Published in Proc Natl Acad Sci U S A on March 16, 2012
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. Science (2013) 3.60
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming. Cell (2016) 2.39
Where is mTOR and what is it doing there? J Cell Biol (2013) 1.91
Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J (2013) 1.65
Feature Article: mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci U S A (2013) 1.42
Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med (2014) 1.18
The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circ Res (2014) 1.18
Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBO J (2014) 1.18
Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart. Circ Res (2012) 1.16
Regulation of muscle protein synthesis and the effects of catabolic states. Int J Biochem Cell Biol (2013) 1.10
HSP72 is a mitochondrial stress sensor critical for Parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes (2013) 1.07
Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart. Cell Metab (2015) 1.02
Tipping the metabolic scales towards increased longevity in mammals. Nat Cell Biol (2015) 1.00
Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. Proc Natl Acad Sci U S A (2016) 1.00
Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol (2015) 0.99
Mitochondrial response to nutrient availability and its role in metabolic disease. EMBO Mol Med (2014) 0.94
Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Mol Cell (2014) 0.93
Mitochondrial Quality Control and Muscle Mass Maintenance. Front Physiol (2016) 0.92
Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production. Elife (2014) 0.92
High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. PLoS One (2014) 0.91
Reduction of endoplasmic reticulum stress attenuates the defects caused by Drosophila mitofusin depletion. J Cell Biol (2014) 0.90
Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus. Nat Rev Endocrinol (2016) 0.90
Mitochondrial metabolism and the control of vascular smooth muscle cell proliferation. Front Cell Dev Biol (2014) 0.89
Mitofusin-2 ameliorates high-fat diet-induced insulin resistance in liver of rats. World J Gastroenterol (2013) 0.88
Stage-specific effects of Notch activation during skeletal myogenesis. Elife (2016) 0.88
Skeletal Muscle Mitochondrial Content, Oxidative Capacity, and Mfn2 Expression Are Reduced in Older Patients With Heart Failure and Preserved Ejection Fraction and Are Related to Exercise Intolerance. JACC Heart Fail (2016) 0.87
Mitochondrial genome linearization is a causative factor for cardiomyopathy in mice and Drosophila. Antioxid Redox Signal (2013) 0.86
Functional implications of mitofusin 2-mediated mitochondrial-SR tethering. J Mol Cell Cardiol (2014) 0.86
Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases. J Nutr Biochem (2014) 0.86
Mitofusin 2-deficiency suppresses cell proliferation through disturbance of autophagy. PLoS One (2015) 0.85
Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation. Sci Rep (2015) 0.83
Over-expressing mitofusin-2 in healthy mature mammalian skeletal muscle does not alter mitochondrial bioenergetics. PLoS One (2013) 0.83
Impaired mitochondrial dynamics and bioenergetics in diabetic skeletal muscle. PLoS One (2014) 0.83
Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol (2016) 0.83
Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle. J Mol Med (Berl) (2015) 0.82
The role of the unfolded protein response in diabetes mellitus. Semin Immunopathol (2013) 0.81
Glucocorticoid modulation of mitochondrial function in hepatoma cells requires the mitochondrial fission protein Drp1. Antioxid Redox Signal (2012) 0.81
A Mitofusin-2-dependent inactivating cleavage of Opa1 links changes in mitochondria cristae and ER contacts in the postprandial liver. Proc Natl Acad Sci U S A (2014) 0.81
Mitophagy: therapeutic potentials for liver disease and beyond. Toxicol Res (2014) 0.81
Diet impact on mitochondrial bioenergetics and dynamics. Front Physiol (2015) 0.80
Mitochondrial Diseases Part II: Mouse models of OXPHOS deficiencies caused by defects in regulatory factors and other components required for mitochondrial function. Mitochondrion (2015) 0.80
Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. J Pineal Res (2016) 0.80
Mitochondrial dynamics in type 2 diabetes: Pathophysiological implications. Redox Biol (2017) 0.79
Titanium Dioxide Nanoparticles Trigger Loss of Function and Perturbation of Mitochondrial Dynamics in Primary Hepatocytes. PLoS One (2015) 0.79
Mitofusin 2 protects hepatocyte mitochondrial function from damage induced by GCDCA. PLoS One (2013) 0.79
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway. EMBO J (2016) 0.78
Leptin-induced mitochondrial fusion mediates hepatic lipid accumulation. Int J Obes (Lond) (2015) 0.78
Conditional knockout of proximal tubule mitofusin 2 accelerates recovery and improves survival after renal ischemia. J Am Soc Nephrol (2014) 0.78
Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction. Front Aging Neurosci (2015) 0.78
ALCAT1 controls mitochondrial etiology of fatty liver diseases, linking defective mitophagy to steatosis. Hepatology (2015) 0.78
Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis. Sci Transl Med (2016) 0.78
Lipopolysaccharide Disrupts Mitochondrial Physiology in Skeletal Muscle via Disparate Effects on Sphingolipid Metabolism. Shock (2015) 0.77
Mitofusin 2 Deficiency Affects Energy Metabolism and Mitochondrial Biogenesis in MEF Cells. PLoS One (2015) 0.77
Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. PLoS One (2014) 0.76
Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors. Oncotarget (2016) 0.76
Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion. Cell Death Dis (2016) 0.76
Aging leads to elevation of O-GlcNAcylation and disruption of mitochondrial homeostasis in retina. Oxid Med Cell Longev (2014) 0.76
Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology. J Cell Sci (2017) 0.75
A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells. Age (Dordr) (2015) 0.75
Mice Hemizygous for a Pathogenic Mitofusin-2 Allele Exhibit Hind Limb/Foot Gait Deficits and Phenotypic Perturbations in Nerve and Muscle. PLoS One (2016) 0.75
Proteomic profiling of mitochondria: what does it tell us about the ageing brain? Aging (Albany NY) (2016) 0.75
T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor. Cell Death Differ (2016) 0.75
Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses. PLoS One (2017) 0.75
Mitofusion-2-mediated alleviation of insulin resistance in rats through reduction in lipid intermediate accumulation in skeletal muscle. J Biomed Sci (2013) 0.75
Of yeast, mice and men: MAMs come in two flavors. Biol Direct (2017) 0.75
Downregulation of Mitofusin 2 in Placenta Is Related to Preeclampsia. Biomed Res Int (2016) 0.75
Mitofusin 2 regulates the oocytes development and quality by modulating meiosis and mitochondrial function. Sci Rep (2016) 0.75
The Association of Mitofusion-2 Gene Polymorphisms with Susceptibility of Essential Hypertension in Northern Han Chinese Population. Int J Med Sci (2016) 0.75
Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases. Mediators Inflamm (2016) 0.75
Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health. PLoS Genet (2017) 0.75
Mitofusin-2 is required for mouse oocyte meiotic maturation. Sci Rep (2016) 0.75
Relationship of oxidative stress in skeletal muscle with obesity and obesity-associated hyperinsulinemia in horses. Can J Vet Res (2015) 0.75
Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice. J Nutr Metab (2016) 0.75
Hypoxia inducible factor-1α activation improves renal oxygenation and mitochondrial function in early chronic kidney disease. Am J Physiol Renal Physiol (2017) 0.75
Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population. Braz J Med Biol Res (2017) 0.75
OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance. EMBO J (2017) 0.75
Role of Cardiolipin in Mitochondrial Signaling Pathways. Front Cell Dev Biol (2017) 0.75
Melatonin, mitochondria and hypertension. Cell Mol Life Sci (2017) 0.75
Light-emitting diode modulates carbohydrate metabolism by pancreatic duct regeneration. Lasers Med Sci (2017) 0.75
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med (2004) 18.86
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J (2008) 12.89
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature (2001) 11.72
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci U S A (2001) 11.06
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes (2002) 10.49
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol (2003) 10.10
Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature (2008) 9.66
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (1997) 9.53
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature (2001) 8.44
Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell (2010) 8.29
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet (2004) 7.45
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med (1993) 6.89
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest (2009) 5.66
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell (2010) 5.14
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem (2001) 5.12
TORCs: transducers of regulated CREB activity. Mol Cell (2003) 4.42
Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell (2007) 4.30
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest (2008) 4.22
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell (2007) 3.82
Mitochondrial dynamics in mammalian health and disease. Physiol Rev (2009) 3.59
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45
Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc Natl Acad Sci U S A (2003) 3.21
MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2. Brain (2006) 2.77
Dysregulation of HSG triggers vascular proliferative disorders. Nat Cell Biol (2004) 2.75
Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes (2007) 2.75
The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet (2005) 2.72
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature (2009) 2.48
c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J Biol Chem (2002) 2.45
Mitofusin 2 inhibits mitochondrial antiviral signaling. Sci Signal (2009) 2.25
Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes. Mol Cell Biol (2011) 2.23
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell (2011) 2.17
Early onset severe and late-onset mild Charcot-Marie-Tooth disease with mitofusin 2 (MFN2) mutations. Brain (2006) 2.16
Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc Natl Acad Sci U S A (2007) 1.58
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care (2009) 1.42
Transgenic mice that express Cre recombinase under control of a skeletal muscle-specific promoter from mef2c. Genesis (2005) 0.95
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes (2007) 14.12
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes (2008) 10.74
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Pancreatic cancers require autophagy for tumor growth. Genes Dev (2011) 6.17
