Platelet formation is the consequence of caspase activation within megakaryocytes.

PubWeight™: 2.62‹?› | Rank: Top 1%

🔗 View Article (PMID 12149212)

Published in Blood on August 15, 2002

Authors

Stephane De Botton1, Siham Sabri, Eric Daugas, Yael Zermati, Jacques Emmanuel Guidotti, Olivier Hermine, Guido Kroemer, William Vainchenker, Najet Debili

Author Affiliations

1: Institut National de la Santé et de la Recherche Médicale U362 and the Centre National de la Recherche Scientifique (Unité Mixte de Recherche 1599), Institut Gustave Roussy, Institut Fédératif de Recherche 54, Villejuif, France.

Articles citing this

NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A (2007) 5.14

Programmed cell death in animal development and disease. Cell (2011) 5.07

Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell (2008) 2.68

The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest (2005) 2.30

Pivotal contributions of megakaryocytes to the biology of idiopathic myelofibrosis. Blood (2007) 2.09

Historical review: megakaryopoiesis and thrombopoiesis. Blood (2008) 2.03

A ubiquitin ligase complex regulates caspase activation during sperm differentiation in Drosophila. PLoS Biol (2007) 1.96

Hematopoietic stem cell responsiveness to exogenous signals is limited by caspase-3. Cell Stem Cell (2008) 1.94

Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles. Blood (2008) 1.93

The Jekyll and Hyde functions of caspases. Dev Cell (2009) 1.87

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function. Blood (2009) 1.85

No death without life: vital functions of apoptotic effectors. Cell Death Differ (2008) 1.80

The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease. Crit Rev Biochem Mol Biol (2009) 1.71

A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans. PLoS Genet (2012) 1.53

Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood (2006) 1.52

Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood (2005) 1.47

Incomplete activation of macrophage apoptosis during intracellular replication of Legionella pneumophila. Infect Immun (2005) 1.44

Tetraspanin CD9 participates in dysmegakaryopoiesis and stromal interactions in primary myelofibrosis. Haematologica (2015) 1.41

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death. J Cell Biol (2003) 1.32

STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. J Clin Invest (2007) 1.27

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med (2011) 1.27

Physiological functions of caspases beyond cell death. Am J Pathol (2006) 1.22

Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J (2005) 1.14

15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. Blood (2008) 1.11

A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation. J Cell Sci (2006) 1.07

In vitro megakaryocyte production and platelet biogenesis: state of the art. Transfus Med Rev (2010) 1.07

Non-apoptotic functions of apoptosis-regulatory proteins. EMBO Rep (2012) 1.06

Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase. Oncogene (2009) 1.05

The kinder side of killer proteases: caspase activation contributes to neuroprotection and CNS remodeling. Apoptosis (2004) 1.01

Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol. Genes Dev (2003) 1.01

SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. J Biol Chem (2008) 0.99

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs. J Cell Biol (2015) 0.98

Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Mol Cell Biol (2004) 0.97

PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development. J Biol Chem (2010) 0.96

Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis. J Biol Chem (2008) 0.94

Transcription factors in late megakaryopoiesis and related platelet disorders. J Thromb Haemost (2013) 0.93

Cell death signaling and anticancer therapy. Front Oncol (2011) 0.91

Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis. Br J Pharmacol (2005) 0.91

A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosis. BMC Genomics (2007) 0.90

New roles for old enzymes: killer caspases as the engine of cell behavior changes. Front Physiol (2014) 0.89

Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells. Blood (2014) 0.89

Diffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death. BMC Syst Biol (2010) 0.87

Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling. Cell Death Differ (2010) 0.87

Regional differences in the temporal expression of non-apoptotic caspase-3-positive bergmann glial cells in the developing rat cerebellum. Front Neuroanat (2009) 0.85

ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation. Cell Death Dis (2013) 0.85

The regulation of proplatelet production. Haematologica (2009) 0.85

Piecing together the humoral and cellular mechanisms of immune thrombocytopenia. Semin Thromb Hemost (2011) 0.84

Gender dependence for a subset of the low-abundance signaling proteome in human platelets. Hum Genomics Proteomics (2010) 0.84

