PubRank

Peter B Dervan

Author PubWeight™ 104.88‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A 2006 2.97
2 Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist. Proc Natl Acad Sci U S A 2004 2.25
3 Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide. Proc Natl Acad Sci U S A 2007 2.04
4 Arresting cancer proliferation by small-molecule gene regulation. Chem Biol 2004 1.90
5 Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates. Nucleic Acids Res 2004 1.84
6 Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface. ACS Chem Biol 2007 1.84
7 Accessibility of nuclear chromatin by DNA binding polyamides. Chem Biol 2003 1.81
8 Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture. Proc Natl Acad Sci U S A 2003 1.80
9 DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia. Proc Natl Acad Sci U S A 2006 1.70
10 Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors. J Infect Dis 2004 1.64
11 Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands. J Mol Biol 2003 1.63
12 Allosteric modulation of DNA by small molecules. Proc Natl Acad Sci U S A 2009 1.61
13 Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron 2007 1.58
14 Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res 2006 1.55
15 Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorg Med Chem 2002 1.52
16 Solid-phase synthesis of DNA binding polyamides on oxime resin. Bioorg Med Chem 2002 1.45
17 Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression. Proc Natl Acad Sci U S A 2009 1.38
18 Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders. Proc Natl Acad Sci U S A 2011 1.36
19 Quantitative microarray profiling of DNA-binding molecules. J Am Chem Soc 2007 1.30
20 Molecular recognition of the nucleosomal "supergroove". Proc Natl Acad Sci U S A 2004 1.25
21 Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides. J Virol 2002 1.24
22 Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit. J Am Chem Soc 2008 1.23
23 Cyclic pyrrole-imidazole polyamides targeted to the androgen response element. J Am Chem Soc 2009 1.21
24 Structural basis for cyclic Py-Im polyamide allosteric inhibition of nuclear receptor binding. J Am Chem Soc 2010 1.15
25 Antitumor activity of a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A 2013 1.13
26 Sequence specific fluorescence detection of double strand DNA. J Am Chem Soc 2003 1.11
27 Blocking transcription through a nucleosome with synthetic DNA ligands. J Mol Biol 2002 1.11
28 Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues. Bioorg Med Chem 2003 1.10
29 Small molecule transcription factor mimic. J Am Chem Soc 2004 1.10
30 Design of artificial transcriptional activators with rigid poly-L-proline linkers. J Am Chem Soc 2002 1.09
31 Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells. J Biol Chem 2012 1.09
32 Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells. Bioorg Med Chem Lett 2008 1.08
33 In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography. Proc Natl Acad Sci U S A 2008 1.07
34 DNA-templated dimerization of hairpin polyamides. J Am Chem Soc 2003 1.07
35 Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly. ACS Chem Biol 2008 1.06
36 Programmable oligomers for minor groove DNA recognition. J Am Chem Soc 2006 1.06
37 Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide. Proc Natl Acad Sci U S A 2012 1.04
38 Pharmacokinetics of Py-Im polyamides depend on architecture: cyclic versus linear. J Am Chem Soc 2012 1.03
39 Toward artificial developmental regulators. J Am Chem Soc 2003 1.02
40 Addressing single molecules on DNA nanostructures. Angew Chem Int Ed Engl 2007 1.02
41 Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates. J Am Chem Soc 2005 1.02
42 Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif. J Mol Biol 2002 1.01
43 DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate. Nucleic Acids Res 2003 1.01
44 Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. J Am Chem Soc 2003 1.01
45 NMR structure of a cyclic polyamide-DNA complex. J Am Chem Soc 2004 0.99
46 Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A 2013 0.98
47 Nucleosomes in solution exist as a mixture of twist-defect states. J Mol Biol 2005 0.98
