Published in Cell on July 12, 2002
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The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Plant Cell (2004) 3.41
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Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle. J Exp Med (2004) 2.67
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Phagocytosis by neutrophils induces an amino acid deprivation response in Saccharomyces cerevisiae and Candida albicans. Proc Natl Acad Sci U S A (2003) 2.19
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The uniformity of phagosome maturation in macrophages. J Cell Biol (2004) 2.13
Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens. Proc Natl Acad Sci U S A (2003) 2.09
Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc Natl Acad Sci U S A (2004) 1.99
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ADP ribosylation factor 6 is activated and controls membrane delivery during phagocytosis in macrophages. J Cell Biol (2003) 1.51
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Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo. J Exp Med (2005) 1.50
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Proteomic analysis of phagocytosis in the enteric protozoan parasite Entamoeba histolytica. Eukaryot Cell (2005) 1.37
Drinking a lot is good for dendritic cells. Immunology (2006) 1.36
Effects of transport inhibitors on the cellular uptake of carboxylated polystyrene nanoparticles in different cell lines. PLoS One (2011) 1.36
Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. PLoS Biol (2005) 1.35
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SEC18/NSF-independent, protein-sorting pathway from the yeast cortical ER to the plasma membrane. J Cell Biol (2005) 1.33
Cholera toxin toxicity does not require functional Arf6- and dynamin-dependent endocytic pathways. Mol Biol Cell (2004) 1.32
Phagosome maturation: a few bugs in the system. J Membr Biol (2003) 1.30
MHC class I assembly: out and about. Trends Immunol (2008) 1.29
Retrograde transport of cholera toxin from the plasma membrane to the endoplasmic reticulum requires the trans-Golgi network but not the Golgi apparatus in Exo2-treated cells. EMBO Rep (2004) 1.28
EspJ of enteropathogenic and enterohaemorrhagic Escherichia coli inhibits opsono-phagocytosis. Cell Microbiol (2008) 1.26
A CD74-dependent MHC class I endolysosomal cross-presentation pathway. Nat Immunol (2012) 1.23
Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A (2011) 1.22
The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle. PLoS Pathog (2009) 1.22
How location governs toll-like receptor signaling. Traffic (2009) 1.16
MHC molecules and microbial antigen processing in phagosomes. Curr Opin Immunol (2009) 1.16
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc Natl Acad Sci U S A (2005) 1.12
Pathways for antigen cross presentation. Springer Semin Immunopathol (2004) 1.10
Chlamydiae assemble a pathogen synapse to hijack the host endoplasmic reticulum. Traffic (2012) 1.09
The endosome-lysosome pathway and information generation in the immune system. Biochim Biophys Acta (2011) 1.08
Legionella pneumophila promotes functional interactions between plasma membrane syntaxins and Sec22b. Traffic (2010) 1.08
The many roads to cross-presentation. J Exp Med (2005) 1.08
Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape. J Control Release (2013) 1.07
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Manipulation of host membrane machinery by bacterial pathogens. Curr Opin Cell Biol (2010) 1.05
Involvement of syntaxin 18, an endoplasmic reticulum (ER)-localized SNARE protein, in ER-mediated phagocytosis. Mol Biol Cell (2006) 1.04
Immunomodulatory molecules are released from the first trimester and term placenta via exosomes. Placenta (2012) 1.04
Stress responses from the endoplasmic reticulum in cancer. Front Oncol (2015) 1.03
Dynamin regulates focal exocytosis in phagocytosing macrophages. Mol Biol Cell (2003) 1.03
The Legionella pneumophila effector DrrA is sufficient to stimulate SNARE-dependent membrane fusion. Cell Host Microbe (2012) 1.03
How to eat something bigger than your head. Cell (2002) 1.02
Cross-presentation: dendritic cells and macrophages bite off more than they can chew! Immunology (2004) 1.01
Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis. Proc Natl Acad Sci U S A (2012) 1.00
The role of phagosomal pH on the size-dependent efficiency of cross-presentation by dendritic cells. Biomaterials (2008) 0.99
Closely related mycobacterial strains demonstrate contrasting levels of efficacy as antitumor vaccines and are processed for major histocompatibility complex class I presentation by multiple routes in dendritic cells. Infect Immun (2005) 0.99
Cross-priming for antitumor CTL induced by soluble Ag + polyI:C depends on the TICAM-1 pathway in mouse CD11c(+)/CD8α(+) dendritic cells. Oncoimmunology (2012) 0.98
The Mycobacterium bovis bacille Calmette-Guerin phagosome proteome. Mol Cell Proteomics (2009) 0.98
The proprotein convertase PC7: unique zymogen activation and trafficking pathways. J Biol Chem (2010) 0.98
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Contributions of proteomics to understanding phagosome maturation. Cell Microbiol (2008) 0.97
MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages. Mol Biol Cell (2007) 0.97
Leishmania parasitophorous vacuoles interact continuously with the host cell's endoplasmic reticulum; parasitophorous vacuoles are hybrid compartments. Cell Microbiol (2010) 0.97
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Functional role(s) of phagosomal Rab GTPases. Small GTPases (2013) 0.94
Memory CD8 T cells specific for plasmodia liver-stage antigens maintain protracted protection against malaria. Front Immunol (2012) 0.94
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A contiguous compartment functions as endoplasmic reticulum and endosome/lysosome in Giardia lamblia. Eukaryot Cell (2009) 0.94
Intracellular events regulating cross-presentation. Front Immunol (2012) 0.93
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Involvement of the AP-1 adaptor complex in early steps of phagocytosis and macropinocytosis. Mol Biol Cell (2003) 0.92
Subcellular localization of iron and heme metabolism related proteins at early stages of erythrophagocytosis. PLoS One (2012) 0.92
Protein disulfide isomerase and host-pathogen interaction. ScientificWorldJournal (2011) 0.91
Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol Cell Proteomics (2012) 0.91
Signal sequence within Fc gamma RIIA controls calcium wave propagation patterns: apparent role in phagolysosome fusion. Proc Natl Acad Sci U S A (2003) 0.91
AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis. Mol Biol Cell (2007) 0.91
Antigen release kinetics in the phagosome are critical to cross-presentation efficiency. J Immunol (2008) 0.91
Virulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages. BMC Microbiol (2010) 0.91
alpha v beta3-dependent cross-presentation of matrix metalloproteinase-2 by melanoma cells gives rise to a new tumor antigen. J Exp Med (2005) 0.90
Into the intracellular logistics of cross-presentation. Front Immunol (2012) 0.90
Leishmania promastigotes: building a safe niche within macrophages. Front Cell Infect Microbiol (2012) 0.90
Selective fusion of azurophilic granules with Leishmania-containing phagosomes in human neutrophils. J Biol Chem (2010) 0.89
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol (2014) 0.89
Dendritic cell cross-priming is essential for immune responses to Listeria monocytogenes. PLoS One (2009) 0.88
Subproteome analysis of the neutrophil cytoskeleton. Proteomics (2009) 0.87
Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer. J Neurosci (2014) 0.87
Expression of sialyltransferase activity on intact human neutrophils. J Leukoc Biol (2008) 0.87
Protection from bacterial-toxin-induced apoptosis in macrophages requires the lipogenic transcription factor sterol regulatory element binding protein 1a. Mol Cell Biol (2012) 0.86
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Nat Genet (2003) 7.25
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet (2012) 6.65
A HUPO test sample study reveals common problems in mass spectrometry-based proteomics. Nat Methods (2009) 4.23
Phagosomes are competent organelles for antigen cross-presentation. Nature (2003) 3.97
Quantitative proteomics analysis of the secretory pathway. Cell (2006) 3.63
Targeting the unfolded protein response in disease. Nat Rev Drug Discov (2013) 3.37