Effector caspases and leukemia. Int J Cell Biol (2011) 0.83

Megakaryocyte apoptosis: sorting out the signals. Br J Pharmacol (2005) 0.83

Covalently immobilized glycosaminoglycans enhance megakaryocyte progenitor expansion and platelet release. J Biomed Mater Res A (2011) 0.83

Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis. Cell Mol Life Sci (2010) 0.83

Tango7 directs cellular remodeling by the Drosophila apoptosome. Genes Dev (2013) 0.82

Separation of in-vitro-derived megakaryocytes and platelets using spinning-membrane filtration. Biotechnol Bioeng (2014) 0.81

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) impairs the regulation of apoptosis in megakaryocytes by activating NF-κB: a proteomic study. Mol Cell Proteomics (2011) 0.78

Apoptosis: role in myeloid cell development. Blood Res (2015) 0.78

Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin. Cell Death Dis (2013) 0.77

M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. Transl Res (2015) 0.77

Actin inhibition increases megakaryocyte proplatelet formation through an apoptosis-dependent mechanism. PLoS One (2015) 0.77

Interspecies Variation in the Functional Consequences of Mutation of Cytochrome c. PLoS One (2015) 0.77

Non-apoptotic functions of caspases in myeloid cell differentiation. Cell Death Differ (2017) 0.76

Thrombin Maybe Plays an Important Role in MK Differentiation into Platelets. Biomed Res Int (2016) 0.75

Platelet formation: a link between apoptosis and differentiation. Blood (2002) 0.75

Stem cell autotomy and niche interaction in different systems. World J Stem Cells (2015) 0.75

Dysregulation of the intrinsic apoptotic pathway mediates megakaryocytic hyperplasia in myeloproliferative neoplasms. J Clin Pathol (2016) 0.75

Restoring TRAIL Induced Apoptosis Using Naturopathy. Hercules Joins Hand with Nature to Triumph Over Lernaean Hydra. Curr Genomics (2017) 0.75

CDPs: caspase-dependent non-lethal cellular processes. Cell Death Differ (2017) 0.75

[Current models of thrombopoiesis]. Pathologe (2010) 0.75

Identifying and enriching the platelet-producing human stem cell-derived megakaryocytes using factor V uptake. Blood (2017) 0.75

More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease. Cell Death Differ (2017) 0.75

Articles by these authors

Autophagy in the pathogenesis of disease. Cell (2008) 34.68

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature (2005) 18.43

Mutation in TET2 in myeloid cancers. N Engl J Med (2009) 16.07

Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol (2007) 15.47

The hallmarks of aging. Cell (2013) 14.29

Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med (2007) 13.90

The pathophysiology of mitochondrial cell death. Science (2004) 13.87

Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J (2007) 11.72

Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med (2006) 10.54

Inhibition of macroautophagy triggers apoptosis. Mol Cell Biol (2005) 10.27

Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors. Nat Med (2009) 6.73

Immunological aspects of cancer chemotherapy. Nat Rev Immunol (2008) 6.61

Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol (2006) 6.13

Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov (2006) 5.99

Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med (2014) 5.98

Regulation of autophagy by cytoplasmic p53. Nat Cell Biol (2008) 5.97

Autophagy and aging. Cell (2011) 5.96

High-dose melphalan versus melphalan plus dexamethasone for AL amyloidosis. N Engl J Med (2007) 5.84

Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science (2011) 5.62

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis. Cancer Cell (2011) 5.28

Cytoplasmic functions of the tumour suppressor p53. Nature (2009) 5.23

Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet (2009) 5.03

Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00

Cell death by mitotic catastrophe: a molecular definition. Oncogene (2004) 4.75

Cell death by necrosis: towards a molecular definition. Trends Biochem Sci (2006) 4.67

The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science (2013) 4.60

Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy (2008) 4.42

An immunosurveillance mechanism controls cancer cell ploidy. Science (2012) 4.35

Immunogenic and tolerogenic cell death. Nat Rev Immunol (2009) 4.34

Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med (2005) 4.32

Targeting mitochondria for cancer therapy. Nat Rev Drug Discov (2010) 4.07

The anticancer immune response: indispensable for therapeutic success? J Clin Invest (2008) 4.01

The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death. J Cell Sci (2005) 3.93

