Published in Am J Hum Genet on August 12, 2002
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet (2002) 2.96
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
Rare variant analysis for family-based design. PLoS One (2013) 1.72
IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol (2004) 1.64
A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits. Biol Psychiatry (2010) 1.62
Power for genetic association studies with random allele frequencies and genotype distributions. Am J Hum Genet (2004) 1.52
Attention-deficit/hyperactivity disorder in a population isolate: linkage to loci at 4q13.2, 5q33.3, 11q22, and 17p11. Am J Hum Genet (2004) 1.49
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Univariate/multivariate genome-wide association scans using data from families and unrelated samples. PLoS One (2009) 1.10
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genomics (2005) 1.09
Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder. Am J Med Genet B Neuropsychiatr Genet (2008) 1.08
ADAM33, a new candidate for psoriasis susceptibility. PLoS One (2007) 1.08
Power calculations for likelihood ratio tests for offspring genotype risks, maternal effects, and parent-of-origin (POO) effects in the presence of missing parental genotypes when unaffected siblings are available. Genet Epidemiol (2007) 1.05
Practical and theoretical considerations in study design for detecting gene-gene interactions using MDR and GMDR approaches. PLoS One (2011) 1.01
Tests of association for quantitative traits in nuclear families using principal components to correct for population stratification. Ann Hum Genet (2009) 1.01
Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcohol Clin Exp Res (2010) 0.99
Association of the type 2 diabetes mellitus susceptibility gene, TCF7L2, with schizophrenia in an Arab-Israeli family sample. PLoS One (2012) 0.99
'Location, Location, Location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. Bioinformatics (2012) 0.95
Comprehensive genotyping in two homogeneous Graves' disease samples reveals major and novel HLA association alleles. PLoS One (2011) 0.95
Power evaluations for family-based tests of association with incomplete parental genotypes. Genetics (2003) 0.88
Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau(). J Am Stat Assoc (2012) 0.86
A survey of current software for genetic power calculations. Hum Genomics (2004) 0.84
Combining genetic association study designs: a GWAS case study. Front Genet (2013) 0.83
Improvement of mapping accuracy by unifying linkage and association analysis. Genetics (2005) 0.82
Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol (2009) 0.81
Statistical Analysis in Genetic Studies of Mental Illnesses. Stat Sci (2011) 0.79
Analytic power and sample size calculation for the genotypic transmission/disequilibrium test in case-parent trio studies. Biom J (2014) 0.78
Hemoglobin binding to A beta and HBG2 SNP association suggest a role in Alzheimer's disease. Neurobiol Aging (2006) 0.78
A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies. Am J Hum Genet (2016) 0.78
A re-formulation of generalized linear mixed models to fit family data in genetic association studies. Front Genet (2015) 0.77
Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations. PLoS One (2013) 0.76
Family-Based Association Tests with longitudinal measurements: handling missing data. Hum Hered (2009) 0.75
Using Incomplete Trios to Boost Confidence in Family Based Association Studies. Front Genet (2016) 0.75
FARVATX: Family-Based Rare Variant Association Test for X-Linked Genes. Genet Epidemiol (2016) 0.75
Linkage and association analysis of ADHD endophenotypes in extended and multigenerational pedigrees from a genetic isolate. Mol Psychiatry (2015) 0.75
A general semi-parametric approach to the analysis of genetic association studies in population-based designs. BMC Genet (2013) 0.75
The future of genetic studies of complex human diseases. Science (1996) 64.76
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet (1993) 51.42
Searching for genetic determinants in the new millennium. Nature (2000) 17.50
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Implementing a unified approach to family-based tests of association. Genet Epidemiol (2000) 10.96
A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered (2000) 10.32
The family based association test method: strategies for studying general genotype--phenotype associations. Eur J Hum Genet (2001) 9.09
Statistical properties of the haplotype relative risk. Genet Epidemiol (1989) 7.07
Genetic association mapping based on discordant sib pairs: the discordant-alleles test. Am J Hum Genet (1998) 7.02
A discordant-sibship test for disequilibrium and linkage: no need for parental data. Am J Hum Genet (1998) 4.32
On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol (2002) 2.76
Genomewide transmission/disequilibrium testing--consideration of the genotypic relative risks at disease loci. Am J Hum Genet (1997) 2.54
A note on power approximations for the transmission/disequilibrium test. Am J Hum Genet (1999) 2.25
A general and accurate approach for computing the statistical power of the transmission disequilibrium test for complex disease genes. Genet Epidemiol (2001) 1.69
Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am J Med Genet (2002) 1.28
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Using exact P values to compare the power between the reconstruction-combined transmission/disequilibrium test and the sib transmission/disequilibrium test. Am J Hum Genet (1999) 1.17
Power comparisons of the transmission/disequilibrium test and sib-transmission/disequilibrium-test statistics. Am J Hum Genet (1999) 1.13
