Published in Proc Natl Acad Sci U S A on January 21, 2005
The immune system in atherosclerosis. Nat Immunol (2011) 6.51
Immune and inflammatory mechanisms of atherosclerosis (*). Annu Rev Immunol (2009) 5.28
Atherosclerosis: current pathogenesis and therapeutic options. Nat Med (2011) 4.95
IL-33 reduces the development of atherosclerosis. J Exp Med (2008) 3.59
The IL-33/ST2 pathway: therapeutic target and novel biomarker. Nat Rev Drug Discov (2008) 2.90
B cell depletion reduces the development of atherosclerosis in mice. J Exp Med (2010) 2.79
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med (2006) 2.38
Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest (2012) 1.57
Adaptive immunity in atherosclerosis: mechanisms and future therapeutic targets. Nat Rev Cardiol (2011) 1.57
Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Am J Pathol (2008) 1.46
Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. Am J Pathol (2009) 1.44
The role of adaptive T cell immunity in atherosclerosis. J Lipid Res (2008) 1.43
Adaptive immunity in atherogenesis: new insights and therapeutic approaches. J Clin Invest (2013) 1.43
Innate and adaptive immunity in atherosclerosis. Semin Immunopathol (2009) 1.40
T-cell costimulation and coinhibition in atherosclerosis. Circ Res (2008) 1.32
Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotype. EMBO Mol Med (2012) 1.28
Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. J Clin Invest (2012) 1.27
CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis. Circ Res (2008) 1.26
Epigenetics in atherosclerosis and inflammation. J Cell Mol Med (2010) 1.21
Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia. Circulation (2011) 1.20
Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J Clin Invest (2007) 1.19
Genetic basis of atherosclerosis: insights from mice and humans. Circ Res (2012) 1.14
The influence of innate and adaptive immune responses on atherosclerosis. Annu Rev Pathol (2013) 1.13
The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm (2010) 1.07
T cells in atherosclerosis. Int Immunol (2013) 1.03
Mineralocorticoid receptors in immune cells: emerging role in cardiovascular disease. Steroids (2014) 1.01
CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe⁻(/)⁻ mice. BMC Immunol (2010) 1.00
Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation (2014) 0.99
Interleukin 17 in vascular inflammation. Cytokine Growth Factor Rev (2010) 0.98
T-helper type 1 bias in healthy people is associated with cytomegalovirus serology and atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc (2013) 0.98
Vaccination against atherosclerosis? Induction of atheroprotective immunity. Semin Immunopathol (2009) 0.97
Treating atherosclerosis with regulatory T cells. Arterioscler Thromb Vasc Biol (2014) 0.95
Lymphocytes in atherosclerosis. Arterioscler Thromb Vasc Biol (2015) 0.90
Beyond vascular inflammation--recent advances in understanding atherosclerosis. Cell Mol Life Sci (2015) 0.90
Cytokine network and T cell immunity in atherosclerosis. Semin Immunopathol (2009) 0.90
Macrophage differentiation and function in atherosclerosis: opportunities for therapeutic intervention? J Innate Immun (2012) 0.90
Elevated frequencies of circulating Th22 cell in addition to Th17 cell and Th17/Th1 cell in patients with acute coronary syndrome. PLoS One (2013) 0.89
Autoimmunity, infectious immunity, and atherosclerosis. J Clin Immunol (2009) 0.86
Attenuation of experimental atherosclerosis by interleukin-19. Arterioscler Thromb Vasc Biol (2013) 0.86
Circulating autoantibodies against the apolipoprotein B-100 peptides p45 and p210 in relation to the occurrence of carotid plaques in 64-year-old women. PLoS One (2015) 0.85
Antigen-induced immunomodulation in the pathogenesis of atherosclerosis. Clin Dev Immunol (2008) 0.85
Lymphocyte migration into atherosclerotic plaque. Arterioscler Thromb Vasc Biol (2014) 0.85
P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall. Trends Cardiovasc Med (2009) 0.84
Anti-inflammatory effects of interleukin-19 in vascular disease. Int J Inflam (2012) 0.84
T helper cell polarization in healthy people: implications for cardiovascular disease. J Cardiovasc Transl Res (2013) 0.82
The role of type 1 angiotensin receptors on T lymphocytes in cardiovascular and renal diseases. Curr Hypertens Rep (2013) 0.81
Vaccination to modulate atherosclerosis. Autoimmunity (2015) 0.81
Adaptive immunity and atherosclerosis: mouse tales in the AJP. Am J Pathol (2012) 0.81
Comprehensive insight into immune regulatory mechanisms and vascular wall determinants of atherogenesis - emerging perspectives of immunomodulation. Arch Med Sci (2013) 0.81
Inflammatory and autoimmune reactions in atherosclerosis and vaccine design informatics. J Biomed Biotechnol (2010) 0.80
Blockade of Tim-1 and Tim-4 Enhances Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice. Arterioscler Thromb Vasc Biol (2016) 0.79
IL-25 inhibits atherosclerosis development in apolipoprotein E deficient mice. PLoS One (2015) 0.79
Immunomodulation strategies for preventing vascular disease of the brain and heart: workshop summary. Stroke (2006) 0.79
Identifying genetic loci and spleen gene coexpression networks underlying immunophenotypes in BXD recombinant inbred mice. Physiol Genomics (2010) 0.79
Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Sci Rep (2015) 0.79
More than just a T-box: the role of T-bet as a possible biomarker and therapeutic target in autoimmune diseases. Immunotherapy (2011) 0.78
STAT4 deficiency reduces the development of atherosclerosis in mice. Atherosclerosis (2015) 0.77
The Role of Immunogenicity in Cardiovascular Disease. World Heart J (2011) 0.77
CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis. Circ Res (2016) 0.77
The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis. Int J Inflam (2016) 0.76
