Published in Diabetes on October 01, 2002
Muscle Insulin Resistance in Aging (Mirage) | NCT02230839
Uncovering the 'ORIGINS' of Diabetes (ORIGINS) | NCT02226640
Bioenergetics and Metabolism in Pediatric Populations | NCT03323294
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev (2007) 6.53
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Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest (2008) 4.22
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Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A (2004) 1.80
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Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients. Diabetologia (2009) 1.74
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Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab (2012) 1.71
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Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Am J Physiol Endocrinol Metab (2010) 1.63
Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proc Natl Acad Sci U S A (2012) 1.61
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Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity. Am J Physiol Endocrinol Metab (2009) 1.59
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2011) 1.57
PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab (2010) 1.56
Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans. Diabetes (2013) 1.55
Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol (2011) 1.55
Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals. Diabetes (2013) 1.54
Cardiac dysfunction during exercise in uncomplicated type 2 diabetes. Med Sci Sports Exerc (2009) 1.54
Blood viscosity and hematocrit as risk factors for type 2 diabetes mellitus: the atherosclerosis risk in communities (ARIC) study. Am J Epidemiol (2008) 1.54
Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes (2009) 1.52
Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res (2007) 1.48
Attenuated mTOR signaling and enhanced autophagy in adipocytes from obese patients with type 2 diabetes. Mol Med (2010) 1.48
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Intensive insulin therapy improves insulin sensitivity and mitochondrial function in severely burned children. Crit Care Med (2010) 1.46
Prolonged fasting identifies skeletal muscle mitochondrial dysfunction as consequence rather than cause of human insulin resistance. Diabetes (2010) 1.43
Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency. Cell Metab (2010) 1.42
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care (2009) 1.42
Bedside-to-Bench conference: research agenda for idiopathic fatigue and aging. J Am Geriatr Soc (2010) 1.41
The Wnt signaling pathway: aging gracefully as a protectionist? Pharmacol Ther (2008) 1.38
Intracellular lipid accumulation in liver and muscle and the insulin resistance syndrome. Endocrinol Metab Clin North Am (2008) 1.38
Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study. QJM (2007) 1.38
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The vitamin nicotinamide: translating nutrition into clinical care. Molecules (2009) 1.36
Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. J Biol Chem (2010) 1.36
Insulin sensitivity and mitochondrial function are improved in children with burn injury during a randomized controlled trial of fenofibrate. Ann Surg (2007) 1.36
Skeletal muscle NAMPT is induced by exercise in humans. Am J Physiol Endocrinol Metab (2009) 1.36
Liver ATP synthesis is lower and relates to insulin sensitivity in patients with type 2 diabetes. Diabetes Care (2011) 1.36
In vivo measurement of synthesis rate of individual skeletal muscle mitochondrial proteins. Am J Physiol Endocrinol Metab (2008) 1.36
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
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Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes (2005) 4.31
Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet (2013) 3.83
Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. Ann Neurol (2011) 2.44
Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci (2006) 2.23
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Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity. J Appl Physiol (1985) (2007) 1.86
Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes (2007) 1.84
Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes (2008) 1.82
Exome sequencing generates high quality data in non-target regions. BMC Genomics (2012) 1.72
Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J (2009) 1.70
Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. Am J Physiol Endocrinol Metab (2004) 1.64
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.62
Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity. Am J Physiol Endocrinol Metab (2009) 1.59
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Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes (2006) 1.44
Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab (2004) 1.41
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Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity. Biochemistry (2007) 1.36
Hedgehog signaling is activated in subsets of esophageal cancers. Int J Cancer (2006) 1.34
The tiger genome and comparative analysis with lion and snow leopard genomes. Nat Commun (2013) 1.32
Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: a randomized phase III ARTIST trial. Chin J Cancer (2011) 1.32
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection. Ophthalmology (2010) 1.30
Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A (2007) 1.29
Natural Anaplasma phagocytophilum infection of ticks and rodents from a forest area of Jilin Province, China. Am J Trop Med Hyg (2006) 1.28
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