Published in J Cell Biol on July 02, 2012
c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. Neuron (2012) 2.45
Schwann cell phenotype is regulated by axon modality and central-peripheral location, and persists in vitro. Exp Neurol (2013) 1.62
The repair Schwann cell and its function in regenerating nerves. J Physiol (2016) 1.26
PI3K-GSK3 signalling regulates mammalian axon regeneration by inducing the expression of Smad1. Nat Commun (2013) 1.19
Schwann Cells: Development and Role in Nerve Repair. Cold Spring Harb Perspect Biol (2015) 1.16
Coordinated cell type-specific epigenetic remodeling in prefrontal cortex begins before birth and continues into early adulthood. PLoS Genet (2013) 1.05
Signals regulating myelination in peripheral nerves and the Schwann cell response to injury. Curr Opin Neurobiol (2013) 1.00
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression. Nat Commun (2014) 0.96
Repair of the Peripheral Nerve-Remyelination that Works. Brain Sci (2013) 0.94
Dynamic regulation of Schwann cell enhancers after peripheral nerve injury. J Biol Chem (2015) 0.92
c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy. Brain (2014) 0.92
cJun promotes CNS axon growth. Mol Cell Neurosci (2014) 0.91
Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation. EMBO J (2013) 0.91
Artemin induced functional recovery and reinnervation after partial nerve injury. Pain (2013) 0.91
Concepts for regulation of axon integrity by enwrapping glia. Front Cell Neurosci (2013) 0.91
Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity. J Cell Biol (2017) 0.90
cAMP-responsive element-binding protein (CREB) and cAMP co-regulate activator protein 1 (AP1)-dependent regeneration-associated gene expression and neurite growth. J Biol Chem (2014) 0.88
Strategies to promote peripheral nerve regeneration: electrical stimulation and/or exercise. Eur J Neurosci (2015) 0.87
Plastic fantastic: Schwann cells and repair of the peripheral nervous system. Stem Cells Transl Med (2013) 0.87
Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity. Exp Neurobiol (2014) 0.86
Role of Schwann cells in the regeneration of penile and peripheral nerves. Asian J Androl (2015) 0.86
Microprocessor Complex Subunit DiGeorge Syndrome Critical Region Gene 8 (Dgcr8) Is Required for Schwann Cell Myelination and Myelin Maintenance. J Biol Chem (2015) 0.85
Nerve injury induces glial cell line-derived neurotrophic factor (GDNF) expression in Schwann cells through purinergic signaling and the PKC-PKD pathway. Glia (2013) 0.85
Negative regulators of schwann cell differentiation-novel targets for peripheral nerve therapies? J Clin Immunol (2012) 0.85
Molecules involved in the crosstalk between immune- and peripheral nerve Schwann cells. J Clin Immunol (2014) 0.84
Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury. J Neurosci (2016) 0.84
c-Jun gene-modified Schwann cells: upregulating multiple neurotrophic factors and promoting neurite outgrowth. Tissue Eng Part A (2015) 0.83
Induction of heat shock protein 70 (Hsp70) prevents neuregulin-induced demyelination by enhancing the proteasomal clearance of c-Jun. ASN Neuro (2012) 0.81
Molecular Mechanisms Involved in Schwann Cell Plasticity. Front Mol Neurosci (2017) 0.80
STAT3 Controls the Long-Term Survival and Phenotype of Repair Schwann Cells during Nerve Regeneration. J Neurosci (2017) 0.79
Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve. PLoS One (2016) 0.78
Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP). J Neuroinflammation (2016) 0.77
Axon degeneration: make the Schwann cell great again. Neural Regen Res (2017) 0.76
Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys. Int J Mol Med (2015) 0.76
Gene delivery to rat and human Schwann cells and nerve segments: a comparison of AAV 1-9 and lentiviral vectors. Gene Ther (2015) 0.76
Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nat Commun (2017) 0.75
Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases: pro-demyelinating and axon-preservative functions. Neural Regen Res (2014) 0.75
Gene expression profiling studies in regenerating nerves in a mouse model for CMT1X: uninjured Cx32-knockout peripheral nerves display expression profile of injured wild type nerves. Exp Neurol (2014) 0.75
Deletion of Jun proteins in adult oligodendrocytes does not perturb cell survival, or myelin maintenance in vivo. PLoS One (2015) 0.75
Physiological Importance of Hydrogen Sulfide: Emerging Potent Neuroprotector and Neuromodulator. Oxid Med Cell Longev (2016) 0.75
Time-dependent differential expression of long non-coding RNAs following peripheral nerve injury. Int J Mol Med (2017) 0.75
Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury. Open Biol (2016) 0.75
Epigenetic profiling reveals a developmental decrease in promoter accessibility during cortical maturation in vivo. Neuroepigenetics (2016) 0.75
Nerve regeneration in the peripheral and central nervous systems. J Physiol (2016) 0.75
The Expression implication of GDNF in ventral horn and associated remote cortex in rhesus monkeys with hemisected spinal cord injury. Iran J Basic Med Sci (2016) 0.75
Wallerian demyelination: chronicle of a cellular cataclysm. Cell Mol Life Sci (2017) 0.75
Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve. Development (2017) 0.75
Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury. Cell Rep (2017) 0.75
Transcriptional inhibition in Schwann cell development and nerve regeneration. Neural Regen Res (2017) 0.75
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell (1988) 7.76
Estimation of nuclear population from microtome sections. Anat Rec (1946) 7.21
Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol (2000) 6.31
The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci (2002) 5.93
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev (2001) 4.68
