Published in Hum Immunol on August 01, 2002
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol (2005) 2.14
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes (2010) 1.62
Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 1.38
Genetics of type 1 diabetes. Clin Chem (2011) 1.37
Genetics of the HLA region in the prediction of type 1 diabetes. Curr Diab Rep (2011) 1.30
Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos. Am J Hum Genet (2003) 1.27
HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. Diabetes (2010) 1.26
Genetics of type 1 diabetes. Cold Spring Harb Perspect Med (2012) 1.25
Evidence for association of the TCF7 locus with type I diabetes. Genes Immun (2009) 1.15
Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes. Clin Immunol (2009) 1.14
Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes. Diabetes (2010) 1.06
Extreme genetic risk for type 1A diabetes in the post-genome era. J Autoimmun (2008) 1.00
Linkage disequilibrium with predisposing DR3 haplotypes accounts for apparent effects of tumor necrosis factor and lymphotoxin-alpha polymorphisms on type 1 diabetes susceptibility. Hum Immunol (2006) 1.00
Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab (2009) 0.98
Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. Diabetes (2013) 0.98
Type 1 diabetes risk for human leukocyte antigen (HLA)-DR3 haplotypes depends on genotypic context: association of DPB1 and HLA class I loci among DR3- and DR4-matched Italian patients and controls. Hum Immunol (2008) 0.94
Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes. J Clin Endocrinol Metab (2009) 0.91
The type 1 diabetes - HLA susceptibility interactome--identification of HLA genotype-specific disease genes for type 1 diabetes. PLoS One (2010) 0.89
T-cell promiscuity in autoimmune diabetes. Diabetes (2008) 0.88
Association analysis of SNPs in the IL4R locus with type I diabetes. Genes Immun (2009) 0.87
Genetic variation within the HLA class III influences T1D susceptibility conferred by high-risk HLA haplotypes. Genes Immun (2010) 0.86
Search for haplotype interactions that influence susceptibility to type 1 diabetes, through use of unphased genotype data. Am J Hum Genet (2003) 0.84
The HLA-B 3906 allele imparts a high risk of diabetes only on specific HLA-DR/DQ haplotypes. Diabetologia (2011) 0.82
Dominant suppression of Addison's disease associated with HLA-B15. J Clin Endocrinol Metab (2011) 0.82
Conditional meta-analysis stratifying on detailed HLA genotypes identifies a novel type 1 diabetes locus around TCF19 in the MHC. Hum Genet (2010) 0.82
The role of HLA class I gene variation in autoimmune diabetes. Rev Diabet Stud (2005) 0.81
HLA class I and II alleles are associated with microvascular complications of type 1 diabetes. Hum Immunol (2013) 0.79
Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex. J Diabetes (2011) 0.78
Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect. Int Immunol (2010) 0.77
Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopes. J Immunol (2012) 0.76
HLA-A*33-DR3 and A*33-DR9 haplotypes enhance the risk of type 1 diabetes in Han Chinese. J Diabetes Investig (2016) 0.76
Prediction of type 1 diabetes. Diabetes (2013) 0.75
An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients. J Diabetes Res (2015) 0.75
Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment. Front Endocrinol (Lausanne) (2017) 0.75
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet (1993) 51.42
Mapping disease genes: family-based association studies. Am J Hum Genet (1995) 5.82
The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med (1994) 3.71
The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet (1996) 2.90
Susceptibility to type I diabetes: HLA-DQ and DR revisited. Immunol Today (1996) 2.72
Polymorphism, recombination, and linkage disequilibrium within the HLA class II region. J Immunol (1992) 2.39
Detecting disease-predisposing variants: the haplotype method. Am J Hum Genet (1997) 2.33
A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia (1994) 2.25
Homozygous parent affected sib pair method for detecting disease predisposing variants: application to insulin dependent diabetes mellitus. Genet Epidemiol (1993) 1.91
Power studies for the transmission/disequilibrium tests with multiple alleles. Am J Hum Genet (1997) 1.85
The HLA class II locus DPB1 can influence susceptibility to type 1 diabetes. Diabetes (2000) 1.69
Genetic analysis of type 1 diabetes using whole genome approaches. Proc Natl Acad Sci U S A (1995) 1.66
HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus. Am J Hum Genet (1984) 1.54
Combinations of specific DRB1, DQA1, DQB1 haplotypes are associated with insulin-dependent diabetes mellitus in Sardinia. Hum Immunol (1993) 1.52
