Published in Proc Natl Acad Sci U S A on June 12, 2006
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nat Immunol (2012) 2.10
In vivo administration of hypomethylating agents mitigate graft-versus-host disease without sacrificing graft-versus-leukemia. Blood (2010) 2.02
HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog (2011) 1.53
FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect (2009) 1.40
Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity (2011) 1.23
Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function. Cell Rep (2012) 1.14
Immune regulation by histone deacetylases: a focus on the alteration of FOXP3 activity. Immunol Cell Biol (2011) 1.08
Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS One (2010) 1.02
Two lysines in the forkhead domain of foxp3 are key to T regulatory cell function. PLoS One (2012) 0.97
T regulatory cells: aid or hindrance in the clearance of disease? J Cell Mol Med (2008) 0.93
Exome sequencing identifies a novel FOXP3 mutation in a 2-generation family with inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2014) 0.92
Foxp3 interacts with c-Rel to mediate NF-κB repression. PLoS One (2011) 0.88
Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation. Endocrinology (2011) 0.88
Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity. PLoS One (2009) 0.88
Forkhead transcription factor FOXP3 upregulates CD25 expression through cooperation with RelA/NF-κB. PLoS One (2012) 0.84
Drosophila FoxP mutants are deficient in operant self-learning. PLoS One (2014) 0.82
IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3. Sci Rep (2015) 0.80
Searching for the Achilles Heel of FOXP3. Front Oncol (2013) 0.79
Regulation of IL-2 gene expression by Siva and FOXP3 in human T cells. BMC Immunol (2011) 0.77
Phase I study of azacitidine following donor lymphocyte infusion for relapsed acute myeloid leukemia post allogeneic stem cell transplantation. Leuk Res (2016) 0.76
Dissecting the role of the FOXP3 gene in the joint genetic susceptibility to autoimmune thyroiditis and diabetes: a genetic and functional analysis. Gene (2014) 0.75
Protein-Protein Interaction Among the FoxP Family Members and their Regulation of Two Target Genes, VLDLR and CNTNAP2 in the Zebra Finch Song System. Front Mol Neurosci (2017) 0.75
IPEX Syndrome, FOXP3 and Cancer. J Syndr (2013) 0.75
Genetic and epigenetic studies of FOXP3 in asthma and allergy. Asthma Res Pract (2015) 0.75
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 26.05
An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol (2003) 19.16
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol (2004) 17.40
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet (2001) 15.27
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet (2001) 14.15
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet (2001) 10.92
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 8.28
A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature (1983) 8.20
Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol (2001) 5.95
Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94
JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest (2000) 5.12
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08
Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med (2005) 4.47
Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation. J Biol Chem (2001) 4.23
CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol (2005) 4.11
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest (2005) 3.83
Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci U S A (2002) 3.41
Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A (2005) 3.33
Human CD4+CD25+ regulatory T cells. Semin Immunol (2004) 3.13
The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol (2002) 3.09
Forkhead-box transcription factors and their role in the immune system. Nat Rev Immunol (2004) 2.62
Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity. Nat Immunol (2004) 2.43
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Control of immune homeostasis by naturally arising regulatory CD4+ T cells. Curr Opin Immunol (2003) 2.04
Structure of the forkhead domain of FOXP2 bound to DNA. Structure (2006) 1.61
The N-Myc oncoprotein is associated in vivo with the phosphoprotein Max(p20/22) in human neuroblastoma cells. EMBO J (1991) 1.52
A unique subpopulation of CD4+ regulatory T cells controls wasting disease, IL-10 secretion and T cell homeostasis. Eur J Immunol (2003) 1.28
Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells. J Immunol (2004) 1.19
Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4+CD25+ regulatory cells. Proc Natl Acad Sci U S A (2005) 0.87
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science (2005) 11.31
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A (2003) 3.46
Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science (2013) 3.45
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest (2007) 2.81
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med (2009) 1.89
Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow. Exp Hematol (2002) 1.88
Detection of β cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci U S A (2011) 1.77
Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis. Proc Natl Acad Sci U S A (2010) 1.73