48 Microwave assisted synthesis of Py-Im polyamides. Org Lett 2012 0.98
49 Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing. J Am Chem Soc 2012 0.97
50 Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides. Biochemistry 2002 0.97
51 Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemother Pharmacol 2012 0.97
52 Minimization of a protein-DNA dimerizer. J Am Chem Soc 2007 0.97
53 Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates. J Am Chem Soc 2003 0.96
54 Design of a sequence-specific DNA bisintercalator. Angew Chem Int Ed Engl 2004 0.96
55 Characterization and solubilization of pyrrole-imidazole polyamide aggregates. J Med Chem 2012 0.96
56 Promoter scanning for transcription inhibition with DNA-binding polyamides. Mol Cell Biol 2002 0.96
57 Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands. Biochemistry 2004 0.96
58 Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates. Nucleic Acids Res 2006 0.94
59 A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle 2006 0.94
60 Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns. Nucleic Acids Res 2011 0.93
61 Fluorescent sequence-specific dsDNA binding oligomers. J Am Chem Soc 2007 0.93
62 Alpha-diaminobutyric acid-linked hairpin polyamides. Bioorg Med Chem 2007 0.92
63 Temperature-sensitive protein-DNA dimerizers. Proc Natl Acad Sci U S A 2005 0.92
64 Activity of a Py-Im polyamide targeted to the estrogen response element. Mol Cancer Ther 2013 0.92
65 Programming multiple protein patterns on a single DNA nanostructure. J Am Chem Soc 2008 0.91
66 Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry 2011 0.91
67 Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia. Mol Cancer Ther 2008 0.91
68 Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides. Biochemistry 2005 0.91
69 Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition. Bioorg Med Chem 2006 0.91
70 Recognition of "mirror-image" DNA by small molecules. Angew Chem Int Ed Engl 2007 0.90
71 Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site. Bioorg Med Chem 2006 0.90
72 Recognition of ten base pairs of DNA by head-to-head hairpin dimers. J Am Chem Soc 2002 0.90
73 U-pin polyamide motif for recognition of the DNA minor groove. Chemistry 2003 0.89
74 Solution-phase synthesis of pyrrole-imidazole polyamides. J Am Chem Soc 2009 0.89
75 Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray. Biophys J 2009 0.87
76 Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate. J Biol Chem 2002 0.87
77 Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition. J Am Chem Soc 2004 0.86
78 Analysis of hairpin polyamide complexes having DNA binding sites in close proximity. J Am Chem Soc 2002 0.85
79 Alternative heterocycles for DNA recognition: the benzimidazole/imidazole pair. Chemistry 2003 0.85
80 Search for the optimal linker in tandem hairpin polyamides. Bioorg Med Chem 2002 0.85
81 Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture. J Med Chem 2009 0.85
82 Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition. J Am Chem Soc 2014 0.84
83 Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA. Angew Chem Int Ed Engl 2012 0.84
84 Synthesis of cyclic Py-Im polyamide libraries. J Org Chem 2012 0.84
85 Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit. J Med Chem 2013 0.83
86 DNA sequence selectivity of hairpin polyamide turn units. Bioorg Med Chem Lett 2009 0.82
87 Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells. Bioorg Med Chem Lett 2012 0.82
88 The reach of linear protein-DNA dimerizers. J Am Chem Soc 2007 0.82
89 Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA. Org Lett 2011 0.82
90 Parallel synthesis of H-pin polyamides by alkene metathesis on solid phase. J Am Chem Soc 2003 0.80
91 Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences. Biochemistry 2003 0.80
92 DNA damage effects of a polyamide-CBI conjugate in SV40 virions. Mol Pharmacol 2004 0.77
93 Oligomerization route to Py-Im polyamide macrocycles. Org Lett 2009 0.77
94 Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted. J Med Chem 2014 0.76
95 DNA minor-groove recognition by 3-methylthiophene/pyrrole pair. Chem Biodivers 2004 0.75
96 Paradoxical effects of DNA binding polyamides on HTLV-1 transcription. Front Biosci 2004 0.75