HLA class II alleles and susceptibility and resistance to insulin dependent diabetes mellitus in Mexican-American families. Nat Genet (1993) 1.50
A method for typing polymorphism at the HLA-A locus using PCR amplification and immobilized oligonucleotide probes. Tissue Antigens (1994) 1.49
The association of specific HLA class I and II alleles with type 1 diabetes among Filipinos. Tissue Antigens (2002) 1.47
Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care (1993) 1.44
Nomenclature for factors of the HLA system, 1995. Tissue Antigens (1995) 1.34
Association of HLA-DPB1*0301 with IDDM in Mexican-Americans. Diabetes (1996) 1.32
A gene telomeric of the HLA class I region is involved in predisposition to both type 1 diabetes and coeliac disease. Tissue Antigens (1999) 1.22
Association between type 1 diabetes age of onset and HLA among sibling pairs. Diabetes (1999) 1.12
Association of HLA-A24 with complete beta-cell destruction in IDDM. Diabetes (1993) 1.08
HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus. Hum Immunol (1995) 1.07
Human leukocyte antigen-A24 and -DQA1*0301 in Japanese insulin-dependent diabetes mellitus: independent contributions to susceptibility to the disease and additive contributions to acceleration of beta-cell destruction. J Clin Endocrinol Metab (1999) 1.06
Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM. Diabetologia (1995) 0.96
Residual beta-cell function and HLA-A24 in IDDM. Markers of glycemic control and subsequent development of diabetic retinopathy. Diabetes (1995) 0.89
A new marker in the HLA class I region is associated with the age at onset of IDDM. Diabetologia (1995) 0.88
HLA-DP and susceptibility to insulin-dependent diabetes mellitus in an ethnically mixed population. Associations with other HLA-alleles. J Autoimmun (1995) 0.83
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res (2010) 5.08
Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA (2003) 4.00
PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis. Am J Hum Genet (2005) 3.95
Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet (2013) 3.87
Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA (2005) 3.61
Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol (2006) 3.55
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med (2002) 3.39
Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected female sibling pairs. Am J Hum Genet (2006) 3.25
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet (2006) 3.13
Common variants near TERC are associated with mean telomere length. Nat Genet (2010) 2.98
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes (2005) 2.85
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet (2003) 2.71
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47
Cohort Profile: TwinsUK and healthy ageing twin study. Int J Epidemiol (2012) 2.37
An integrated haplotype map of the human major histocompatibility complex. Am J Hum Genet (2003) 2.29
Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies. Hum Immunol (2008) 2.22
Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab (2004) 2.19
Human telomere biology: pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol (2006) 2.16
Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol (2005) 2.14
Prognostic markers of radiographic progression in early rheumatoid arthritis. Arthritis Rheum (2004) 2.08
Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women. Clin Chem (2007) 2.05
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes (2009) 2.02
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum (2010) 2.02
Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects. Arthritis Rheum (2010) 1.99
Reevaluation of the interaction between HLA-DRB1 shared epitope alleles, PTPN22, and smoking in determining susceptibility to autoantibody-positive and autoantibody-negative rheumatoid arthritis in a large UK Caucasian population. Arthritis Rheum (2009) 1.95
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet (2002) 1.93
Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A (2006) 1.90
Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex. Diabetes (2007) 1.84
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan. J Natl Cancer Inst (2002) 1.79
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet (2012) 1.77
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
Nevus size and number are associated with telomere length and represent potential markers of a decreased senescence in vivo. Cancer Epidemiol Biomarkers Prev (2007) 1.75
The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance. Ann Rheum Dis (2010) 1.70
Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes (2010) 1.67
HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium. Diabetes (2010) 1.62
Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis (2012) 1.62
HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clin Trials (2010) 1.61
