Published in Nucleic Acids Res on July 24, 2008
Type IIA topoisomerase inhibition by a new class of antibacterial agents. Nature (2010) 3.58
DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition. Chem Rev (2009) 2.65
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64
Structural basis of gate-DNA breakage and resealing by type II topoisomerases. PLoS One (2010) 1.45
DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia. PLoS Negl Trop Dis (2013) 1.38
Effects of magnesium and related divalent metal ions in topoisomerase structure and function. Nucleic Acids Res (2009) 1.32
Probing the differential interactions of quinazolinedione PD 0305970 and quinolones with gyrase and topoisomerase IV. Antimicrob Agents Chemother (2009) 1.24
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance. Nucleic Acids Res (2013) 1.04
DNA Topology and Topoisomerases: Teaching a "Knotty" Subject. Biochem Mol Biol Educ (2008) 1.04
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry (2011) 1.01
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci U S A (2012) 0.99
The use of divalent metal ions by type II topoisomerases. Metallomics (2010) 0.98
Iron chelators with topoisomerase-inhibitory activity and their anticancer applications. Antioxid Redox Signal (2012) 0.91
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry (2009) 0.86
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Res (2011) 0.86
Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry (2009) 0.85
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry (2009) 0.83
Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage. Acc Chem Res (2011) 0.82
Arginine as a general acid catalyst in serine recombinase-mediated DNA cleavage. J Biol Chem (2013) 0.80
Recovery of the poisoned topoisomerase II for DNA religation: coordinated motion of the cleavage core revealed with the microsecond atomistic simulation. Nucleic Acids Res (2015) 0.75
Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site. Biochim Biophys Acta (2015) 0.75
Interactions between quinolones and Bacillus anthracis gyrase and the basis of drug resistance. Biochemistry (2017) 0.75
DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem (2001) 12.53
Cellular roles of DNA topoisomerases: a molecular perspective. Nat Rev Mol Cell Biol (2002) 11.79
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Nature (1998) 10.49
Structure and mechanism of DNA topoisomerase II. Nature (1996) 4.56
Cleavage of DNA by mammalian DNA topoisomerase II. J Biol Chem (1983) 3.05
Metal-ion coordination by U6 small nuclear RNA contributes to catalysis in the spliceosome. Nature (2000) 2.97
Tumor cell death induced by topoisomerase-targeting drugs. Annu Rev Pharmacol Toxicol (2001) 2.97
General acid catalysis by the hepatitis delta virus ribozyme. Nat Chem Biol (2005) 2.88
Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins. Nucleic Acids Res (1998) 2.82
Structural basis for gate-DNA recognition and bending by type IIA topoisomerases. Nature (2007) 2.79
Double strand DNA cleavage by type II DNA topoisomerase from Drosophila melanogaster. J Biol Chem (1983) 2.69
Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine. Q Rev Biophys (1998) 2.62
Etoposide, topoisomerase II and cancer. Curr Med Chem Anticancer Agents (2005) 2.49
Acids and bases. Science (1966) 2.47
Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae. J Biol Chem (1989) 2.33
Understanding the immutability of restriction enzymes: crystal structure of BglII and its DNA substrate at 1.5 A resolution. Nat Struct Biol (2000) 2.22
Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. Biochemistry (1993) 2.19
Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog Nucleic Acid Res Mol Biol (2000) 2.13
Investigating the biological functions of DNA topoisomerases in eukaryotic cells. Biochim Biophys Acta (1998) 2.06
Structural evidence for a two-metal-ion mechanism of group I intron splicing. Science (2005) 2.05
Stability constants of Mg2+ and Cd2+ complexes of adenine nucleotides and thionucleotides and rate constants for formation and dissociation of MgATP and MgADP. Biochemistry (1984) 2.01
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
Metal ion catalysis during splicing of premessenger RNA. Nature (1997) 1.94
Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates. J Mol Biol (1998) 1.78
The Tn7 transposase is a heteromeric complex in which DNA breakage and joining activities are distributed between different gene products. EMBO J (1996) 1.74
Involvement of a specific metal ion in the transition of the hammerhead ribozyme to its catalytic conformation. J Biol Chem (1997) 1.55
The role of metals in catalysis by the restriction endonuclease BamHI. Nat Struct Biol (1998) 1.55
Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly. J Am Chem Soc (2004) 1.55
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing. Nat Struct Mol Biol (2006) 1.55
Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule. Nature (2001) 1.54
Visualizing polynucleotide polymerase machines at work. EMBO J (2006) 1.52
Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form. Biochemistry (1987) 1.50
The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism. J Mol Biol (2002) 1.48
Spontaneous DNA lesions poison human topoisomerase IIalpha and stimulate cleavage proximal to leukemic 11q23 chromosomal breakpoints. Biochemistry (1997) 1.45
A novel endonuclease mechanism directly visualized for I-PpoI. Nat Struct Biol (1999) 1.43
Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome. Genes Dev (1999) 1.42
Regulation of DNA repair fidelity by molecular checkpoints: "gates" in DNA polymerase beta's substrate selection. Biochemistry (2006) 1.40
Thiophilic metal ion rescue of phosphorothioate interference within the Tetrahymena ribozyme P4-P6 domain. RNA (1999) 1.34
Structures of normal single-stranded DNA and deoxyribo-3'-S-phosphorothiolates bound to the 3'-5' exonucleolytic active site of DNA polymerase I from Escherichia coli. Biochemistry (1999) 1.31
Double-stranded DNA cleavage/religation reaction of eukaryotic topoisomerase II: evidence for a nicked DNA intermediate. Biochemistry (1989) 1.25
All three residues of the Tn 10 transposase DDE catalytic triad function in divalent metal ion binding. J Mol Biol (1999) 1.18
Interfacial inhibitors of protein-nucleic acid interactions. Curr Med Chem Anticancer Agents (2005) 1.15
PvuII endonuclease contains two calcium ions in active sites. J Mol Biol (2000) 1.12
Structural studies of E. coli topoisomerase III-DNA complexes reveal a novel type IA topoisomerase-DNA conformational intermediate. J Mol Biol (2007) 1.11
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry (2008) 1.11
A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine. J Biol Chem (1995) 1.08
Identification of an active site ligand for a group I ribozyme catalytic metal ion. Biochemistry (2002) 1.05
The cleavage of DNA at phosphorothioate internucleotidic linkages by DNA gyrase. Nucleic Acids Res (1992) 1.03
Role of the divalent cation in topoisomerase II mediated reactions. Biochemistry (1987) 1.00
Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2004) 0.97
Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry (2002) 0.97
A further investigation and reappraisal of the thio effect in the cleavage reaction catalyzed by a hammerhead ribozyme. Nucleic Acids Res (2000) 0.89
Leaving group stabilization by metal ion coordination and hydrogen bond donation is an evolutionarily conserved feature of group I introns. Biochim Biophys Acta (2001) 0.84
Topoisomerase II inhibitors. Cancer Chemother Biol Response Modif (2005) 0.81
Restriction endonucleases: one of these things is not like the others. Nat Struct Biol (2000) 0.79
Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell (2012) 5.71
The mechanism of topoisomerase I poisoning by a camptothecin analog. Proc Natl Acad Sci U S A (2002) 3.71
DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med (2005) 3.06
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64
Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex. J Med Chem (2005) 2.12
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J Biol Chem (2005) 1.68
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59
Mechanisms of camptothecin resistance by human topoisomerase I mutations. J Mol Biol (2004) 1.46
Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst) (2006) 1.41
A two-drug model for etoposide action against human topoisomerase IIalpha. J Biol Chem (2002) 1.38
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes. Curr Top Med Chem (2003) 1.36
A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Mol Cancer Ther (2006) 1.36
Mechanism of quinolone action and resistance. Biochemistry (2014) 1.34
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One (2010) 1.29
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proc Natl Acad Sci U S A (2012) 1.28
From music to macromolecules: using rich media/podcast lecture recordings to enhance the preclinical educational experience. Med Teach (2008) 1.22
Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res (2010) 1.21
1,4-Benzoquinone is a topoisomerase II poison. Biochemistry (2004) 1.21
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem Res Toxicol (2008) 1.15
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
Substrate specificity of tyrosyl-DNA phosphodiesterase I (Tdp1). J Biol Chem (2005) 1.12
Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography. J Med Chem (2009) 1.12
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. Biochemistry (2006) 1.12
Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry (2006) 1.11
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood (2008) 1.11
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry (2008) 1.11
Analysis of human tyrosyl-DNA phosphodiesterase I catalytic residues. J Mol Biol (2004) 1.10
