress responses. Mol Cell (2010) 4.46
Wnt signaling promotes reprogramming of somatic cells to pluripotency. Cell Stem Cell (2008) 4.43
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol (2008) 4.41
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell (2010) 4.32
Monoclonal mice generated by nuclear transfer from mature B and T donor cells. Nature (2002) 4.16
Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc Natl Acad Sci U S A (2006) 4.02
The RNAi revolution. Nature (2004) 3.96
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron (2010) 3.96
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res (2010) 3.94
Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell (2009) 3.92
MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90
H2AZ is enriched at polycomb complex target genes in ES cells and is necessary for lineage commitment. Cell (2008) 3.90
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction. Nat Genet (2009) 3.73
RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Res (2004) 3.70
Nuclear reprogramming and pluripotency. Nature (2006) 3.68
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res (2013) 3.50
RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci U S A (2003) 3.48
Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell (2009) 3.42
Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell (2013) 3.31
Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells. Cell Stem Cell (2011) 3.31
DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30
Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc Natl Acad Sci U S A (2002) 3.29
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc Natl Acad Sci U S A (2009) 3.23
Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development (2003) 3.22