Published in Trends Genet on November 01, 2003
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature (2006) 7.52
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev (2004) 6.20
Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth. Mol Cell Biol (2006) 5.74
Global and Hox-specific roles for the MLL1 methyltransferase. Proc Natl Acad Sci U S A (2005) 5.53
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol (2008) 4.25
The site-specific installation of methyl-lysine analogs into recombinant histones. Cell (2007) 4.22
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
The SET-domain protein superfamily: protein lysine methyltransferases. Genome Biol (2005) 3.93
The splicing factor SC35 has an active role in transcriptional elongation. Nat Struct Mol Biol (2008) 3.86
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging. Proc Natl Acad Sci U S A (2006) 3.86
Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLoS Genet (2007) 3.75
Functional cooperation between HP1 and DNMT1 mediates gene silencing. Genes Dev (2007) 3.43
The Chd family of chromatin remodelers. Mutat Res (2007) 2.69
Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences. Mol Cell Biol (2006) 2.68
The parafibromin tumor suppressor protein is part of a human Paf1 complex. Mol Cell Biol (2005) 2.58
Structural and functional analysis of SET8, a histone H4 Lys-20 methyltransferase. Genes Dev (2005) 2.56
Distinct regulation of histone H3 methylation at lysines 27 and 9 by CpG methylation in Arabidopsis. EMBO J (2005) 2.37
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell (2011) 2.30
Histone methylation regulates memory formation. J Neurosci (2010) 2.30
A novel mammalian flavin-dependent histone demethylase. J Biol Chem (2009) 2.25
Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A (2007) 2.17
Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer (2006) 2.09
Gfi1 coordinates epigenetic repression of p21Cip/WAF1 by recruitment of histone lysine methyltransferase G9a and histone deacetylase 1. Mol Cell Biol (2005) 2.07
Isolation of neuronal chromatin from brain tissue. BMC Neurosci (2008) 2.02
Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation. Genes Dev (2005) 1.92
Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc Natl Acad Sci U S A (2004) 1.80
The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. Mol Cell Biol (2008) 1.67
JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). Mol Cell Biol (2005) 1.67
GAD1 mRNA expression and DNA methylation in prefrontal cortex of subjects with schizophrenia. PLoS One (2007) 1.66
A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat. Genes Dev (2005) 1.66
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol (2009) 1.65
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line. Development (2006) 1.63
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res (2008) 1.61
HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance. Oncogene (2008) 1.59
Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics (2013) 1.53
Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. PLoS Biol (2005) 1.53
Multi-tasking on chromatin with the SAGA coactivator complexes. Mutat Res (2007) 1.50
Methylation patterns of histone H3 Lys 4, Lys 9 and Lys 27 in transcriptionally active and inactive Arabidopsis genes and in atx1 mutants. Nucleic Acids Res (2005) 1.48
How do SET-domain protein lysine methyltransferases achieve the methylation state specificity? Revisited by Ab initio QM/MM molecular dynamics simulations. J Am Chem Soc (2008) 1.48
Histone methyltransferase Suv39h1 represses MyoD-stimulated myogenic differentiation. EMBO J (2006) 1.47
Partitioning of the maize epigenome by the number of methyl groups on histone H3 lysines 9 and 27. Genetics (2006) 1.47
Lymphocytes from patients with type 1 diabetes display a distinct profile of chromatin histone H3 lysine 9 dimethylation: an epigenetic study in diabetes. Diabetes (2008) 1.46
Lsh, an epigenetic guardian of repetitive elements. Nucleic Acids Res (2004) 1.40
Ab initio quantum mechanical/molecular mechanical molecular dynamics simulation of enzyme catalysis: the case of histone lysine methyltransferase SET7/9. J Phys Chem B (2007) 1.40
SDG714, a histone H3K9 methyltransferase, is involved in Tos17 DNA methylation and transposition in rice. Plant Cell (2007) 1.39
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol Cell (2008) 1.38
The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol (2004) 1.38
Establishment of histone modifications after chromatin assembly. Nucleic Acids Res (2009) 1.36
Plant SET domain-containing proteins: structure, function and regulation. Biochim Biophys Acta (2007) 1.36
Altered nucleosome occupancy and histone H3K4 methylation in response to 'transcriptional stress'. EMBO J (2005) 1.35
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Nat Immunol (2004) 1.34