Proteomics of organelles and large cellular structures. Nat Rev Mol Cell Biol (2005) 2.98
Mass spectrometry in high-throughput proteomics: ready for the big time. Nat Methods (2010) 2.91
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol (2009) 2.80
Tandem MS analysis of brain clathrin-coated vesicles reveals their critical involvement in synaptic vesicle recycling. Proc Natl Acad Sci U S A (2004) 2.78
Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer. Pharmacol Rev (2008) 2.75
Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia. Proc Natl Acad Sci U S A (2010) 2.46
Integrated endoplasmic reticulum stress responses in cancer. Cancer Res (2007) 2.43
Chlamydial IFN-gamma immune evasion is linked to host infection tropism. Proc Natl Acad Sci U S A (2005) 2.34
Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival. Cell Microbiol (2009) 2.13
The phagosomal proteome in interferon-gamma-activated macrophages. Immunity (2009) 1.95
Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. J Neurosci (2005) 1.85
The ER protein folding sensor UDP-glucose glycoprotein-glucosyltransferase modifies substrates distant to local changes in glycoprotein conformation. Nat Struct Mol Biol (2004) 1.78
The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt. J Biol Chem (2005) 1.74
Taking possession: biogenesis of the Salmonella-containing vacuole. Traffic (2003) 1.70
Protein quality control in the ER: the recognition of misfolded proteins. Semin Cell Dev Biol (2010) 1.69
Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes. Mol Microbiol (2003) 1.67
Phagocytosis: at the crossroads of innate and adaptive immunity. Annu Rev Cell Dev Biol (2005) 1.63
Salmonella trafficking is defined by continuous dynamic interactions with the endolysosomal system. Traffic (2007) 1.55
The Salmonella effector protein PipB2 is a linker for kinesin-1. Proc Natl Acad Sci U S A (2006) 1.54
The endosomal proteome of macrophage and dendritic cells. Proteomics (2011) 1.52
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress. J Biol Chem (2004) 1.49
Problems with co-funding in Canada. Science (2005) 1.48
The mechanism of Salmonella entry determines the vacuolar environment and intracellular gene expression. Traffic (2006) 1.41
Dengue virus serotype infection specifies the activation of the unfolded protein response. Virol J (2007) 1.41
Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma. Proc Natl Acad Sci U S A (2010) 1.41
Human invariant chain isoform p35 restores thymic selection and antigen presentation in CD74-deficient mice. Immunol Cell Biol (2012) 1.40
The Salmonella SPI1 effector SopB stimulates nitric oxide production long after invasion. Cell Microbiol (2005) 1.31
Dynamic behavior of Salmonella-induced membrane tubules in epithelial cells. Traffic (2008) 1.31
Organelle proteomics: looking at less to see more. Trends Cell Biol (2003) 1.30
IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Res (2007) 1.29
Induction of Salmonella pathogenicity island 1 under different growth conditions can affect Salmonella-host cell interactions in vitro. Microbiology (2009) 1.28
The Salmonella effector PipB2 affects late endosome/lysosome distribution to mediate Sif extension. Mol Biol Cell (2005) 1.27
HilD-mediated transcriptional cross-talk between SPI-1 and SPI-2. Proc Natl Acad Sci U S A (2008) 1.25
Redox signaling loops in the unfolded protein response. Cell Signal (2012) 1.24
Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo. J Immunol (2006) 1.22
Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Mol Biol Cell (2004) 1.19
Early stages of Golgi vesicle and tubule formation require diacylglycerol. Mol Biol Cell (2008) 1.18
Trafficking of Leishmania donovani promastigotes in non-lytic compartments in neutrophils enables the subsequent transfer of parasites to macrophages. Cell Microbiol (2007) 1.18
Lectin control of protein folding and sorting in the secretory pathway. Trends Biochem Sci (2003) 1.17
Specific interaction of ERp57 and calnexin determined by NMR spectroscopy and an ER two-hybrid system. EMBO J (2004) 1.16
Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol (2010) 1.15
Modulation of the phagosome proteome by interferon-gamma. Mol Cell Proteomics (2007) 1.15
Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking. Cell Microbiol (2002) 1.14