Marrow-derived cells as vehicles for delivery of gene therapy to pulmonary epithelium. Am J Respir Cell Mol Biol (2002) 1.70
Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments. Genes Dev (2003) 1.69
Synergistic reversal of type 1 diabetes in NOD mice with anti-CD3 and interleukin-1 blockade: evidence of improved immune regulation. Diabetes (2011) 1.52
Administration of BMP2/7 in utero partially reverses Rubinstein-Taybi syndrome-like skeletal defects induced by Pdk1 or Cbp mutations in mice. J Clin Invest (2011) 1.50
Engraftment of a vascularized human skin equivalent. FASEB J (2003) 1.43
Intranasal delivery of the cytoplasmic domain of CTLA-4 using a novel protein transduction domain prevents allergic inflammation. Nat Med (2006) 1.41
RAGE ligation affects T cell activation and controls T cell differentiation. J Immunol (2008) 1.41
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5. Nat Immunol (2004) 1.34
Immunopathology of human T cell responses to skin, artery and endothelial cell grafts in the human peripheral blood lymphocyte/severe combined immunodeficient mouse. Springer Semin Immunopathol (2003) 1.29
Osteoporosis with increased osteoclastogenesis in hematopoietic cell-specific STAT3-deficient mice. Biochem Biophys Res Commun (2005) 1.27
The kinase Btk negatively regulates the production of reactive oxygen species and stimulation-induced apoptosis in human neutrophils. Nat Immunol (2012) 1.25
Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol (2009) 1.23
Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc Natl Acad Sci U S A (2002) 1.14
Human trophoblast noncoding RNA suppresses CIITA promoter III activity in murine B-lymphocytes. Biochem Biophys Res Commun (2003) 1.13
Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. Mol Cancer Ther (2006) 1.11
Teplizumab induces human gut-tropic regulatory cells in humanized mice and patients. Sci Transl Med (2012) 1.10
Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes. J Immunol (2002) 1.10
RAGE expression in human T cells: a link between environmental factors and adaptive immune responses. PLoS One (2012) 1.09
Mesenchymal stem cells pretreated with delivered Hph-1-Hsp70 protein are protected from hypoxia-mediated cell death and rescue heart functions from myocardial injury. Stem Cells (2009) 1.05
Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study. Biol Psychiatry (2006) 1.03
Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis. Proc Natl Acad Sci U S A (2008) 1.03
Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation. Proc Natl Acad Sci U S A (2010) 1.03
B cells and osteoblast and osteoclast development. Immunol Rev (2005) 1.02
Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors. J Immunol (2004) 1.02
Epigenetic abnormalities associated with a chromosome 18(q21-q22) inversion and a Gilles de la Tourette syndrome phenotype. Proc Natl Acad Sci U S A (2003) 1.01
The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases. Mol Cells (2012) 1.00
Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. J Biol Chem (2008) 1.00
Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus. Mol Cell Biol (2008) 0.99
Bcl-2 transduction protects human endothelial cell synthetic microvessel grafts from allogeneic T cells in vivo. J Immunol (2004) 0.97
Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model. Arterioscler Thromb Vasc Biol (2011) 0.96
Interplay between DNA repair and inflammation, and the link to cancer. Crit Rev Biochem Mol Biol (2014) 0.96
Trichomonas vaginalis inhibits proinflammatory cytokine production in macrophages by suppressing NF-kappaB activation. Mol Cells (2004) 0.96
Interferon-gamma augments CD95(APO-1/Fas) and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95-mediated apoptosis. Am J Pathol (2002) 0.95
Receptor activator of NF-kappa B ligand stimulates recruitment of SHP-1 to the complex containing TNFR-associated factor 6 that regulates osteoclastogenesis. J Immunol (2003) 0.95
IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice. Biochem Biophys Res Commun (2011) 0.95
Children with Tourette's syndrome may suffer immunoglobulin A dysgammaglobulinemia: preliminary report. Biol Psychiatry (2009) 0.94
Elevated expression of MCP-1, IL-2 and PTPR-N in basal ganglia of Tourette syndrome cases. Brain Behav Immun (2010) 0.93
Class II transactivator promoter activity is suppressed through regulation by a trophoblast noncoding RNA. Transplantation (2003) 0.92
SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis (2004) 0.92
Alleviation of rheumatoid arthritis by cell-transducible methotrexate upon transcutaneous delivery. Biomaterials (2011) 0.91
Quantification of cellular uptake and in vivo tracking of transduction using real-time monitoring. Biochem Biophys Res Commun (2010) 0.91
A limited number of genes are involved in the differentiation of germinal center B cells. J Cell Biochem (2006) 0.91
Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. Circulation (2011) 0.90
Porcine endothelial cells, unlike human endothelial cells, can be killed by human CTL via Fas ligand and cannot be protected by Bcl-2. J Immunol (2002) 0.89
JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol (2005) 0.89
