Published in Neurobiol Aging on January 14, 2012
Klotho as a potential biomarker and therapy for acute kidney injury. Nat Rev Nephrol (2012) 1.06
Renal and extrarenal actions of Klotho. Semin Nephrol (2013) 1.04
The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem (2014) 1.00
α-Klotho protects against oxidative damage in pulmonary epithelia. Am J Physiol Lung Cell Mol Physiol (2014) 1.00
Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J Neurosci (2015) 0.91
Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood. Brain Res (2013) 0.87
Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients. J Neuroinflammation (2013) 0.83
The anti-aging and tumor suppressor protein Klotho enhances differentiation of a human oligodendrocytic hybrid cell line. J Mol Neurosci (2014) 0.82
Development and characterization of monoclonal antibodies to detect klotho. Monoclon Antib Immunodiagn Immunother (2014) 0.78
Altered KLOTHO and NF-κB-TNF-α Signaling Are Correlated with Nephrectomy-Induced Cognitive Impairment in Rats. PLoS One (2015) 0.78
Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression. PLoS One (2015) 0.77
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The age-regulating protein klotho is vital to sustain retinal function. Invest Ophthalmol Vis Sci (2013) 0.76
Klotho and fibroblast growth factor 23 in cerebrospinal fluid in children. J Bone Miner Metab (2016) 0.75
Novel functions of circulating Klotho. Bone (2016) 0.75
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Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature (2006) 9.40
Suppression of aging in mice by the hormone Klotho. Science (2005) 8.11
FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res (2003) 6.81
Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem (2006) 6.50
Augmented Wnt signaling in a mammalian model of accelerated aging. Science (2007) 5.62
Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett (2004) 4.02
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol (2007) 3.73
The beta-glucuronidase klotho hydrolyzes and activates the TRPV5 channel. Science (2005) 3.59
Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proc Natl Acad Sci U S A (2007) 3.13
Regulation of oxidative stress by the anti-aging hormone klotho. J Biol Chem (2005) 2.94
Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. FASEB J (2010) 2.91
Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun (2000) 2.90
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A (2008) 2.62
Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct (2004) 2.28
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene (2008) 1.97
Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol (2009) 1.75
Klotho protein protects against endothelial dysfunction. Biochem Biophys Res Commun (1998) 1.74
Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun (2005) 1.68
Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol (2011) 1.55
Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress. FASEB J (2002) 1.52
Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS Lett (2009) 1.45
Oxidative stress decreases klotho expression in a mouse kidney cell line. Nephron Exp Nephrol (2005) 1.44
Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Cell Mol Life Sci (2000) 1.42
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A (2010) 1.38
Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells. Mol Biol Cell (1996) 1.24
Regulation of multiple ageing-like phenotypes by inducible klotho gene expression in klotho mutant mice. Mech Ageing Dev (2005) 1.19
Expression of Klotho protein in the inner ear. Hear Res (2002) 0.96
Calbindin-D28k in nerve cell nuclei. Neuroscience (1997) 0.85
FGF23 induces left ventricular hypertrophy. J Clin Invest (2011) 7.22
A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (2007) 6.64
SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (2002) 5.69
An isolated pool of vesicles recycles at rest and drives spontaneous neurotransmission. Neuron (2005) 4.05
Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. J Biol Chem (2005) 3.06
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RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell (2011) 2.90
Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci U S A (2004) 2.62
Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1. Proc Natl Acad Sci U S A (2008) 2.62
Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44
Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell (2013) 2.39
Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nat Cell Biol (2004) 2.11
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A (2007) 2.08
Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A (2003) 2.07
Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A. J Cell Biol (2003) 2.02
Development of vesicle pools during maturation of hippocampal synapses. J Neurosci (2002) 1.87
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. J Cell Biol (2009) 1.80
Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A (2007) 1.74
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging. Blood (2006) 1.71
Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice. J Clin Invest (2013) 1.66
Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc Natl Acad Sci U S A (2011) 1.63
Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission. J Neurosci (2010) 1.62
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Proc Natl Acad Sci U S A (2002) 1.62
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci (2006) 1.61
Fast vesicle recycling supports neurotransmission during sustained stimulation at hippocampal synapses. J Neurosci (2002) 1.59
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell (2013) 1.56
FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis. J Cell Biol (2008) 1.53
The Klotho gene family as a regulator of endocrine fibroblast growth factors. Mol Cell Endocrinol (2008) 1.47
Delayed caffeine treatment prevents nigral dopamine neuron loss in a progressive rat model of Parkinson's disease. Exp Neurol (2012) 1.46
Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission. J Neurophysiol (2007) 1.43
Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors. J Cell Sci (2013) 1.38
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis. Proc Natl Acad Sci U S A (2010) 1.38
Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling. J Physiol (2006) 1.35
Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. J Neurosci (2002) 1.33
Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. EMBO J (2003) 1.29
Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. J Cell Biol (2006) 1.28
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart. Nat Commun (2012) 1.25
Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease. J Neurosci (2008) 1.24
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron (2009) 1.23
Transgenic mice expressing variants of complement factor H develop AMD-like retinal findings. Invest Ophthalmol Vis Sci (2010) 1.17
Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One (2010) 1.10
Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery. J Neurosci (2009) 1.06
Progressively reduced synaptic vesicle pool size in cultured neurons derived from neuronal ceroid lipofuscinosis-1 knockout mice. Neurobiol Dis (2005) 1.04
Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway. Proc Natl Acad Sci U S A (2006) 1.03
Mouse models for Usher syndrome 1B. Adv Exp Med Biol (2003) 0.97
Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands. Mol Cell Biol (2012) 0.96
Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections. Nat Neurosci (2012) 0.96
Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. J Biol Chem (2012) 0.96
The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice. Eur J Pharmacol (2012) 0.96
Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions. Proteome Sci (2011) 0.94
Hyperaldosteronism in Klotho-deficient mice. Am J Physiol Renal Physiol (2010) 0.94
Silibinin inhibits the toxic aggregation of human islet amyloid polypeptide. Biochem Biophys Res Commun (2012) 0.93
A survivin-mediated oncolytic adenovirus induces non-apoptotic cell death in lung cancer cells and shows antitumoral potential in vivo. J Gene Med (2006) 0.90
Massive Ca-induced membrane fusion and phospholipid changes triggered by reverse Na/Ca exchange in BHK fibroblasts. J Gen Physiol (2008) 0.89
Coffee components inhibit amyloid formation of human islet amyloid polypeptide in vitro: possible link between coffee consumption and diabetes mellitus. J Agric Food Chem (2011) 0.88
Minimum essential factors required for vesicle mobilization at hippocampal synapses. J Neurosci (2004) 0.87
Endocrine fibroblast growth factors as regulators of metabolic homeostasis. Biofactors (2009) 0.87
Membrane adhesion dictates Golgi stacking and cisternal morphology. Proc Natl Acad Sci U S A (2014) 0.86
Protective roles of DMP1 in high phosphate homeostasis. PLoS One (2012) 0.86
Synergistic antitumor effect of TRAIL and IL-24 with complete eradication of hepatoma in the CTGVT-DG strategy. Acta Biochim Biophys Sin (Shanghai) (2012) 0.85
Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Novartis Found Symp (2004) 0.85
Differential spatial and temporal phosphorylation of the visual receptor, rhodopsin, at two primary phosphorylation sites in mice exposed to light. Biochem J (2003) 0.84
Accelerated suicidal erythrocyte death in Klotho-deficient mice. Pflugers Arch (2009) 0.83
Alteration in N-glycomics during mouse aging: a role for FUT8. Aging Cell (2011) 0.83
Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis. Gastroenterology (2013) 0.82
Pin1 null mice exhibit low bone mass and attenuation of BMP signaling. PLoS One (2013) 0.82
Fluorescence-based analysis of cellular protein lysate arrays using quantum dots. Methods Mol Biol (2007) 0.79
Cancer targeting gene-viro-therapy specific for liver cancer by α-fetoprotein-controlled oncolytic adenovirus expression of SOCS3 and IL-24. Acta Biochim Biophys Sin (Shanghai) (2011) 0.79
Structural organization and function of mouse photoreceptor ribbon synapses involve the immunoglobulin protein synaptic cell adhesion molecule 1. J Comp Neurol (2014) 0.79
Hyperspectral imaging and characterization of live cells by broadband coherent anti-Stokes Raman scattering (CARS) microscopy with singular value decomposition (SVD) analysis. Appl Spectrosc (2014) 0.79
Suppression of colorectal tumor growth by regulated survivin targeting. J Mol Med (Berl) (2006) 0.78
Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. J Clin Invest (2015) 0.77
Amadori products promote cellular senescence activating insulin-like growth factor-1 receptor and down-regulating the antioxidant enzyme catalase. Int J Biochem Cell Biol (2013) 0.76
Amyloidogenicity of p53: a hidden link between protein misfolding and cancer. Curr Protein Pept Sci (2015) 0.75
Extent of Serosal Changes Predicts Peritoneal Recurrence and Poor Prognosis After Curative Surgery for Gastric Cancer. Medicine (Baltimore) (2015) 0.75
Distribution, sources and ecological risk of polycyclic aromatic hydrocarbons in the estuarine-coastal sediments in the East China Sea. Environ Sci Process Impacts (2017) 0.75
High-frequency background modulation fringe patterns based on a fringe-wavelength geometry-constraint model for 3D surface-shape measurement. Opt Express (2017) 0.75
Strongly coupled excitonic states in H-aggregated single crystalline nanoparticles of 2,5-bis(4-methoxybenzylidene) cyclopentanone. J Phys Chem B (2008) 0.75
Investigation into atmospheric PM2.5-borne PAHs in Eastern cities of China: concentration, source diagnosis and health risk assessment. Environ Sci Process Impacts (2016) 0.75
Correction: Central Presynaptic Terminals Are Enriched in ATP but the Majority Lack Mitochondria. PLoS One (2017) 0.75
Analysis of the relationship between fringe angle and three-dimensional profilometry system sensitivity. Appl Opt (2014) 0.75
Distribution and sources of solvent extractable organic compounds in PM2.5 during 2007 Chinese Spring Festival in Beijing. J Environ Sci (China) (2009) 0.75
Central vascular catheter insertion in the NICU: a Lean approach. Neonatal Netw (2014) 0.75