Published in J Biol Chem on June 24, 2003
GammaH2AX and cancer. Nat Rev Cancer (2008) 9.77
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res (2008) 4.79
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol (2010) 2.88
Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1. Mol Cell (2011) 2.46
Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks. Genes Dev (2006) 2.27
Hdac3 is essential for the maintenance of chromatin structure and genome stability. Cancer Cell (2010) 2.20
Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast. Mol Cell Biol (2004) 2.20
The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J (2010) 1.83
Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. J Virol (2006) 1.61
Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage. Nucleic Acids Res (2007) 1.48
Tying the loose ends together in DNA double strand break repair with 53BP1. Cell Div (2006) 1.47
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
An oligomerized 53BP1 tudor domain suffices for recognition of DNA double-strand breaks. Mol Cell Biol (2008) 1.45
The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem (2006) 1.45
53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A (2006) 1.27
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. Nucleic Acids Res (2009) 1.21
The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus (2009) 1.13
Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity. PLoS Genet (2010) 1.12
Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons. Environ Health Perspect (2005) 1.06
Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. Mol Cell (2014) 1.05
RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks. Proc Natl Acad Sci U S A (2013) 1.00
Protein arginine methylation of non-histone proteins and its role in diseases. Cell Cycle (2013) 1.00
Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice. Radiat Res (2013) 1.00
Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends. EMBO J (2013) 0.99
Tudor nuclease genes and programmed DNA rearrangements in Tetrahymena thermophila. Eukaryot Cell (2007) 0.97
Replication independent ATR signalling leads to G2/M arrest requiring Nbs1, 53BP1 and MDC1. Hum Mol Genet (2008) 0.94
USP28 is recruited to sites of DNA damage by the tandem BRCT domains of 53BP1 but plays a minor role in double-strand break metabolism. Mol Cell Biol (2014) 0.94
Functional interaction between Epstein-Barr virus replication protein Zta and host DNA damage response protein 53BP1. J Virol (2009) 0.93
RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1. J Biol Chem (2012) 0.90
The checkpoint Saccharomyces cerevisiae Rad9 protein contains a tandem tudor domain that recognizes DNA. Nucleic Acids Res (2007) 0.90
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature (2017) 0.87
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol (2015) 0.87
Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation. Mol Cell Biol (2010) 0.86
Genetic polymorphisms and cervical cancer development: ATM G5557A and p53bp1 C1236G. Oncol Rep (2011) 0.86
Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage. J Biol Chem (2009) 0.84
Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells. PLoS One (2013) 0.82
Double-strand breaks and the concept of short- and long-term epigenetic memory. Chromosoma (2010) 0.82
Boundaries and physical characterization of a new domain shared between mammalian 53BP1 and yeast Rad9 checkpoint proteins. Protein Sci (2005) 0.82
Structures and Functions of the Multiple KOW Domains of Transcription Elongation Factor Spt5. Mol Cell Biol (2015) 0.81
Regulation of 53BP1 protein stability by RNF8 and RNF168 is important for efficient DNA double-strand break repair. PLoS One (2014) 0.80
Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell (2015) 0.79
Acetylation of lysine 382 and phosphorylation of serine 392 in p53 modulate the interaction between p53 and MDC1 in vitro. PLoS One (2013) 0.79
Reading chromatin signatures after DNA double-strand breaks. Philos Trans R Soc Lond B Biol Sci (2017) 0.78
Defining genome maintenance pathways using functional genomic approaches. Crit Rev Biochem Mol Biol (2011) 0.77
Effects of Chronic Low-Dose Radiation on Human Neural Progenitor Cells. Sci Rep (2016) 0.76
Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168. Cell Cycle (2015) 0.76
DNA Double Strand Break Response and Limited Repair Capacity in Mouse Elongated Spermatids. Int J Mol Sci (2015) 0.75
miR-300 regulates cellular radiosensitivity through targeting p53 and apaf1 in human lung cancer cells. Cell Cycle (2017) 0.75
ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol Cell (2008) 6.60
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res (2004) 6.38
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat Genet (2003) 6.03
A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell (2004) 5.29
gammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization. Cell Cycle (2010) 3.56
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer (2007) 3.54
The role of double-strand break repair - insights from human genetics. Nat Rev Genet (2006) 3.25
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. Nat Genet (2007) 3.08
ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J (2006) 3.05
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J (2009) 2.94
A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity. Cancer Res (2004) 2.55
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J (2011) 2.46
A heterotrimeric PCNA in the hyperthermophilic archaeon Sulfolobus solfataricus. Mol Cell (2003) 2.34
Identification of a DNA nonhomologous end-joining complex in bacteria. Science (2002) 2.27
Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol (2006) 2.20
Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science (2004) 2.04
Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron (2002) 1.95
Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum Mol Genet (2004) 1.95
Nbs1 is required for ATR-dependent phosphorylation events. EMBO J (2004) 1.95
Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO J (2002) 1.92
Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nat Genet (2011) 1.76
APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis. Exp Neurol (2003) 1.73
Perturbed gap-filling synthesis in nucleotide excision repair causes histone H2AX phosphorylation in human quiescent cells. J Cell Sci (2007) 1.68
The impact of heterochromatin on DSB repair. Biochem Soc Trans (2009) 1.65
Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Mol Cell (2004) 1.64
The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity. J Clin Invest (2006) 1.62
Targeted disruption of Np95 gene renders murine embryonic stem cells hypersensitive to DNA damaging agents and DNA replication blocks. J Biol Chem (2002) 1.62
Structure of a NHEJ polymerase-mediated DNA synaptic complex. Science (2007) 1.60
Structure and function of a mycobacterial NHEJ DNA repair polymerase. J Mol Biol (2006) 1.58
Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. J Biol Chem (2004) 1.55
Forkhead transcription factor FoxO1 in adipose tissue regulates energy storage and expenditure. Diabetes (2007) 1.53
Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res (2003) 1.52
PrimPol bypasses UV photoproducts during eukaryotic chromosomal DNA replication. Mol Cell (2013) 1.50
Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos. J Biol Chem (2006) 1.50
Nonhomologous end-joining in bacteria: a microbial perspective. Annu Rev Microbiol (2007) 1.49
53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. DNA Repair (Amst) (2010) 1.46
A seed for Alzheimer amyloid in the brain. J Neurosci (2004) 1.45
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res (2008) 1.44
Increased levels of tissue endostatin in human malignant gliomas. Clin Cancer Res (2002) 1.43
The FoxO transcription factors and metabolic regulation. FEBS Lett (2007) 1.37
Domain structure of a NHEJ DNA repair ligase from Mycobacterium tuberculosis. J Mol Biol (2005) 1.37
NHEJ protects mycobacteria in stationary phase against the harmful effects of desiccation. DNA Repair (Amst) (2007) 1.34
Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J (2003) 1.34
Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Mol Cancer Ther (2010) 1.34
Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms. Hum Mol Genet (2004) 1.33
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene (2002) 1.33
Role of DNA repair by nonhomologous-end joining in Bacillus subtilis spore resistance to extreme dryness, mono- and polychromatic UV, and ionizing radiation. J Bacteriol (2007) 1.33
Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLoS Genet (2006) 1.31
Rice WRKY45 plays important roles in fungal and bacterial disease resistance. Mol Plant Pathol (2011) 1.31
The GAR motif of 53BP1 is arginine methylated by PRMT1 and is necessary for 53BP1 DNA binding activity. Cell Cycle (2005) 1.30
Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest. Mol Cell Biol (2010) 1.30
The role of the DNA damage response pathways in brain development and microcephaly: insight from human disorders. DNA Repair (Amst) (2008) 1.27
An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle (2007) 1.27
Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes (2007) 1.26
Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. Hum Mol Genet (2009) 1.26
Understanding the limitations of radiation-induced cell cycle checkpoints. Crit Rev Biochem Mol Biol (2011) 1.22
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1. Nucleic Acids Res (2009) 1.21
The Smc5-Smc6 DNA repair complex. bridging of the Smc5-Smc6 heads by the KLEISIN, Nse4, and non-Kleisin subunits. J Biol Chem (2006) 1.20
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair (Amst) (2007) 1.19
Harmonising the response to DSBs: a new string in the ATM bow. DNA Repair (Amst) (2005) 1.17
PPL2 translesion polymerase is essential for the completion of chromosomal DNA replication in the African trypanosome. Mol Cell (2013) 1.15
Terahertz time-domain observation of spin reorientation in orthoferrite ErFeO3 through magnetic free induction decay. Phys Rev Lett (2013) 1.13
The two edges of the ATM sword: co-operation between repair and checkpoint functions. Radiother Oncol (2005) 1.10
Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights. Hum Mol Genet (2005) 1.10
Differential inhibition of CYP17A1 and CYP21A2 activities by the P450 oxidoreductase mutant A287P. Mol Endocrinol (2007) 1.09
The Gam protein of bacteriophage Mu is an orthologue of eukaryotic Ku. EMBO Rep (2003) 1.07
X-irradiation of cells on glass slides has a dose doubling impact. DNA Repair (Amst) (2007) 1.07
Mycobacteriophage exploit NHEJ to facilitate genome circularization. Mol Cell (2006) 1.07
The direct interaction between 53BP1 and MDC1 is required for the recruitment of 53BP1 to sites of damage. J Biol Chem (2008) 1.06
PRKDC mutations in a SCID patient with profound neurological abnormalities. J Clin Invest (2013) 1.06
Identification of the first ATRIP-deficient patient and novel mutations in ATR define a clinical spectrum for ATR-ATRIP Seckel Syndrome. PLoS Genet (2012) 1.06
PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake. Am J Physiol Endocrinol Metab (2010) 1.06
Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling. Am J Hum Genet (2007) 1.06
Ku stimulation of DNA ligase IV-dependent ligation requires inward movement along the DNA molecule. J Biol Chem (2003) 1.05
Structure of a preternary complex involving a prokaryotic NHEJ DNA polymerase. Mol Cell (2011) 1.04
DNA toroids: framework for DNA repair in Deinococcus radiodurans and in germinating bacterial spores. J Bacteriol (2004) 1.04
The limitations of the G1-S checkpoint. Cancer Res (2010) 1.02
The heterochromatic barrier to DNA double strand break repair: how to get the entry visa. Int J Mol Sci (2012) 1.02
Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci (2011) 1.01
Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection. Nucleic Acids Res (2013) 1.00
Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proc Natl Acad Sci U S A (2005) 1.00
Irradiation induced foci (IRIF) as a biomarker for radiosensitivity. Mutat Res (2011) 0.99
Opposing roles for 53BP1 during homologous recombination. Nucleic Acids Res (2013) 0.99
Clinical impact of ATR checkpoint signalling failure in humans. Cell Cycle (2003) 0.99
Expression of Mycobacterium tuberculosis Ku and Ligase D in Escherichia coli results in RecA and RecB-independent DNA end-joining at regions of microhomology. DNA Repair (Amst) (2007) 0.98
Crystal structure of the ENT domain of human EMSY. J Mol Biol (2005) 0.97
HIV-1 replication and latency are regulated by translational control of cyclin T1. J Mol Biol (2011) 0.97
Expression and intracellular localization of FKHRL1 in mammary gland neoplasms. Acta Med Okayama (2004) 0.97
New insights into NHEJ repair processes in prokaryotes. Cell Cycle (2005) 0.96