Helicobacter pylori proinflammatory protein up-regulates NF-kappaB as a cell-translocating Ser/Thr kinase. Proc Natl Acad Sci U S A (2010) 0.89
Apoptosis of macrophages induced by Trichomonas vaginalis through the phosphorylation of p38 mitogen-activated protein kinase that locates at downstream of mitochondria-dependent caspase activation. Int J Biochem Cell Biol (2005) 0.88
Skin-penetrating methotrexate alleviates imiquimod-induced psoriasiform dermatitis via decreasing IL-17-producing gamma delta T cells. Exp Dermatol (2014) 0.88
DNA polymerase beta interacts with TRF2 and induces telomere dysfunction in a murine mammary cell line. Cancer Res (2004) 0.88
Antioxidant properties of neohesperidin dihydrochalcone: inhibition of hypochlorous acid-induced DNA strand breakage, protein degradation, and cell death. Biol Pharm Bull (2007) 0.86
Mitochondrial ATP synthase is a target for TNBS-induced protein carbonylation in XS-106 dendritic cells. Proteomics (2008) 0.86
A humanized mouse model of autoimmune insulitis. Diabetes (2014) 0.85
The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model. Mol Med (2010) 0.85
NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti-CD3 antibody. Eur J Immunol (2011) 0.85
Regulatory transplantation tolerance and "stemness": evidence that Foxp3 may play a regulatory role in SOCS-3 gene transcription. Transplantation (2007) 0.85
Inflammatory regulation by TLR3 in acute hepatitis. J Immunol (2009) 0.84
An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds. Biomaterials (2013) 0.83
An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice. PLoS One (2010) 0.83
Altered immunoglobulin profiles in children with Tourette syndrome. Brain Behav Immun (2010) 0.83
Promotion of beta-cell differentiation in pancreatic precursor cells by adult islet cells. Endocrinology (2008) 0.83
Transducible form of p47phox and p67phox compensate for defective NADPH oxidase activity in neutrophils of patients with chronic granulomatous disease. Biochem Biophys Res Commun (2011) 0.82
Manganese treatment modulates the expression of peroxisome proliferator-activated receptors in astrocytoma and neuroblastoma cells. Neurochem Res (2006) 0.82
Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells. J Biol Chem (2004) 0.82
T Cell-specific immunosuppression using tautomycetin or PTD-conjugated protein drugs. Yonsei Med J (2004) 0.81
Cell permeable NFAT inhibitory peptide Sim-2-VIVIT inhibits T-cell activation and alleviates allergic airway inflammation and hyper-responsiveness. Immunol Lett (2012) 0.80
Risperidone-related improvement of irritability in children with autism is not associated with changes in serum of epidermal growth factor and interleukin-13. J Child Adolesc Psychopharmacol (2011) 0.80
Qualitatively differential regulation of T cell activation and apoptosis by T cell receptor zeta chain ITAMs and their tyrosine residues. Int Immunol (2004) 0.80
Activation of CD4 T cells by Raf-independent effectors of Ras. Proc Natl Acad Sci U S A (2003) 0.80
Amelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of interferon-gamma production by infiltrating T cells. Transplantation (2008) 0.80
Enhanced anti-serpin antibody activity inhibits autoimmune inflammation in type 1 diabetes. J Immunol (2012) 0.79
Amelioration of neurodegenerative diseases by cell death-induced cytoplasmic delivery of humanin. J Control Release (2013) 0.79
Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes. J Biol Chem (2012) 0.79
Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases. J Exp Med (2006) 0.79
Evidence for a dual pathway of activation in CD43-stimulated Th2 cells: differential requirement for the Lck tyrosine kinase. Int Immunol (2004) 0.78
Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione. Apoptosis (2013) 0.78
Cell-penetrating DNA-binding protein as a safe and efficient naked DNA delivery carrier in vitro and in vivo. Biochem Biophys Res Commun (2009) 0.77
Controlled release of cell-permeable gene complex from poly(L-lactide) scaffold for enhanced stem cell tissue engineering. J Control Release (2011) 0.77
Impaired cell adhesion, apoptosis, and signaling in WASP gene-disrupted Nalm-6 pre-B cells and recovery of cell adhesion using a transducible form of WASp. Int J Hematol (2012) 0.77
Alleviation of abnormal synaptic neurotransmitter release by cell-permeable form of the truncated SNAP-25 upon transcutaneous delivery. Neurosci Lett (2013) 0.77
Intranuclear interactomic inhibition of FoxP3 suppresses functions of Treg cells. Biochem Biophys Res Commun (2014) 0.76
Qualitative and quantitative differences in the intensity of Fas-mediated intracellular signals determine life and death in T cells. Int J Hematol (2010) 0.76
Synergistic inhibition of T-cell activation by a cell-permeable ZAP-70 mutant and ctCTLA-4. Biochem Biophys Res Commun (2009) 0.76
Inhibition of alloresponse by a human trophoblast non-coding RNA suppressing class II transactivator promoter III and major histocompatibility class II expression in murine B-lymphocytes. J Heart Lung Transplant (2004) 0.75
Characterization of a severe parenchymal phenotype of experimental autoimmune encephalomyelitis in (C57BL6xB10.PL)F1 mice. J Neuroimmunol (2007) 0.75
Attenuation of contact hypersensitivity by cell-permeable heat shock protein 70 in BALB/c mouse model. Exp Dermatol (2012) 0.75