Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80

CD4 T cells: fates, functions, and faults. Blood (2008) 7.03

Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity (2009) 6.87

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 6.65

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med (2011) 4.50

Transcriptional control of adipose lipid handling by IRF4. Cell Metab (2011) 2.95

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89

The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol (2014) 2.82

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 2.61

A brief history of IL-9. J Immunol (2011) 2.27

IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A (2008) 2.13

Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development. Proc Natl Acad Sci U S A (2004) 2.08

BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature (2012) 2.00

Cellular sources and immune functions of interleukin-9. Nat Rev Immunol (2010) 1.92

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol (2015) 1.89

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87

Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev (2010) 1.61

Th9 cells: differentiation and disease. Immunol Rev (2013) 1.61

Interferon regulatory factor 4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS. Proc Natl Acad Sci U S A (2005) 1.58

CD4⁺T cells: differentiation and functions. Clin Dev Immunol (2012) 1.56

IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol (2009) 1.51

Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks. Nat Rev Immunol (2013) 1.50

How diverse--CD4 effector T cells and their functions. J Mol Cell Biol (2009) 1.44

Interferon regulatory factor 4 and 8 in B-cell development. Trends Immunol (2008) 1.41

Understanding the development and function of T follicular helper cells. Cell Mol Immunol (2010) 1.40

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest (2012) 1.40

Molecular orchestration of differentiation and function of regulatory T cells. Genes Dev (2009) 1.38

Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A (2012) 1.32

Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol Rev (2013) 1.28

Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells. Immunity (2012) 1.28

The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest (2008) 1.24

Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL-4 and STAT6. J Leukoc Biol (2010) 1.23

The development and in vivo function of T helper 9 cells. Nat Rev Immunol (2015) 1.18

Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest (2013) 1.15

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation. Proc Natl Acad Sci U S A (2012) 1.13

Regulating Il9 transcription in T helper cells. Trends Immunol (2011) 1.12

IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol Rev (2010) 1.12

The symphony of the ninth: the development and function of Th9 cells. Curr Opin Immunol (2012) 1.12

Interferon regulatory factor 4 differentially regulates the production of Th2 cytokines in naive vs. effector/memory CD4+ T cells. Proc Natl Acad Sci U S A (2008) 1.12

miR-182 and miR-10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation. PLoS Pathog (2013) 1.11

The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells. Proc Natl Acad Sci U S A (2013) 1.07

Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells. J Exp Med (2004) 1.04

Graded levels of IRF4 regulate CD8+ T cell differentiation and expansion, but not attrition, in response to acute virus infection. J Immunol (2014) 1.04

Nature and nurture in Foxp3(+) regulatory T cell development, stability, and function. Hum Immunol (2011) 1.02

Multiple treg suppressive modules and their adaptability. Front Immunol (2012) 1.01

Molecular characterization of in vivo adjuvant activity in ferrets vaccinated against influenza virus. J Virol (2010) 0.98

Signal transduction and Th17 cell differentiation. Microbes Infect (2009) 0.98

Transcriptional regulation of T helper 17 cell differentiation. Yonsei Med J (2010) 0.98

Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development. PLoS One (2011) 0.95

Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev (2014) 0.93

Regulatory mechanisms of helper T cell differentiation: new lessons learned from interleukin 17 family cytokines. Pharmacol Ther (2008) 0.93

T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production. Cytokine (2015) 0.92

Interferon regulatory factor 3 controls interleukin-17 expression in CD8 T lymphocytes. Proc Natl Acad Sci U S A (2013) 0.92

Murine gammaherpesvirus M2 protein induction of IRF4 via the NFAT pathway leads to IL-10 expression in B cells. PLoS Pathog (2014) 0.91

Regulatory T cells and immune tolerance in the intestine. Cold Spring Harb Perspect Biol (2013) 0.88

IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production. J Am Soc Nephrol (2011) 0.87

Transcriptional regulatory networks for CD4 T cell differentiation. Curr Top Microbiol Immunol (2014) 0.86

Transcriptional regulation of Th2 cell differentiation. Immunol Cell Biol (2010) 0.86

Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol (2013) 0.85

The transcription factor network in Th9 cells. Semin Immunopathol (2016) 0.84

Counter-regulation of T cell effector function by differentially activated p38. J Exp Med (2014) 0.84

IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV. Cell Death Differ (2014) 0.84

Th9 and other IL-9-producing cells in allergic asthma. Semin Immunopathol (2016) 0.84

Plasticity within the αβ⁺CD4⁺ T-cell lineage: when, how and what for? Open Biol (2013) 0.83

Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4. J Biol Chem (2009) 0.83

Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance. Front Genet (2013) 0.82

FoxO1 regulates allergic asthmatic inflammation through regulating polarization of the macrophage inflammatory phenotype. Oncotarget (2016) 0.80

Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr Top Microbiol Immunol (2014) 0.80

BCG induces protection against Mycobacterium tuberculosis infection in the Wistar rat model. PLoS One (2011) 0.80

Increased expression of IRF4 and ETS1 in CD4+ cells from patients with intermittent allergic rhinitis. Allergy (2011) 0.80

Blimp-1 connects the intrinsic and extrinsic regulation of T cell homeostasis. J Clin Immunol (2007) 0.80

Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis. Mediators Inflamm (2015) 0.79

IRF4 and IRF8: Governing the virtues of B Lymphocytes. Front Biol (Beijing) (2014) 0.79

Role of IL-9 and STATs in hematological malignancies (Review). Oncol Lett (2013) 0.79

Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism. Sci Rep (2016) 0.78

The infectious march: the complex interaction between microbes and the immune system in asthma. Immunol Allergy Clin North Am (2010) 0.77

Differential Expression of miRNA Regulates T Cell Differentiation and Plasticity During Visceral Leishmaniasis Infection. Front Microbiol (2016) 0.77

IRF4-Dependent and IRF4-Independent Pathways Contribute to DC Dysfunction in Lupus. PLoS One (2015) 0.76

Chromatin Remodeling Protein SMAR1 Is a Critical Regulator of T Helper Cell Differentiation and Inflammatory Diseases. Front Immunol (2017) 0.75

IFN regulatory factors 4 and 8 expression in the NOD mouse. Clin Dev Immunol (2011) 0.75

Targeting Th17 Cells with Small Molecules and Small Interference RNA. Mediators Inflamm (2015) 0.75

Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex. Nat Immunol (2017) 0.75

Estrogen Receptor-Dependent Regulation of Dendritic Cell Development and Function. Front Immunol (2017) 0.75

Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis. Front Immunol (2016) 0.75

IL-9 and Th9 cells in health and diseases-From tolerance to immunopathology. Cytokine Growth Factor Rev (2017) 0.75

IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination. Immunohorizons (2017) 0.75

RAG-1-deficient mice have no mature B and T lymphocytes. Cell (1992) 20.97

Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science (1993) 19.80

'Green mice' as a source of ubiquitous green cells. FEBS Lett (1997) 17.06

The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68

The regulation of immunity to Leishmania major. Annu Rev Immunol (1995) 8.05

IL-4 directs the development of Th2-like helper effectors. J Immunol (1990) 7.20

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09

Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity (1998) 5.75

An interleukin-4-induced transcription factor: IL-4 Stat. Science (1994) 4.71

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23

Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16

Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity (1996) 3.05

Interferon regulatory factors: the next generation. Gene (1999) 2.98

IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol (1995) 2.72

Multistage regulation of Th1-type immune responses by the transcription factor IRF-1. Immunity (1997) 1.89

Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression. J Exp Med (1997) 1.73

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells. J Immunol (1990) 1.73

Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo. Immunity (1997) 1.70

T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc Natl Acad Sci U S A (1998) 1.58

Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells. J Exp Med (2000) 1.57

Impaired interleukin 4 signaling in T helper type 1 cells. J Exp Med (1998) 1.41

Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4. J Exp Med (1999) 1.29

Different response of TH1 cells for stimulation with anti-CD3 antibodies. Eur J Immunol (1990) 1.05

Establishment of different T cell sublines using either interleukin 2 or interleukin 4 as growth factors. Eur J Immunol (1990) 1.05