The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron (2004) 3.33
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature (2005) 3.05
Multiple sclerosis: re-expression of a developmental pathway that restricts oligodendrocyte maturation. Nat Med (2002) 3.04
Characterization of a multicomponent receptor for GDNF. Nature (1996) 2.92
GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell (1996) 2.86
A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo. Neuron (2012) 2.72
Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia (2008) 2.72
EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting. Cell (2010) 2.54
Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development (2000) 2.43
Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection. J Cell Biol (1987) 2.40
Conditional disruption of beta 1 integrin in Schwann cells impedes interactions with axons. J Cell Biol (2002) 2.35
Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell (1998) 2.29
c-Jun is a negative regulator of myelination. J Cell Biol (2008) 2.27
GDNF signalling through the Ret receptor tyrosine kinase. Nature (1996) 2.21
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J (2002) 2.15
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
The molecular machinery of myelin gene transcription in Schwann cells. Glia (2008) 1.91
Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. Neuron (1998) 1.89
The GDNF family ligands and receptors - implications for neural development. Curr Opin Neurobiol (2000) 1.88
Enhanced synthesis of brain-derived neurotrophic factor in the lesioned peripheral nerve: different mechanisms are responsible for the regulation of BDNF and NGF mRNA. J Cell Biol (1992) 1.87
Neurotrophic factors and axonal growth. Curr Opin Neurobiol (2002) 1.86
The effects of cAMP on differentiation of cultured Schwann cells: progression from an early phenotype (04+) to a myelin phenotype (P0+, GFAP-, N-CAM-, NGF-receptor-) depends on growth inhibition. J Cell Biol (1991) 1.83
Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science (2009) 1.76
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol (2007) 1.72
Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron (2006) 1.71
Brain microglia and blood-derived macrophages: molecular profiles and functional roles in multiple sclerosis and animal models of autoimmune demyelinating disease. Brain Res Brain Res Rev (2004) 1.61
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia. Nature (2008) 1.52
The 5'-flanking region of the rat synapsin I gene directs neuron-specific and developmentally regulated reporter gene expression in transgenic mice. J Biol Chem (1993) 1.49
Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury. Nat Neurosci (2008) 1.47
GDNF family receptor complexes are emerging drug targets. Trends Pharmacol Sci (2007) 1.28
Differential regulation of mRNAs for GDNF and its receptors Ret and GDNFR alpha after sciatic nerve lesion in the mouse. Eur J Neurosci (1997) 1.26
Impaired axonal regeneration in alpha7 integrin-deficient mice. J Neurosci (2000) 1.25
The nerve regenerative microenvironment: early behavior and partnership of axons and Schwann cells. Exp Neurol (2009) 1.23
Retrograde axonal transport of LIF is increased by peripheral nerve injury: correlation with increased LIF expression in distal nerve. Neuron (1994) 1.22
Glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor sustain the axonal regeneration of chronically axotomized motoneurons in vivo. Exp Neurol (2003) 1.17
Ret is a multifunctional coreceptor that integrates diffusible- and contact-axon guidance signals. Cell (2012) 1.12
Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival. J Biol Chem (2001) 1.11
Transgenic activation of Ras in neurons promotes hypertrophy and protects from lesion-induced degeneration. J Cell Biol (2000) 1.08
Integrin family of cell adhesion molecules in the injured brain: regulation and cellular localization in the normal and regenerating mouse facial motor nucleus. J Comp Neurol (1999) 1.08
Axon-Schwann cell interactions regulate the expression of c-jun in Schwann cells. J Neurosci Res (1996) 1.04
Regulation of thrombospondin in the regenerating mouse facial motor nucleus. Glia (1996) 1.01
c-Jun expression in human neuropathies: a pilot study. J Peripher Nerv Syst (2011) 1.00
Interleukin-6 (IL6) and cellular response to facial nerve injury: effects on lymphocyte recruitment, early microglial activation and axonal outgrowth in IL6-deficient mice. Eur J Neurosci (2001) 0.98
Multiple effects of artemin on sympathetic neurone generation, survival and growth. Development (2001) 0.94
Spontaneously immortalized adult mouse Schwann cells secrete autocrine and paracrine growth-promoting activities. J Neurosci Res (1995) 0.92
GDNF gene delivery via the p75(NTR) receptor rescues injured motor neurons. Exp Neurol (2006) 0.90
GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells. Eur J Neurosci (1998) 0.84
Mechanisms and functions of Eph and ephrin signalling. Nat Rev Mol Cell Biol (2002) 6.92
The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci (2005) 5.59
Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med (2005) 4.42
The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron (2004) 3.33
PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. Genes Dev (2005) 3.29
EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion. Nat Cell Biol (2003) 3.26
The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer. Cell (2012) 3.10
Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature (2005) 3.05
Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol (2007) 2.83
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science (2004) 2.83
Negative regulation of myelination: relevance for development, injury, and demyelinating disease. Glia (2008) 2.72
Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest (2004) 2.72
Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell (2007) 2.69
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med (2006) 2.59
c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration. Neuron (2012) 2.45
Hippocampal plasticity requires postsynaptic ephrinBs. Nat Neurosci (2003) 2.37
Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol (2008) 2.35
EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Mol Cell (2002) 2.31
c-Jun is a negative regulator of myelination. J Cell Biol (2008) 2.27
Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci (2010) 2.23
NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment. Cell Stem Cell (2012) 2.15
Control of skeletal patterning by ephrinB1-EphB interactions. Dev Cell (2003) 2.11
NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression. EMBO J (2011) 2.09
JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet (2002) 2.07
Mechanism of TrkB-mediated hippocampal long-term potentiation. Neuron (2002) 2.03
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet (2008) 2.00
Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development (2002) 1.99
Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance. Cancer Cell (2013) 1.95
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner. Appl Opt (2009) 1.90
Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF. J Neurosci (2002) 1.88
Loss of function of C9orf72 causes motor deficits in a zebrafish model of amyotrophic lateral sclerosis. Ann Neurol (2013) 1.79
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J (2009) 1.74
Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system. PLoS Biol (2007) 1.72
Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron (2006) 1.71
Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport. Nat Neurosci (2009) 1.70
Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones. EMBO J (2009) 1.68
Parkin mutations are frequent in patients with isolated early-onset parkinsonism. Brain (2003) 1.68
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J Exp Med (2011) 1.62
Signaling from axon guidance receptors. Cold Spring Harb Perspect Biol (2010) 1.62
Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death. J Cell Biol (2004) 1.60
GDNF acts as a chemoattractant to support ephrinA-induced repulsion of limb motor axons. Curr Biol (2010) 1.59
Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells (2007) 1.59
Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development (2006) 1.49
F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. Gastroenterology (2010) 1.49
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol (2007) 1.48
EphA4-dependent axon guidance is mediated by the RacGAP alpha2-chimaerin. Neuron (2007) 1.48
The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo. Cancer Res (2009) 1.47
Molecular mechanisms in successful peripheral regeneration. FEBS J (2005) 1.46
Role of the AP-1 transcription factor c-Jun in developing, adult and injured brain. Prog Neurobiol (2006) 1.45
Echogenicity of the substantia nigra: association with increased iron content and marker for susceptibility to nigrostriatal injury. Arch Neurol (2002) 1.45
Regulation of EphA 4 kinase activity is required for a subset of axon guidance decisions suggesting a key role for receptor clustering in Eph function. Neuron (2005) 1.44
c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. Nature (2011) 1.39
Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nat Neurosci (2008) 1.34
Specific pathophysiological functions of JNK isoforms in the brain. Eur J Neurosci (2005) 1.34
The making of successful axonal regeneration: genes, molecules and signal transduction pathways. Brain Res Rev (2006) 1.32
The links between transcription, beta-catenin/JNK signaling, and carcinogenesis. Mol Cancer Res (2009) 1.32
Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics (2006) 1.32
PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells. Int J Oncol (2011) 1.31
Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases. Int J Cancer (2007) 1.30
Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy. Hum Mol Genet (2006) 1.30
Mistargeting of SH3TC2 away from the recycling endosome causes Charcot-Marie-Tooth disease type 4C. Hum Mol Genet (2009) 1.29
The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression. Gastroenterology (2009) 1.28
Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model. Brain (2012) 1.25
Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS. J Neurosci (2007) 1.25
ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J (2007) 1.25
Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system. PLoS One (2011) 1.24
A crucial role for fibroblast growth factor signaling in embryonic mammary gland development. J Mammary Gland Biol Neoplasia (2004) 1.21
p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination. J Neurosci (2012) 1.20
Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes Dev (2002) 1.20
Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci (2009) 1.20
Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (ApcMin/+) mice. Cancer Res (2004) 1.19
CTGF expression during mouse embryonic development. Cell Tissue Res (2003) 1.18
Novel zinc-based fixative for high quality DNA, RNA and protein analysis. Nucleic Acids Res (2007) 1.18
Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. J Cell Biol (2005) 1.18
Embryonic NANOG activity defines colorectal cancer stem cells and modulates through AP1- and TCF-dependent mechanisms. Stem Cells (2012) 1.16
The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci U S A (2008) 1.15
Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. J Neurosci (2002) 1.15
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target. J Pathol (2012) 1.14
Schwann cells as regulators of nerve development. J Physiol Paris (2001) 1.13