Published in Curr Biol on October 29, 2002
Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol Biol Cell (2003) 3.30
The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol (2004) 2.69
TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly. Mol Biol Cell (2004) 2.65
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51
Dynein/dynactin regulate metaphase spindle length by targeting depolymerizing activities to spindle poles. J Cell Biol (2004) 2.46
Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function. Mol Biol Cell (2007) 1.66
Deciphering protein function during mitosis in PtK cells using RNAi. BMC Cell Biol (2006) 1.49
The Drosophila kinesin-like protein KLP67A is essential for mitotic and male meiotic spindle assembly. Mol Biol Cell (2003) 1.44
Interdependency of fission yeast Alp14/TOG and coiled coil protein Alp7 in microtubule localization and bipolar spindle formation. Mol Biol Cell (2004) 1.25
Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules. Semin Cell Dev Biol (2010) 1.25
The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly. Mol Biol Cell (2006) 1.21
Full-length dimeric MCAK is a more efficient microtubule depolymerase than minimal domain monomeric MCAK. Mol Biol Cell (2005) 1.18
Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association. Curr Biol (2013) 1.14
Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1. Mol Cell Biol (2010) 1.13
Aurora B suppresses microtubule dynamics and limits central spindle size by locally activating KIF4A. J Cell Biol (2013) 1.13
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target. Oncotarget (2011) 1.13
How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays. Semin Cell Dev Biol (2010) 1.10
MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment. J Cell Biol (2012) 1.07
Regulation of KinI kinesin ATPase activity by binding to the microtubule lattice. J Cell Biol (2003) 1.00
CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation. EMBO J (2005) 0.99
A new model for binding of kinesin 13 to curved microtubule protofilaments. J Cell Biol (2009) 0.98
Xenopus Shugoshin 2 regulates the spindle assembly pathway mediated by the chromosomal passenger complex. EMBO J (2012) 0.95
GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK. J Cell Biol (2016) 0.90
The expanded Kinesin-13 repertoire of trypanosomes contains only one mitotic Kinesin indicating multiple extra-nuclear roles. PLoS One (2010) 0.89
A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain. PLoS Genet (2006) 0.89
Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach. Protein Sci (2013) 0.88
The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. Mol Biol Cell (2012) 0.88
The molecular basis for kinesin functional specificity during mitosis. Cytoskeleton (Hoboken) (2013) 0.84
Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization. Structure (2014) 0.84
KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly. J Cell Biol (2015) 0.79
The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans. PLoS One (2015) 0.78
The far C-terminus of MCAK regulates its conformation and spindle pole focusing. Mol Biol Cell (2016) 0.77
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (2003) 12.41
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A (2008) 10.09
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell (2006) 8.44
Molecular architecture of the kinetochore-microtubule interface. Nat Rev Mol Cell Biol (2008) 8.21
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev (2004) 5.23
The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. Nat Cell Biol (2006) 4.89
Self- and actin-templated assembly of Mammalian septins. Dev Cell (2002) 4.48
A standardized kinesin nomenclature. J Cell Biol (2004) 4.43
Reassembly of contractile actin cortex in cell blebs. J Cell Biol (2006) 4.31
Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science (2002) 4.27
Animal cytokinesis: from parts list to mechanisms. Annu Rev Biochem (2006) 4.23
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr Biol (2004) 4.20
Protein architecture of the human kinetochore microtubule attachment site. Cell (2009) 3.68
Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell (2004) 3.51
A combined approach for the localization and tandem affinity purification of protein complexes from metazoans. Sci STKE (2005) 3.49
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell (2009) 3.44
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell (2013) 3.26
Centriole assembly requires both centriolar and pericentriolar material proteins. Dev Cell (2004) 3.23
The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. J Cell Biol (2006) 3.23
A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans. J Cell Biol (2005) 3.18
Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Poly(ADP-ribose) is required for spindle assembly and structure. Nature (2004) 3.11
Life and times of a cellular bleb. Biophys J (2007) 3.05
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol (2003) 3.01
EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell (2002) 2.92
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
Determining the position of the cell division plane. Nature (2003) 2.80
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol (2005) 2.70
A high-resolution C. elegans essential gene network based on phenotypic profiling of a complex tissue. Cell (2011) 2.64
