Published in Dev Cell on August 01, 2003
The life and miracles of kinetochores. EMBO J (2009) 4.59
Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol (2004) 3.49
Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments. Mol Biol Cell (2003) 3.30
Chromosomal passengers: the four-dimensional regulation of mitotic events. Chromosoma (2004) 2.94
Traffic control: regulation of kinesin motors. Nat Rev Mol Cell Biol (2009) 2.87
The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J Cell Biol (2004) 2.69
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51
Kinetochores use a novel mechanism for coordinating the dynamics of individual microtubules. Curr Biol (2006) 2.05
Merotelic kinetochores in mammalian tissue cells. Philos Trans R Soc Lond B Biol Sci (2005) 1.90
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol (2008) 1.77
Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance. Mol Biol Cell (2006) 1.43
Kinetochore-microtubule interactions: steps towards bi-orientation. EMBO J (2010) 1.30
Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation. PLoS One (2009) 1.27
Basic mechanism of eukaryotic chromosome segregation. Philos Trans R Soc Lond B Biol Sci (2005) 1.26
Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules. Semin Cell Dev Biol (2010) 1.25
PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activity. J Biol Chem (2010) 1.24
Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. Mol Biol Cell (2004) 1.22
TIP150 interacts with and targets MCAK at the microtubule plus ends. EMBO Rep (2009) 1.19
Bi-orienting chromosomes: acrobatics on the mitotic spindle. Chromosoma (2008) 1.19
C-terminus of mitotic centromere-associated kinesin (MCAK) inhibits its lattice-stimulated ATPase activity. Biochem J (2004) 1.19
Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1. Mol Cell Biol (2010) 1.13
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target. Oncotarget (2011) 1.13
Towards a quantitative understanding of mitotic spindle assembly and mechanics. J Cell Sci (2010) 1.10
Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK. Curr Biol (2013) 1.10
Mechanism and function of poleward flux in Xenopus extract meiotic spindles. Philos Trans R Soc Lond B Biol Sci (2005) 1.08
ICIS and Aurora B coregulate the microtubule depolymerase Kif2a. Curr Biol (2009) 1.08
Regulation of localization and activity of the microtubule depolymerase MCAK. Bioarchitecture (2011) 1.01
CaMKIIgamma-mediated inactivation of the Kin I kinesin MCAK is essential for bipolar spindle formation. EMBO J (2005) 0.99
Sequential assembly of centromeric proteins in male mouse meiosis. PLoS Genet (2009) 0.97
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores. Nat Commun (2016) 0.95
RMD-1, a novel microtubule-associated protein, functions in chromosome segregation in Caenorhabditis elegans. J Cell Biol (2007) 0.95
Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction. J Mol Cell Biol (2014) 0.93
Genomic characterization of the human mitochondrial tumor suppressor gene 1 (MTUS1): 5' cloning and preliminary analysis of the multiple gene promoters. BMC Res Notes (2009) 0.92
Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma. Mol Oncol (2011) 0.91
GTSE1 tunes microtubule stability for chromosome alignment and segregation by inhibiting the microtubule depolymerase MCAK. J Cell Biol (2016) 0.90
A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain. PLoS Genet (2006) 0.89
NuSAP modulates the dynamics of kinetochore microtubules by attenuating MCAK depolymerisation activity. Sci Rep (2016) 0.87
The molecular basis for kinesin functional specificity during mitosis. Cytoskeleton (Hoboken) (2013) 0.84
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. Mol Biol Cell (2007) 0.80
Building the Microtubule Cytoskeleton Piece by Piece. J Biol Chem (2015) 0.79
A regulatory effect of INMAP on centromere proteins: antisense INMAP induces CENP-B variation and centromeric halo. PLoS One (2014) 0.77
Heterogeneous architecture of vertebrate kinetochores revealed by three-dimensional superresolution fluorescence microscopy. Mol Biol Cell (2016) 0.76
Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (2003) 12.41
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol (2005) 11.63
A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A (2008) 10.09
Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem (2003) 5.86
A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature (2009) 5.55
Multidimensional drug profiling by automated microscopy. Science (2004) 5.45
Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol Cell (2006) 5.40
ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Mol Cell (2006) 5.01
Self- and actin-templated assembly of Mammalian septins. Dev Cell (2002) 4.48
A standardized kinesin nomenclature. J Cell Biol (2004) 4.43
Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Mol Cell Biol (2004) 4.31
Reassembly of contractile actin cortex in cell blebs. J Cell Biol (2006) 4.31
Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science (2002) 4.27
Animal cytokinesis: from parts list to mechanisms. Annu Rev Biochem (2006) 4.23
HDAC6 modulates cell motility by altering the acetylation level of cortactin. Mol Cell (2007) 3.99
Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Cell (2011) 3.95
Ordered phosphorylation governs oscillation of a three-protein circadian clock. Science (2007) 3.78
Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell (2002) 3.71
Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell (2004) 3.51
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell (2009) 3.44
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain. J Biol Chem (2002) 3.33
Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell (2013) 3.26
HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol (2003) 3.22
Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol (2007) 3.17
Poly(ADP-ribose) is required for spindle assembly and structure. Nature (2004) 3.11