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry (2007) 1.10
Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification. Nucleic Acids Res (2011) 1.10
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol (2012) 1.09
Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain. Biochemistry (2008) 1.09
Topoisomerase II and leukemia. Ann N Y Acad Sci (2014) 1.04
Catalytic residues of the telomere resolvase ResT: a pattern similar to, but distinct from, tyrosine recombinases and type IB topoisomerases. J Biol Chem (2004) 1.04
Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. PLoS Genet (2013) 1.04
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance. Nucleic Acids Res (2013) 1.04
DNA Topology and Topoisomerases: Teaching a "Knotty" Subject. Biochem Mol Biol Educ (2008) 1.04
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry (2011) 1.03
Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. Chem Res Toxicol (2005) 1.02
Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme. Biochemistry (2005) 1.02
Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry (2012) 1.02
N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. Biochemistry (2004) 1.01
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry (2011) 1.01
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci U S A (2012) 0.99
Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. Mol Biol Cell (2008) 0.99
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. Biochemistry (2008) 0.99
Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. Chem Res Toxicol (2008) 0.99
Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry (2007) 0.98
The use of divalent metal ions by type II topoisomerases. Metallomics (2010) 0.98
Regulation of site-specific recombination by the C-terminus of lambda integrase. Nucleic Acids Res (2002) 0.97
Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2004) 0.97
Biological characterization of MLN944: a potent DNA binding agent. Mol Cancer Ther (2004) 0.97
Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry (2002) 0.97
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. ACS Chem Biol (2013) 0.96
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2005) 0.96
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Nucleic Acids Res (2007) 0.95
Artificial neural networks trained to detect viral and phage structural proteins. PLoS Comput Biol (2012) 0.95
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Nucleic Acids Res (2010) 0.94
Design and synthesis of fluorescent substrates for human tyrosyl-DNA phosphodiesterase I. Nucleic Acids Res (2004) 0.93
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood (2009) 0.92
Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks. Nucleic Acids Res (2003) 0.92
Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions. Biochemistry (2012) 0.90
Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex. J Biol Chem (2003) 0.89
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol (2007) 0.89
Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I. J Biol Chem (2004) 0.88
Uncoupling the chemical steps of telomere resolution by ResT. J Biol Chem (2005) 0.88
The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. Biochemistry (2008) 0.88
Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chem Biol Interact (2005) 0.88
Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage. Biochemistry (2003) 0.88
Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks. Radiat Res (2003) 0.86
Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes. Biochemistry (2006) 0.86
Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes. Biochemistry (2005) 0.86
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry (2009) 0.86
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Res (2011) 0.86
Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV. Biochemistry (2014) 0.85
Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry (2009) 0.85
Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease. Neurotherapeutics (2015) 0.84
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Blood (2008) 0.84
Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry (2011) 0.84
Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα. Chem Res Toxicol (2014) 0.84
Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα. J Biol Chem (2013) 0.83
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry (2009) 0.83
Small molecule allosteric modulators of phosphodiesterase 4. Handb Exp Pharmacol (2011) 0.82
First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA. Inorg Chem (2010) 0.82
Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism. Biochemistry (2014) 0.81
DNA ligation catalyzed by human topoisomerase II alpha. Biochemistry (2004) 0.81
Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism. J Biol Chem (2002) 0.81
Etoposide quinone is a covalent poison of human topoisomerase IIβ. Biochemistry (2014) 0.80