Published in Nat Genet on September 03, 2006
A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33
Microsatellite instability in colorectal cancer. Gastroenterology (2010) 7.39
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. Nat Genet (2008) 4.44
Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet (2011) 3.73
Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nat Rev Genet (2012) 2.93
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev (2007) 2.34
Environmental epigenetics. Heredity (Edinb) (2010) 1.99
Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study. Lancet Oncol (2010) 1.98
Allele-specific chromatin immunoprecipitation studies show genetic influence on chromatin state in human genome. PLoS Genet (2007) 1.71
The future of epigenetic therapy in solid tumours--lessons from the past. Nat Rev Clin Oncol (2013) 1.70
Mismatch repair deficient colorectal cancer in the era of personalized treatment. Nat Rev Clin Oncol (2010) 1.62
Epigenetics of colorectal cancer. Gastroenterology (2012) 1.60
The case for transgenerational epigenetic inheritance in humans. Mamm Genome (2008) 1.54
An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet (2008) 1.49
Epigenome mapping in normal and disease States. Circ Res (2010) 1.47
Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Hum Genet (2012) 1.47
Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS One (2010) 1.40
Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2009) 1.39
CANDID: a flexible method for prioritizing candidate genes for complex human traits. Genet Epidemiol (2008) 1.36
Epigenetics and colorectal cancer pathogenesis. Cancers (Basel) (2013) 1.33
BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype. Breast Cancer Res (2008) 1.30
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer. Br J Cancer (2007) 1.16
Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer. World J Gastroenterol (2014) 1.16
Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers. Cancer Res (2010) 1.14
Human placental-specific epipolymorphism and its association with adverse pregnancy outcomes. PLoS One (2009) 1.14
Recent insights into the pathogenesis of colorectal cancer. Curr Opin Gastroenterol (2010) 1.13
Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer. Hum Mol Genet (2009) 1.13
Evidence for transgenerational transmission of epigenetic tumor susceptibility in Drosophila. PLoS Genet (2007) 1.12
LINE-1 methylation is inherited in familial testicular cancer kindreds. BMC Med Genet (2010) 1.11
Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in Drosophila. Curr Genomics (2008) 1.09
The A/G allele of rs16906252 predicts for MGMT methylation and is selectively silenced in premalignant lesions from smokers and in lung adenocarcinomas. Clin Cancer Res (2011) 1.09
Scrutinizing the epigenetics revolution. Biosocieties (2014) 1.08
Heritable germline epimutation is not the same as transgenerational epigenetic inheritance. Nat Genet (2007) 1.04
Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases. J Mol Diagn (2010) 1.04
Germline deletions in the EPCAM gene as a cause of Lynch syndrome - literature review. Hered Cancer Clin Pract (2013) 1.02
Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry. Genet Med (2012) 0.99
A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Cancer Prev Res (Phila) (2009) 0.96
EPCAM deletion carriers constitute a unique subgroup of Lynch syndrome patients. Fam Cancer (2013) 0.95
Genome-wide epigenetic modifications in cancer. Prog Drug Res (2011) 0.93
Differential Features of Microsatellite-Unstable Colorectal Carcinomas Depending on EPCAM Expression Status. Korean J Pathol (2014) 0.93
Constitutional epimutation as a mechanism for cancer causality and heritability? Nat Rev Cancer (2015) 0.92
Antifungal drug resistance evoked via RNAi-dependent epimutations. Nature (2014) 0.92
Natural single-nucleosome epi-polymorphisms in yeast. PLoS Genet (2010) 0.91
Hybrid vigor and transgenerational epigenetic effects on early mouse embryo phenotype. Biol Reprod (2008) 0.91
EPCAM germ line deletions as causes of Lynch syndrome in Spanish patients. J Mol Diagn (2010) 0.90
Application of molecular diagnostics for the detection of Lynch syndrome. Expert Rev Mol Diagn (2010) 0.89
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer. Eur J Hum Genet (2014) 0.89
