Published in Nat Neurosci on July 01, 2002
Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron (2013) 2.94
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93
Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1. Proc Natl Acad Sci U S A (2005) 1.71
E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Proc Natl Acad Sci U S A (2007) 1.67
Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol (2010) 1.58
Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. J Cell Biol (2003) 1.51
Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. PLoS Biol (2015) 1.49
Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release. Neuron (2013) 1.32
Phosphatidylinositol phosphate kinase type I gamma regulates dynamics of large dense-core vesicle fusion. Proc Natl Acad Sci U S A (2005) 1.32
Insulin granule biogenesis, trafficking and exocytosis. Vitam Horm (2009) 1.32
Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release. EMBO J (2012) 1.31
Visualization of synaptotagmin I oligomers assembled onto lipid monolayers. Proc Natl Acad Sci U S A (2003) 1.30
Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. EMBO J (2003) 1.29
Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. J Biol Chem (2008) 1.25
Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. J Biol Chem (2008) 1.18
Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. EMBO J (2006) 1.11
Push-and-pull regulation of the fusion pore by synaptotagmin-7. Proc Natl Acad Sci U S A (2010) 1.00
RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells. Biochem J (2004) 0.91
SNAP-23 functions in docking/fusion of granules at low Ca2+. Mol Biol Cell (2004) 0.88
Expression of exocytosis proteins in rat supraoptic nucleus neurones. J Neuroendocrinol (2012) 0.85
Ca2+-dependent release of Munc18-1 from presynaptic mGluRs in short-term facilitation. Proc Natl Acad Sci U S A (2009) 0.85
The role of non-canonical SNAREs in synaptic vesicle recycling. Cell Logist (2012) 0.85
Relevance of partially structured states in the non-classical secretion of acidic fibroblast growth factor. Biochemistry (2007) 0.83
Synaptic proteins as multi-sensor devices of neurotransmission. BMC Neurosci (2006) 0.82
Synaptotagmins interact with APP and promote Aβ generation. Mol Neurodegener (2015) 0.80
Molecular origins of synaptotagmin 1 activities on vesicle docking and fusion pore opening. Sci Rep (2015) 0.79
High metal concentrations are required for self-association of synaptotagmin II. Biophys J (2004) 0.77
Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proc Natl Acad Sci U S A (2017) 0.75
Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76
Membrane fusion. Cell (2003) 7.68
Induction of human neuronal cells by defined transcription factors. Nature (2011) 6.84
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell (2005) 6.31
Neuroligins determine synapse maturation and function. Neuron (2006) 5.70
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (2010) 5.42
Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature (2003) 5.19
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature (2002) 4.37
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell (2006) 4.36
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron (2007) 4.32
A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron (2005) 3.93
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature (2007) 3.91
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. Nature (2010) 3.87
Three-dimensional structure of the complexin/SNARE complex. Neuron (2002) 3.69
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52
Snares and Munc18 in synaptic vesicle fusion. Nat Rev Neurosci (2002) 3.33
Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (2009) 3.30
RIM1alpha is required for presynaptic long-term potentiation. Nature (2002) 3.28
The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20. Mol Cell (2002) 3.24
Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron (2007) 3.18
Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol (2006) 3.14
CASK Functions as a Mg2+-independent neurexin kinase. Cell (2008) 3.10
Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron (2005) 3.09
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06
Munc18-1 binds directly to the neuronal SNARE complex. Proc Natl Acad Sci U S A (2007) 3.03
Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A (2009) 2.93
RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
The Mad2 spindle checkpoint protein has two distinct natively folded states. Nat Struct Mol Biol (2004) 2.87
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods (2006) 2.80
A broken alpha -helix in folded alpha -Synuclein. J Biol Chem (2003) 2.80
Reconstitution of the vital functions of Munc18 and Munc13 in neurotransmitter release. Science (2012) 2.70
Distinct domains of complexin I differentially regulate neurotransmitter release. Nat Struct Mol Biol (2007) 2.63
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Common circuit defect of excitatory-inhibitory balance in mouse models of autism. J Neurodev Disord (2009) 2.61
Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proc Natl Acad Sci U S A (2007) 2.60
Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics (2002) 2.58
Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint. EMBO J (2004) 2.57
Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. J Neurosci (2010) 2.57
Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell (2011) 2.52
Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron (2010) 2.52
Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron (2013) 2.51
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron (2007) 2.43
Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Dev Cell (2002) 2.43
The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron (2004) 2.43
Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. J Neurosci (2006) 2.42
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron (2012) 2.35
Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. J Biol Chem (2004) 2.31
How Tlg2p/syntaxin 16 'snares' Vps45. EMBO J (2002) 2.31
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell (2002) 2.31
LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron (2009) 2.30
RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron (2011) 2.29
p31comet blocks Mad2 activation through structural mimicry. Cell (2007) 2.26
A complete genetic analysis of neuronal Rab3 function. J Neurosci (2004) 2.21
The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annu Rev Cell Dev Biol (2012) 2.19
Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron (2013) 2.18
Cell biology of Ca2+-triggered exocytosis. Curr Opin Cell Biol (2010) 2.15
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14
Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proc Natl Acad Sci U S A (2005) 2.13
Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11
Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. J Neurosci (2007) 2.02
A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nat Struct Mol Biol (2003) 1.98
Synaptic vesicle exocytosis. Cold Spring Harb Perspect Biol (2011) 1.97
Selective capability of SynCAM and neuroligin for functional synapse assembly. J Neurosci (2005) 1.97
A neural circuit for memory specificity and generalization. Science (2013) 1.96
Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nat Neurosci (2009) 1.95
Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol (2011) 1.95
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol (2010) 1.95
Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. EMBO J (2006) 1.93
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92
SNARE-mediated lipid mixing depends on the physical state of the vesicles. Biophys J (2005) 1.91
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. EMBO J (2012) 1.91
RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron (2011) 1.89
Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities. EMBO J (2002) 1.88
Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. PLoS Biol (2006) 1.88
Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. J Neurosci (2005) 1.87
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? EMBO J (2005) 1.86
A protein sequence that can encode native structure by disfavoring alternate conformations. Nat Struct Biol (2002) 1.85
A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis. J Neurosci (2006) 1.82
Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem (2003) 1.82
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron (2007) 1.81
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol (2009) 1.80