Published in Am J Hum Genet on February 01, 2004
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet (2007) 9.80
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
PGA: power calculator for case-control genetic association analyses. BMC Genet (2008) 2.71
Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysis. BMJ (2011) 2.68
Genome-wide association studies in ADHD. Hum Genet (2009) 2.58
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
Multiple genes for essential-hypertension susceptibility on chromosome 1q. Am J Hum Genet (2006) 2.34
The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults. Biol Psychiatry (2007) 2.19
Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull (2008) 2.09
Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol (2005) 2.08
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 1.98
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum Mol Genet (2010) 1.89
A generalized family-based association test for dichotomous traits. Am J Hum Genet (2009) 1.70
TATES: efficient multivariate genotype-phenotype analysis for genome-wide association studies. PLoS Genet (2013) 1.63
Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort. Genes Immun (2007) 1.60
Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD (2010) 1.60
The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. PLoS One (2009) 1.58
Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.51
Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma. Clin Exp Allergy (2012) 1.50
Follow-up association study of linkage regions reveals multiple candidate genes for carotid plaque in Dominicans. Atherosclerosis (2012) 1.47
Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program. Eur J Hum Genet (2008) 1.45
Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans. Am J Respir Crit Care Med (2008) 1.43
Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample. Neuropsychopharmacology (2008) 1.42
Significant association of DRD1 with nicotine dependence. Hum Genet (2007) 1.33
Comprehensive testing of positionally cloned asthma genes in two populations. Am J Respir Crit Care Med (2007) 1.32
TSLP polymorphisms are associated with asthma in a sex-specific fashion. Allergy (2010) 1.29
The IL12B gene is associated with asthma. Am J Hum Genet (2004) 1.29
Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry (2014) 1.29
The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Behav Brain Funct (2008) 1.27
Assessment of Alzheimer's disease case-control associations using family-based methods. Neurogenetics (2008) 1.23
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.18
Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol (2008) 1.16
GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Arch Neurol (2009) 1.13
Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis. Hum Mol Genet (2008) 1.12
A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. Am J Respir Crit Care Med (2009) 1.12
Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected. PLoS Genet (2008) 1.12
PRKCA: a positional candidate gene for body mass index and asthma. Am J Hum Genet (2009) 1.11
Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One (2011) 1.11
Evaluation of OPRM1 variants in heroin dependence by family-based association testing and meta-analysis. Drug Alcohol Depend (2007) 1.10
SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. Genes Brain Behav (2009) 1.09
On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls. Am J Hum Genet (2010) 1.09
Family-based association testing strongly implicates DRD2 as a risk gene for schizophrenia in Han Chinese from Taiwan. Mol Psychiatry (2008) 1.09
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genomics (2005) 1.09
IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol (2007) 1.08
Comparison of methods to account for relatedness in genome-wide association studies with family-based data. PLoS Genet (2014) 1.07
WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels. Am J Hum Genet (2008) 1.06
Single-nucleotide polymorphism rs498055 on chromosome 10q24 is not associated with Alzheimer disease in two independent family samples. Am J Hum Genet (2006) 1.06
Power calculations for likelihood ratio tests for offspring genotype risks, maternal effects, and parent-of-origin (POO) effects in the presence of missing parental genotypes when unaffected siblings are available. Genet Epidemiol (2007) 1.05
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics (2008) 1.04
A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol. Arterioscler Thromb Vasc Biol (2009) 1.04
Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology (2012) 0.99
Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. Am J Respir Cell Mol Biol (2009) 0.98
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk. Neurology (2014) 0.97
Pathway analysis shows association between FGFBP1 and hypertension. J Am Soc Nephrol (2011) 0.95
Genetic research in schizophrenia: new tools and future perspectives. Schizophr Bull (2008) 0.94
Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. Am J Respir Crit Care Med (2005) 0.93
Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet (2011) 0.93
Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma. Clin Mol Allergy (2011) 0.92
Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population. J Med Genet (2012) 0.91
Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology (2012) 0.90
Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. Behav Genet (2011) 0.90
Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med (2010) 0.89
Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes. BMC Med Genet (2011) 0.89
The robustness of generalized estimating equations for association tests in extended family data. Hum Hered (2012) 0.88
Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. Respir Res (2012) 0.88
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. PLoS Genet (2011) 0.88
Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med (2008) 0.88
SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development. Am J Respir Crit Care Med (2011) 0.88
A -436C>A polymorphism in the human FAS gene promoter associated with severe childhood malaria. PLoS Genet (2011) 0.87
Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations. Am J Respir Crit Care Med (2010) 0.87
