Published in J Exp Med on April 25, 2011
Transcriptional control of effector and memory CD8+ T cell differentiation. Nat Rev Immunol (2012) 4.44
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24
Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity (2011) 2.64
Bcl-6 directly represses the gene program of the glycolysis pathway. Nat Immunol (2014) 2.47
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol (2012) 2.26
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83
MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat Rev Immunol (2013) 1.75
Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol (2013) 1.71
T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol (2013) 1.70
Pathogen-induced inflammatory environment controls effector and memory CD8+ T cell differentiation. J Immunol (2011) 1.66
Helper T cell diversity and plasticity. Curr Opin Immunol (2012) 1.63
CD4⁺T cells: differentiation and functions. Clin Dev Immunol (2012) 1.56
Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol (2012) 1.36
The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity (2015) 1.20
Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease. J Allergy Clin Immunol (2013) 1.19
Insights into the role of Bcl6 in follicular Th cells using a new conditional mutant mouse model. J Immunol (2013) 1.14
T follicular helper cell diversity and plasticity. Trends Immunol (2013) 1.14
The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J Exp Med (2015) 1.09
Memory T follicular helper CD4 T cells. Front Immunol (2015) 1.06
IL-27 enhances the survival of tumor antigen-specific CD8+ T cells and programs them into IL-10-producing, memory precursor-like effector cells. Eur J Immunol (2013) 1.06
Helper T-cell identity and evolution of differential transcriptomes and epigenomes. Immunol Rev (2013) 1.05
Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol (2012) 1.03
CD8(+) T-cell effector function and transcriptional regulation during HIV pathogenesis. Immunol Rev (2013) 1.00
CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int Immunol (2016) 0.97
Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97
β-catenin/TCF-1 pathway in T cell development and differentiation. J Neuroimmune Pharmacol (2012) 0.97
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. J Clin Invest (2014) 0.96
Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation. Blood (2013) 0.93
Complex interactions of transcription factors in mediating cytokine biology in T cells. Immunol Rev (2014) 0.93
Transcription factor interplay in T helper cell differentiation. Brief Funct Genomics (2013) 0.92
ICOS and Bcl6-dependent pathways maintain a CD4 T cell population with memory-like properties during tuberculosis. J Exp Med (2015) 0.92
New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes. Curr Opin Immunol (2013) 0.91
T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol (2011) 0.88
Transcriptional regulatory networks for CD4 T cell differentiation. Curr Top Microbiol Immunol (2014) 0.86
Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4. J Immunol (2013) 0.85
The role of protein modifications of T-bet in cytokine production and differentiation of T helper cells. J Immunol Res (2014) 0.85
Autoreactive Tbet-positive CD4 T cells develop independent of classic Th1 cytokine signaling during experimental autoimmune encephalomyelitis. J Immunol (2011) 0.85
PRDM Proteins: Molecular Mechanisms in Signal Transduction and Transcriptional Regulation. Biology (Basel) (2013) 0.83
Single-cell profiling of lineage determining transcription factors in antigen-specific CD4(+) T cells reveals unexpected complexity in recall responses during immune reconstitution. Immunol Cell Biol (2017) 0.82
The role of IL-27 in the induction of anti-tumor cytotoxic T lymphocyte response. Am J Transl Res (2013) 0.80
Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes. Curr Top Microbiol Immunol (2014) 0.80
Impact of suppressing retinoic acid-related orphan receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity. Clin Exp Immunol (2015) 0.78
From a gene-centric to whole-proteome view of differentiation of T helper cell subsets. Brief Funct Genomics (2013) 0.78
Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory. J Immunol (2016) 0.77
Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells. Sci Rep (2015) 0.77
Human memory, but not naive, CD4+ T cells expressing transcription factor T-bet might drive rapid cytokine production. J Biol Chem (2014) 0.76
Identification of a novel mechanism of action of fingolimod (FTY720) on human effector T cell function through TCF-1 upregulation. J Neuroinflammation (2015) 0.76
Cross-talk between T and B Cells in the Germinal Center following Transplantation. Transplantation (2016) 0.75
Bcl6 Sets a Threshold for Antiviral Signaling by Restraining IRF7 Transcriptional Program. Sci Rep (2016) 0.75
T-bet overexpression regulates AHR-mediated Th-17 differentiation through an IFNγ-independent pathway. Clin Exp Immunol (2016) 0.75
Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases. J Transl Med (2015) 0.75
Regulators of Tfh Cell Differentiation. Front Immunol (2016) 0.75
T-bet Is Required for the Rapid Clearance of Attenuated Rabies Virus from Central Nervous System Tissue. J Immunol (2015) 0.75
IL-15 Complexes Induce Migration of Resting Memory CD8 T Cells into Mucosal Tissues. J Immunol (2017) 0.75
Bcl6 promotes follicular helper T-cell differentiation and PD-1 expression in a Blimp1-independent manner in mice. Eur J Immunol (2017) 0.75
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell (2006) 33.94
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell (1997) 12.68