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet (2009) 1.61
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. J Clin Endocrinol Metab (2004) 1.60
A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet (2011) 1.60
Polymorphisms of the renin-angiotensin system genes predict progression of subclinical coronary atherosclerosis. Diabetes (2007) 1.56
Association of IL4R haplotypes with type 1 diabetes. Diabetes (2002) 1.54
PyPop: a software framework for population genomics: analyzing large-scale multi-locus genotype data. Pac Symp Biocomput (2003) 1.50
Impact of shared epitope genotype and ethnicity on erosive disease: a meta-analysis of 3,240 rheumatoid arthritis patients. Arthritis Rheum (2004) 1.50
Metabolomic study of carotid-femoral pulse-wave velocity in women. J Hypertens (2015) 1.49
Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol (2013) 1.48
Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr (2007) 1.47
When is a replication not a replication? Or how to spot a good genetic association study. Arthritis Rheum (2006) 1.47
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs. Diabetes (2011) 1.44
Multi-SNP analysis of MHC region: remarkable conservation of HLA-A1-B8-DR3 haplotype. Diabetes (2006) 1.38
Signatures of demographic history and natural selection in the human major histocompatibility complex Loci. Genetics (2006) 1.37
Polymorphism in the P-selectin and interleukin-4 genes as determinants of stroke: a population-based, prospective genetic analysis. Hum Mol Genet (2003) 1.33
Normal but increasing hemoglobin A1c levels predict progression from islet autoimmunity to overt type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). Pediatr Diabetes (2006) 1.33
Improved weight management using genetic information to personalize a calorie controlled diet. Nutr J (2007) 1.30
Genetics of the HLA region in the prediction of type 1 diabetes. Curr Diab Rep (2011) 1.30
Newborn HLA-DR,DQ genotype screening: age- and ethnicity-specific type 1 diabetes risk estimates. Pediatr Diabetes (2005) 1.28
Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach. Stroke (2006) 1.28
Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. Proc Natl Acad Sci U S A (2012) 1.28
Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations. Philos Trans R Soc Lond B Biol Sci (2012) 1.28
Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos. Am J Hum Genet (2003) 1.27
Genetics of type 1 diabetes. Cold Spring Harb Perspect Med (2012) 1.25
A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients. Stroke (2009) 1.20
Association of the single nucleotide polymorphism C1858T of the PTPN22 gene with type 1 diabetes. Hum Immunol (2005) 1.18
Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. Arterioscler Thromb Vasc Biol (2003) 1.18
A beta-lactamase with reduced immunogenicity for the targeted delivery of chemotherapeutics using antibody-directed enzyme prodrug therapy. Mol Cancer Ther (2005) 1.17
Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer. Int J Cancer (2007) 1.15
Polymorphism in the beta2-adrenergic receptor and lipoprotein lipase genes as risk determinants for idiopathic venous thromboembolism: a multilocus, population-based, prospective genetic analysis. Circulation (2006) 1.15
Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes. Clin Immunol (2009) 1.14
Nomenclature for Factors of the HLA System, 2004. Hum Immunol (2005) 1.14
Targeted metabolomics profiles are strongly correlated with nutritional patterns in women. Metabolomics (2012) 1.13
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region. Ann Rheum Dis (2012) 1.13
DPB1 alleles are associated with type 1 diabetes susceptibility in multiple ethnic groups. Diabetes (2004) 1.13
Genetic analysis of multiple sclerosis in Europeans. J Neuroimmunol (2003) 1.12
Novel sequence feature variant type analysis of the HLA genetic association in systemic sclerosis. Hum Mol Genet (2009) 1.10
Miniaturized sealed-tube allele-specific PCR. Hum Mutat (2002) 1.09
Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY). Diabetes Res Clin Pract (2003) 1.09
A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes (2003) 1.09
Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures. Calcif Tissue Int (2008) 1.08
Next-generation DNA re-sequencing identifies common variants of TYR and HLA-A that modulate the risk of generalized vitiligo via antigen presentation. J Invest Dermatol (2012) 1.07
Millennium award recipient contribution. Identification of children with early onset and high incidence of anti-islet autoantibodies. Clin Immunol (2002) 1.07
Inference of the genetic architecture underlying BMI and height with the use of 20,240 sibling pairs. Am J Hum Genet (2013) 1.04
The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet (2011) 1.04