Published in Diabetes on October 01, 2005
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Res (2006) 3.25
Standards of medical care in diabetes--2015: summary of revisions. Diabetes Care (2015) 3.16
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes (2009) 2.02
Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am (2010) 2.02
Extreme genetic risk for type 1A diabetes. Proc Natl Acad Sci U S A (2006) 1.90
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms. Endocr Rev (2008) 1.66
HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clin Trials (2010) 1.61
Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008. J Clin Endocrinol Metab (2008) 1.61
Overview of the Rapid Response data. Genes Immun (2009) 1.58
Genetic mapping at 3-kilobase resolution reveals inositol 1,4,5-triphosphate receptor 3 as a risk factor for type 1 diabetes in Sweden. Am J Hum Genet (2006) 1.50
Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs. Diabetes (2011) 1.44
Designing and implementing sample and data collection for an international genetics study: the Type 1 Diabetes Genetics Consortium (T1DGC). Clin Trials (2010) 1.44
Collection and processing of whole blood for transformation of peripheral blood mononuclear cells and extraction of DNA: the Type 1 Diabetes Genetics Consortium. Clin Trials (2010) 1.42
Summarizing historical information on controls in clinical trials. Clin Trials (2010) 1.38
Genetics of type 1 diabetes. Clin Chem (2011) 1.37
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases. Genome Biol (2007) 1.27
HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the type 1 diabetes genetics consortium families. Diabetes (2010) 1.26
Genetic determination and linkage mapping of Plasmodium falciparum malaria related traits in Senegal. PLoS One (2008) 1.20
Evidence for association of the TCF7 locus with type I diabetes. Genes Immun (2009) 1.15
Were genome-wide linkage studies a waste of time? Exploiting candidate regions within genome-wide association studies. Genet Epidemiol (2010) 1.12
Approaches in type 1 diabetes research: A status report. Int J Diabetes Dev Ctries (2009) 1.08
Effects of non-HLA gene polymorphisms on development of islet autoimmunity and type 1 diabetes in a population with high-risk HLA-DR,DQ genotypes. Diabetes (2012) 1.01
Extreme genetic risk for type 1A diabetes in the post-genome era. J Autoimmun (2008) 1.00
Association of the CpG methylation pattern of the proximal insulin gene promoter with type 1 diabetes. PLoS One (2012) 0.99
The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome. Genes Immun (2009) 0.98
Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. Diabetes (2013) 0.98
Overview of the Type I Diabetes Genetics Consortium. Genes Immun (2009) 0.95
Meta-analysis of genome-wide linkage studies across autoimmune diseases. Eur J Hum Genet (2008) 0.92
Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis. Proc Natl Acad Sci U S A (2011) 0.91
Association analysis of SNPs in the IL4R locus with type I diabetes. Genes Immun (2009) 0.87
Association analyses of the vitamin D receptor gene in 1654 families with type I diabetes. Genes Immun (2009) 0.86
Susceptibility to type 1 diabetes conferred by the PTPN22 C1858T polymorphism in the Spanish population. BMC Med Genet (2007) 0.84
Genetic loci linked to type 1 diabetes and multiple sclerosis families in Sardinia. BMC Med Genet (2008) 0.84
Design and Measurement of Nonislet-Specific Autoantibodies for the Type 1 Diabetes Genetics Consortium Autoantibody Workshop. Diabetes Care (2015) 0.84
Expression profiling of human genetic and protein interaction networks in type 1 diabetes. PLoS One (2009) 0.84
Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFα) signaling in endothelial cells. BMC Genomics (2012) 0.83
Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11. BMC Genet (2007) 0.83
The changing landscape of type 1 diabetes: recent developments and future frontiers. Curr Diab Rep (2013) 0.83
Genes mediating environment interactions in type 1 diabetes. Rev Diabet Stud (2006) 0.82
Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes. J Autoimmun (2011) 0.81
Current status and the future for the genetics of type I diabetes. Genes Immun (2009) 0.80
Questioning four preconceived ideas on immunotherapy of clinical type 1 diabetes: lessons from recent CD3 antibody trials. Rev Diabet Stud (2005) 0.80
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes. BMC Genet (2006) 0.80
A genome-wide scan for type 1 diabetes susceptibility genes in nuclear families with multiple affected siblings in Finland. BMC Genet (2007) 0.79
Familial type 1 diabetes mellitus - gender distribution and age at onset of diabetes distinguish between parent-offspring and sib-pair subgroups. Pediatr Diabetes (2009) 0.79
Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin. Diabetologia (2013) 0.79
Effect of linkage status of affected sib-pairs on the search for novel type 1 diabetes susceptibility genes in the HLA complex. Diabetes Obes Metab (2009) 0.79
Type 1 Diabetes at-risk children highly recognize Mycobacterium avium subspecies paratuberculosis epitopes homologous to human Znt8 and Proinsulin. Sci Rep (2016) 0.79