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity (2009) 9.73
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 8.08
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity (2007) 6.48
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science (2010) 6.06
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection. Immunity (2009) 4.85
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol (2006) 4.81
Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties. Immunity (2009) 4.42
SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell (1999) 4.29
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91
Blimp-1 transcription factor is required for the differentiation of effector CD8(+) T cells and memory responses. Immunity (2009) 3.66
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
Heterogeneity and plasticity of T helper cells. Cell Res (2009) 3.09
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell (2010) 2.60
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity (2000) 2.54
Rapid and selective remodeling of a positioned nucleosome during the induction of IL-12 p40 transcription. Immunity (1999) 2.24
T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem (2006) 2.24
Regulation of TCRbeta gene assembly by a promoter/enhancer holocomplex. Immunity (2006) 2.23
Evolutionarily conserved sequence elements that positively regulate IFN-gamma expression in T cells. Proc Natl Acad Sci U S A (2004) 2.21
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med (2003) 2.20
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc Natl Acad Sci U S A (2003) 2.12
Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J Immunol (2002) 2.04
BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. Adv Immunol (2010) 2.03
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-gamma. Nat Immunol (2009) 1.99
Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function. Trends Immunol (2009) 1.89
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes. Proc Natl Acad Sci U S A (2009) 1.86
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev (2008) 1.79
Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. Oncogene (2006) 1.79
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons. Blood (1998) 1.68
Point mutations in BCL6 DNA-binding domain reveal distinct roles for the six zinc fingers. Biochem Biophys Res Commun (2003) 1.47
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol Cell Biol (2007) 1.28
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. Biochem Biophys Res Commun (2003) 1.27
Bcl6 controls granzyme B expression in effector CD8+ T cells. Eur J Immunol (2006) 1.24
Functional polymorphism in the suppressor of cytokine signaling 1 gene associated with adult asthma. Am J Respir Cell Mol Biol (2006) 1.23
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem (2002) 1.18
Evidence for association of the TCF7 locus with type I diabetes. Genes Immun (2009) 1.15
Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction. J Immunol (2004) 1.10
A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. Diabetes (2003) 1.09
Suppressor of cytokine signaling 3 (SOCS-3) protects beta -cells against interleukin-1beta - and interferon-gamma -mediated toxicity. Proc Natl Acad Sci U S A (2001) 1.08
CD4+ T cell plasticity-Th2 cells join the crowd. Immunity (2010) 1.02
Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression. J Immunol (2005) 1.02
SOCS-1 protein prevents Janus Kinase/STAT-dependent inhibition of beta cell insulin gene transcription and secretion in response to interferon-gamma. J Biol Chem (2001) 0.85
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat Immunol (2011) 2.76
Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression. Mol Cell (2010) 2.60
Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile. Nat Immunol (2012) 2.26
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
T-bet binding to newly identified target gene promoters is cell type-independent but results in variable context-dependent functional effects. J Biol Chem (2006) 2.24
T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med (2009) 1.86
Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expression. Genes Dev (2008) 1.79
NFATc2 and T-bet contribute to T-helper-cell-subset-specific regulation of IL-21 expression. Proc Natl Acad Sci U S A (2005) 1.45
A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature (2012) 1.44
Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors. Nat Rev Immunol (2012) 1.36
T-bet's ability to regulate individual target genes requires the conserved T-box domain to recruit histone methyltransferase activity and a separate family member-specific transactivation domain. Mol Cell Biol (2007) 1.28
Molecular mechanisms by which T-bet regulates T-helper cell commitment. Immunol Rev (2010) 1.07
Transcriptional mechanisms that regulate T helper 1 cell differentiation. Curr Opin Immunol (2012) 1.03
Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box, GATA and ROR families. Immunology (2009) 0.97
T-bet employs diverse regulatory mechanisms to repress transcription. Trends Immunol (2011) 0.88
Encoding stability versus flexibility: lessons learned from examining epigenetics in T helper cell differentiation. Curr Top Microbiol Immunol (2012) 0.84
Ikaros changes the face of NuRD remodeling. Nat Immunol (2011) 0.78
Multiple mutant T alleles cause haploinsufficiency of Brachyury and short tails in Manx cats. Mamm Genome (2013) 0.78
An essential interaction between T-box proteins and histone-modifying enzymes. Epigenetics (2009) 0.77
In vitro and in vivo characterization of a West Nile virus MAD78 infectious clone. Arch Virol (2014) 0.75