Published in Biochemistry on June 15, 2004
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment. Carcinogenesis (2011) 1.26
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem Res Toxicol (2008) 1.15
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry (2007) 1.10
Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II. Nucleic Acids Res (2005) 1.06
Topoisomerase II and leukemia. Ann N Y Acad Sci (2014) 1.04
Evidence that humans metabolize benzene via two pathways. Environ Health Perspect (2009) 1.03
Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry (2012) 1.02
Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme. Biochemistry (2005) 1.02
Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. Chem Res Toxicol (2008) 0.99
Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2). J Biol Chem (2014) 0.91
Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons. Phytochem Rev (2014) 0.91
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol (2007) 0.89
Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry (2011) 0.84
Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα. Chem Res Toxicol (2014) 0.84
The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action. J Biol Chem (2012) 0.83
Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases. Biochemistry (2015) 0.82
Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism. Biochemistry (2014) 0.81
Etoposide quinone is a covalent poison of human topoisomerase IIβ. Biochemistry (2014) 0.80
Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases. Chem Res Toxicol (2013) 0.80
Topoisomerase II inhibition involves characteristic chromosomal expression patterns. BMC Genomics (2008) 0.78
Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα. Chem Res Toxicol (2016) 0.77
Synthesis and biological evaluation of phenanthrenes as cytotoxic agents with pharmacophore modeling and ChemGPS-NP prediction as topo II inhibitors. PLoS One (2012) 0.75
Inhibition of Glucose-6-Phosphate Dehydrogenase Could Enhance 1,4-Benzoquinone-Induced Oxidative Damage in K562 Cells. Oxid Med Cell Longev (2016) 0.75
Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα. Bioorg Med Chem Lett (2016) 0.75
Cleavage of plasmid DNA by eukaryotic topoisomerase II. Methods Mol Biol (2009) 0.75
Environmental and chemotherapeutic agents induce breakage at genes involved in leukemia-causing gene rearrangements in human hematopoietic stem/progenitor cells. Mutat Res (2015) 0.75
Long-term effects of chromatin remodeling and DNA damage in stem cells induced by environmental and dietary agents. J Environ Pathol Toxicol Oncol (2013) 0.75
A mechanism for 1,4-Benzoquinone-induced genotoxicity. Oncotarget (2016) 0.75
Thiols oxidation and covalent binding of BSA by cyclolignanic quinones are enhanced by the magnesium cation. Free Radic Res (2008) 0.75
Cadmium is a catalytic inhibitor of DNA topoisomerase II. J Inorg Biochem (2011) 0.75
Genome-wide TOP2A DNA cleavage is biased towards translocated and highly transcribed loci. Genome Res (2017) 0.75
DNA topoisomerase II in therapy-related acute promyelocytic leukemia. N Engl J Med (2005) 3.06
The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothing. Nucleic Acids Res (2008) 2.64
The molecular basis of leukemia. Hematology Am Soc Hematol Educ Program (2004) 2.23
DNA topoisomerase II, genotoxicity, and cancer. Mutat Res (2007) 1.95
Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Blood (2004) 1.90
Human topoisomerase IIalpha rapidly relaxes positively supercoiled DNA: implications for enzyme action ahead of replication forks. J Biol Chem (2005) 1.68
A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature (2010) 1.59
Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children. Blood (2002) 1.46
Topoisomerase II and the etiology of chromosomal translocations. DNA Repair (Amst) (2006) 1.41
Maternal diet and infant leukemia: the DNA topoisomerase II inhibitor hypothesis: a report from the children's oncology group. Cancer Epidemiol Biomarkers Prev (2005) 1.39
A two-drug model for etoposide action against human topoisomerase IIalpha. J Biol Chem (2002) 1.38
Stabilization of eukaryotic topoisomerase II-DNA cleavage complexes. Curr Top Med Chem (2003) 1.36
Mechanism of quinolone action and resistance. Biochemistry (2014) 1.34
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One (2010) 1.29
Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study. Blood (2011) 1.25
Abundant anti-apoptotic BCL-2 is a molecular target in leukaemias with t(4;11) translocation. Br J Haematol (2008) 1.24
From music to macromolecules: using rich media/podcast lecture recordings to enhance the preclinical educational experience. Med Teach (2008) 1.22
Metnase promotes restart and repair of stalled and collapsed replication forks. Nucleic Acids Res (2010) 1.21
Human topoisomerase IIalpha uses a two-metal-ion mechanism for DNA cleavage. Nucleic Acids Res (2008) 1.17
(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerases. Chem Res Toxicol (2008) 1.15
Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate. Nucleic Acids Res (2002) 1.15
The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs. Biochemistry (2006) 1.12
Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate. Biochemistry (2006) 1.11
Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis. Blood (2008) 1.11
Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha. Biochemistry (2008) 1.11
Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405. Biochemistry (2007) 1.10
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification. Nucleic Acids Res (2011) 1.10
Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol (2012) 1.09
Bimodal recognition of DNA geometry by human topoisomerase II alpha: preferential relaxation of positively supercoiled DNA requires elements in the C-terminal domain. Biochemistry (2008) 1.09
