Published in J Exp Med on June 26, 2006
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med (2007) 3.09
PUMA, a potent killer with or without p53. Oncogene (2008) 3.09
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med (2006) 2.65
Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol (2009) 2.32
Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells. J Exp Med (2006) 2.27
BH3-only proteins in apoptosis and beyond: an overview. Oncogene (2008) 2.13
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1. Nat Immunol (2007) 1.97
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals. Immunity (2013) 1.96
The cunning little vixen: Foxo and the cycle of life and death. Nat Immunol (2009) 1.91
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members. J Cell Biol (2009) 1.83
JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. J Biol Chem (2009) 1.82
PUMA is directly activated by NF-kappaB and contributes to TNF-alpha-induced apoptosis. Cell Death Differ (2009) 1.81
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med (2008) 1.78
Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages. J Immunol (2008) 1.77
CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia (2013) 1.76
The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci U S A (2007) 1.73
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Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease. Immunol Rev (2011) 1.70
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FOXO transcription factors throughout T cell biology. Nat Rev Immunol (2012) 1.60
Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal (2010) 1.59
Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. J Biol Chem (2008) 1.58
p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion. Gut (2006) 1.56
miR-125b promotes growth of prostate cancer xenograft tumor through targeting pro-apoptotic genes. Prostate (2010) 1.55
Unregulated miR-96 induces cell proliferation in human breast cancer by downregulating transcriptional factor FOXO3a. PLoS One (2010) 1.49
Axon Degeneration Gated by Retrograde Activation of Somatic Pro-apoptotic Signaling. Cell (2016) 1.49
Sp1 and p73 activate PUMA following serum starvation. Carcinogenesis (2008) 1.46
PUMA-mediated intestinal epithelial apoptosis contributes to ulcerative colitis in humans and mice. J Clin Invest (2011) 1.43
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev (2007) 1.43
Growth factors protect intestinal stem cells from radiation-induced apoptosis by suppressing PUMA through the PI3K/AKT/p53 axis. Oncogene (2009) 1.43
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. Blood (2009) 1.40
The BCL-2 protein family, BH3-mimetics and cancer therapy. Cell Death Differ (2015) 1.38
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
PUMA mediates EGFR tyrosine kinase inhibitor-induced apoptosis in head and neck cancer cells. Oncogene (2009) 1.32
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A (2009) 1.32
Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther (2010) 1.30
FOXO3a regulates glycolysis via transcriptional control of tumor suppressor TSC1. J Biol Chem (2010) 1.29
PUMA and BIM are required for oncogene inactivation-induced apoptosis. Sci Signal (2013) 1.28
T cells require Foxo1 to populate the peripheral lymphoid organs. Eur J Immunol (2009) 1.27
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. J Biol Chem (2010) 1.27
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa gene. J Exp Med (2008) 1.27
EPO receptor circuits for primary erythroblast survival. Blood (2008) 1.26
PCAF is an HIF-1alpha cofactor that regulates p53 transcriptional activity in hypoxia. Oncogene (2008) 1.26
The p53 circuit board. Biochim Biophys Acta (2012) 1.24
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells. Proc Natl Acad Sci U S A (2006) 1.23
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment. Genes Cancer (2011) 1.23
The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. EMBO J (2008) 1.20
Apoptosis of CD4+ CD25(high) T cells in type 1 diabetes may be partially mediated by IL-2 deprivation. PLoS One (2009) 1.19
BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection. Proc Natl Acad Sci U S A (2008) 1.18
The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood (2007) 1.18
CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PLoS One (2012) 1.18
Evading apoptosis in cancer. Trends Cell Biol (2013) 1.17
PUMA promotes Bax translocation by both directly interacting with Bax and by competitive binding to Bcl-X L during UV-induced apoptosis. Mol Biol Cell (2009) 1.16
Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis. Diabetes (2012) 1.16
The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics. Cancer Discov (2015) 1.15
FOXO transcription factors: their clinical significance and regulation. Biomed Res Int (2014) 1.14
The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor. Oncogene (2011) 1.13
PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Mol Cancer Ther (2010) 1.13
The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death Dis (2014) 1.12
In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. J Cereb Blood Flow Metab (2011) 1.11
Phosphorylation of Puma modulates its apoptotic function by regulating protein stability. Cell Death Dis (2010) 1.10