The immunology of atherosclerosis. Nat Rev Nephrol (2017) 0.75
Angiotensin II Promotes the Development of Carotid Atherosclerosis in Type 2 Diabetes Patients via Regulating the T Cells Activities: A Cohort Study. Med Sci Monit (2016) 0.75
Once Upon a Time: The Adaptive Immune Response in Atherosclerosis-a Fairy Tale No More. Mol Med (2015) 0.75
γδT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice. PLoS One (2014) 0.75
2015 Russell Ross Memorial Lecture in Vascular Biology: Protective Autoimmunity in Atherosclerosis. Arterioscler Thromb Vasc Biol (2016) 0.75
Cortistatin reduces atherosclerosis in hyperlipidemic ApoE-deficient mice and the formation of foam cells. Sci Rep (2017) 0.75
T-bet Promotes Acute Graft-versus-Host Disease by Regulating Recipient Hematopoietic Cells in Mice. J Immunol (2016) 0.75
T-Cells Specific for a Self-Peptide of ApoB-100 Exacerbate Aortic Atheroma in Murine Atherosclerosis. Front Immunol (2017) 0.75
Plaque Size Is Decreased but M1 Macrophage Polarization and Rupture Related Metalloproteinase Expression Are Maintained after Deleting T-Bet in ApoE Null Mice. PLoS One (2016) 0.75
Batf3-dependent CD8α(+) Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages. EBioMedicine (2017) 0.75
Interleukin-27 polymorphisms are associated with premature coronary artery disease and metabolic parameters in the Mexican population: the genetics of atherosclerotic disease (GEA) Mexican study. Oncotarget (2017) 0.75
Similarities in the Metabolic Reprogramming of Immune System and Endothelium. Front Immunol (2017) 0.75
Functional diversity of helper T lymphocytes. Nature (1996) 18.09
A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell (2000) 17.61
The lineage decisions of helper T cells. Nat Rev Immunol (2002) 10.61
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest (1993) 9.56
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med (2003) 4.47
Innate and acquired immunity in atherogenesis. Nat Med (2002) 4.22
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest (1997) 4.18
Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol (1989) 3.82
T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci U S A (1995) 3.54
Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity. J Clin Invest (2000) 3.51
Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature (1998) 3.31
Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis (1999) 3.21
Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J Clin Invest (1999) 2.81
T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A (2002) 2.63
Autoimmune and inflammatory mechanisms in atherosclerosis. Annu Rev Immunol (2004) 2.59
IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest (2004) 2.56
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A (2003) 2.34
Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J Clin Invest (1998) 2.27
T lymphocytes in human atherosclerotic plaques are memory cells expressing CD45RO and the integrin VLA-1. Arterioscler Thromb (1992) 2.09
T-cell subsets (Th1 versus Th2). Ann Allergy Asthma Immunol (2000) 2.08
Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice. Am J Pathol (1996) 1.88
Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouse. Arterioscler Thromb Vasc Biol (2003) 1.69
In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice. Circulation (2001) 1.69
IFN-gamma deficiency exerts gender-specific effects on atherogenesis in apolipoprotein E-/- mice. J Interferon Cytokine Res (2002) 1.58
Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Arterioscler Thromb Vasc Biol (1999) 1.57
Immunohistochemical detection of macrophages and T lymphocytes in atherosclerotic lesions of cholesterol-fed rabbits. Arterioscler Thromb (1991) 1.46
Effects of sex and age on atherosclerosis and autoimmunity in apoE-deficient mice. Atherosclerosis (1999) 1.38
B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Circulation (2004) 1.30
Autoimmunity to heat shock protein 60 and antigen-specific production of interleukin-10. Infect Immun (1997) 1.01
CD4+ T cells in atherosclerosis. Biomed Pharmacother (2003) 0.92
Co-stimulation and plaque-antigen-specific T-cell responses in atherosclerosis. Trends Cardiovasc Med (2004) 0.84
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol (2003) 11.17
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell (2008) 8.43
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell (2007) 8.42
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science (2002) 8.34
Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1. Nat Immunol (2003) 7.06
XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity (2004) 6.72
A comprehensive classification system for lipids. J Lipid Res (2005) 6.52
T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity (2004) 6.43
Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37
Molecular mechanisms regulating Th1 immune responses. Annu Rev Immunol (2001) 6.30
Regulation of hepatic lipogenesis by the transcription factor XBP1. Science (2008) 6.02
Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J Exp Med (2004) 5.13
Homeostasis and inflammation in the intestine. Cell (2010) 4.60
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol (2010) 4.56
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe (2010) 4.54
Proteasome inhibitors disrupt the unfolded protein response in myeloma cells. Proc Natl Acad Sci U S A (2003) 4.47
Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL. Nat Med (2003) 4.47
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha. Science (2006) 4.46
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat Immunol (2002) 4.38
Innate and acquired immunity in atherogenesis. Nat Med (2002) 4.22
Oxidized phospholipids, Lp(a) lipoprotein, and coronary artery disease. N Engl J Med (2005) 4.16