Analysis of cytokine patterns produced by individual CD4+ lymph node cells during experimental murine leishmaniasis in resistant and susceptible mice. Int Immunol (1998) 0.97

Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44

Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells. Am J Physiol Cell Physiol (2006) 7.75

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer (2006) 7.53

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21

An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol (2003) 6.46

Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit. Science (2011) 5.87

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol (2007) 5.83

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. J Exp Med (2010) 5.68

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis. Cell (2005) 5.37

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature (2005) 5.37

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev (2008) 4.85

Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72

Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe (2009) 4.20

WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity (2003) 4.07

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature (2012) 4.04

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol (2008) 3.91

Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2006) 3.85

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci U S A (2005) 3.83

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal. J Exp Med (2006) 3.78

Pathways of apoptotic and non-apoptotic death in tumour cells. Nat Rev Cancer (2004) 3.76

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature (2002) 3.74

Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med (2005) 3.70

IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell (2011) 3.61

Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev (2002) 3.55

Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol (2013) 3.55

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2. Proc Natl Acad Sci U S A (2006) 3.41

Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19

The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol (2003) 3.18

DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell (2005) 3.12

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3. Hepatology (2015) 3.10

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell (2006) 3.10

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08

Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol (2003) 3.07

Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev (2011) 2.97

The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell (2010) 2.97

Cytochrome c: functions beyond respiration. Nat Rev Mol Cell Biol (2008) 2.95

Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem (2009) 2.86

The role of cytokines in classical Hodgkin lymphoma. Blood (2002) 2.86

Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10). Am J Respir Crit Care Med (2005) 2.86

High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One (2011) 2.82

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A (2004) 2.74

Metabolic targeting as an anticancer strategy: dawn of a new era? Sci STKE (2007) 2.71

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev (2006) 2.66

Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity (2003) 2.63

RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev (2005) 2.59

Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. Mol Cell Biol (2005) 2.57

Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. J Immunol (2007) 2.43

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38

Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell (2007) 2.38

HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32

Mitochondrial cell death effectors. Curr Opin Cell Biol (2009) 2.29

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med (2009) 2.26

IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood (2012) 2.23

Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer Discov (2013) 2.22

Regulatory CD4+CD25+ T cells restrict memory CD8+ T cell responses. J Exp Med (2002) 2.20

iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (2012) 2.14

The p53 family: guardians of maternal reproduction. Nat Rev Mol Cell Biol (2011) 2.13

Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo. Blood (2003) 2.12

FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell (2007) 2.09

The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol (2009) 2.06

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev (2010) 2.06

Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep (2012) 2.06

ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J Biol Chem (2002) 2.03

Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta (2011) 2.01

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity. Proc Natl Acad Sci U S A (2011) 1.98

Bioenergetic profile experiment using C2C12 myoblast cells. J Vis Exp (2010) 1.96

CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells. Proc Natl Acad Sci U S A (2006) 1.96

Thymic stromal lymphopoetin-induced expression of the endogenous inhibitory enzyme SLPI mediates recovery from colonic inflammation. Immunity (2011) 1.96

Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med (2006) 1.95

Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol (2009) 1.93

Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93

PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A (2008) 1.92

Systemic NKG2D down-regulation impairs NK and CD8 T cell responses in vivo. J Immunol (2005) 1.85

NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80

Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80

Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med (2004) 1.80

Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci U S A (2009) 1.80

A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur J Immunol (2009) 1.79

Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell (2006) 1.78

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med (2009) 1.78

Lymphocyte-derived ACh regulates local innate but not adaptive immunity. Proc Natl Acad Sci U S A (2013) 1.78

Signaling via the RIP2 adaptor protein in central nervous system-infiltrating dendritic cells promotes inflammation and autoimmunity. Immunity (2011) 1.78

Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity (2008) 1.77

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis. J Clin Invest (2013) 1.77

The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol (2008) 1.76

Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood (2002) 1.76

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood (2012) 1.76

Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci U S A (2007) 1.75

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity (2009) 1.73

Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice. Arthritis Rheum (2011) 1.71