Modulation of protein translation by Nck-1. Proc Natl Acad Sci U S A (2002) 1.13
Glycopeptide specificity of the secretory protein folding sensor UDP-glucose glycoprotein:glucosyltransferase. EMBO Rep (2003) 1.13
Phosphoprotein analysis: from proteins to proteomes. Proteome Sci (2006) 1.12
Sorting out glycosylation enzymes in the Golgi apparatus. FEBS Lett (2009) 1.10
Cloning vectors and fluorescent proteins can significantly inhibit Salmonella enterica virulence in both epithelial cells and macrophages: implications for bacterial pathogenesis studies. Infect Immun (2005) 1.09
Molecular characterization of the evolution of phagosomes. Mol Syst Biol (2010) 1.08
Alternative pathways for MHC class I presentation: a new function for autophagy. Cell Mol Life Sci (2011) 1.08
Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane. Cell Microbiol (2009) 1.07
Differences in endoplasmic reticulum stress signalling kinetics determine cell survival outcome through activation of MKP-1. Cell Signal (2010) 1.07
GTPase-mediated regulation of the unfolded protein response in Caenorhabditis elegans is dependent on the AAA+ ATPase CDC-48. Mol Cell Biol (2008) 1.06
The bimodal lifestyle of intracellular Salmonella in epithelial cells: replication in the cytosol obscures defects in vacuolar replication. PLoS One (2012) 1.05
Methods for peptide identification by spectral comparison. Proteome Sci (2007) 1.05
A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells. Proteomics (2013) 1.04
Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8. Cell Host Microbe (2013) 1.02
P97/CDC-48: proteostasis control in tumor cell biology. Cancer Lett (2013) 1.01
Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death. Mol Cancer Ther (2012) 1.00
p58(IPK)-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose. Mol Cell (2013) 1.00
Distinct endoplasmic reticulum stress responses are triggered during human liver transplantation. J Pathol (2005) 0.99
Salmonella - at home in the host cell. Front Microbiol (2011) 0.99
Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis. J Biol Chem (2011) 0.98
Remodeling of endosomes during lysosome biogenesis involves 'kiss and run' fusion events regulated by rab5. J Cell Sci (2003) 0.97
Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses: application to cell signaling events of interferon-gamma-stimulated macrophages. Mol Cell Proteomics (2007) 0.97
Nck-1 antagonizes the endoplasmic reticulum stress-induced inhibition of translation. J Biol Chem (2003) 0.97
Organization of the Sec61 translocon, studied by high resolution native electrophoresis. J Proteome Res (2010) 0.97
Leishmania donovani lipophosphoglycan disrupts phagosome microdomains in J774 macrophages. Cell Microbiol (2005) 0.97
Proteomic analysis reveals a role for protein kinase C-alpha in phagosome maturation. Biochem Biophys Res Commun (2004) 0.96
Brain-specific proteins decline in the cerebrospinal fluid of humans with Huntington disease. Mol Cell Proteomics (2008) 0.96
Gamma-secretase is a functional component of phagosomes. J Biol Chem (2005) 0.96
Tau interacts with Golgi membranes and mediates their association with microtubules. Cell Motil Cytoskeleton (2006) 0.95
Yersinia pestis survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages. J Leukoc Biol (2013) 0.95
Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress. FASEB J (2011) 0.94
Cell biology through proteomics--ad astra per alia porci. Trends Cell Biol (2010) 0.93
Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA. J Cell Sci (2012) 0.93
The protein microscope: incorporating mass spectrometry into cell biology. Nat Methods (2007) 0.92
Subcellular localization of iron and heme metabolism related proteins at early stages of erythrophagocytosis. PLoS One (2012) 0.92
The ER glycoprotein quality control system. Curr Issues Mol Biol (2004) 0.92
Loss of tumorigenicity and metastatic potential in carcinoma cells expressing the extracellular domain of the type 1 insulin-like growth factor receptor. Cancer Res (2004) 0.92
Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases. BMC Cancer (2005) 0.92
Endoplasmic reticulum stress signaling: the microRNA connection. Am J Physiol Cell Physiol (2013) 0.91
Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome. Mol Cell Proteomics (2012) 0.91