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24
A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet (2011) 3.13
Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet (2002) 2.96
On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol (2002) 2.76
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet (2007) 2.45
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol (2004) 2.15
Cigarette smoking in relation to depression: historical trends from the Stirling County Study. Am J Psychiatry (2003) 1.90
Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians. Science (2009) 1.77
Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. Am J Respir Crit Care Med (2013) 1.67
Binge-eating disorder as a distinct familial phenotype in obese individuals. Arch Gen Psychiatry (2006) 1.58
Family, peer, and media predictors of becoming eating disordered. Arch Pediatr Adolesc Med (2008) 1.53
Co-occurrence of binge eating disorder with psychiatric and medical disorders. J Clin Psychiatry (2008) 1.50
On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. Genet Epidemiol (2008) 1.47
Gene-environment interaction tests for dichotomous traits in trios and sibships. Genet Epidemiol (2009) 1.43
Prospective association of common eating disorders and adverse outcomes. Pediatrics (2012) 1.41
Family-based association tests for survival and times-to-onset analysis. Stat Med (2004) 1.35
On the optimal design of genetic variant discovery studies. Stat Appl Genet Mol Biol (2010) 1.35
A new multimarker test for family-based association studies. Genet Epidemiol (2007) 1.34
Family-based association analysis of beta2-adrenergic receptor polymorphisms in the childhood asthma management program. J Allergy Clin Immunol (2003) 1.34
Family study of affective spectrum disorder. Arch Gen Psychiatry (2003) 1.30
Familiality and heritability of binge eating disorder: results of a case-control family study and a twin study. Int J Eat Disord (2008) 1.17
The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder. Biol Psychiatry (2005) 1.15
Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. Biol Psychiatry (2003) 1.07
Variance calculations for identity-by-descent estimation. Am J Hum Genet (2006) 1.02
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet (2003) 1.01
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel. J Thorac Oncol (2011) 0.96
fgui: A Method for Automatically Creating Graphical User Interfaces for Command-Line R Packages. J Stat Softw (2009) 0.96
Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer (2009) 0.95
Alternative methods for testing treatment effects on the basis of multiple outcomes: simulation and case study. Stat Med (2011) 0.93
Regression analysis of multiple-source longitudinal outcomes: a "Stirling County" depression study. Am J Epidemiol (2002) 0.91
Tests for compositional epistasis under single interaction-parameter models. Ann Hum Genet (2010) 0.90
Multivariate logistic regression with incomplete covariate and auxiliary information. J Multivar Anal (2010) 0.89
A structural approach to the familial coaggregation of disorders. Epidemiology (2008) 0.88
Mortality associated with depression: a forty-year perspective from the Stirling County Study. Soc Psychiatry Psychiatr Epidemiol (2008) 0.88
On the frequency of copy number variants. Bioinformatics (2008) 0.86
Estimating disease prevalence using relatives of case and control probands. Biometrics (2009) 0.85
Penalized solutions to functional regression problems. Comput Stat Data Anal (2007) 0.84
Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus. Am J Med Genet B Neuropsychiatr Genet (2010) 0.83
Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. Hum Genomics (2010) 0.83
Incorporating missingness for estimation of marginal regression models with multiple source predictors. Stat Med (2007) 0.83
Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study. Respir Res (2013) 0.82
Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered (2015) 0.82
Identifying rare variants using a Bayesian regression approach. BMC Proc (2011) 0.82
Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol (2009) 0.81
Genomic screening in family-based association testing. BMC Genet (2005) 0.80
Incidence of major depression: prediction from subthreshold categories in the Stirling County Study. J Affect Disord (2002) 0.80
Biostatistic tools in pharmacogenomics--advances, challenges, potential. Curr Pharm Des (2010) 0.79
On the parsing of statistical information in family-based association testing. Nat Genet (2007) 0.79
Non-linear hierarchical models for monitoring compliance. Stat Med (2002) 0.77
LongCriSP: a test for bump hunting in longitudinal data. Stat Med (2007) 0.77
Combining disease models to test for gene-environment interaction in nuclear families. Biometrics (2011) 0.76
Self-disparagement as feature and forerunner of depression: findings from the Stirling County Study. Compr Psychiatry (2002) 0.76
Marginal regression models with a time to event outcome and discrete multiple source predictors. Lifetime Data Anal (2006) 0.75
Estimating the effect of a predictor measured by two informants on a continuous outcome: a comparison of methods. Epidemiology (2011) 0.75
Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered (2009) 0.75
Comparison of linkage and association strategies for quantitative traits using the COGA dataset. BMC Genet (2005) 0.75
Differentiating population stratification from genotyping error using family data. Ann Hum Genet (2011) 0.75
FBAT-SNP-PC: an approach for multiple markers and single trait in family-based association tests. Hum Hered (2008) 0.75