Published in J Immunol on September 01, 2002
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med (2004) 8.98
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08
Continuous activation of autoreactive CD4+ CD25+ regulatory T cells in the steady state. J Exp Med (2003) 4.39
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med (2004) 4.35
Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol (2011) 4.29
CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol (2008) 3.51
Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response. Immunity (2009) 3.32
Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity (2009) 3.21
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med (2007) 3.17
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med (2007) 2.86
A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest (2005) 2.71
Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J Exp Med (2004) 2.57
Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood (2005) 2.55
Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. J Exp Med (2005) 2.42
CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells. J Exp Med (2007) 2.39
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood (2005) 1.89
CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J Exp Med (2006) 1.88
CD28 costimulation is essential for human T regulatory expansion and function. J Immunol (2008) 1.86
Regulatory T-cell compartmentalization and trafficking. Blood (2006) 1.86
Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. J Clin Invest (2004) 1.74
Regulatory T cells interfere with the development of bronchus-associated lymphoid tissue. J Exp Med (2007) 1.74
Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood (2007) 1.70
pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes (2013) 1.70
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
The stromal and haematopoietic antigen-presenting cells that reside in secondary lymphoid organs. Nat Rev Immunol (2010) 1.60
Regulatory T cells inhibit Th1 cell-mediated bile duct injury in murine biliary atresia. J Hepatol (2013) 1.54
Activation of aryl hydrocarbon receptor by TCDD prevents diabetes in NOD mice and increases Foxp3+ T cells in pancreatic lymph nodes. Immunotherapy (2009) 1.53
The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A (2006) 1.41
CCR4-dependent regulatory T cell function in inflammatory bowel disease. J Exp Med (2007) 1.41
Myeloid-derived suppressor cells prevent type 1 diabetes in murine models. J Immunol (2010) 1.38
Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease. Prog Retin Eye Res (2012) 1.32
Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes. J Immunol (2008) 1.27
Signatures of human regulatory T cells: an encounter with old friends and new players. Genome Biol (2006) 1.27
Diversity of regulatory CD4+T cells controlling distinct organ-specific autoimmune diseases. Proc Natl Acad Sci U S A (2003) 1.14
Dicer insufficiency and microRNA-155 overexpression in lupus regulatory T cells: an apparent paradox in the setting of an inflammatory milieu. J Immunol (2010) 1.13
A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol (2008) 1.13
Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure. Proc Natl Acad Sci U S A (2004) 1.12
Organ-specific and memory treg cells: specificity, development, function, and maintenance. Front Immunol (2014) 1.11
Regulatory T cell migration during an immune response. Trends Immunol (2012) 1.10
Regulatory T cells in experimental autoimmune disease. Springer Semin Immunopathol (2006) 1.06
Suppression of glomerulonephritis in NZB/NZW lupus prone mice by adoptive transfer of ex vivo expanded regulatory T cells. PLoS One (2009) 1.03
CD4(+) CD25(+) T cells prevent arthritis associated with Borrelia vaccination and infection. Clin Diagn Lab Immunol (2005) 1.01
Disruption of the homeostatic balance between autoaggressive (CD4+CD40+) and regulatory (CD4+CD25+FoxP3+) T cells promotes diabetes. J Leukoc Biol (2008) 1.00
The CXCR4/CXCL12 (SDF-1) signalling pathway protects non-obese diabetic mouse from autoimmune diabetes. Clin Exp Immunol (2007) 0.97
Anti-CD4-mediated selection of Treg in vitro - in vitro suppression does not predict in vivo capacity to prevent graft rejection. Eur J Immunol (2008) 0.95
Fatal attraction: chemokines and type 1 diabetes. J Clin Invest (2002) 0.95
Periodic accumulation of regulatory T cells in the uterus: preparation for the implantation of a semi-allogeneic fetus? PLoS One (2007) 0.92
The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model. J Immunol (2012) 0.92
Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system. J Immunol (2011) 0.91
The CD4(+) AT2R(+) T cell subpopulation improves post-infarction remodelling and restores cardiac function. J Cell Mol Med (2015) 0.90
Therapy for pneumonitis and sialadenitis by accumulation of CCR2-expressing CD4+CD25+ regulatory T cells in MRL/lpr mice. Arthritis Res Ther (2007) 0.90
Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression. Crit Rev Immunol (2010) 0.90
Regulatory T cells in microbial infection. Springer Semin Immunopathol (2006) 0.88
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity. Eur J Immunol (2011) 0.88
B7-1 mediated costimulation regulates pancreatic autoimmunity. Mol Immunol (2007) 0.86
Lower frequency of CD62L(high) and higher frequency of TNFR2(+) Tregs are associated with inflammatory conditions in type 1 diabetic patients. Mediators Inflamm (2011) 0.85
Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation. J Neuroinflammation (2012) 0.84
Tolerance and lymphoid organ structure and function. Front Immunol (2011) 0.83
β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice. Diabetes (2013) 0.83
T cells stimulated in vitro have a suppressive function but do not contain only regulatory T cells. Clin Exp Immunol (2007) 0.83
Roles of Wnt/β-catenin signaling in retinal neuron-like differentiation of bone marrow mesenchymal stem cells from nonobese diabetic mice. J Mol Neurosci (2012) 0.82
Clinical efficacy of buprenorphine to minimize distress in MRL/lpr mice. Eur J Pharmacol (2007) 0.81
Bidirectional homing of Tregs between the skin and lymph nodes. J Clin Invest (2010) 0.81
Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells. Curr Top Microbiol Immunol (2010) 0.81
Serum transforming growth factor β1 during diabetes development in non-obese diabetic mice and humans. Clin Exp Immunol (2010) 0.81