A gene-family analysis of 61 genetic variants in the nicotinic acetylcholine receptor genes for insulin resistance and type 2 diabetes in American Indians. Diabetes (2012) 0.87
Power and sample size calculations for SNP association studies with censored time-to-event outcomes. Genet Epidemiol (2012) 0.86
Variation in MSRA modifies risk of neonatal intestinal obstruction in cystic fibrosis. PLoS Genet (2012) 0.86
Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma. Respir Res (2009) 0.86
Association of TTR polymorphisms with hippocampal atrophy in Alzheimer disease families. Neurobiol Aging (2009) 0.86
Single-nucleotide polymorphisms in the IL2RA gene are associated with age at diagnosis in late-onset Finnish type 1 diabetes subjects. Immunogenetics (2009) 0.85
A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics. Pharmacogenomics J (2012) 0.85
The impact of self-identified race on epidemiologic studies of gene expression. Genet Epidemiol (2011) 0.84
Significant associations of CHRNA2 and CHRNA6 with nicotine dependence in European American and African American populations. Hum Genet (2013) 0.83
Handling the data management needs of high-throughput sequencing data: SpeedGene, a compression algorithm for the efficient storage of genetic data. BMC Bioinformatics (2012) 0.83
Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth. Hum Genet (2009) 0.83
Combining genetic association study designs: a GWAS case study. Front Genet (2013) 0.83
A splicing-regulatory polymorphism in DRD2 disrupts ZRANB2 binding, impairs cognitive functioning and increases risk for schizophrenia in six Han Chinese samples. Mol Psychiatry (2015) 0.83
Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol (2008) 0.83
Common genetic variation in the GAD1 gene and the entire family of DLX homeobox genes and autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet (2010) 0.82
Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene. Thorax (2006) 0.81
Haplotype thinking in lung disease. Proc Am Thorac Soc (2007) 0.81
Association of SERPINE2 with asthma. Chest (2011) 0.81
KIAA0319 and ROBO1: evidence on association with reading and pleiotropic effects on language and mathematics abilities in developmental dyslexia. J Hum Genet (2014) 0.81
Asthma-susceptibility variants identified using probands in case-control and family-based analyses. BMC Med Genet (2010) 0.81
An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes. Eur J Hum Genet (2010) 0.80
Genomic screening in family-based association testing. BMC Genet (2005) 0.80
Family-based bivariate association tests for quantitative traits. PLoS One (2009) 0.79
On family-based genome-wide association studies with large pedigrees: observations and recommendations. BMC Proc (2014) 0.79
Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension. J Med Genet (2007) 0.79
A general test of association for quantitative traits in nuclear families. Am J Hum Genet (2000) 22.45
Implementing a unified approach to family-based tests of association. Genet Epidemiol (2000) 10.96
A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information. Hum Hered (2000) 10.32
The family based association test method: strategies for studying general genotype--phenotype associations. Eur J Hum Genet (2001) 9.09
A discordant-sibship test for disequilibrium and linkage: no need for parental data. Am J Hum Genet (1998) 4.32
Family-based tests of association in the presence of linkage. Am J Hum Genet (2000) 3.74
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet (2002) 2.96
On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol (2002) 2.76
Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus. Am J Hum Genet (2000) 2.62
Power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet (2002) 2.55
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered (2003) 1.89
IL10 gene polymorphisms are associated with asthma phenotypes in children. Genet Epidemiol (2004) 1.64
Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol (2002) 1.46
Family-based association tests for survival and times-to-onset analysis. Stat Med (2004) 1.35
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med (2009) 4.64
Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet (2006) 4.59
Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med (2005) 4.34
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol (2004) 4.17
GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98
Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol (2007) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr (2007) 3.89
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr (2007) 3.40
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24
A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet (2011) 3.13
Rapid diagnosis of smear-negative tuberculosis by bronchoalveolar lavage enzyme-linked immunospot. Am J Respir Crit Care Med (2006) 3.12
Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet (2002) 2.96
Genetic model testing and statistical power in population-based association studies of quantitative traits. Genet Epidemiol (2007) 2.95
The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91
On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol (2002) 2.76
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med (2008) 2.61
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
Power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet (2002) 2.55
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. Am J Med Genet B Neuropsychiatr Genet (2008) 2.53
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
Estimating the number of unseen variants in the human genome. Proc Natl Acad Sci U S A (2009) 2.47
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet (2007) 2.45
Uric acid and the development of hypertension: the normative aging study. Hypertension (2006) 2.45
Obesity and asthma. Am J Respir Crit Care Med (2006) 2.43
Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet (2008) 2.40
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med (2013) 2.36
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood (2006) 2.33
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet (2009) 2.27
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23
Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J Am Med Inform Assoc (2009) 2.20
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol (2005) 2.16