Life and times of a cellular bleb. Biophys J (2007) 3.05
A human protein complex homologous to the Drosophila MSL complex is responsible for the majority of histone H4 acetylation at lysine 16. Mol Cell Biol (2005) 3.04
Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol (2003) 3.01
EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell (2002) 2.92
Determining the position of the cell division plane. Nature (2003) 2.80
A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes. Proc Natl Acad Sci U S A (2002) 2.78
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain. Biochem J (2005) 2.76
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol (2005) 2.70
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell (2004) 2.51
Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (2009) 2.48
Structural plasticity in actin and tubulin polymer dynamics. Science (2009) 2.45
Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (2011) 2.44
SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell (2007) 2.42
Bacterial glycosidases for the production of universal red blood cells. Nat Biotechnol (2007) 2.41
Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell (2004) 2.33
Yeast enhancer of polycomb defines global Esa1-dependent acetylation of chromatin. Genes Dev (2003) 2.30
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage. EMBO J (2005) 2.29
Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem Biol (2002) 2.28
EB1 targets to kinetochores with attached, polymerizing microtubules. Mol Biol Cell (2002) 2.27
Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol (2002) 2.27
Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications. Genes Dev (2006) 2.15
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Force and length in the mitotic spindle. Curr Biol (2009) 2.11
A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol (2004) 2.08
Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A (2004) 2.08
Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol (2006) 2.07
The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol (2004) 2.06
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem (2004) 2.05
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res (2011) 1.99
System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chem Biol (2008) 1.97
Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov (2009) 1.95
Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol (2008) 1.95
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. Genes Dev (2010) 1.95
The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol (2003) 1.94
Evidence for an upper limit to mitotic spindle length. Curr Biol (2008) 1.94
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription. J Biol Chem (2005) 1.93
Cell polarization during monopolar cytokinesis. J Cell Biol (2008) 1.92
Small molecule screening by imaging. Curr Opin Chem Biol (2006) 1.90
Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proc Natl Acad Sci U S A (2003) 1.83
Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature (2006) 1.83
Isolation of human NURF: a regulator of Engrailed gene expression. EMBO J (2003) 1.80
Direct identification of PTEN phosphorylation sites. FEBS Lett (2002) 1.80
Slide-and-cluster models for spindle assembly. Curr Biol (2007) 1.79
Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem (2005) 1.76
Human Elongator facilitates RNA polymerase II transcription through chromatin. Proc Natl Acad Sci U S A (2002) 1.75
A model for cleavage plane determination in early amphibian and fish embryos. Curr Biol (2010) 1.72
Nonredundant functions of Kinesin-13s during meiotic spindle assembly. Curr Biol (2007) 1.69
Inhibition of GLUT4 translocation by Tbc1d1, a Rab GTPase-activating protein abundant in skeletal muscle, is partially relieved by AMP-activated protein kinase activation. J Biol Chem (2008) 1.68
A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes. J Biol Chem (2002) 1.67
A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci U S A (2004) 1.64
Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis. J Cell Biol (2008) 1.64
Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol (2004) 1.62
Somatic acquisition and signaling of TGFBR1*6A in cancer. JAMA (2005) 1.59
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol (2002) 1.58
Functional analysis of the subunits of the chromatin assembly factor RSF. Mol Cell Biol (2003) 1.56
ATM activates p53 by regulating MDM2 oligomerization and E3 processivity. EMBO J (2009) 1.56
XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol (2004) 1.56
The Association of Biomolecular Resource Facilities Proteomics Research Group 2006 study: relative protein quantitation. Mol Cell Proteomics (2007) 1.53
Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell (2011) 1.53
Noble metals strip peptides from class II MHC proteins. Nat Chem Biol (2006) 1.53
Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther (2008) 1.53
Functional characterization of core promoter elements: DPE-specific transcription requires the protein kinase CK2 and the PC4 coactivator. Mol Cell (2005) 1.52
KIF4 regulates midzone length during cytokinesis. Curr Biol (2011) 1.51
Midbody assembly and its regulation during cytokinesis. Mol Biol Cell (2012) 1.50
Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A (2008) 1.50
How does a millimeter-sized cell find its center? Cell Cycle (2009) 1.48
The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly. Curr Biol (2002) 1.46
A new method reveals microtubule minus ends throughout the meiotic spindle. J Cell Biol (2006) 1.46
Microtubule plus-end dynamics in Xenopus egg extract spindles. Mol Biol Cell (2004) 1.45
Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol (2009) 1.44
Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. Biochemistry (2004) 1.44
Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol (2005) 1.43
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43