Published in Stat Appl Genet Mol Biol on August 12, 2004
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
Pleiotropy in complex traits: challenges and strategies. Nat Rev Genet (2013) 3.65
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Genome-wide association studies in ADHD. Hum Genet (2009) 2.58
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet (2007) 2.45
Analyze multivariate phenotypes in genetic association studies by combining univariate association tests. Genet Epidemiol (2010) 2.19
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts. Am J Respir Crit Care Med (2008) 1.34
Moving toward System Genetics through Multiple Trait Analysis in Genome-Wide Association Studies. Front Genet (2012) 1.32
An integrated phenomic approach to multivariate allelic association. Eur J Hum Genet (2009) 1.32
The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Behav Brain Funct (2008) 1.27
Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies. J Probab Stat (2012) 1.20
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.18
PRKCA: a positional candidate gene for body mass index and asthma. Am J Hum Genet (2009) 1.11
SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample. Genes Brain Behav (2009) 1.09
PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. Hum Genomics (2005) 1.09
Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. Genomics (2008) 1.04
Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population. Hum Mol Genet (2010) 0.98
IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatr Pulmonol (2009) 0.98
Projection regression models for multivariate imaging phenotype. Genet Epidemiol (2012) 0.91
Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness. Eur Respir J (2009) 0.90
Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations. Am J Respir Crit Care Med (2010) 0.87
Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma. Respir Res (2009) 0.86
Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample. J Neural Transm (Vienna) (2006) 0.85
Joint Analysis of Multiple Traits Using "Optimal" Maximum Heritability Test. PLoS One (2016) 0.83
A rapid gene-based genome-wide association test with multivariate traits. Hum Hered (2013) 0.83
Integrating Multiple Correlated Phenotypes for Genetic Association Analysis by Maximizing Heritability. Hum Hered (2015) 0.82
Impact of population stratification on family-based association tests with longitudinal measurements. Stat Appl Genet Mol Biol (2009) 0.81
Principal-component-based multivariate regression for genetic association studies of metabolic syndrome components. BMC Genet (2010) 0.81
An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes. Eur J Hum Genet (2010) 0.80
Genomic screening in family-based association testing. BMC Genet (2005) 0.80
Family-based bivariate association tests for quantitative traits. PLoS One (2009) 0.79
Semiparametric Allelic Tests for Mapping Multiple Phenotypes: Binomial Regression and Mahalanobis Distance. Genet Epidemiol (2015) 0.79
On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples. Genet Epidemiol (2010) 0.78
Joint Analysis of Multiple Traits in Rare Variant Association Studies. Ann Hum Genet (2016) 0.77
Principal components methods for narrow-sense heritability in the analysis of multidimensional longitudinal cognitive phenotypes. Am J Med Genet B Neuropsychiatr Genet (2013) 0.76
Joint association analysis of a binary and a quantitative trait in family samples. Eur J Hum Genet (2016) 0.75
Statistical challenges for genome-wide association studies of suicidality using family data. Eur Psychiatry (2010) 0.75
Dosage transmission disequilibrium test (dTDT) for linkage and association detection. PLoS One (2013) 0.75
Family-Based Association Tests with longitudinal measurements: handling missing data. Hum Hered (2009) 0.75
A common genetic variant is associated with adult and childhood obesity. Science (2006) 14.95
The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. Chest (2006) 8.43
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol (2004) 5.57
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Genomic screening and replication using the same data set in family-based association testing. Nat Genet (2005) 5.44
Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med (2006) 5.42
Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res (2010) 5.17
Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains. Genome Res (2010) 5.08
Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet (2004) 5.01
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
PBAT: tools for family-based association studies. Am J Hum Genet (2004) 4.68
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Am J Respir Crit Care Med (2009) 4.64
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys. J Allergy Clin Immunol (2004) 4.17
GOLD 2011 disease severity classification in COPDGene: a prospective cohort study. Lancet Respir Med (2012) 3.98
Is vitamin D deficiency to blame for the asthma epidemic? J Allergy Clin Immunol (2007) 3.97
MMP12, lung function, and COPD in high-risk populations. N Engl J Med (2009) 3.96
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 3.92
Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr (2007) 3.89
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med (2011) 3.80
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 3.70
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol (2010) 3.54
A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics (2003) 3.52
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Six-minute-walk test in chronic obstructive pulmonary disease: minimal clinically important difference for death or hospitalization. Am J Respir Crit Care Med (2012) 3.44
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet (2009) 3.41
Maternal vitamin D intake during pregnancy and early childhood wheezing. Am J Clin Nutr (2007) 3.40
On the replication of genetic associations: timing can be everything! Am J Hum Genet (2008) 3.32
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q. Am J Hum Genet (2005) 3.24
A new testing strategy to identify rare variants with either risk or protective effect on disease. PLoS Genet (2011) 3.13
Power and design considerations for a general class of family-based association tests: quantitative traits. Am J Hum Genet (2002) 2.96
The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations. Am J Respir Crit Care Med (2007) 2.91
On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. Genet Epidemiol (2002) 2.76
Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med (2004) 2.62
Airway responsiveness in mild to moderate childhood asthma: sex influences on the natural history. Am J Respir Crit Care Med (2008) 2.61
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease. Am J Hum Genet (2009) 2.56
Power calculations for a general class of family-based association tests: dichotomous traits. Am J Hum Genet (2002) 2.55
A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One (2012) 2.52
The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet (2005) 2.46
Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan. Am J Hum Genet (2007) 2.45
Uric acid and the development of hypertension: the normative aging study. Hypertension (2006) 2.45
Obesity and asthma. Am J Respir Crit Care Med (2006) 2.43
Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med (2003) 2.39
Statin exposure is associated with decreased asthma-related emergency department visits and oral corticosteroid use. Am J Respir Crit Care Med (2013) 2.36
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet (2007) 2.35
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Minimal haplotype tagging. Proc Natl Acad Sci U S A (2003) 2.28
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. PLoS Genet (2009) 2.27
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. Am J Respir Crit Care Med (2004) 2.24
Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet (2002) 2.23
Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J Am Med Inform Assoc (2009) 2.20
The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet (2004) 2.19
Comparison of warfarin versus aspirin for the prevention of recurrent stroke or death: subgroup analyses from the Warfarin-Aspirin Recurrent Stroke Study. Cerebrovasc Dis (2006) 2.19
Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet (2003) 2.18
Cytokines, allergy, and asthma. Curr Opin Allergy Clin Immunol (2005) 2.16
Clarification of the risk of chronic obstructive pulmonary disease in α1-antitrypsin deficiency PiMZ heterozygotes. Am J Respir Crit Care Med (2014) 2.14
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Hum Mol Genet (2004) 2.14
Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy. J Allergy Clin Immunol (2004) 2.11
Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Am J Respir Crit Care Med (2009) 2.10
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population. Nat Genet (2011) 2.10
A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. Nat Genet (2010) 2.10