Published in J Biol Chem on December 08, 2002
Targeting DNA topoisomerase II in cancer chemotherapy. Nat Rev Cancer (2009) 5.06
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2. Carcinogenesis (2008) 3.19
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64
Numerical analysis of etoposide induced DNA breaks. PLoS One (2009) 1.13
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry (2008) 1.11
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
Physical interaction between replication protein A (RPA) and MRN: involvement of RPA2 phosphorylation and the N-terminus of RPA1. Biochemistry (2009) 1.07
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry (2011) 1.03
Nucleotide-resolution mapping of topoisomerase-mediated and apoptotic DNA strand scissions at or near an MLL translocation hotspot. Am J Hum Genet (2006) 1.00
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci U S A (2012) 0.99
Tyrosine phosphorylation controls nuclear export of Fyn, allowing Nrf2 activation of cytoprotective gene expression. FASEB J (2010) 0.98
Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2). J Biol Chem (2014) 0.91
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents. Proc Natl Acad Sci U S A (2003) 0.85
Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry (2011) 0.84
Moxifloxacin enhances antiproliferative and apoptotic effects of etoposide but inhibits its proinflammatory effects in THP-1 and Jurkat cells. Br J Cancer (2006) 0.83
Replication-dependent and transcription-dependent mechanisms of DNA double-strand break induction by the topoisomerase 2-targeting drug etoposide. PLoS One (2013) 0.83
Two novel determinants of etoposide resistance in small cell lung cancer. Cancer Res (2011) 0.82
Etoposide quinone is a covalent poison of human topoisomerase IIβ. Biochemistry (2014) 0.80
Molecular basis of the targeting of topoisomerase II-mediated DNA cleavage by VP16 derivatives conjugated to triplex-forming oligonucleotides. Nucleic Acids Res (2006) 0.80
Direct observation of strand passage by DNA-topoisomerase and its limited processivity. PLoS One (2012) 0.80
DNA-AP sites generation by etoposide in whole blood cells. BMC Cancer (2009) 0.80
DNA repair in Etoposide-induced DNA damage in lymphocytes of breast cancer patients and healthy women. Int J Clin Exp Med (2009) 0.80
Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha. Nucleic Acids Res (2003) 0.79
Changes in DNA methylation and transgenerational mobilization of a transposable element (mPing) by the topoisomerase II inhibitor, etoposide, in rice. BMC Plant Biol (2012) 0.79
DNA double-strand breaks with 5' adducts are efficiently channeled to the DNA2-mediated resection pathway. Nucleic Acids Res (2015) 0.78
Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex. Biochemistry (2011) 0.78
Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. Bioorg Med Chem (2013) 0.77
Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers. Bioorg Med Chem Lett (2014) 0.77
Toward discovering new anti-cancer agents targeting topoisomerase IIα: a facile screening strategy adaptable to high throughput platform. PLoS One (2014) 0.75
Manipulating DNA damage-response signaling for the treatment of immune-mediated diseases. Proc Natl Acad Sci U S A (2017) 0.75
Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5' Adducts. Genes (Basel) (2016) 0.75
Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons. PLoS Genet (2017) 0.75
Genome-wide TOP2A DNA cleavage is biased towards translocated and highly transcribed loci. Genome Res (2017) 0.75
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell (2012) 5.71
The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci U S A (2002) 3.71
DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med (2005) 3.06
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. J Med Chem (2005) 2.12
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J Biol Chem (2005) 1.68
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59
Mechanisms of camptothecin resistance by human topoisomerase I mutations. J Mol Biol (2004) 1.46
Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst) (2006) 1.41
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes. Curr Top Med Chem (2003) 1.36
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther (2006) 1.36
Mechanism of quinolone action and resistance. Biochemistry (2014) 1.34
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One (2010) 1.29
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proc Natl Acad Sci U S A (2012) 1.28
From music to macromolecules: using rich media/podcast lecture recordings to enhance the preclinical educational experience. Med Teach (2008) 1.22
Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res (2010) 1.21
1,4-Benzoquinone is a topoisomerase II poison. Biochemistry (2004) 1.21
Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic Acids Res (2008) 1.17
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem Res Toxicol (2008) 1.15
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1). J Biol Chem (2005) 1.12
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J Med Chem (2009) 1.12
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. Biochemistry (2006) 1.12
Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry (2006) 1.11
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood (2008) 1.11
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry (2008) 1.11
Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues. J Mol Biol (2004) 1.10
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry (2007) 1.10
Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification. Nucleic Acids Res (2011) 1.10
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol (2012) 1.09
Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain. Biochemistry (2008) 1.09
Topoisomerase II and leukemia. Ann N Y Acad Sci (2014) 1.04
Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from, tyrosine recombinases and type IB topoisomerases. J Biol Chem (2004) 1.04
Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. PLoS Genet (2013) 1.04
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance. Nucleic Acids Res (2013) 1.04
DNA Topology and Topoisomerases: Teaching a "Knotty" Subject. Biochem Mol Biol Educ (2008) 1.04
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry (2011) 1.03
Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. Chem Res Toxicol (2005) 1.02
Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry (2012) 1.02
Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme. Biochemistry (2005) 1.02
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry (2011) 1.01
N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. Biochemistry (2004) 1.01
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci U S A (2012) 0.99
Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. Mol Biol Cell (2008) 0.99
Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. Chem Res Toxicol (2008) 0.99
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. Biochemistry (2008) 0.99
Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry (2007) 0.98
The use of divalent metal ions by type II topoisomerases. Metallomics (2010) 0.98
Regulation of site-specific recombination by the C-terminus of lambda integrase. Nucleic Acids Res (2002) 0.97
Biological characterization of MLN944: a potent DNA binding agent. Mol Cancer Ther (2004) 0.97
Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2004) 0.97
Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry (2002) 0.97
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. ACS Chem Biol (2013) 0.96
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2005) 0.96
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Nucleic Acids Res (2007) 0.95
Artificial neural networks trained to detect viral and phage structural proteins. PLoS Comput Biol (2012) 0.95
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Nucleic Acids Res (2010) 0.94
Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I. Nucleic Acids Res (2004) 0.93
Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks. Nucleic Acids Res (2003) 0.92
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood (2009) 0.92
Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions. Biochemistry (2012) 0.90
Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex. J Biol Chem (2003) 0.89
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol (2007) 0.89
Uncoupling the chemical steps of telomere resolution by ResT. J Biol Chem (2005) 0.88
The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. Biochemistry (2008) 0.88
Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I. J Biol Chem (2004) 0.88
Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chem Biol Interact (2005) 0.88
Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage. Biochemistry (2003) 0.88
Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes. Biochemistry (2006) 0.86
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry (2009) 0.86
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Res (2011) 0.86
Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks. Radiat Res (2003) 0.86
Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes. Biochemistry (2005) 0.86
Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV. Biochemistry (2014) 0.85
Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry (2009) 0.85
Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease. Neurotherapeutics (2015) 0.84
Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα. Chem Res Toxicol (2014) 0.84
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Blood (2008) 0.84
Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry (2011) 0.84
Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα. J Biol Chem (2013) 0.83
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry (2009) 0.83
Small molecule allosteric modulators of phosphodiesterase 4. Handb Exp Pharmacol (2011) 0.82
First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA. Inorg Chem (2010) 0.82
Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism. Biochemistry (2014) 0.81
Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism. J Biol Chem (2002) 0.81
DNA ligation catalyzed by human topoisomerase II alpha. Biochemistry (2004) 0.81