Human proinsulin C-peptide reduces high glucose-induced proliferation and NF-kappaB activation in vascular smooth muscle cells.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMID 18294642)

Published in Atherosclerosis on February 21, 2008

Authors

Vincenza Cifarelli1, Patrizia Luppi, Hubert M Tse, Jing He, Jon Piganelli, Massimo Trucco

Author Affiliations

1: Division of Immunogenetics, Department of Pediatrics, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.

Articles citing this

C-peptide in the natural history of type 1 diabetes. Diabetes Metab Res Rev (2009) 1.27

The clinical potential of C-peptide replacement in type 1 diabetes. Diabetes (2012) 0.94

Cellular mechanisms by which proinsulin C-peptide prevents insulin-induced neointima formation in human saphenous vein. Diabetologia (2010) 0.94

C-peptide activates AMPKα and prevents ROS-mediated mitochondrial fission and endothelial apoptosis in diabetes. Diabetes (2013) 0.94

Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells. Exp Mol Med (2011) 0.93

C-peptide prevents hyperglycemia-induced endothelial apoptosis through inhibition of reactive oxygen species-mediated transglutaminase 2 activation. Diabetes (2012) 0.91

Inflammation in Diabetic Encephalopathy is Prevented by C-Peptide. Rev Diabet Stud (2009) 0.87

Mitochondrial mutations are associated with atherosclerotic lesions in the human aorta. Clin Dev Immunol (2012) 0.84

SDF-1α/CXCR4 axis is involved in glucose-potentiated proliferation and chemotaxis in rat vascular smooth muscle cells. Int J Exp Pathol (2010) 0.84

Sequential abnormalities in type 1 diabetic encephalopathy and the effects of C-Peptide. Rev Diabet Stud (2009) 0.83

Isolation of human islets for autologous islet transplantation in children and adolescents with chronic pancreatitis. J Transplant (2012) 0.83

Physiological effects and therapeutic potential of proinsulin C-peptide. Am J Physiol Endocrinol Metab (2014) 0.81

C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia. Inflamm Res (2011) 0.79

Histidine Prevents Cu-Induced Oxidative Stress and the Associated Decreases in mRNA from Encoding Tight Junction Proteins in the Intestine of Grass Carp (Ctenopharyngodon idella). PLoS One (2016) 0.78

Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action. Biologics (2008) 0.78

Molecular effects of C-Peptide in microvascular blood flow regulation. Rev Diabet Stud (2009) 0.77

Interferon gamma contributes to preimplantation embryonic development and to implantation site structure in NOD mice. Hum Reprod (2010) 0.77

Molecular Pathways Regulating Macrovascular Pathology and Vascular Smooth Muscle Cells Phenotype in Type 2 Diabetes. Int J Mol Sci (2015) 0.76

Anti-inflammatory properties of C-Peptide. Rev Diabet Stud (2009) 0.76

Effects of pyrrolidine dithiocarbamate on proliferation and nuclear factor-κB activity in autosomal dominant polycystic kidney disease cells. BMC Nephrol (2015) 0.76

New tricks by an old dog. Exp Diabetes Res (2008) 0.75

Articles by these authors

Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes (2002) 10.49

Evaluation of tumor-size response metrics to predict overall survival in Western and Chinese patients with first-line metastatic colorectal cancer. J Clin Oncol (2013) 5.55

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet (2011) 5.26

Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes (2005) 4.31

Tolerogenic immunosuppression for organ transplantation. Lancet (2003) 4.09

Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (2002) 3.96

On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am J Hum Genet (2008) 3.95

Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet (2013) 3.83

Screen and clean: a tool for identifying interactions in genome-wide association studies. Genet Epidemiol (2010) 2.70

Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. Ann Neurol (2011) 2.44

A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene. Clin Immunol (2007) 2.23

Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes (2004) 2.16

Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience. J Clin Endocrinol Metab (2015) 2.14

Uterine massage to reduce blood loss after vaginal delivery: a randomized controlled trial. Obstet Gynecol (2013) 1.96

Clinical xenotransplantation: the next medical revolution? Lancet (2011) 1.84

Exome sequencing generates high quality data in non-target regions. BMC Genomics (2012) 1.72

Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J (2009) 1.70

Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69

Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care (2011) 1.65

Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies. Pediatr Diabetes (2005) 1.64

Monocytes are progressively activated in the circulation of pregnant women. J Leukoc Biol (2002) 1.63

Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc Natl Acad Sci U S A (2013) 1.62

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol (2006) 1.58

Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage. Atherosclerosis (2012) 1.56

Genome of the Chinese tree shrew. Nat Commun (2013) 1.55

Common variants in HSPB7 and FRMD4B associated with advanced heart failure. Circ Cardiovasc Genet (2010) 1.51

Postnatal intracerebroventricular exposure to neuropeptide Y causes weight loss in female adult rats. Am J Physiol Regul Integr Comp Physiol (2003) 1.51

Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond. Pediatr Diabetes (2008) 1.50

Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis (2006) 1.49

Factors influencing the removal of fluoride from aqueous solution by calcined Mg-Al-CO3 layered double hydroxides. J Hazard Mater (2005) 1.49

PEG-based hydrogels as an in vitro encapsulation platform for testing controlled beta-cell microenvironments. Acta Biomater (2005) 1.46

Aberrant Forkhead box O1 function is associated with impaired hepatic metabolism. Endocrinology (2006) 1.46

