Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers.

PubWeight™: 1.18‹?› | Rank: Top 10%

🔗 View Article (PMID 12386821)

Published in Oncogene on October 24, 2002

Authors

Siu Tsan Yuen1, Tsun Leung Chan, Judy W C Ho, Annie S Y Chan, Lap Ping Chung, Polly W Y Lam, Chun Wah Tse, Andrew H Wyllie, Suet Yi Leung

Author Affiliations

1: Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.

Articles citing this

ColoSeq provides comprehensive lynch and polyposis syndrome mutational analysis using massively parallel sequencing. J Mol Diagn (2012) 1.99

Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Mol Cancer (2003) 1.73

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. EMBO Mol Med (2009) 1.49

Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications. Histopathology (2010) 1.46

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. Nat Med (2011) 1.34

Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers. Cancer Res (2010) 1.14

Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E. J Virol (2005) 1.04

Ultradeep sequencing of a human ultraconserved region reveals somatic and constitutional genomic instability. PLoS Biol (2010) 0.99

MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population. Am J Hum Genet (2004) 0.96

Colorectal cancer in Chinese patients: current and emerging treatment options. Onco Targets Ther (2014) 0.95

Microsatellite instability analysis and/or immunostaining for the diagnosis of hereditary nonpolyposis colorectal cancer? Virchows Arch (2003) 0.93

Effects of calcium and vitamin D on MLH1 and MSH2 expression in rectal mucosa of sporadic colorectal adenoma patients. Cancer Epidemiol Biomarkers Prev (2010) 0.91

Genome-wide copy neutral LOH is infrequent in familial and sporadic microsatellite unstable carcinomas. Fam Cancer (2008) 0.88

Genetic diagnosis strategy of hereditary non-polyposis colorectal cancer. World J Gastroenterol (2009) 0.84

Double frameshift mutations in APC and MSH2 in the same individual. Int J Colorectal Dis (2005) 0.83

Prevalence of pathological germline mutations of hMLH1 and hMSH2 genes in colorectal cancer. PLoS One (2013) 0.82

Novel DNA variants and mutation frequencies of hMLH1 and hMSH2 genes in colorectal cancer in the Northeast China population. PLoS One (2013) 0.82

Assay validation for identification of hereditary nonpolyposis colon cancer-causing mutations in mismatch repair genes MLH1, MSH2, and MSH6. J Mol Diagn (2005) 0.82

Missense mutations of MLH1 and MSH2 genes detected in patients with gastrointestinal cancer are associated with exonic splicing enhancers and silencers. Oncol Lett (2013) 0.81

Multiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis. Yale J Biol Med (2006) 0.79

Partial loss of heterozygosity events at the mutated gene in tumors from MLH1/MSH2 large genomic rearrangement carriers. BMC Cancer (2009) 0.77

Functional analysis in mouse embryonic stem cells reveals wild-type activity for three MSH6 variants found in suspected Lynch syndrome patients. PLoS One (2013) 0.76

Hereditary Colorectal Cancer Syndromes in Hong Kong: a Registry's Perspective. Hered Cancer Clin Pract (2005) 0.75

In Silico Systems Biology Analysis of Variants of Uncertain Significance in Lynch Syndrome Supports the Prioritization of Functional Molecular Validation. Cancer Prev Res (Phila) (2017) 0.75

Articles by these authors

Mutations of the BRAF gene in human cancer. Nature (2002) 65.42

Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41

MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA (2008) 12.26

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21

Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA (2004) 6.96

Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet (2011) 6.77

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. Nat Genet (2008) 6.26

Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet (2011) 5.68

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. Nat Genet (2008) 4.44

Physical activity for cancer survivors: meta-analysis of randomised controlled trials. BMJ (2012) 4.19

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. Nat Genet (2006) 3.89

Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med (2008) 3.76

Recurrent KRAS codon 146 mutations in human colorectal cancer. Cancer Biol Ther (2006) 3.56

Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res (2006) 3.40

Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20

PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proc Natl Acad Sci U S A (2010) 2.91

Variation in gene expression patterns in human gastric cancers. Mol Biol Cell (2003) 2.39

Mutations of PIK3CA in gastric adenocarcinoma. BMC Cancer (2005) 2.06

Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci U S A (2002) 1.81

Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer. Mol Biol Cell (2007) 1.69

Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. Clin Cancer Res (2009) 1.67

Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Clin Cancer Res (2008) 1.64

Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy. J Gastrointest Surg (2007) 1.53

Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors. Dis Colon Rectum (2006) 1.49

Outcome of anterior resection for stage II rectal cancer without radiation: the role of adjuvant chemotherapy. Dis Colon Rectum (2005) 1.48

Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. Gut (2010) 1.44

Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer. Hum Mol Genet (2008) 1.40

Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology (2010) 1.38

Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene (2004) 1.30

Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours. Carcinogenesis (2005) 1.30

Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer: a case-matched study. J Gastrointest Surg (2006) 1.27

Diverse proteomic alterations in gastric adenocarcinoma. Proteomics (2004) 1.24

A gene expression signature of genetic instability in colon cancer. Cancer Res (2005) 1.23

Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology (2004) 1.23

Topological and functional discovery in a gene coexpression meta-network of gastric cancer. Cancer Res (2006) 1.22

Epigenetic inactivation of the miR-124-1 in haematological malignancies. PLoS One (2011) 1.22

Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology (2006) 1.20

Prognostic relevance of DNA copy number changes in colorectal cancer. J Pathol (2010) 1.14

Laparoscopic and open anterior resection for upper and mid rectal cancer: an evaluation of outcomes. Dis Colon Rectum (2006) 1.13

High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines. Cancer Lett (2006) 1.13

Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains. Eur J Immunol (2005) 1.12

Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines. Oncogene (2002) 1.11

Quantification of plasma beta-catenin mRNA in colorectal cancer and adenoma patients. Clin Cancer Res (2004) 1.10

Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. Oncogene (2003) 1.09

Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer. PLoS One (2012) 1.08

Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays. Nucleic Acids Res (2005) 1.07

Evidence for an age-related influence of microsatellite instability on colorectal cancer survival. Int J Cancer (2002) 1.03

Epigenetic inactivation of the hsa-miR-203 in haematological malignancies. J Cell Mol Med (2011) 1.03

Hopefulness predicts resilience after hereditary colorectal cancer genetic testing: a prospective outcome trajectories study. BMC Cancer (2010) 1.03

Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Lancet Oncol (2012) 1.01

Comparison of mRNA splicing assay protocols across multiple laboratories: recommendations for best practice in standardized clinical testing. Clin Chem (2013) 1.01

EFA6A enhances glioma cell invasion through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling. Cancer Res (2006) 1.01

MMASS: an optimized array-based method for assessing CpG island methylation. Nucleic Acids Res (2006) 1.00

Decisional consideration of hereditary colon cancer genetic test results among Hong Kong chinese adults. Cancer Epidemiol Biomarkers Prev (2003) 0.99

Acinar cell cystadenoma of the pancreas: a new entity? Am J Surg Pathol (2002) 0.97

Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. Gastroenterology (2009) 0.96

Mutations of BRAF and KRAS in gastric cancer and their association with microsatellite instability. Int J Cancer (2004) 0.96

MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population. Am J Hum Genet (2004) 0.96

Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci (2011) 0.95

Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. Chin J Dig Dis (2006) 0.91

Primary hepatolithiasis, recurrent pyogenic cholangitis, and oriental cholangiohepatitis: a tale of 3 countries. Adv Anat Pathol (2011) 0.90

Inflammatory pseudotumor-like follicular dendritic cell tumor of liver and spleen: granulomatous and eosinophil-rich variants mimicking inflammatory or infective lesions. Am J Surg Pathol (2014) 0.88

Primary adenocarcinomas of the lung in nonsmokers show a distinct pattern of allelic imbalance. Cancer Res (2002) 0.88

Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer. Gut (2007) 0.87

Bowel preparation for colonoscopy: a randomized controlled trial comparing polyethylene glycol solution, one dose and two doses of oral sodium phosphate solution. Asian J Surg (2004) 0.86

Stress responses of PML nuclear domains are ablated by ataxin-1 and other nucleoprotein inclusions. J Pathol (2004) 0.86

Elucidating the prognostic significance of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese patients with metastatic colorectal cancer. Asia Pac J Clin Oncol (2015) 0.82

Antralization at the edge of proximal gastric ulcers: does Helicobacter pylori infection play a role? World J Gastroenterol (2003) 0.80

A comprehensive training programme for nurse endoscopist performing flexible sigmoidoscopy in Hong Kong. J Clin Nurs (2010) 0.79

Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background. Oncogene (2002) 0.78

Disorientation and reconstruction:the meaning searching pathways of patients with colorectal cancer. J Psychosoc Oncol (2007) 0.77

A 33-year-old Chinese woman with a left frontal tumor. Brain Pathol (2009) 0.77

[13C]-urea breath test without prior fasting and without test meal is accurate for the detection of Helicobacter pylori infection in Chinese. J Gastroenterol Hepatol (2002) 0.75

Nuclear phospholipase C gamma: punctate distribution and association with the promyelocytic leukemia protein. J Proteome Res (2007) 0.75

Treatment of Gastric Metaplasia or Dysplasia by Endoscopic Radiofrequency Ablation: A Pilot Study. Hepatogastroenterology (2015) 0.75

De novo sarcoma of donor origin in a liver allograft determined by microsatellite analysis: a short report. Liver Transpl (2004) 0.75