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Blood (2009) 1.10
Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep (2012) 1.10
Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression. Nucleic Acids Res (2011) 1.09
Highly specialized role of Forkhead box O transcription factors in the immune system. Antioxid Redox Signal (2010) 1.08
Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Res (2010) 1.06
The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death. J Biol Chem (2014) 1.06
FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway. Autophagy (2012) 1.05
FoxO3a and disease progression. World J Biol Chem (2014) 1.05
Bcl-2-regulated cell death signalling in the prevention of autoimmunity. Cell Death Dis (2010) 1.04
Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment. Proc Natl Acad Sci U S A (2012) 1.04
Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth. Oncogene (2012) 1.04
Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma. FASEB J (2009) 1.03
Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol (2011) 1.03
Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis. Clin Cancer Res (2014) 1.03
BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina. Mol Neurodegener (2011) 1.02
Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica (2009) 1.01
Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance. Adv Enzyme Regul (2007) 1.01
MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins. Proc Natl Acad Sci U S A (2009) 1.00
miR-128 exerts pro-apoptotic effect in a p53 transcription-dependent and -independent manner via PUMA-Bak axis. Cell Death Dis (2013) 0.99
Gene expression profiling of pulmonary fibrosis identifies Twist1 as an antiapoptotic molecular "rectifier" of growth factor signaling. Am J Pathol (2009) 0.98
Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma. J Immunol (2012) 0.97
Regulation of T cell homeostasis and responses by pten. Front Immunol (2012) 0.97
FoxO3a is activated and executes neuron death via Bim in response to β-amyloid. Cell Death Dis (2013) 0.96
Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation. Blood (2009) 0.96
Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa. Cell Death Differ (2011) 0.95
The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA. PLoS One (2012) 0.95
bis-Dehydroxy-Curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS One (2013) 0.94
Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level. Cell Death Differ (2011) 0.94
The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation. PLoS One (2012) 0.93
Regulation of neuroblastoma differentiation by forkhead transcription factors FOXO1/3/4 through the receptor tyrosine kinase PDGFRA. Proc Natl Acad Sci U S A (2012) 0.93
Cutting edge: regulatory T cells do not mediate suppression via programmed cell death pathways. J Immunol (2011) 0.93
Apoptosis induced by overall metabolic stress converges on the Bcl-2 family proteins Noxa and Mcl-1. Apoptosis (2011) 0.93
Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death. Cell Death Differ (2011) 0.93
Role of dual PI3/Akt and mTOR inhibition in Waldenstrom's Macroglobulinemia. Oncotarget (2010) 0.93
Critical role of p53 upregulated modulator of apoptosis in benzyl isothiocyanate-induced apoptotic cell death. PLoS One (2012) 0.92
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PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell (2003) 7.60
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DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science (2002) 4.88
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol (2002) 4.85
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Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell (2005) 3.73
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FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2. Mol Cell (2007) 2.09
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Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med (2006) 1.95
Lipocalin 2 is required for pulmonary host defense against Klebsiella infection. J Immunol (2009) 1.93
Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol (2005) 1.93
PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a). Proc Natl Acad Sci U S A (2008) 1.92
NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80
Survivin loss in thymocytes triggers p53-mediated growth arrest and p53-independent cell death. J Exp Med (2004) 1.80
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Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell (2006) 1.78
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development. J Exp Med (2008) 1.78
Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med (2009) 1.78
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The impact of p53 and p73 on aneuploidy and cancer. Trends Cell Biol (2008) 1.76
HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. Blood (2012) 1.76
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The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Immunity (2008) 1.73
Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim. Immunity (2009) 1.73
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J Exp Med (2006) 1.72
Bcl2 family proteins in carcinogenesis and the treatment of cancer. Apoptosis (2009) 1.72