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51
Structural plasticity in actin and tubulin polymer dynamics. Science (2009) 2.45
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (2011) 2.44
Structural memory in the contractile ring makes the duration of cytokinesis independent of cell size. Cell (2009) 2.42
Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin. J Cell Biol (2007) 2.37
Broad chromosomal domains of histone modification patterns in C. elegans. Genome Res (2010) 2.36
A role for Rab5 in structuring the endoplasmic reticulum. J Cell Biol (2007) 2.34
Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell (2004) 2.33
HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. Genes Dev (2007) 2.32
Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem Biol (2002) 2.28
EB1 targets to kinetochores with attached, polymerizing microtubules. Mol Biol Cell (2002) 2.27
Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol (2002) 2.27
Fibrils connect microtubule tips with kinetochores: a mechanism to couple tubulin dynamics to chromosome motion. Cell (2008) 2.23
KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. Mol Biol Cell (2007) 2.20
Force and length in the mitotic spindle. Curr Biol (2009) 2.11
Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J Cell Biol (2005) 2.11
A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol (2004) 2.08
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol (2006) 2.07
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol (2004) 2.06
Visualization of eukaryotic DNA mismatch repair reveals distinct recognition and repair intermediates. Cell (2011) 2.02
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res (2011) 1.99
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov (2009) 1.95
Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol (2008) 1.95
The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol (2003) 1.94
Evidence for an upper limit to mitotic spindle length. Curr Biol (2008) 1.94
Cell polarization during monopolar cytokinesis. J Cell Biol (2008) 1.92
Small molecule screening by imaging. Curr Opin Chem Biol (2006) 1.90
"Holo"er than thou: chromosome segregation and kinetochore function in C. elegans. Chromosome Res (2004) 1.88
Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature (2006) 1.83
A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown. Dev Cell (2007) 1.81
Kinetochore-microtubule interactions: the means to the end. Curr Opin Cell Biol (2008) 1.80
Slide-and-cluster models for spindle assembly. Curr Biol (2007) 1.79
A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension. Cell (2006) 1.79
Kinetochore-spindle microtubule interactions during mitosis. Curr Opin Cell Biol (2005) 1.77
An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell (2003) 1.76
Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat Cell Biol (2005) 1.76
SAS-4 is recruited to a dynamic structure in newly forming centrioles that is stabilized by the gamma-tubulin-mediated addition of centriolar microtubules. J Cell Biol (2008) 1.74
Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis. Science (2008) 1.74
Anillin and the septins promote asymmetric ingression of the cytokinetic furrow. Dev Cell (2007) 1.74
A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev (2008) 1.73
A model for cleavage plane determination in early amphibian and fish embryos. Curr Biol (2010) 1.72
Nonredundant functions of Kinesin-13s during meiotic spindle assembly. Curr Biol (2007) 1.69
Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Science (2013) 1.68
Removal of Spindly from microtubule-attached kinetochores controls spindle checkpoint silencing in human cells. Genes Dev (2010) 1.66
A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci U S A (2004) 1.64
Direct ribosomal binding by a cellular inhibitor of translation. Nat Struct Mol Biol (2006) 1.64
Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol (2004) 1.62
Distinct roles for two C. elegans anillins in the gonad and early embryo. Development (2005) 1.59
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol (2002) 1.58
XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol (2004) 1.56
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53
Noble metals strip peptides from class II MHC proteins. Nat Chem Biol (2006) 1.53
Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther (2008) 1.53
A two-step mechanism for epigenetic specification of centromere identity and function. Nat Cell Biol (2013) 1.52
Orientation and structure of the Ndc80 complex on the microtubule lattice. J Cell Biol (2008) 1.51
KIF4 regulates midzone length during cytokinesis. Curr Biol (2011) 1.51
Midbody assembly and its regulation during cytokinesis. Mol Biol Cell (2012) 1.50
Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A (2008) 1.50
The minus end in sight. Curr Biol (2003) 1.49
How does a millimeter-sized cell find its center? Cell Cycle (2009) 1.48
A new method reveals microtubule minus ends throughout the meiotic spindle. J Cell Biol (2006) 1.46
Microtubule plus-end dynamics in Xenopus egg extract spindles. Mol Biol Cell (2004) 1.45
Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest. PLoS One (2011) 1.45
Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol (2009) 1.44