Published in Nat Immunol on July 01, 2002
Metagenomic analysis of the medicinal leech gut microbiota. Front Microbiol (2014) 0.82
Intracellular bacterial biofilm-like pods in urinary tract infections. Science (2003) 7.10
Role of Escherichia coli curli operons in directing amyloid fiber formation. Science (2002) 5.58
Identification of genes subject to positive selection in uropathogenic strains of Escherichia coli: a comparative genomics approach. Proc Natl Acad Sci U S A (2006) 5.13
Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis. Proc Natl Acad Sci U S A (2004) 4.12
The biology and future prospects of antivirulence therapies. Nat Rev Microbiol (2008) 3.83
Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med (2007) 3.54
Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract. Proc Natl Acad Sci U S A (2006) 3.36
Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection. Mol Microbiol (2002) 3.26
Optical mapping as a routine tool for bacterial genome sequence finishing. BMC Genomics (2007) 2.71
Fiber formation across the bacterial outer membrane by the chaperone/usher pathway. Cell (2008) 2.69
Chaperone priming of pilus subunits facilitates a topological transition that drives fiber formation. Cell (2002) 2.54
Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nat Chem Biol (2009) 2.52
Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Cell Microbiol (2007) 2.48
Molecular regulation of urothelial renewal and host defenses during infection with uropathogenic Escherichia coli. J Biol Chem (2001) 2.34
Morphological plasticity as a bacterial survival strategy. Nat Rev Microbiol (2008) 2.28
Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coli. Infect Immun (2002) 2.20
Structural biology of the chaperone-usher pathway of pilus biogenesis. Nat Rev Microbiol (2009) 2.19
Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. Kidney Int (2004) 2.17
Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Sci Transl Med (2011) 2.16
Filamentation by Escherichia coli subverts innate defenses during urinary tract infection. Proc Natl Acad Sci U S A (2006) 2.15
A murine model of urinary tract infection. Nat Protoc (2009) 2.15
Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein. Mol Microbiol (2006) 2.14
Escherichia coli from urine of female patients with urinary tract infections is competent for intracellular bacterial community formation. Infect Immun (2006) 2.11
Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization. Infect Immun (2005) 2.10
Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli. Proc Natl Acad Sci U S A (2003) 2.02
Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli. Microbes Infect (2010) 1.95
Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin. Mol Microbiol (2005) 1.90
Fiber assembly by the chaperone-usher pathway. Biochim Biophys Acta (2004) 1.89
Genomic diversity and fitness of E. coli strains recovered from the intestinal and urinary tracts of women with recurrent urinary tract infection. Sci Transl Med (2013) 1.88
Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection. PLoS Pathog (2010) 1.88
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria. Proc Natl Acad Sci U S A (2006) 1.87
Quantitative metabolomics reveals an epigenetic blueprint for iron acquisition in uropathogenic Escherichia coli. PLoS Pathog (2009) 1.83
Antibody responses and protection from pyelonephritis following vaccination with purified Escherichia coli PapDG protein. J Urol (2004) 1.82
Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism. Mol Cell (2006) 1.81
A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131. J Infect Dis (2013) 1.76
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrate. Nature (2011) 1.67
Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled. J Biol Chem (2007) 1.64
Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection. Infect Immun (2012) 1.64
Intracellular bacterial communities of uropathogenic Escherichia coli in urinary tract pathogenesis. Trends Microbiol (2004) 1.62
Experimental evidence for negative selection in the evolution of a Yersinia pestis pseudogene. Proc Natl Acad Sci U S A (2008) 1.61
The extracytoplasmic adaptor protein CpxP is degraded with substrate by DegP. Proc Natl Acad Sci U S A (2005) 1.58
Maturation of intracellular Escherichia coli communities requires SurA. Infect Immun (2006) 1.56
Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proc Natl Acad Sci U S A (2009) 1.56
Suppression of bladder epithelial cytokine responses by uropathogenic Escherichia coli. Infect Immun (2005) 1.55
Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection. FEMS Microbiol Rev (2012) 1.55
Bone morphogenetic protein 4 signaling regulates epithelial renewal in the urinary tract in response to uropathogenic infection. Cell Host Microbe (2009) 1.51
Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific. J Infect Dis (2012) 1.48
QseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli. Mol Microbiol (2009) 1.47
The entomopathogenic bacterial endosymbionts Xenorhabdus and Photorhabdus: convergent lifestyles from divergent genomes. PLoS One (2011) 1.47
A tale of two pili: assembly and function of pili in bacteria. Trends Microbiol (2010) 1.47
Localized and efficient curli nucleation requires the chaperone-like amyloid assembly protein CsgF. Proc Natl Acad Sci U S A (2009) 1.43
Structure-based drug design and optimization of mannoside bacterial FimH antagonists. J Med Chem (2010) 1.40