Functionally important glycosyltransferase gain and loss during catarrhine primate emergence. Proc Natl Acad Sci U S A (2006) 1.46

Peregrine and saker falcon genome sequences provide insights into evolution of a predatory lifestyle. Nat Genet (2013) 1.45

Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes (2006) 1.45

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities. Amino Acids (2010) 1.41

Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab (2004) 1.41

Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 1.38

Control of salicylic acid synthesis and systemic acquired resistance by two members of a plant-specific family of transcription factors. Proc Natl Acad Sci U S A (2010) 1.36

Hedgehog signaling is activated in subsets of esophageal cancers. Int J Cancer (2006) 1.34

The tiger genome and comparative analysis with lion and snow leopard genomes. Nat Commun (2013) 1.32

Efficacy and safety of bevacizumab plus chemotherapy in Chinese patients with metastatic colorectal cancer: a randomized phase III ARTIST trial. Chin J Cancer (2011) 1.32

Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection. Ophthalmology (2010) 1.30

The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis. Ann N Y Acad Sci (2013) 1.30

Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci U S A (2007) 1.29

Natural Anaplasma phagocytophilum infection of ticks and rodents from a forest area of Jilin Province, China. Am J Trop Med Hyg (2006) 1.28

Dense genotyping of candidate gene loci identifies variants associated with high-density lipoprotein cholesterol. Circ Cardiovasc Genet (2011) 1.27

Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes (2005) 1.27

Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex. Chem Biol (2003) 1.27

Clinical islet xenotransplantation: how close are we? Diabetes (2012) 1.26

Cancer type-specific modulation of mitochondrial haplogroups in breast, colorectal and thyroid cancer. BMC Cancer (2010) 1.25

Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes (2002) 1.23

FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes (2009) 1.22

Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol (2011) 1.21

Diabetogenic T-cell clones recognize an altered peptide of chromogranin A. Diabetes (2012) 1.20

Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness. J Immunol (2007) 1.19

PPAR{alpha} mediates the hypolipidemic action of fibrates by antagonizing FoxO1. Am J Physiol Endocrinol Metab (2006) 1.18

Molecular basis of evolutionary loss of the alpha 1,3-galactosyltransferase gene in higher primates. J Biol Chem (2001) 1.18

Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB. PLoS One (2013) 1.18

Genome analysis and signature discovery for diving and sensory properties of the endangered Chinese alligator. Cell Res (2013) 1.18

Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes (2002) 1.17

Antisense oligonucleotides down-regulating costimulation confer diabetes-preventive properties to nonobese diabetic mouse dendritic cells. J Immunol (2004) 1.16

Caspase-1 is not required for type 1 diabetes in the NOD mouse. Diabetes (2004) 1.16

Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes (2003) 1.15

The role of external and matrix pH in mitochondrial reactive oxygen species generation. J Biol Chem (2008) 1.13

Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing. Rheumatology (Oxford) (2011) 1.12

Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem (2003) 1.12

Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes. Diabetes (2011) 1.12

Potentially functional variants of PLCE1 identified by GWASs contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One (2012) 1.12

Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies. Stat Med (2010) 1.11

Hepatocyte growth factor modulates interleukin-6 production in bone marrow derived macrophages: implications for inflammatory mediated diseases. PLoS One (2010) 1.10

Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia. PLoS Comput Biol (2009) 1.10

The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer. BMC Med Genet (2011) 1.10

Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells. Diabetes (2006) 1.10

Long-term neuroprotection from a potent redox-modulating metalloporphyrin in the rat. Free Radic Biol Med (2009) 1.10

Degradation of MDM2 by the interaction between berberine and DAXX leads to potent apoptosis in MDM2-overexpressing cancer cells. Cancer Res (2010) 1.10

Suppression of glypican 3 inhibits growth of hepatocellular carcinoma cells through up-regulation of TGF-β2. Neoplasia (2011) 1.09

Footer: a quantitative comparative genomics method for efficient recognition of cis-regulatory elements. Genome Res (2005) 1.09

Hepatitis B virus polymerase impairs interferon-α-induced STA T activation through inhibition of importin-α5 and protein kinase C-δ. Hepatology (2013) 1.08

Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes (2003) 1.08

Immunosuppressive effects of glucosamine. J Biol Chem (2002) 1.08

Evaluating genetic risk for prostate cancer among Japanese and Latinos. Cancer Epidemiol Biomarkers Prev (2012) 1.08

Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J Immunol (2008) 1.08

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels. Eur Heart J (2011) 1.07

Angiopoietin-1 production in islets improves islet engraftment and protects islets from cytokine-induced apoptosis. Diabetes (2007) 1.07

Prevalence and significance of anti-peptidylarginine deiminase 4 antibodies in rheumatoid arthritis. J Rheumatol (2008) 1.07

RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells. Carcinogenesis (2008) 1.07

Recovery of the endogenous beta cell function in the NOD model of autoimmune diabetes. Stem Cells (2003) 1.07

Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes. Carcinogenesis (2013) 1.07

The skinny on Slug. Mol Carcinog (2010) 1.06

Suppression of autoimmune diabetes by soluble galectin-1. J Immunol (2009) 1.06

Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. Am J Epidemiol (2011) 1.05

T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes. Diabetes (2004) 1.04

Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies. Xenotransplantation (2007) 1.02

Body window-enabled in vivo multicolor imaging of transplanted mouse islets expressing an insulin-Timer fusion protein. Biotechniques (2003) 1.02