Published in Gastroenterology on June 11, 2010
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature (2010) 5.81
Mesenchymal cells of the intestinal lamina propria. Annu Rev Physiol (2011) 2.18
Stromal response to Hedgehog signaling restrains pancreatic cancer progression. Proc Natl Acad Sci U S A (2014) 1.89
Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer. J Pathol (2013) 1.71
Regulation of self-renewal and differentiation by the intestinal stem cell niche. Cell Mol Life Sci (2011) 1.56
An in vivo model of human small intestine using pluripotent stem cells. Nat Med (2014) 1.42
Intestinal myofibroblasts: targets for stem cell therapy. Am J Physiol Gastrointest Liver Physiol (2011) 1.33
Intestinal mesenchymal cells. Curr Gastroenterol Rep (2010) 1.05
Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol (2011) 1.01
Regenerative inflammation: lessons from Drosophila intestinal epithelium in health and disease. Pathogens (2013) 0.96
Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells. Infect Immun (2015) 0.92
LKB1 signaling in advancing cell differentiation. Fam Cancer (2011) 0.85
Paneth cells expand from newly created and preexisting cells during repair after doxorubicin-induced damage. Am J Physiol Gastrointest Liver Physiol (2013) 0.85
Major signaling pathways in intestinal stem cells. Biochim Biophys Acta (2012) 0.83
Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem (2013) 0.83
The Hippo pathway in intestinal regeneration and disease. Nat Rev Gastroenterol Hepatol (2016) 0.82
Foxf2: a mesenchymal regulator of intestinal adenoma development. Gastroenterology (2013) 0.81
IGF1 stimulates crypt expansion via differential activation of 2 intestinal stem cell populations. FASEB J (2015) 0.80
Expression of Indian hedgehog is negatively correlated with APC gene mutation in colorectal tumors. Int J Clin Exp Med (2014) 0.79
Lysozyme-rich mucus metaplasia in duodenal crypts supersedes Paneth cells in celiac disease. Virchows Arch (2011) 0.79
Mesenchymal-epithelial interactions during digestive tract development and epithelial stem cell regeneration. Cell Mol Life Sci (2015) 0.78
Mechanisms of intestinal adaptation. Best Pract Res Clin Gastroenterol (2016) 0.77
Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. PLoS One (2014) 0.77
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. Nat Commun (2016) 0.77
Hedgehog signalling is downregulated in celiac disease. Can J Gastroenterol (2013) 0.77
Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis. Dev Biol (2014) 0.76
Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. Cell Discov (2015) 0.76
Requirement of Gαq/Gα11 Signaling in the Preservation of Mouse Intestinal Epithelial Homeostasis. Cell Mol Gastroenterol Hepatol (2016) 0.76
Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation. PLoS One (2015) 0.75
Control of inflammation by stromal Hedgehog pathway activation restrains colitis. Proc Natl Acad Sci U S A (2016) 0.75
Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1. Dev Biol (2015) 0.75
Stem Cells in Functional Bladder Engineering. Transfus Med Hemother (2016) 0.75
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet (2008) 10.22
A paracrine requirement for hedgehog signalling in cancer. Nature (2008) 8.16
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet (2004) 7.37
Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08
Hedgehog signaling in development and cancer. Dev Cell (2008) 6.60
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferation. Development (2001) 4.89
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (2004) 4.39
The intestinal stem cell. Genes Dev (2008) 4.21
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A (2007) 4.15
Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (2000) 3.77
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20
Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development (2004) 2.62
Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet (2004) 2.59
Effects of forced expression of an NH2-terminal truncated beta-Catenin on mouse intestinal epithelial homeostasis. J Cell Biol (1998) 2.36
Hedgehog signaling in development and homeostasis of the gastrointestinal tract. Physiol Rev (2007) 2.02
PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology (2006) 2.01
Epithelial cells and their neighbors I. Role of intestinal myofibroblasts in development, repair, and cancer. Am J Physiol Gastrointest Liver Physiol (2005) 1.77
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology (2009) 1.76
Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation. J Pathol (2005) 1.57
The stem cell niche. J Pathol (2009) 1.50
Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int J Cancer (2004) 1.41
Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology (2010) 1.17
Depletion of the colonic epithelial precursor cell compartment upon conditional activation of the hedgehog pathway. Gastroenterology (2009) 1.10
The Hedgehog pathway as a drug target in cancer therapy. Curr Opin Investig Drugs (2007) 1.04
Hedgehog signaling pathway is inactive in colorectal cancer cell lines. Int J Cancer (2007) 1.02
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32
Wnt signalling in stem cells and cancer. Nature (2005) 19.26
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature (2009) 19.18
The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell (2002) 13.92
MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA (2008) 12.26
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell (2010) 12.23
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature (2010) 10.60
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol (2002) 8.60
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell (2002) 8.08
Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta (2003) 7.85
Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol (2011) 7.84
Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell (2005) 7.64
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Coexistence of quiescent and active adult stem cells in mammals. Science (2010) 7.54
Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol (2009) 7.29
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro. Cell Stem Cell (2010) 7.25
Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell (2009) 7.08
FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol (2005) 7.02
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA (2004) 6.96
The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44. Nat Med (2011) 6.85
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science (2012) 6.55
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev (2003) 6.27
BMP4 initiates human embryonic stem cell differentiation to trophoblast. Nat Biotechnol (2002) 6.20
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature (2011) 6.09
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet (2011) 5.68
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev (2004) 5.66
Self-renewal and cancer of the gut: two sides of a coin. Science (2005) 5.44
Myc deletion rescues Apc deficiency in the small intestine. Nature (2007) 5.42
Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov (2006) 5.29
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
dbCAN: a web resource for automated carbohydrate-active enzyme annotation. Nucleic Acids Res (2012) 4.91
The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell (2011) 4.79
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors. Proc Natl Acad Sci U S A (2003) 4.67
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties. Cell (2012) 4.58
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
The Intestinal Wnt/TCF Signature. Gastroenterology (2006) 4.48
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. Nat Genet (2008) 4.44
Wnt signaling controls the phosphorylation status of beta-catenin. J Biol Chem (2002) 4.40
De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science (2004) 4.39
Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol (2005) 4.34
Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev (2005) 4.27
The intestinal stem cell. Genes Dev (2008) 4.21
SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology (2007) 4.17
Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine. Gastroenterology (2009) 4.16
Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology (2005) 4.09
Signaling pathways in intestinal development and cancer. Annu Rev Cell Dev Biol (2004) 4.00
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell (2013) 3.97
Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. Nat Genet (2006) 3.89
The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol (2004) 3.84
Transcriptome profile of human colorectal adenomas. Mol Cancer Res (2007) 3.82
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab (2012) 3.81
Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell (2012) 3.77
Directed neural differentiation of human embryonic stem cells via an obligated primitive anterior stage. Stem Cells (2007) 3.71
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J (2012) 3.70
Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue. Cell Stem Cell (2010) 3.65
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol (2011) 3.60
Multigait soft robot. Proc Natl Acad Sci U S A (2011) 3.57
Recurrent KRAS codon 146 mutations in human colorectal cancer. Cancer Biol Ther (2006) 3.56
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications. Science (2013) 3.43
OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells. Gastroenterology (2009) 3.39
Strategies for homeostatic stem cell self-renewal in adult tissues. Cell (2011) 3.33
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. Nat Cell Biol (2012) 3.30
SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol (2004) 3.24
Isolation and in vitro expansion of human colonic stem cells. Nat Med (2011) 3.20
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature (2011) 3.19
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat Neurosci (2009) 3.18