Dynamic chromatin boundaries delineate a latency control region of Epstein-Barr virus. J Virol (2004) 1.33
Epigenetic regulation of transcription in intermediate heterochromatin. EMBO Rep (2006) 1.33
Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases. Mol Pharmacol (2010) 1.30
Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1. J Virol (2009) 1.29
Epigenetic aberrations and cancer. Mol Cancer (2006) 1.29
Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa. Eukaryot Cell (2005) 1.29
Involvement of histone demethylase LSD1 in Blimp-1-mediated gene repression during plasma cell differentiation. Mol Cell Biol (2009) 1.29
Histone modifications in Trypanosoma brucei. Mol Biochem Parasitol (2007) 1.27
Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol (2007) 1.26
Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates. EMBO Rep (2008) 1.25
Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci (2006) 1.22
Epigenetic alterations in aging. J Appl Physiol (1985) (2010) 1.20
Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis. Mol Cell Biol (2010) 1.19
Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev (2012) 1.19
G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation. J Neurosci (2012) 1.18
Immunohistochemical Analysis of Histone H3 Modifications in Germ Cells during Mouse Spermatogenesis. Acta Histochem Cytochem (2011) 1.17
Regulation of the androgen receptor by SET9-mediated methylation. Nucleic Acids Res (2010) 1.17
HP1: heterochromatin binding proteins working the genome. Epigenetics (2010) 1.16
The interplay of histone modifications - writers that read. EMBO Rep (2015) 1.15
Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res (2007) 1.15
Epigenetics: definition, mechanisms and clinical perspective. Semin Reprod Med (2009) 1.14
Chromatin remodeling in the aging genome of Drosophila. Aging Cell (2010) 1.14
The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol (2011) 1.13
Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition. Nucleic Acids Res (2004) 1.11
Large-scale global identification of protein lysine methylation in vivo. Epigenetics (2013) 1.09
Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon. Cancer Cell Int (2010) 1.09
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res (2014) 1.08
KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest (2013) 1.07
Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell Biosci (2013) 1.07
Cardiac deletion of Smyd2 is dispensable for mouse heart development. PLoS One (2010) 1.06
Post-translational modifications of histones H3 and H4 associated with the histone methyltransferases Suv39h1 and G9a. Genome Biol (2007) 1.05
Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones. Histochem Cell Biol (2005) 1.04
Chromatin modification and the endothelial-specific activation of the E-selectin gene. J Biol Chem (2005) 1.04
Interplay between Epigenetics and Genetics in Cancer. Genomics Inform (2013) 1.03
Active chromatin and noncoding RNAs: an intimate relationship. Curr Opin Genet Dev (2011) 1.02
Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proc Natl Acad Sci U S A (2005) 1.02
Pygo2 associates with MLL2 histone methyltransferase and GCN5 histone acetyltransferase complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion. Mol Cell Biol (2010) 1.01
p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol (2012) 1.00
Dimethylated lysine 9 of histone 3 is elevated in schizophrenia and exhibits a divergent response to histone deacetylase inhibitors in lymphocyte cultures. J Psychiatry Neurosci (2009) 0.99
Epigenetic regulation in RCC: opportunities for therapeutic intervention? Nat Rev Urol (2012) 0.99
Cabin1 restrains p53 activity on chromatin. Nat Struct Mol Biol (2009) 0.99
Recruitment of the histone methyltransferase SUV39H1 and its role in the oncogenic properties of the leukemia-associated PML-retinoic acid receptor fusion protein. Mol Cell Biol (2006) 0.99
Barrier-to-Autointegration Factor influences specific histone modifications. Nucleus (2011) 0.99
Telomeres, histone code, and DNA damage response. Cytogenet Genome Res (2009) 0.98
Protein arginine methylation in parasitic protozoa. Eukaryot Cell (2011) 0.97
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
A unified theory of gene expression. Cell (2002) 7.61
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83
Epigenetic dynamics of imprinted X inactivation during early mouse development. Science (2003) 5.80
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
The key to development: interpreting the histone code? Curr Opin Genet Dev (2005) 4.96
Molecular signals of epigenetic states. Science (2010) 4.81
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04
Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82
L3MBTL1, a histone-methylation-dependent chromatin lock. Cell (2007) 3.70
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science (2003) 3.22
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01
Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell (2007) 2.94
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93
Histone H3 Lys 4 methylation: caught in a bind? Genes Dev (2006) 2.86
Asymmetrically modified nucleosomes. Cell (2012) 2.79
A double take on bivalent promoters. Genes Dev (2013) 2.79
Genomic comparison of the ants Camponotus floridanus and Harpegnathos saltator. Science (2010) 2.78
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation. Nature (2007) 2.76
The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev (2005) 2.70
Is there a code embedded in proteins that is based on post-translational modifications? Nat Rev Mol Cell Biol (2008) 2.64
G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem (2010) 2.64
Histone lysine demethylases and their impact on epigenetics. Cell (2006) 2.54
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev (2005) 2.51
Specificity and mechanism of the histone methyltransferase Pr-Set7. Genes Dev (2005) 2.50
Genome-wide and caste-specific DNA methylomes of the ants Camponotus floridanus and Harpegnathos saltator. Curr Biol (2012) 2.50
Histone variants meet their match. Nat Rev Mol Cell Biol (2005) 2.47
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol Cell Biol (2009) 2.47
PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell (2005) 2.44
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage. Mol Cell (2010) 2.39
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Drosophila Paf1 modulates chromatin structure at actively transcribed genes. Mol Cell Biol (2006) 2.16
Chromatin higher-order structures and gene regulation. Curr Opin Genet Dev (2011) 2.08
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem (2009) 2.06
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins. J Biol Chem (2009) 2.02
The constantly changing face of chromatin. Sci Aging Knowledge Environ (2003) 2.02
Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. Proc Natl Acad Sci U S A (2004) 2.01
PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells. Nat Struct Mol Biol (2013) 2.01
Recent highlights of RNA-polymerase-II-mediated transcription. Curr Opin Cell Biol (2004) 1.91
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription. Genes Dev (2012) 1.81
Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell (2012) 1.78
Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75
Methylation-acetylation interplay activates p53 in response to DNA damage. Mol Cell Biol (2007) 1.75
The program for processing newly synthesized histones H3.1 and H4. Nat Struct Mol Biol (2010) 1.71
Drosophila GAGA factor directs histone H3.3 replacement that prevents the heterochromatin spreading. Genes Dev (2007) 1.66
CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes Dev (2014) 1.62
Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56
Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52
MBT domain proteins in development and disease. Semin Cell Dev Biol (2009) 1.49
Functional characterization of core promoter elements: the downstream core element is recognized by TAF1. Mol Cell Biol (2005) 1.46
Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality. Genome Res (2013) 1.45
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo. Genes Dev (2011) 1.43
The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation. J Biol Chem (2010) 1.41
The mediator coactivator complex: functional and physical roles in transcriptional regulation. J Cell Sci (2003) 1.41
Facts about FACT and transcript elongation through chromatin. Curr Opin Genet Dev (2004) 1.40
Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. Mol Cell Biol (2004) 1.38
ASAP, a novel protein complex involved in RNA processing and apoptosis. Mol Cell Biol (2003) 1.34
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32
Histone chaperone FACT action during transcription through chromatin by RNA polymerase II. Proc Natl Acad Sci U S A (2013) 1.32
Methods and tips for the purification of human histone methyltransferases. Methods (2003) 1.31
Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem (2009) 1.28
Phylogenetic and transcriptomic analysis of chemosensory receptors in a pair of divergent ant species reveals sex-specific signatures of odor coding. PLoS Genet (2012) 1.27
FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. Mol Cell Biol (2002) 1.26
The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev (2012) 1.22
Facile synthesis of site-specifically acetylated and methylated histone proteins: reagents for evaluation of the histone code hypothesis. Proc Natl Acad Sci U S A (2003) 1.20
Epigenetic inheritance: uncontested? Cell Res (2011) 1.19
Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev (2012) 1.19
Transcription through chromatin: understanding a complex FACT. Biochim Biophys Acta (2004) 1.15
SIRT3 functions in the nucleus in the control of stress-related gene expression. Mol Cell Biol (2012) 1.12