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82

Increased risk of locoregional recurrence for women with T1-2N0 triple-negative breast cancer treated with modified radical mastectomy without adjuvant radiation therapy compared with breast-conserving therapy. J Clin Oncol (2011) 3.75

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging. Science (2011) 3.74

Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. Immunity (2013) 3.73

Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell proliferation. J Exp Med (2005) 3.64

The secret ally: immunostimulation by anticancer drugs. Nat Rev Drug Discov (2012) 3.60

Decoding cell death signals in inflammation and immunity. Cell (2010) 3.41

Immune parameters affecting the efficacy of chemotherapeutic regimens. Nat Rev Clin Oncol (2011) 3.41

Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol (2011) 3.40

JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis. Blood (2006) 3.37

Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity (2013) 3.26

Basophils and the T helper 2 environment can promote the development of lupus nephritis. Nat Med (2010) 3.24

Does autophagy contribute to cell death? Autophagy (2005) 3.21

A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med (2006) 3.21

Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle (2006) 3.21

AIF deficiency compromises oxidative phosphorylation. EMBO J (2004) 3.19

Prognostic score including gene mutations in chronic myelomonocytic leukemia. J Clin Oncol (2013) 3.10

BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L). Autophagy (2007) 3.08

Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat Med (2011) 3.03

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy. Immunol Rev (2007) 2.96

Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations. J Invest Dermatol (2009) 2.94

Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. Nat Genet (2012) 2.80

Two routes to leukemic transformation after a JAK2 mutation-positive myeloproliferative neoplasm. Blood (2009) 2.77

Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle (2009) 2.72

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J (2009) 2.72

Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol (2008) 2.67

Analysis of risk factors for myelodysplasias, leukemias and death from infection among patients with congenital neutropenia. Experience of the French Severe Chronic Neutropenia Study Group. Haematologica (2005) 2.66

Necroptosis: a specialized pathway of programmed necrosis. Cell (2008) 2.61

Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion. J Exp Med (2003) 2.56

Autophagy regulation by p53. Curr Opin Cell Biol (2010) 2.56

Can autophagy promote longevity? Nat Cell Biol (2010) 2.55

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells. Blood (2008) 2.54

Cell death assays for drug discovery. Nat Rev Drug Discov (2011) 2.51

Myeloproliferative neoplasms: molecular pathophysiology, essential clinical understanding, and treatment strategies. J Clin Oncol (2011) 2.50

A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat Immunol (2002) 2.47

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. J Cell Biol (2002) 2.47

WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12. Blood (2004) 2.41

The IKK complex contributes to the induction of autophagy. EMBO J (2009) 2.41

Presentation and long-term follow-up of refractory celiac disease: comparison of type I with type II. Gastroenterology (2008) 2.39

Fatty acids trigger mitochondrion-dependent necrosis. Cell Cycle (2010) 2.37

Complex inhibitory effects of nitric oxide on autophagy. Mol Cell (2011) 2.36

An AIF orthologue regulates apoptosis in yeast. J Cell Biol (2004) 2.33

Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32

Defining the critical hurdles in cancer immunotherapy. J Transl Med (2011) 2.32

Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway. Clin Cancer Res (2010) 2.29

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

Meta-analysis on the use of zidovudine and interferon-alfa in adult T-cell leukemia/lymphoma showing improved survival in the leukemic subtypes. J Clin Oncol (2010) 2.27

miR-181a and miR-630 regulate cisplatin-induced cancer cell death. Cancer Res (2010) 2.24

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol (2011) 2.23

Viral control of mitochondrial apoptosis. PLoS Pathog (2008) 2.21

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol Cell (2007) 2.20

TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). Blood (2009) 2.18

Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development (2002) 2.16

Prognostic and predictive impact of intra- and peritumoral immune infiltrates. Cancer Res (2011) 2.16

Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity. Mol Cell (2012) 2.14

Alternative cell death mechanisms in development and beyond. Genes Dev (2010) 2.14

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine. Oncogene (2003) 2.09

A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis. Blood (2009) 2.08

Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells. Cell Cycle (2010) 2.08

Infection-associated lymphomas derived from marginal zone B cells: a model of antigen-driven lymphoproliferation. Blood (2006) 2.06

Decoding cell death signals in liver inflammation. J Hepatol (2013) 2.05