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab (2013) 4.88
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest (2003) 4.11
Mitochondrial dynamics in mammalian health and disease. Physiol Rev (2009) 3.59
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity. J Biol Chem (2003) 3.45
Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr (2008) 2.77
The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet (2005) 2.72
The gut microbiota modulates host energy and lipid metabolism in mice. J Lipid Res (2009) 2.59
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med (2011) 2.25
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. J Clin Invest (2004) 2.11
Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. Endocrinology (2009) 2.05
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage. J Clin Invest (2005) 2.01
Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise. J Physiol (2005) 1.94
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell (2012) 1.91
Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes (2011) 1.91
Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-gamma coactivator-1 alpha, estrogen-related receptor-alpha, and mitofusin 2. Diabetes (2006) 1.91
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans. PLoS Biol (2011) 1.89
Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol (2013) 1.87
Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes (2006) 1.83
Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin. Endocrinology (2006) 1.81
Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification. J Am Soc Nephrol (2002) 1.73
CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance. Cell Metab (2009) 1.68
Mfn2 modulates the UPR and mitochondrial function via repression of PERK. EMBO J (2013) 1.65
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress. J Cell Sci (2011) 1.65
Changes in mitochondrial dynamics during ceramide-induced cardiomyocyte early apoptosis. Cardiovasc Res (2007) 1.63
dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr Biol (2010) 1.62
Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice. EMBO J (2012) 1.58
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One (2008) 1.50
Apelin stimulates glucose utilization in normal and obese insulin-resistant mice. Cell Metab (2008) 1.48
Cord serum lipidome in prediction of islet autoimmunity and type 1 diabetes. Diabetes (2013) 1.47
Mitochondrial fusion proteins: dual regulators of morphology and metabolism. Semin Cell Dev Biol (2010) 1.44
Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1{alpha}/Mitofusin-2 regulatory pathway in response to physical activity. Diabetes Care (2009) 1.42
Pathophysiology and treatment of cystinuria. Nat Rev Nephrol (2010) 1.40
Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension. Diabetes (2004) 1.38
Clustering of cardiovascular risk factors mimicking the human metabolic syndrome X in eNOS null mice. Swiss Med Wkly (2003) 1.38
Insulin stimulates long-chain fatty acid utilization by rat cardiac myocytes through cellular redistribution of FAT/CD36. Diabetes (2002) 1.38
Molecular basis of substrate-induced permeation by an amino acid antiporter. Proc Natl Acad Sci U S A (2011) 1.37
Identification of LAT4, a novel amino acid transporter with system L activity. J Biol Chem (2005) 1.36
The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med (2013) 1.36
Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes. Int J Biochem Cell Biol (2009) 1.32
PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. Cell Metab (2010) 1.29
Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues. Methods Mol Biol (2011) 1.28
Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. Am J Physiol Cell Physiol (2010) 1.27
Caveolin-1 loss of function accelerates glucose transporter 4 and insulin receptor degradation in 3T3-L1 adipocytes. Endocrinology (2009) 1.26
Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutr Biochem (2010) 1.26
Brain glucagon-like peptide 1 signaling controls the onset of high-fat diet-induced insulin resistance and reduces energy expenditure. Endocrinology (2008) 1.25
Physiological and pharmacological mechanisms through which the DPP-4 inhibitor sitagliptin regulates glycemia in mice. Endocrinology (2011) 1.25
Data analysis tool for comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Anal Chem (2011) 1.24
GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion. Mol Cell Endocrinol (2007) 1.24
Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. Diabetes (2008) 1.24
Endoplasmic reticulum and the unfolded protein response: dynamics and metabolic integration. Int Rev Cell Mol Biol (2013) 1.23
Role of central nervous system glucagon-like Peptide-1 receptors in enteric glucose sensing. Diabetes (2008) 1.22
The genetics of heteromeric amino acid transporters. Physiology (Bethesda) (2005) 1.18
Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure. EMBO J (2014) 1.18
Localization and functional analyses of the MLC1 protein involved in megalencephalic leukoencephalopathy with subcortical cysts. Hum Mol Genet (2004) 1.18
A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res (2013) 1.18
Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis. Hum Mol Genet (2003) 1.15
Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages. J Immunol (2006) 1.15
The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells. EMBO Rep (2009) 1.14
Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes. Diabetes (2011) 1.14