The endoplasmic reticulum stress response in immunity and autoimmunity. Nat Rev Immunol (2008) 4.09
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands. EMBO J (2005) 3.92
Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science (2002) 3.91
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol (2006) 3.70
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
Lipoprotein management in patients with cardiometabolic risk: consensus statement from the American Diabetes Association and the American College of Cardiology Foundation. Diabetes Care (2008) 3.65
Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress. Cell Metab (2010) 3.29
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res (2004) 3.24
Antigen-driven effector CD8 T cell function regulated by T-bet. Proc Natl Acad Sci U S A (2003) 3.23
Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARalpha, beta/delta, and gamma. J Clin Invest (2004) 3.23
The role of Th1/Th2 polarization in mucosal immunity. Nat Med (2002) 3.19
Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression. J Exp Med (2002) 3.16
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity (2003) 3.15
Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation. J Am Coll Cardiol (2008) 3.15
BAX inhibitor-1 is a negative regulator of the ER stress sensor IRE1alpha. Mol Cell (2009) 3.07
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev (2009) 3.03
T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood (2005) 2.95
Endothelial expression of PD-L1 and PD-L2 down-regulates CD8+ T cell activation and cytolysis. Eur J Immunol (2003) 2.91
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunity. Circ Res (2011) 2.89
Is the oxidative modification hypothesis relevant to human atherosclerosis? Do the antioxidant trials conducted to date refute the hypothesis? Circulation (2002) 2.80
B cell depletion reduces the development of atherosclerosis in mice. J Exp Med (2010) 2.79
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest (2009) 2.75
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol (2006) 2.73
Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3. Science (2006) 2.70
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol (2010) 2.68
Minimally modified LDL binds to CD14, induces macrophage spreading via TLR4/MD-2, and inhibits phagocytosis of apoptotic cells. J Biol Chem (2002) 2.66
Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature (2011) 2.64
T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A (2002) 2.63
IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest (2004) 2.56
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest (2007) 2.53
Critical role of IL-17RA in immunopathology of influenza infection. J Immunol (2009) 2.51
The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiol Rev (2011) 2.50
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest (2003) 2.48
Disease-specific molecular events in cortical multiple sclerosis lesions. Brain (2013) 2.48
Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome. Mol Cell (2009) 2.47
Toll-like receptor 4-dependent and -independent cytokine secretion induced by minimally oxidized low-density lipoprotein in macrophages. Arterioscler Thromb Vasc Biol (2005) 2.41
Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity (2013) 2.37
T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A (2003) 2.34
NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest (2008) 2.29
A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy. J Exp Med (2008) 2.26
Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes. Mol Cell (2004) 2.20
C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids. Proc Natl Acad Sci U S A (2002) 2.20
The X-box binding protein-1 transcription factor is required for plasma cell differentiation and the unfolded protein response. Immunol Rev (2003) 2.20
The transcription factor XBP-1 is essential for the development and survival of dendritic cells. J Exp Med (2007) 2.12
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res (2003) 2.12
Signaling pathways in Th2 development. Immunol Rev (2004) 2.10
Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A (2010) 2.10
Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med (2004) 2.10
T-bet in disease. Nat Immunol (2011) 2.09
Targeting APOC3 in the familial chylomicronemia syndrome. N Engl J Med (2014) 2.06
Generation and biological activities of oxidized phospholipids. Antioxid Redox Signal (2010) 2.04
Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia. N Engl J Med (2015) 2.03
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest (2010) 1.98
Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. Neuron (2012) 1.97
High-dose atorvastatin reduces total plasma levels of oxidized phospholipids and immune complexes present on apolipoprotein B-100 in patients with acute coronary syndromes in the MIRACL trial. Circulation (2004) 1.97
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell (2009) 1.95
Oxidative damage in multiple sclerosis lesions. Brain (2011) 1.95
The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling. Cell Host Microbe (2013) 1.91
Evidence mandating earlier and more aggressive treatment of hypercholesterolemia. Circulation (2008) 1.91
Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. Cell Metab (2012) 1.90
Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res (2009) 1.89
Lipid peroxidation is enhanced in patients with systemic lupus erythematosus and is associated with arterial and renal disease manifestations. Arthritis Rheum (2005) 1.89
T-bet controls autoaggressive CD8 lymphocyte responses in type 1 diabetes. J Exp Med (2004) 1.88
BAFF receptor deficiency reduces the development of atherosclerosis in mice--brief report. Arterioscler Thromb Vasc Biol (2012) 1.87
Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell (2011) 1.87