Expansion of CD4+CD25+ suppressive regulatory T cells from rhesus macaque peripheral blood by FN18/antihuman CD28-coated Dynal beads. Hum Immunol (2007) 0.81
L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation. Am J Transplant (2010) 0.81
Monitoring of CD4+CD25highIL-7Rαhigh activated T cells in kidney transplant recipients. Clin J Am Soc Nephrol (2011) 0.80
Differences in phenotype, homing properties and suppressive activities of regulatory T cells induced by epicutaneous, oral or sublingual immunotherapy in mice sensitized to peanut. Cell Mol Immunol (2016) 0.79
Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology (2004) 0.79
Mechanisms of T cell organotropism. Cell Mol Life Sci (2016) 0.79
Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes. Mol Ther (2012) 0.78
β-cell-specific IL-35 therapy suppresses ongoing autoimmune diabetes in NOD mice. Eur J Immunol (2016) 0.78
Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunol Cell Biol (2016) 0.78
Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue. Immunology (2012) 0.75
Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients. Int J Biomed Sci (2015) 0.75
Skin-derived TSLP systemically expands regulatory T cells. J Autoimmun (2017) 0.75
Chronic follicular bronchiolitis requires antigen-specific regulatory T cell control to prevent fatal disease progression. J Immunol (2013) 0.75
The function of regulatory T cells at the ocular surface: Review. Ocul Surf (2017) 0.75
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med (2003) 7.78
Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med (2002) 6.11
Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood (2004) 2.95
The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J Exp Med (2002) 2.93
Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity (2004) 2.76
GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity (2003) 2.18
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature (2012) 2.08
Protein microarrays for multiplex analysis of signal transduction pathways. Nat Med (2004) 1.89
Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Transplantation (2005) 1.82
A model for harmonizing flow cytometry in clinical trials. Nat Immunol (2010) 1.70
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol (2009) 1.65
Two isoforms of otubain 1 regulate T cell anergy via GRAIL. Nat Immunol (2003) 1.57
CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol (2002) 1.56
Pillars article: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell. 2000. 100: 655-669. J Immunol (2015) 1.44
Cd4+Cd25+ regulatory T cells and their therapeutic potential. Annu Rev Med (2006) 1.39
The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. J Immunol (2004) 1.36
Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol (2008) 1.33
Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol (2008) 1.29
A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. J Immunol (2006) 1.18
Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice. Diabetes (2003) 1.17
New tools for classification and monitoring of autoimmune diseases. Nat Rev Rheumatol (2012) 1.13
Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. J Immunol (2008) 1.13
Naive and memory T cells induce different types of graft-versus-host disease. J Immunol (2007) 1.12
GRAIL is up-regulated in CD4+ CD25+ T regulatory cells and is sufficient for conversion of T cells to a regulatory phenotype. J Biol Chem (2007) 1.11
Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines. Nat Chem Biol (2012) 1.10
Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells. Blood (2009) 1.10
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. J Biol Chem (2008) 1.09
Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins. J Biol Chem (2012) 1.07
Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: image-based estimation of the number of cells accumulating in mouse paws. J Biomed Opt (2007) 0.99
Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. J Immunol (2004) 0.97
Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. J Immunol (2009) 0.95
The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells. J Immunol (2009) 0.94
GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness. FEBS J (2010) 0.89
Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3. J Mol Cell Biol (2012) 0.89
Costimulatory signals controlling regulatory T cells. Proc Natl Acad Sci U S A (2003) 0.89
A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice. Mol Ther (2010) 0.89
Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4. Clin Immunol (2002) 0.88
Treatment of autoimmune disease by adoptive cellular gene therapy. Ann N Y Acad Sci (2003) 0.88
It's time to bring dendritic cell therapy to type 1 diabetes. Diabetes (2014) 0.85
Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. Clin Immunol (2011) 0.82
Type 1 diabetes in mice and men: gene expression profiling to investigate disease pathogenesis. Immunol Res (2014) 0.82
Targeted gene therapy: frontiers in the development of 'smart drugs'. Trends Biotechnol (2004) 0.82
Diminished adenosine A1 receptor expression in pancreatic α-cells may contribute to the pathology of type 1 diabetes. Diabetes (2013) 0.81
Adoptive cellular gene therapy of autoimmune disease. Autoimmun Rev (2002) 0.80
Targeted gene therapy of autoimmune diseases: advances and prospects. Expert Rev Clin Immunol (2005) 0.79
T-cell anergy: from phenotype to genotype and back. Immunol Res (2003) 0.79
Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis. Circ J (2002) 0.77
Does our current understanding of the molecular basis of immune tolerance predict new therapies for autoimmune disease? Nat Clin Pract Rheumatol (2006) 0.77
High cell surface expression of CD4 allows distinction of CD4(+)CD25(+) antigen-specific effector T cells from CD4(+)CD25(+) regulatory T cells in murine experimental autoimmune encephalomyelitis. J Neuroimmunol (2007) 0.77
T cell anergy: where it's LAT. Immunity (2006) 0.76
Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis. Autoimmun Rev (2005) 0.75
Gene therapy for type 1 diabetes: a novel approach for targeted treatment of autoimmunity. J Clin Invest (2004) 0.75
CYLD: deubiquitination-induced TCR signaling. Nat Immunol (2006) 0.75
Scratching the (T cell) surface. Genome Biol (2003) 0.75
The potential for gene therapy in the treatment of autoimmune disease. Clin Immunol (2002) 0.75
30. Defining the spectrum of clinical immunology. J Allergy Clin Immunol (2003) 0.75
Immunomodulatory vaccination in autoimmune disease. Endocrinol Metab Clin North Am (2002) 0.75