Methylation of cancer related genes in tumor and peripheral blood DNA from the same breast cancer patient as two independent events. Diagn Pathol (2011) 0.89
Performance of clinical guidelines compared with molecular tumour screening methods in identifying possible Lynch syndrome among colorectal cancer patients: a Norwegian population-based study. Br J Cancer (2010) 0.88
Detection of allelic imbalance in MLH1 expression by pyrosequencing serves as a tool for the identification of germline defects in Lynch syndrome. Fam Cancer (2010) 0.87
Endometrial tumour BRAF mutations and MLH1 promoter methylation as predictors of germline mismatch repair gene mutation status: a literature review. Fam Cancer (2014) 0.87
Inherited epimutation or a haplotypic basis for the propensity to silence? Nat Genet (2007) 0.87
Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer. Hum Mol Genet (2012) 0.86
Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics. Biochem Res Int (2012) 0.86
Differential MSH2 promoter methylation in blood cells of Neurofibromatosis type 1 (NF1) patients. Eur J Hum Genet (2010) 0.85
Genomic instability and carcinogenesis: an update. Curr Genomics (2008) 0.84
Promoter methylation of candidate genes associated with familial testicular cancer. Int J Mol Epidemiol Genet (2012) 0.83
Epimutation and cancer: a new carcinogenic mechanism of Lynch syndrome (Review). Int J Oncol (2012) 0.83
Germline allele-specific expression of DAPK1 in chronic lymphocytic leukemia. PLoS One (2013) 0.83
Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients. Mol Cancer (2009) 0.82
Coevolution between simple sequence repeats (SSRs) and virus genome size. BMC Genomics (2012) 0.82
Heritable germline epimutations in humans. Nat Genet (2007) 0.82
A seven-gene CpG-island methylation panel predicts breast cancer progression. BMC Cancer (2015) 0.82
The clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancer. Oncotarget (2016) 0.81
Allele-specific gene expression and epigenetic modifications and their application to understanding inheritance and cancer. Biochim Biophys Acta (2012) 0.80
Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer. World J Gastrointest Oncol (2016) 0.80
Colorectal cancer carcinogenesis: a review of mechanisms. Cancer Biol Med (2016) 0.80
Application of DNA methylation biomarkers for endometrial cancer management. Expert Rev Mol Diagn (2008) 0.79
The role of epigenetics in Lynch syndrome. Fam Cancer (2013) 0.79
Constitutional promoter methylation and risk of familial melanoma. Epigenetics (2014) 0.78
Integrative analysis of hereditary nonpolyposis colorectal cancer: the contribution of allele-specific expression and other assays to diagnostic algorithms. PLoS One (2013) 0.77
Gene regulation in the vascular endothelium: why epigenetics is important for the kidney. Semin Nephrol (2012) 0.77
Normal epigenetic inheritance in mice conceived by in vitro fertilization and embryo transfer. J Zhejiang Univ Sci B (2011) 0.76
CAF-like state in primary skin fibroblasts with constitutional BRCA1 epimutation sheds new light on tumor suppressor deficiency-related changes in healthy tissue. Epigenetics (2016) 0.75
Methylation Analysis of DNA Mismatch Repair Genes Using DNA Derived from the Peripheral Blood of Patients with Endometrial Cancer: Epimutation in Endometrial Carcinogenesis. Genes (Basel) (2016) 0.75
Epigenetic remodelling and dysregulation of DLGAP4 is linked with early-onset cerebellar ataxia. Hum Mol Genet (2014) 0.75
High risk of endometrial cancer in colorectal cancer kindred is pathognomonic for MMR-mutation carriers. Fam Cancer (2008) 0.75
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA (2008) 12.26
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA (2004) 6.96
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature (2011) 6.09
Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat Genet (2011) 5.68
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1. Nat Genet (2008) 4.44
Recurrent KRAS codon 146 mutations in human colorectal cancer. Cancer Biol Ther (2006) 3.56
Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc Natl Acad Sci U S A (2007) 3.20
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell (2012) 2.45
Variation in gene expression patterns in human gastric cancers. Mol Biol Cell (2003) 2.39