Replication and further characterization of a Type 1 diabetes-associated locus at the telomeric end of the major histocompatibility complex. J Diabetes (2011) 0.78
MHC-environment interactions leading to type 1 diabetes: feasibility of an analysis of HLA DR-DQ alleles in relation to manifestation periods and dates of birth. Diabetes Obes Metab (2009) 0.77
Next-Generation Sequencing Reveals That HLA-DRB3, -DRB4, and -DRB5 May Be Associated With Islet Autoantibodies and Risk for Childhood Type 1 Diabetes. Diabetes (2016) 0.77
APECED: A Paradigm of Complex Interactions between Genetic Background and Susceptibility Factors. Front Immunol (2013) 0.77
Country-specific birth weight and length in type 1 diabetes high-risk HLA genotypes in combination with prenatal characteristics. J Perinatol (2011) 0.77
Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes. BMC Genet (2006) 0.77
Heat-shock protein gene is not associated with type-1 diabetes in African Americans. J Natl Med Assoc (2007) 0.76
Assessment of type 1 diabetes risk conferred by HLA-DRB1, INS-VNTR and PTPN22 genes using the Bayesian network approach. PLoS One (2013) 0.75
From markers to molecular mechanisms: type 1 diabetes in the post-GWAS era. Rev Diabet Stud (2012) 0.75
Prediction of type 1 diabetes. Diabetes (2013) 0.75
Association of CD247 (CD3ζ) gene polymorphisms with T1D and AITD in the population of northern Sweden. BMC Med Genet (2016) 0.75
Progress and challenges for treating Type 1 diabetes. J Autoimmun (2016) 0.75
Macrophages from lupus-prone MRL mice have a conditional signaling abnormality that leads to dysregulated expression of numerous genes. Immunogenetics (2011) 0.75
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered (2003) 14.37
Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
A human phenome-interactome network of protein complexes implicated in genetic disorders. Nat Biotechnol (2007) 9.90
The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet (2004) 9.37
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Gut microbiomes of Malawian twin pairs discordant for kwashiorkor. Science (2013) 6.98
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet (2011) 6.36
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
Robust relationship inference in genome-wide association studies. Bioinformatics (2010) 5.57
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes (2004) 4.81
Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med (2014) 4.70
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet (2012) 4.46
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA (2003) 4.00
The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet (2003) 3.96
Risk of celiac disease autoimmunity and timing of gluten introduction in the diet of infants at increased risk of disease. JAMA (2005) 3.61
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am J Gastroenterol (2006) 3.55
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet (2010) 3.50
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Res (2006) 3.25
Genetics of type 1A diabetes. N Engl J Med (2009) 3.18
Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf) (2007) 3.17
Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes (2009) 3.16
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. PLoS Genet (2011) 3.07
Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One (2013) 3.07
The landscape of recombination in African Americans. Nature (2011) 3.06
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release. Lancet Neurol (2007) 2.99
Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92
Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet (2010) 2.91
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans. J Clin Endocrinol Metab (2008) 2.87
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes (2008) 2.74
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet (2003) 2.71
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One (2013) 2.65
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet (2013) 2.60
Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke. Ann Neurol (2009) 2.55
Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53
Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods. Ann Epidemiol (2003) 2.51
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet (2009) 2.38
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. PLoS Genet (2011) 2.33
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses. PLoS One (2008) 2.28
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet (2011) 2.25
Overview of the MHC fine mapping data. Diabetes Obes Metab (2009) 2.24
The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci (2006) 2.22
Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY). J Clin Endocrinol Metab (2004) 2.19
Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset. Hum Immunol (2005) 2.14
Prognostic markers of radiographic progression in early rheumatoid arthritis. Arthritis Rheum (2004) 2.08
Homocysteine, 5,10-methylenetetrahydrofolate reductase 677C>T polymorphism, nutrient intake, and incident cardiovascular disease in 24,968 initially healthy women. Clin Chem (2007) 2.05
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet (2015) 2.04
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes (2009) 2.02