The Legionella pneumophila PilT homologue DotB exhibits ATPase activity that is critical for intracellular growth. J Bacteriol (2004) 1.39
Bacterial biofilms: development, dispersal, and therapeutic strategies in the dawn of the postantibiotic era. Cold Spring Harb Perspect Med (2013) 1.38
CD14- and Toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli. Infect Immun (2003) 1.38
LeuX tRNA-dependent and -independent mechanisms of Escherichia coli pathogenesis in acute cystitis. Mol Microbiol (2007) 1.37
Utilization of an intracellular bacterial community pathway in Klebsiella pneumoniae urinary tract infection and the effects of FimK on type 1 pilus expression. Infect Immun (2008) 1.36
Population dynamics and niche distribution of uropathogenic Escherichia coli during acute and chronic urinary tract infection. Infect Immun (2011) 1.36
Periplasmic peptidyl prolyl cis-trans isomerases are not essential for viability, but SurA is required for pilus biogenesis in Escherichia coli. J Bacteriol (2005) 1.35
CsgE is a curli secretion specificity factor that prevents amyloid fibre aggregation. Mol Microbiol (2011) 1.34
Requirement of Rho-family GTPases in the invasion of Type 1-piliated uropathogenic Escherichia coli. Cell Microbiol (2002) 1.34
Enterococcus faecalis tropism for the kidneys in the urinary tract of C57BL/6J mice. Infect Immun (2005) 1.26
A central metabolic circuit controlled by QseC in pathogenic Escherichia coli. Mol Microbiol (2011) 1.26
Bacterial outer membrane ushers contain distinct targeting and assembly domains for pilus biogenesis. J Bacteriol (2002) 1.24
Mechanism for sortase localization and the role of sortase localization in efficient pilus assembly in Enterococcus faecalis. J Bacteriol (2009) 1.23
Contribution of autolysin and Sortase a during Enterococcus faecalis DNA-dependent biofilm development. Infect Immun (2009) 1.23
Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity. J Med Chem (2010) 1.22
G-CSF induction early in uropathogenic Escherichia coli infection of the urinary tract modulates host immunity. Cell Microbiol (2008) 1.22
Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence. J Biol Chem (2004) 1.21
A novel endogenous inhibitor of the secreted streptococcal NAD-glycohydrolase. PLoS Pathog (2005) 1.20
Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis. Infect Immun (2010) 1.19
Enterococcal biofilm formation and virulence in an optimized murine model of foreign body-associated urinary tract infections. Infect Immun (2010) 1.19
A movable surface: formation of Yersinia sp. biofilms on motile Caenorhabditis elegans. J Bacteriol (2004) 1.19
Differential control of Yersinia pestis biofilm formation in vitro and in the flea vector by two c-di-GMP diguanylate cyclases. PLoS One (2011) 1.18
Catalysis of protein folding by chaperones in pathogenic bacteria. Proc Natl Acad Sci U S A (2004) 1.18
Escherichia coli biofilms have an organized and complex extracellular matrix structure. MBio (2013) 1.17
Escherichia coli DegP protease cleaves between paired hydrophobic residues in a natural substrate: the PapA pilin. J Bacteriol (2002) 1.16
Mechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation. J Am Chem Soc (2012) 1.15
Interaction of uropathogenic Escherichia coli with host uroepithelium. Curr Opin Microbiol (2005) 1.13
Crystal structure of the P pilus rod subunit PapA. PLoS Pathog (2007) 1.11
Structural and energetic basis of folded-protein transport by the FimD usher. Nature (2013) 1.11
Host subversion by formation of intracellular bacterial communities in the urinary tract. Microbes Infect (2004) 1.11
Molecular variations in Klebsiella pneumoniae and Escherichia coli FimH affect function and pathogenesis in the urinary tract. Infect Immun (2008) 1.07
Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. J Med Chem (2012) 1.05
Chaperone-subunit-usher interactions required for donor strand exchange during bacterial pilus assembly. J Bacteriol (2003) 1.04
Targeting virulence for antimicrobial chemotherapy. Curr Opin Pharmacol (2003) 1.03
Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor. Proc Natl Acad Sci U S A (2013) 1.03
P pilus assembly motif necessary for activation of the CpxRA pathway by PapE in Escherichia coli. J Bacteriol (2004) 1.02
Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors. J Bacteriol (2012) 1.02
Streptozocin-induced diabetic mouse model of urinary tract infection. Infect Immun (2008) 1.02
Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrob Agents Chemother (2012) 1.02
Glycosylation genes expressed in seam cells determine complex surface properties and bacterial adhesion to the cuticle of Caenorhabditis elegans. Genetics (2010) 1.02
Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation. Proc Natl Acad Sci U S A (2013) 1.02
Sticky fibers and uropathogenesis: bacterial adhesins in the urinary tract. Future Microbiol (2006) 0.99
Immune activation and suppression by group B streptococcus in a murine model of urinary tract infection. Infect Immun (2011) 0.99
Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis. Infect Immun (2010) 0.99
The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT. J Bacteriol (2012) 0.98
Enterococcus faecalis overcomes foreign body-mediated inflammation to establish urinary tract infections. Infect Immun (2012) 0.98
Yersinia pestis YrbH is a multifunctional protein required for both 3-deoxy-D-manno-oct-2-ulosonic acid biosynthesis and biofilm formation. Mol Microbiol (2006) 0.98