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J (2013) 2.24
Mutations of PIK3CA in gastric adenocarcinoma. BMC Cancer (2005) 2.06
Outcomes and prognostic factors in 267 patients with severe acute respiratory syndrome in Hong Kong. Ann Intern Med (2003) 1.94
The leukemia-associated Mllt10/Af10-Dot1l are Tcf4/β-catenin coactivators essential for intestinal homeostasis. PLoS Biol (2010) 1.81
Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proc Natl Acad Sci U S A (2002) 1.81
Parallels between global transcriptional programs of polarizing Caco-2 intestinal epithelial cells in vitro and gene expression programs in normal colon and colon cancer. Mol Biol Cell (2007) 1.69
Association of inflammation-related and microRNA gene expression with cancer-specific mortality of colon adenocarcinoma. Clin Cancer Res (2009) 1.67
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma. Clin Cancer Res (2008) 1.64
Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma. Head Neck (2009) 1.49
Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development. Gastroenterology (2010) 1.38
Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles. Oncogene (2004) 1.30
Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours. Carcinogenesis (2005) 1.30
The kinase TNIK is an essential activator of Wnt target genes. EMBO J (2009) 1.26
Diverse proteomic alterations in gastric adenocarcinoma. Proteomics (2004) 1.24
A gene expression signature of genetic instability in colon cancer. Cancer Res (2005) 1.23
Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer. Gastroenterology (2004) 1.23
Topological and functional discovery in a gene coexpression meta-network of gastric cancer. Cancer Res (2006) 1.22
Systemic infection of avian influenza A virus H5N1 subtype in humans. Hum Pathol (2009) 1.21
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts". Mol Cell Biol (2012) 1.21
Correlation between the single-site CpG methylation and expression silencing of the XAF1 gene in human gastric and colon cancers. Gastroenterology (2006) 1.20
Germline, somatic and epigenetic events underlying mismatch repair deficiency in colorectal and HNPCC-related cancers. Oncogene (2002) 1.18
Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains. Eur J Immunol (2005) 1.12
Comprehensive analysis of the gene expression profiles in human gastric cancer cell lines. Oncogene (2002) 1.11
Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. Oncogene (2003) 1.09
Integration of DNA copy number alterations and transcriptional expression analysis in human gastric cancer. PLoS One (2012) 1.08
The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One (2011) 1.03
EFA6A enhances glioma cell invasion through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling. Cancer Res (2006) 1.01
Gastrointestinal stromal tumors in a cohort of Chinese patients in Hong Kong. World J Gastroenterol (2006) 1.00
Mutations of BRAF and KRAS in gastric cancer and their association with microsatellite instability. Int J Cancer (2004) 0.96
Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms. Gastroenterology (2009) 0.96
MSH2 c.1452-1455delAATG is a founder mutation and an important cause of hereditary nonpolyposis colorectal cancer in the southern Chinese population. Am J Hum Genet (2004) 0.96
Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis. J Biol Chem (2008) 0.94
Direct sequencing of SARS-coronavirus S and N genes from clinical specimens shows limited variation. J Infect Dis (2004) 0.92
Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with hereditary non-polyposis colorectal cancer. Chin J Dig Dis (2006) 0.91
MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway. Biol Chem (2010) 0.90
Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer. Gut (2007) 0.87
Comprehensive analysis of 19q12 amplicon in human gastric cancers. Mod Pathol (2006) 0.82
Myopathic changes associated with severe acute respiratory syndrome: a postmortem case series. Arch Neurol (2005) 0.82
Another patient with pulmonary hypoplasia, microphthalmia and diaphragmatic hernia. Clin Dysmorphol (2006) 0.81
Antralization at the edge of proximal gastric ulcers: does Helicobacter pylori infection play a role? World J Gastroenterol (2003) 0.80
A 33-year-old Chinese woman with a left frontal tumor. Brain Pathol (2009) 0.77