Published in Biochemistry on October 16, 2008
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1,4-Benzoquinone is a topoisomerase II poison. Biochemistry (2004) 1.21
Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic Acids Res (2008) 1.17
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem Res Toxicol (2008) 1.15
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. Biochemistry (2006) 1.12
Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry (2006) 1.11
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood (2008) 1.11
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry (2008) 1.11
Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry (2007) 1.10
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DNA Topology and Topoisomerases: Teaching a "Knotty" Subject. Biochem Mol Biol Educ (2008) 1.04
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry (2011) 1.03
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Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry (2012) 1.02
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The use of divalent metal ions by type II topoisomerases. Metallomics (2010) 0.98
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Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2004) 0.97
Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry (2002) 0.97
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2005) 0.96
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. ACS Chem Biol (2013) 0.96
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Nucleic Acids Res (2007) 0.95
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Nucleic Acids Res (2010) 0.94
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood (2009) 0.92
Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks. Nucleic Acids Res (2003) 0.92
Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions. Biochemistry (2012) 0.90
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol (2007) 0.89
Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chem Biol Interact (2005) 0.88
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Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes. Biochemistry (2005) 0.86
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry (2009) 0.86
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Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry (2009) 0.85
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