The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis. PLoS One (2008) 1.05
Topoisomerase II and leukemia. Ann N Y Acad Sci (2014) 1.04
Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. PLoS Genet (2013) 1.04
Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance. Nucleic Acids Res (2013) 1.04
DNA Topology and Topoisomerases: Teaching a "Knotty" Subject. Biochem Mol Biol Educ (2008) 1.04
Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry (2011) 1.03
Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison. Chem Res Toxicol (2005) 1.02
Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme. Biochemistry (2005) 1.02
Oxidative metabolites of curcumin poison human type II topoisomerases. Biochemistry (2012) 1.02
N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. Biochemistry (2004) 1.01
Drug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance. Biochemistry (2011) 1.01
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci U S A (2012) 0.99
Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition. Mol Biol Cell (2008) 0.99
Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity. Biochemistry (2008) 0.99
Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement. Chem Res Toxicol (2008) 0.99
Potent obatoclax cytotoxicity and activation of triple death mode killing across infant acute lymphoblastic leukemia. Blood (2013) 0.99
Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry (2007) 0.98
Proteomics-based strategy to identify biomarkers and pharmacological targets in leukemias with t(4;11) translocations. J Proteome Res (2006) 0.98
The use of divalent metal ions by type II topoisomerases. Metallomics (2010) 0.98
Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2004) 0.97
Biological characterization of MLN944: a potent DNA binding agent. Mol Cancer Ther (2004) 0.97
Site-specific DNA cleavage by Chlorella virus topoisomerase II. Biochemistry (2002) 0.97
Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6. Proc Natl Acad Sci U S A (2002) 0.96
Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. ACS Chem Biol (2013) 0.96
Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry (2005) 0.96
Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal. Nucleic Acids Res (2007) 0.95
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I. Nucleic Acids Res (2010) 0.94
Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth. J Biol Chem (2009) 0.93
Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos (2004) 0.93
JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Mol Cell Biol (2005) 0.92
Yeast recombination pathways triggered by topoisomerase II-mediated DNA breaks. Nucleic Acids Res (2003) 0.92
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia. Blood (2009) 0.92
Amsacrine as a topoisomerase II poison: importance of drug-DNA interactions. Biochemistry (2012) 0.90
Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate. Chem Res Toxicol (2007) 0.89
The efficacy of topoisomerase II-targeted anticancer agents reflects the persistence of drug-induced cleavage complexes in cells. Biochemistry (2008) 0.88
Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites. Chem Biol Interact (2005) 0.88
Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage. Biochemistry (2003) 0.88
Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences. Methods Mol Biol (2009) 0.87
Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Res (2011) 0.86
Chlorella virus Marburg topoisomerase II: high DNA cleavage activity as a characteristic of Chlorella virus type II enzymes. Biochemistry (2005) 0.86
Activation of the DNA-dependent protein kinase by drug-induced and radiation-induced DNA strand breaks. Radiat Res (2003) 0.86
Ability of viral topoisomerase II to discern the handedness of supercoiled DNA: bimodal recognition of DNA geometry by type II enzymes. Biochemistry (2006) 0.86
Use of divalent metal ions in the dna cleavage reaction of human type II topoisomerases. Biochemistry (2009) 0.86
Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV. Biochemistry (2014) 0.85
Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons. Biochemistry (2009) 0.85
p53 mutations in leukemia and myelodysplastic syndrome after ovarian cancer. Clin Cancer Res (2002) 0.85
Etoposide quinone is a redox-dependent topoisomerase II poison. Biochemistry (2011) 0.84
Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα. Chem Res Toxicol (2014) 0.84
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Blood (2008) 0.84
Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. Biochemistry (2009) 0.83
Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα. J Biol Chem (2013) 0.83
First ruthenium organometallic complex of antibacterial agent ofloxacin. Crystal structure and interactions with DNA. Inorg Chem (2010) 0.82
Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide. Clin Cancer Res (2004) 0.82
Human topoisomerase IIalpha possesses an intrinsic nucleic acid specificity for DNA ligation. Use of 5' covalently activated oligonucleotide substrates to study enzyme mechanism. J Biol Chem (2002) 0.81
Characterization of an etoposide-glutathione conjugate derived from metabolic activation by human cytochrome p450. Curr Drug Metab (2006) 0.81
Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism. Biochemistry (2014) 0.81
DNA ligation catalyzed by human topoisomerase II alpha. Biochemistry (2004) 0.81
Etoposide quinone is a covalent poison of human topoisomerase IIβ. Biochemistry (2014) 0.80
Intensified chemotherapy without SCT in infant ALL: results from COG P9407 (Cohort 3). Pediatr Blood Cancer (2014) 0.80
Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases. Chem Res Toxicol (2013) 0.80